Novel α7 Nicotinic Acetylcholine Receptor Modulators as Potential Antitussive Agents.

A novel series of α7 nicotinic acetylcholine receptor (nAChR) modulators was designed and evaluated for antitussive activity in an in vivo guinea pig model of chemically induced cough. Compound 16 significantly (p<0.01) reduced the cumulative number of coughs and showed similar results to a positive control (30 mg/kg codeine) at concentration 3-fold, when compared to negative control (saline or air). Among three different administration routes (intraperitoneal, oral and inhalation), compound 16 exerted a significant antitussive effect in guinea pigs at an inhaled dose as low as 0.4 mg/kg (p<0.05). α7 nAChR modulators may provide a novel, non-narcotic approach to therapy in patients with acute and chronic cough.

• Publication year

  2022

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2022-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2022.129067PMID 36395996
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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