AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

No abstract is available for this paper.

• Publication year

  2017

• Venue

  EMBO Journal

• Publication date

  2017-03-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.15252/embj.201695534PMID 28279977PMCID PMC5391142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

  2017cited by this paper
• FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway.

  2014cited by this paper
• The function of FOXO1 in the late phases of the cell cycle is suppressed by PLK1-mediated phosphorylation

  2014cited by this paper
• Upregulation of miR-96 Enhances Cellular Proliferation of Prostate Cancer Cells through FOXO1

  2013cited by this paper
• IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

  2013cited by this paper
• BRCA1 is a negative modulator of the PRC2 complex

  2013cited by this paper
• IQGAP1 and its binding proteins control diverse biological functions.

  2012cited by this paper
• Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

  2012cited by this paper
• Rationally Designed Treatment for Solid Tumors with MAPK Pathway Activation: A Phase I Study of Paclitaxel and Bortezomib Using an Adaptive Dose-Finding Approach

  2011cited by this paper
• PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

  2011influential reference
• AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.

  2011influential reference
• Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling.

  2011cited by this paper
• FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.

  2011cited by this paper
• IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation

  2010cited by this paper
• Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells

  2010cited by this paper
• Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis

  2010cited by this paper
• Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

  2010cited by this paper
• Experimental Therapeutics , Molecular Targets , and Chemical Biology Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer

  2009cited by this paper
• Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells.

  2009cited by this paper
• Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis

  2009cited by this paper
• A transcription-independent function of FOXO1 in inhibition of androgen-independent activation of the androgen receptor in prostate cancer cells.

  2008cited by this paper
• Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model.

  2008cited by this paper
• IQGAP1 Integrates Ca2+/Calmodulin and B-Raf Signaling*

  2008cited by this paper
• PI3K pathway alterations in cancer: variations on a theme

  2008cited by this paper
• Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers

  2008cited by this paper
• The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian cancers

  2008cited by this paper
• Dynamic FoxO transcription factors

  2007cited by this paper
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

  2007cited by this paper
• IQGAP1 modulates activation of B-Raf

  2007cited by this paper
• FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

  2006cited by this paper
• FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer.

  2006cited by this paper
• Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

  2006influential reference
• CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage

  2006influential reference
• IQGAP1 Is a Scaffold for Mitogen-Activated Protein Kinase Signaling

  2005cited by this paper
• FOXO transcription factors at the interface between longevity and tumor suppression

  2005cited by this paper
• Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.

  2005cited by this paper
• Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

  2005cited by this paper
• Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.

  2004cited by this paper
• Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer.

  2004cited by this paper
• IQGAP1 Binds ERK2 and Modulates Its Activity*

  2004cited by this paper
• Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer.

  2004cited by this paper
• IQGAP1 Binds Rap1 and Modulates Its Activity*

  2004cited by this paper
• Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome*

  2003cited by this paper
• Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

  2003cited by this paper
• FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

  2003cited by this paper
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

  2002influential reference
• FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression

  2002cited by this paper
• Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

  2002cited by this paper
• 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

  2002cited by this paper
• Regulation of Raf-Akt Cross-talk

  2002cited by this paper
• Conformational analysis of the GTP‐binding protein MxA using limited proteolysis

  2002cited by this paper
• Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway

  2002cited by this paper
• Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.

  2001cited by this paper
• PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression*

  2001cited by this paper
• AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

  2000cited by this paper
• Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

  2000cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Negative Regulation of the Forkhead Transcription Factor FKHR by Akt*

  1999cited by this paper
• Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.

  1999cited by this paper

• Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain

  2026cites this paper
• Prostate Cancer-Associated Fibroblasts: A Review on CAF Functions, Heterogeneity, Resistance Mechanisms, and Future in a Chip

  2026cites this paper
• Immunotherapy and targeted therapy for high grade gliomas: current and future directions

  2025cites this paper
• Potential Regulatory Role of miR-15b, miR-99b, and miR-181a of the Shikonin-Induced MAPK/ERK Apoptotic Signaling Pathway in Renal Carcinoma

  2025cites this paper
• Multiscale Modeling of Tumor-Macrophage Interactions Underlying Immunotherapy Resistance in Glioblastoma

  2025cites this paper
• Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis

  2025cites this paper
• Royal Jelly Acid Alleviates Diet-Induced Hyperlipidemia through Regulation of Oxidative Stress and Tryptophan Metabolism.

  2025cites this paper
• Harnessing natural saponins: Advancements in mitochondrial dysfunction and therapeutic applications.

  2025cites this paper
• Identifying regulators of aged fibroblast activation in 3D tissue models

  2025cites this paper
• Post-Translational Modifications: Key “Regulators” of Pancreatic Cancer Malignant Phenotype—Advances in Mechanisms and Targeted Therapies

  2025cites this paper
• The Protective Mechanism of Tao Hong Si Wu Decoction Against Breast Cancer Through Regulation of EGFR/ERK1/2 Signaling.

  2024cites this paper
• Platelet related gene IQGAP1 contributes to the onset and abnormal immune landscape of ischemic stroke patients.

  2024cites this paper
• FoxO is required for neoblast differentiation during planarian regeneration.

  2024cites this paper
• Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer

  2024cites this paper
• Role of scaffold proteins in the heterogeneity of glioblastoma

  2024cites this paper
• FoxO transcription factors actuate the formative pluripotency specific gene expression programme

  2024cites this paper
• CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition

  2024cites this paper
• Differential expression of host oncogenes in human papillomavirus‐associated nasopharyngeal and cervical epithelial cancers

  2024cites this paper
• Could Insulin Be a Better Regulator of Appetite/Satiety Balance and Body Weight Maintenance in Response to Glucose Exposure Compared to Sucrose Substitutes? Unraveling Current Knowledge and Searching for More Appropriate Choices

  2024cites this paper
• Pan-EGFR Inhibitor Dacomitinib Resensitizes Paclitaxel and Induces Apoptosis via Elevating Intracellular ROS Levels in Ovarian Cancer SKOV3-TR Cells

  2024cites this paper
• METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N6‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury

  2023cites this paper
• M6A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer

  2023cites this paper
• Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a

  2023cites this paper
• PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors

  2023cites this paper
• Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging mice

  2023cites this paper
• Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells

  2023cites this paper
• HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

  2023cites this paper
• PTPN22 activates the PI3K pathway via 14‐3‐3τ in T cells

  2023cites this paper
• TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs

  2023cites this paper
• Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer.

  2022cites this paper
• Identification of significant modules and hub genes involved in hepatic encephalopathy using WGCNA

  2022cites this paper
• The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

  2022cites this paper
• The molecular rationale for the combination of polatuzumab vedotin plus rituximab in diffuse large B‐cell lymphoma

  2022cites this paper
• Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions

  2022cites this paper
• Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition.

  2022cites this paper
• Autophagy Modulators in Coronavirus Diseases: A Double Strike in Viral Burden and Inflammation

  2022cites this paper
• Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides

  2022cites this paper
• Forkhead Box 1(FoxO1) mediates psychological stress-induced neuroinflammation

  2022cites this paper
• OTT_A_289722 979..988

  2021cites this paper
• Loss of DAB2IP Contributes to Cell Proliferation and Cisplatin Resistance in Gastric Cancer

  2021cites this paper
• An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.

  2021cites this paper
• FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys

  2021cites this paper
• Genetic variants associated with expression of TCF19 contribute to the risk of head and neck cancer in Chinese population

  2021cites this paper
• MiRNA‐1271‐5p regulates osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells by targeting forkhead box O1 (FOXO1)

  2021cites this paper
• MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.

  2021cites this paper
• Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status

  2021cites this paper
• Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis

  2021cites this paper
• MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3

  2021cites this paper
• Role of Forkhead Box O Proteins in Hepatocellular Carcinoma Biology and Progression (Review)

  2021cites this paper
• RPA facilitates rescue of keratinocytes from UVB radiation damage through insulin-like growth factor-I signalling.

  2021cites this paper
• Akt scaffold proteins: the key to controlling specificity of Akt signaling.

  2021cites this paper
• Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis

  2021cites this paper
• cDNA-detector: detection and removal of cDNA contamination in DNA sequencing libraries

  2021cites this paper
• Role of IQGAP1 in Carcinogenesis

  2021cites this paper
• SPOP mutation induces DNA methylation via stabilizing GLP/G9a

  2021cites this paper
• IQ Motif-Containing GTPase-Activating Protein 2 Inhibits Breast Cancer Angiogenesis by Suppressing VEGFR2–AKT Signaling

  2021cites this paper
• Simultaneous Knockdown of Sprouty2 and PTEN Promotes Axon Elongation of Adult Sensory Neurons

  2020cites this paper
• Cdc20 induces the radioresistance of bladder cancer cells by targeting FoxO1 degradation.

  2020cites this paper
• Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.

  2020cites this paper
• Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function

  2020cites this paper
• BmFoxO Gene Regulation of the Cell Cycle Induced by 20-Hydroxyecdysone in BmN-SWU1 Cells

  2020cites this paper
• A targetable epigenetic vulnerability in PI3K/AKT inhibitor resistant cancers

  2020cites this paper
• The disruption of protein-protein interactions as a therapeutic strategy for prostate cancer.

  2020cites this paper
• Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

  2020cites this paper
• Proteome activity landscapes of tumor cell lines determine drug responses

  2020cites this paper
• Anti‐tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma

  2020cites this paper
• FOXO1 and hsa-microRNA-204-5p affect the biologic behavior of MDA-MB-231 breast cancer cells.

  2020cites this paper
• Forkhead Transcription Factors in Health and Disease.

  2020cites this paper
• Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.

  2020cites this paper
• The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution

  2020cites this paper
• Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway

  2020cites this paper
• FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor

  2020cites this paper
• Photoperiodic effect on the testicular transcriptome in broiler roosters.

  2020cites this paper
• Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

  2020influential citation
• Molecular mechanisms of FOXO 1 in adipocyte differentiation

  2019cites this paper
• Identification of key genes and pathways in Ewing’s sarcoma patients associated with metastasis and poor prognosis

  2019cites this paper
• Interplay Among PI3K/AKT, PTEN/FOXO and AR Signaling in Prostate Cancer.

  2019cites this paper
• Whole Transcriptome Analysis of Obese Adipose Tissue Suggests u001kfc.1 as a Potential Regulator to Glucose Homeostasis

  2019cites this paper
• A PI3K/AKT Scaffolding Protein, IQ Motif–Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis

  2019cites this paper
• A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma

  2019cites this paper
• FoxO1 is a critical regulator of hepatocyte lipid deposition in chronic stress mice

  2019cites this paper
• Immune Cytolytic Activity Is Associated With Genetic and Clinical Properties of Glioma

  2019cites this paper
• The Role of Forkhead Box Proteins in Acute Myeloid Leukemia

  2019cites this paper
• The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

  2019cites this paper
• Identi fi cation of key genes and pathways in Ewing ’ s sarcoma patients associated with metastasis and poor prognosis

  2019cites this paper
• Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis

  2019cites this paper
• ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer

  2019cites this paper
• Downregulation of IQGAP1 inhibits epithelial‐mesenchymal transition via the HIF1α/VEGF‐A signaling pathway in gastric cancer

  2019cites this paper
• Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer.

  2019cites this paper
• The Prostate

  2019cites this paper
• Molecular mechanisms of FOXO1 in adipocyte differentiation.

  2019cites this paper
• microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells

  2019cites this paper
• Role of FoxO Proteins in Cellular Response to Antitumor Agents

  2019influential citation
• miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression

  2018cites this paper
• Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo

  2018cites this paper
• Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis.

  2018cites this paper
• Effect of microRNA-370 on coronary atherosclerosis and its underlying mechanism

  2018cites this paper
• Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

  2018cites this paper
• In Vitro and In Vivo Characterization of a Preclinical Irradiation-Adapted Model for Ewing Sarcoma.

  2018cites this paper
• Nuclear division cycle 80 promotes malignant progression and predicts clinical outcome in colorectal cancer

  2018cites this paper