Telomere maintenance as a target for anticancer drug discovery

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Nature reviews. Drug discovery

• Publication date

  2002-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrd793PMID 12120414
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

  2002cited by this paper
• RHO–GTPases and cancer

  2002cited by this paper
• A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.

  2002cited by this paper
• Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate*

  2002cited by this paper
• c-myc Suppression in Burkitt's lymphoma cells.

  2002cited by this paper
• Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands

  2002cited by this paper
• Perylene diimide G-quadruplex DNA binding selectivity is mediated by ligand aggregation.

  2002cited by this paper
• Bcr-Abl inhibition as a modality of CML therapeutics.

  2001cited by this paper
• Selective interactions of cationic porphyrins with G-quadruplex structures.

  2001cited by this paper
• Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.

  2001cited by this paper
• Fluorescence Resonance Energy Transfer as a Probe for G‐Quartet Formation by a Telomeric Repeat

  2001cited by this paper
• G-Quadruplex DNA Structures Variations on a Theme

  2001cited by this paper
• Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes.

  2001cited by this paper
• Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus.

  2001cited by this paper
• Switching and signaling at the telomere.

  2001cited by this paper
• G-quadruplex DNA: A Potential Target for Anti-cancer Drug Design

  2001cited by this paper
• A highly selective telomerase inhibitor limiting human cancer cell proliferation

  2001cited by this paper
• Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.

  2001cited by this paper
• TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression*

  2001cited by this paper
• G-quadruplex DNA binding by a series of carbocyanine dyes.

  2001cited by this paper
• Telomerase and cancer: time to move from a promising target to a clinical reality

  2001cited by this paper
• Stable Association of hsp90 and p23, but Not hsp70, with Active Human Telomerase*

  2001cited by this paper
• Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

  2001cited by this paper
• Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule*

  2001cited by this paper
• Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.

  2001cited by this paper
• Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.

  2001cited by this paper
• Cleavage of telomeric G-quadruplex DNA with perylene-EDTA*Fe(II).

  2001cited by this paper
• The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability.

  2001cited by this paper
• Recognition and stabilization of quadruplex DNA by a potent new telomerase inhibitor: NMR studies of the 2:1 complex of a pentacyclic methylacridinium cation with d(TTAGGGT)4

  2001cited by this paper
• T‐loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang

  2001cited by this paper
• Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

  2001cited by this paper
• Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

  2001cited by this paper
• Structural characterization of a guanine-quadruplex ligand complex.

  2000cited by this paper
• Telomere maintenance by recombination in human cells

  2000cited by this paper
• G-Quadruplex DNA as a target for drug design.

  2000cited by this paper
• Identification of human Rap1: implications for telomere evolution.

  2000cited by this paper
• Telomere fusions caused by mutating the terminal region of telomeric DNA.

  2000cited by this paper
• Secondary structure of vertebrate telomerase RNA.

  2000cited by this paper
• Ku acts in a unique way at the mammalian telomere to prevent end joining.

  2000cited by this paper
• Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang*

  2000cited by this paper
• G-quadruplex DNA: a potential target for anti-cancer drug design.

  2000cited by this paper
• Telomere maintenance mechanisms as a target for drug development

  2000cited by this paper
• Telomerase inhibition by peptide nucleic acids reverses `immortality' of transformed human cells

  1999cited by this paper
• Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.

  1999cited by this paper
• Creation of human tumour cells with defined genetic elements

  1999cited by this paper
• 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.

  1999cited by this paper
• Inhibition of telomerase limits the growth of human cancer cells

  1999cited by this paper
• Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.

  1999cited by this paper
• Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.

  1999cited by this paper
• p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.

  1999cited by this paper
• Four-dimensional control of the cell cycle

  1999cited by this paper
• Accelerated assembly of G-quadruplex structures by a small molecule.

  1999cited by this paper
• TIN2, a new regulator of telomere length in human cells

  1999cited by this paper
• Direct activation of TERT transcription by c-MYC

  1999cited by this paper
• Human telomerase inhibition by substituted acridine derivatives.

  1999cited by this paper
• Mammalian telomeres end in a large duplex loop.

  1999cited by this paper
• Telomerase and the maintenance of chromosome ends.

  1999cited by this paper
• Telomerase assay using biotinylated-primer extension and magnetic separation of the products.

  1998cited by this paper
• The Bloom’s Syndrome Helicase Unwinds G4 DNA*

  1998cited by this paper
• TRF2 protects human telomeres from end-to-end fusions.

  1998cited by this paper
• Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

  1998cited by this paper
• Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.

  1998cited by this paper
• Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.

  1998cited by this paper
• G-quadruplex DNA: A target for drug design

  1998cited by this paper
• Inhibition of human telomerase by 2'-O-methyl-RNA.

  1998cited by this paper
• NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

  1998cited by this paper
• Normal human chromosomes have long G-rich telomeric overhangs at one end.

  1997cited by this paper
• Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning.

  1997cited by this paper
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

  1997cited by this paper
• Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

  1997cited by this paper
• Control of telomere length by the human telomeric protein TRF1

  1997cited by this paper
• The terminal DNA structure of mammalian chromosomes

  1997cited by this paper
• hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.

  1997cited by this paper
• Telomerase catalytic subunit homologs from fission yeast and human.

  1997cited by this paper
• Inhibition of human telomerase by a G-quadruplex-interactive compound.

  1997cited by this paper
• Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.

  1996cited by this paper
• The RNA component of human telomerase

  1995cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex.

  1993cited by this paper
• Interaction of the dye ethidium bromide with DNA containing guanine repeats.

  1992cited by this paper
• Inhibition of telomerase by G-quartet DMA structures

  1991cited by this paper
• Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.

  1985cited by this paper
• STRUCTURE—ACTIVITY RELATIONSHIPS

  1958cited by this paper

• An antiparallel G-quadruplex structure with a 5'-end overhang forms predominantly at the human telomeric ds-ss DNA junction.

  2025cites this paper
• Probing Residual Water in G‑Quadruplex Structures through Molecular Vibrations

  2025cites this paper
• Synthesis and Molecular Dynamic Simulation of Novel Cationic and Non-cationic Pyrimidine Derivatives as Potential G-quadruplex-ligands.

  2024cites this paper
• Synthesis of 1,10‐Phenanthroline‐2,9‐bistriazoles: Evaluation as G‐Quadruplex Binders and Anti‐Tumor Activity

  2024cites this paper
• Solution structures and effects of a platinum compound successively bound MYC G-quadruplex

  2024cites this paper
• Benzimidazole-based small molecules as anticancer agents targeting telomeric G-quadruplex and inhibiting telomerase enzyme.

  2024cites this paper
• A Modular Engineered DNA Nanodevice for Precise Profiling of Telomerase RNA Location and Activity

  2024cites this paper
• Binding of berberine derivates to G-quadruplex: insight from a computational study.

  2023cites this paper
• Stability of Human Telomeric G-Quadruplexes Complexed with Photosensitive Ligands and Irradiated with Visible Light

  2023cites this paper
• New triazole-attached quinoxalines selectively recognize the telomeric multimeric G-quadruplexes and inhibit breast cancer cell growth.

  2023cites this paper
• In vivo dynamics and regulation of DNA G-quadruplex structures in mammals

  2023cites this paper
• G-Quadruplexes in Human Telomere: Structures, Properties, and Applications

  2023cites this paper
• Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A review

  2022cites this paper
• Facile induction and stabilization of intramolecular antiparallel G-quadruplex of d(TTAGGG)n on interaction with triazine-2-imidazole ethyl amine compound and its Cu(II), Zn(II) complexes under no-salt conditions

  2022cites this paper
• Solvent Vibrations as a Proxy of the Telomere G-Quadruplex Rearrangements across Thermal Unfolding

  2022cites this paper
• Retracted: G-quadruplex structural transition driven by a platinum compound

  2022cites this paper
• DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting.

  2022cites this paper
• Targeting G-Quadruplex Dna For Cancer Chemotherapy.

  2022cites this paper
• Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space

  2022cites this paper
• An atomistic investigation on the interaction of distamycin A and its derivative with the telomeric G-Quadruplex as anticancer agents by molecular dynamics simulation.

  2021cites this paper
• G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands

  2021cites this paper
• Characterization of In Vitro G-Quadruplex Formation of Imetelstat Telomerase Inhibitor

  2021cites this paper
• Frontiers in G‐Quadruplex therapeutics in cancer: Selection of small molecules, peptides and aptamers

  2021cites this paper
• Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.

  2021cites this paper
• NLDock: a Fast Nucleic Acid-Ligand Docking Algorithm for Modeling RNA/DNA-Ligand Complexes

  2021cites this paper
• Transcriptional regulation of telomeric repeat-containing RNA by acridine derivatives

  2021cites this paper
• Identification of a non-planar imidazole-cored small molecule for selective telomeric G4 DNA targeting

  2021cites this paper
• G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy.

  2021cites this paper
• Estudos de modelagem molecular na caracterização da interação entre o domínio de ligação da colchicina da αβ-tubulina e agentes antitumorais

  2021cites this paper
• The regulation and functions of DNA and RNA G-quadruplexes

  2020cites this paper
• Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug adriamycin

  2020cites this paper
• Functional G-Quadruplex Binding Molecules

  2020cites this paper
• Quadruplex targets in neurodegenerative diseases

  2020cites this paper
• Artificial Metalloenzymes: Recent Developments and Innovations in Bioinorganic Catalysis.

  2020cites this paper
• Screening the binding potential of quercetin with parallel, antiparallel and mixed G-quadruplexes of human telomere and cancer protooncogenes using molecular docking approach

  2020cites this paper
• Structural basis for stabilization of human telomeric G-quadruplex [d-(TTAGGGT)]4 by anticancer drug epirubicin.

  2020cites this paper
• Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells

  2020cites this paper
• Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci

  2020cites this paper
• The solution structures of higher-order human telomere G-quadruplex multimers

  2020cites this paper
• Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

  2020cites this paper
• Characterization of G-quadruplex antibody reveals differential specificity for G4 DNA forms

  2020cites this paper
• Polymorphism of human telomeric quadruplexes with drugs: a multi-technique biophysical study.

  2020cites this paper
• Copper(ii) l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity.

  2020cites this paper
• ITScore-NL: An Iterative Knowledge-Based Scoring Function for Nucleic Acid-Ligand Interactions

  2020cites this paper
• Telomeric DNA-RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells.

  2020cites this paper
• Assessing the key photophysical properties of triangulenium dyes for DNA binding by alteration of the fluorescent core.

  2020cites this paper
• Cationic porphyrins with large side arm substituents as resonance light scattering ratiometric probes for specific recognition of nucleic acid G-quadruplexes

  2019cites this paper
• Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition

  2019cites this paper
• Binding of anticancer drug adriamycin to parallel G‐quadruplex DNA [d‐(TTAGGGT)]4 comprising human telomeric DNA leads to thermal stabilization: A multiple spectroscopy study

  2019cites this paper
• Targeted Covalent Inhibition of Telomerase.

  2019cites this paper
• Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives.

  2019cites this paper
• NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.

  2019cites this paper
• Cytotoxic Activity and Related Mechanisms of Prenylflavonoids Isolated from Mallotus conspurcatus Croizat

  2019cites this paper
• Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres

  2019cites this paper
• DNA and RNA telomeric G-quadruplexes: what topology features can be inferred from ion mobility mass spectrometry?

  2019cites this paper
• 19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures Using 19F-Labeled Nucleobase.

  2019cites this paper
• Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes

  2019cites this paper
• Real-time Monitoring Excitation Dynamics of Human Telomeric Guanine Quadruplexes: Effect of Folding Topology, Metal Cation, and Confinement by Nanocavity Water Pool.

  2019cites this paper
• G-Quadruplex Nucleic Acids: Methods and Protocols

  2019influential citation
• Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes

  2019cites this paper
• Structural and biological study of synthesized anthraquinone series of compounds with sulfonamide feature

  2019cites this paper
• Design, synthesis of 4,5-diazafluorene derivatives and their anticancer activity via targeting telomeric DNA G-quadruplex.

  2019cites this paper
• Molecular recognition of 3 + 1 hybrid human telomeric G-quadruplex DNA d-[AGGG(TTAGGG)3] by anticancer drugs epirubicin and adriamycin leads to thermal stabilization.

  2019cites this paper
• G-Quadruplex DNA and RNA

  2019cites this paper
• Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

  2019cites this paper
• Exploration of the Structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its Transcriptional Regulation

  2019cites this paper
• A hydroxyquinoline-appended ruthenium(II)-polypyridyl complex that induces and stabilizes G-quadruplex DNA

  2019cites this paper
• Theoretical study on the DNA interaction properties of copper(II) complexes

  2019cites this paper
• The application of click chemistry for targeting quadruplex nucleic acids.

  2019cites this paper
• Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells

  2019cites this paper
• Molecular chemotherapeutic potential of butein: A concise review.

  2018cites this paper
• NMR based structure reveals groove binding of mitoxantrone to two sites of [d-(TTAGGGT)]4 having human telomeric DNA sequence leading to thermal stabilization of G-quadruplex.

  2018cites this paper
• Novel Naphthalimide Derivatives as Selective G-Quadruplex DNA Binders

  2018cites this paper
• Low-Energy Electron-Induced Strand Breaks in Telomere-Derived DNA Sequences-Influence of DNA Sequence and Topology.

  2018cites this paper
• Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.

  2018cites this paper
• Spectroscopic studies on the interactions of 5-ethyl-6-phenyl-3,8-bis((3-aminoalkyl)propanamido)phenanthridin-5-ium derivatives with G-quadruplex DNA.

  2018cites this paper
• Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

  2018cites this paper
• Stable and Label-Free Fluorescent Probe Based on G-triplex DNA and Thioflavin T.

  2018cites this paper
• A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+ solution

  2018cites this paper
• 5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions.

  2018cites this paper
• Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions.

  2018cites this paper
• The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors

  2018cites this paper
• High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads

  2018cites this paper
• Computational studies on G-quadruplex DNA-stabilizing property of novel Wittig-based Schiff-Base ligands and their copper(II) complexes

  2018cites this paper
• The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers

  2018cites this paper
• Nucleic acid structures containing g-quadruplex and duplex motifs : a structural study and potential targeting approach

  2018cites this paper
• Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

  2018cites this paper
• Molecular Recognition of Parallel G-quadruplex [d-(TTGGGGT)]4 Containing Tetrahymena Telomeric DNA Sequence by Anticancer Drug Daunomycin: NMR-Based Structure and Thermal Stability

  2018cites this paper
• A 5′-BODIPY End-label for Monitoring DNA Duplex-Quadruplex Exchange

  2018cites this paper
• Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds.

  2017influential citation
• Conformational and electronic effects on the formation of anti cyclobutane pyrimidine dimers in G-quadruplex structures.

  2017cites this paper
• Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations

  2017cites this paper
• Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations

  2017cites this paper
• Targeting human telomeric and c-myc G-quadruplexes with alkynylplatinum(II) terpyridine complexes under molecular crowding conditions.

  2017cites this paper
• Ligand-induced conformational preorganization of loops of c-MYC G-quadruplex DNA and its implications in structure-specific drug design.

  2017cites this paper
• Naphthalenediimide-Linked Bisbenzimidazole Derivatives as Telomeric G-Quadruplex-Stabilizing Ligands with Improved Anticancer Activity

  2017cites this paper
• Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone‐containing drugs. A critical examination of their clinical effectiveness within a twenty‐year timeframe in antitumor chemotherapy and treatment of infectious diseases

  2017cites this paper
• Thermodynamic Analyses of G-Quadruplexes Formed by DNA Molecules Containing Four Repeats of the Human Telomeric Sequence

  2017cites this paper
• Aza-bridged bisphenanthrolinyl Pt(II) complexes: Efficient stabilization and topological selectivity on telomeric G-quadruplexes.

  2017cites this paper
• Synthesis and Molecular Modeling of Thermally Stable DNA G‐Quadruplexes with Anthraquinone Insertions

  2017cites this paper