Discovery and development of α7 nicotinic acetylcholine receptor modulators.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Medicinal Chemistry

• Publication date

  2011-09-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jm2007672PMID 21919481
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 5-HT3 Receptors

  2012cited by this paper
• Treatment of cognitive disorders with certain alpha- nicotinic acid receptor agonists in combination with acetylcholinesterase inhibitors

  2011cited by this paper
• RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents

  2011cited by this paper
• Single‐ and Multiple‐Dose Pharmacokinetics, Safety, and Tolerability of the Selective α7 Neuronal Nicotinic Receptor Agonist, ABT‐107, in Healthy Human Volunteers

  2011cited by this paper
• Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

  2010cited by this paper
• An α7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes

  2010cited by this paper
• Abstracts from the ASENT 2010 annual meeting March 4–6, 2010

  2010cited by this paper
• In Vivo Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107: Preclinical Considerations in Alzheimer's Disease

  2010cited by this paper
• Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.

  2010cited by this paper
• Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).

  2010cited by this paper
• In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

  2010cited by this paper
• A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia

  2010cited by this paper
• Discovery of novel alpha7 nicotinic receptor antagonists.

  2010cited by this paper
• Repeated administration of α7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases α7 nAChR levels in the brain

  2010cited by this paper
• Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.

  2009cited by this paper
• Pro-Cognitive and Antipsychotic Efficacy of the α7 Nicotinic Partial Agonist SSR180711 in Pharmacological and Neurodevelopmental Latent Inhibition Models of Schizophrenia

  2009cited by this paper
• SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.

  2009cited by this paper
• Targeting α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia

  2009cited by this paper
• In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

  2009cited by this paper
• Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

  2009cited by this paper
• Old and New Pharmacology: Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide)

  2009cited by this paper
• Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.

  2009cited by this paper
• Foundation review : a 7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma ?

  2009cited by this paper
• The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.

  2009cited by this paper
• Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof

  2009cited by this paper
• P4‐348: Evp‐6124: Safety, Tolerability And Cognitive Effects Of A Novel A7 Nicotinic Receptor Agonist In Alzheimer's Disease Patients On Stable Donepezil Or Rivastigmine Therapy

  2009cited by this paper
• Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

  2009cited by this paper
• TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.

  2009cited by this paper
• Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.

  2009cited by this paper
• Tropisetron attenuates naloxone-induced place aversion in single-dose morphine-treated rats: role of alpha7 nicotinic receptors.

  2009cited by this paper
• Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.

  2009cited by this paper
• Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.

  2009cited by this paper
• Alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators.

  2008cited by this paper
• Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

  2008cited by this paper
• [3H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity α7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain

  2008cited by this paper
• Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.

  2008cited by this paper
• Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.

  2008cited by this paper
• SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia

  2007cited by this paper
• The Novel (cid:1) 7 Nicotinic Acetylcholine Receptor Agonist N -[(3 R Improves Working and Recognition Memory in Rodents

  2007cited by this paper
• [H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)- 5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity 7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain

  2007cited by this paper
• Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist.

  2007cited by this paper
• The alpha7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat.

  2007cited by this paper
• An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo

  2007cited by this paper
• Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes

  2007cited by this paper
• JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.

  2007cited by this paper
• Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

  2007cited by this paper
• SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (1) Binding and Functional Profile

  2007cited by this paper
• Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.

  2006cited by this paper
• Selective alpha7 nicotinic acetylcholine receptor ligands.

  2006cited by this paper
• 5-HT3 receptors.

  2006cited by this paper
• Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of tropisetron: role of alpha7 nicotinic receptors.

  2006cited by this paper
• Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.

  2006cited by this paper
• (R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.

  2006cited by this paper
• Selective α7 Nicotinic Acetylcholine Receptor Ligands

  2006cited by this paper
• Nicotinic Antagonists in the Treatment of Nerve Agent Intoxication

  2005cited by this paper
• A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization

  2005cited by this paper
• Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.

  2005cited by this paper
• High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.

  2005cited by this paper
• 2-(Arylmethyl)-3-substituted quinuclidines as selective α7 nicotinic receptor ligands

  2005cited by this paper
• Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

  2005cited by this paper
• 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands.

  2005cited by this paper
• Nicotinic antagonists in the treatment of nerve agent intoxication.

  2005cited by this paper
• (+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.

  2004cited by this paper
• The Neuroprotective Effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a Novel α7 Ligand, Is Prevented through Angiotensin II Activation of a Tyrosine Phosphatase

  2004cited by this paper
• AR-R 17779 improves social recognition in rats by activation of nicotinic α7 receptors

  2004cited by this paper
• Conus venoms: a rich source of novel ion channel-targeted peptides.

  2004cited by this paper
• Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia

  2004cited by this paper
• Alkaloids Indolizidine 235B′, Quinolizidine 1-epi-207I, and the Tricyclic 205B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors

  2004cited by this paper
• Beeinflusst die Depressivität den Behandlungseffekt von Tropisetron bei Fibromyalgiepatienten?

  2003cited by this paper
• Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda.

  2003cited by this paper
• [The influence of depression on the effect of Tropisetron in the therapy of fibromyalgia].

  2003cited by this paper
• Effects of alpha 4/beta 2- and alpha 7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice.

  2002cited by this paper
• The Interactions of the 5-HT(3) receptor with arylpiperazine, tropane, and quinuclidine ligands.

  2002cited by this paper
• Risk of hip fracture in women: not only a smoking issue.

  2002cited by this paper
• Lotronex withdrawal.

  2002cited by this paper
• Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

  2002cited by this paper
• Treatment of tendopathies with tropisetron

  2002cited by this paper
• The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.

  2001cited by this paper
• Effects of α4/β2- and α7-nicotine acetylcholine receptor agonists on prepulse inhibition of the acoustic startle response in rats and mice

  2001cited by this paper
• Use of the selective serotonin 3 receptor antagonist ondansetron in the treatment of neuroleptic-induced tardive dyskinesia.

  2000cited by this paper
• Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task.

  2000cited by this paper
• (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.

  2000cited by this paper
• Chapter One - Alkaloids from Amphibian Skins

  1999cited by this paper
• AR-R 17779, an α7 nicotinic agonist, improves learning and memory in rats

  1999cited by this paper
• AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.

  1999cited by this paper
• Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.

  1998cited by this paper
• Nicotinic receptor desensitization and sensory gating deficits in schizophrenia.

  1998cited by this paper
• Different effects of tropisetron and ondansetron in learning and memory paradigms.

  1997cited by this paper
• Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

  1996cited by this paper
• In vitro and in vivo profile of SB 206553, a potent 5‐HT2C/5‐HT2B receptor antagonist with anxiolytic‐like properties

  1996cited by this paper
• Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

  1995cited by this paper

• 5-HT3 receptors in GtoPdb v.2025.3

  2025cites this paper
• Nicotinic acetylcholine receptors (nACh) in GtoPdb v.2025.3

  2025cites this paper
• Spectroscopic Characterization, Quantum Chemical Studies, Molecular Docking and Drug Likeness of 5-Acetyl-2,4 Dimethyl-1H-Pyrrole-3-Carboxylic Acid as a Potent Anti-melanoma Drug

  2023cites this paper
• Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596.

  2023cites this paper
• 5-HT3 receptors in GtoPdb v.2023.3

  2023cites this paper
• Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators

  2023cites this paper
• Nicotinic acetylcholine receptors (nACh) in GtoPdb v.2023.3

  2023cites this paper
• Novel α7 Nicotinic Acetylcholine Receptor Modulators as Potential Antitussive Agents.

  2022cites this paper
• Nicotinic acetylcholine receptors (nACh) in GtoPdb v.2021.3

  2021cites this paper
• Optical Control of Invertebrate nAChR and Behaviors with Dithienylethene-Imidacloprid

  2021cites this paper
• Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development, and Promising Results Obtained from Multi-target Approaches.

  2020cites this paper
• Hydride Transfer Initiated Redox-Neutral Cascade Cyclizations of Aurones: Facile Access to [6,5] Spirocycles.

  2020cites this paper
• Spectroscopic characterization, DFT studies, molecular docking and cytotoxic evaluation of 4‐nitro‐indole‐3‐carboxaldehyde: A potent lung cancer agent

  2020cites this paper
• Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists.

  2020cites this paper
• Nicotinic acetylcholine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• 5-HT3 receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors.

  2019cites this paper
• Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities.

  2018cites this paper
• Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors

  2018cites this paper
• Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

  2018cites this paper
• Competitive docking model for prediction of the human nicotinic acetylcholine receptor α7 binding of tobacco constituents

  2018influential citation
• The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [18F]ASEM

  2018cites this paper
• Design, synthesis and biological evaluation of 1,4-Diazobicylco[3.2.2]nonane derivatives as α7-Nicotinic acetylcholine receptor PET/CT imaging agents and agonists for Alzheimer's disease.

  2018cites this paper
• Characterization of the binding mode of the PET tracer [18F]ASEM to a chimera structure of the α7 nicotinic acetylcholine receptor

  2017cites this paper
• Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning

  2017cites this paper
• The binding orientation of epibatidine at α7 nACh receptors

  2017cites this paper
• Insights into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment

  2017cites this paper
• Conformational analysis of 2-substituted piperazines.

  2016cites this paper
• N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.

  2016cites this paper
• 1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.

  2016cites this paper
• Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity

  2016cites this paper
• New quinoline derivatives as nicotinic receptor modulators.

  2016cites this paper
• Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds.

  2016cites this paper
• Fluorescent Agonists of the α 7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine

  2016cites this paper
• Role of Microglial α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator in Neuroinflammatory Pain Models in Mice

  2016cites this paper
• The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors

  2015cites this paper
• Concise synthesis of alkaloid (-)-205B.

  2015cites this paper
• From Molecular Understanding to Structure–Thermodynamic Relationships, the Case of Acetylcholine Binding Proteins

  2015cites this paper
• Allosteric modulation of nicotinic acetylcholine receptors.

  2015cites this paper
• Development of [(18)F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography.

  2015cites this paper
• Selectivity optimization of substituted 1,2,3-triazoles as α7 nicotinic acetylcholine receptor agonists.

  2015cites this paper
• Allosteric Modulation of Alpha7 Nicotinic Receptors: Mechanistic Insight through Metadynamics and Essential Dynamics

  2015cites this paper
• Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.

  2014cites this paper
• Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy

  2014cites this paper
• Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor.

  2014cites this paper
• Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors.

  2014cites this paper
• Total Synthesis of Alkaloid 205B

  2014cites this paper
• Nicotinic Acetylcholine Receptor Modulators

  2014cites this paper
• The Literature of Heterocyclic Chemistry, Part XII, 2010–2011

  2014cites this paper
• Use of alpha 7 nicotinic acetylcholine receptor agonists

  2014cites this paper
• The use of spirocyclic scaffolds in drug discovery.

  2014cites this paper
• Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors.

  2013cites this paper
• Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease.

  2013cites this paper
• Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists.

  2013cites this paper
• Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors.

  2013cites this paper
• Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodides are competitive antagonists for the human α4β2 and α7 nicotinic acetylcholine receptors

  2013cites this paper
• An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline

  2013cites this paper
• The role of the alpha7 nicotinic receptor in regulating the Pophyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes

  2013cites this paper
• Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors

  2013cites this paper
• Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.

  2012cites this paper
• Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).

  2012cites this paper
• N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.

  2012cites this paper
• Cognitive Enhancers (Nootropics). Part 1: Drugs Interacting with Receptors

  2012cites this paper
• Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.

  2012cites this paper