Role of the host stroma in cancer and its therapeutic significance

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cancer Metastasis Review

• Publication date

  2013-04-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10555-013-9438-4PMID 23625010
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Insights into cancer metastasis from a clinicopathologic perspective: Epithelial‐Mesenchymal Transition is not a necessary step

  2013cited by this paper
• Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

  2012cited by this paper
• To differentiate or not — routes towards metastasis

  2012cited by this paper
• The Use of Automated Quantitative Analysis to Evaluate Epithelial-to-Mesenchymal Transition Associated Proteins in Clear Cell Renal Cell Carcinoma

  2012cited by this paper
• Inappropriate gene expression in human cancer and its far-reaching biological and clinical significance

  2012cited by this paper
• Mesenchymal Stem Cells Modified to Express Interferon-β Inhibit the Growth of Prostate Cancer in a Mouse Model

  2012cited by this paper
• Clinical and Biological Implications of the Tumor Microenvironment

  2012cited by this paper
• Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

  2012cited by this paper
• Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

  2012cited by this paper
• CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer

  2011cited by this paper
• Comprar Paraneoplastic Syndromes | MD, FAAN | 9780199772735 | Oxford University Press

  2011cited by this paper
• Cancer theory faces doubts

  2011cited by this paper
• The three R's of lung health and disease: repair, remodeling, and regeneration.

  2011cited by this paper
• Angiogenesis , Metastasis , and the Cellular Microenvironment Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

  2011cited by this paper
• Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance.

  2011cited by this paper
• Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development

  2011cited by this paper
• Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression

  2011cited by this paper
• Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

  2010cited by this paper
• Paraneoplastic syndromes: an approach to diagnosis and treatment.

  2010cited by this paper
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

  2010cited by this paper
• Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.

  2010cited by this paper
• The Pathology of EMT in Mouse Mammary Tumorigenesis

  2010cited by this paper
• The basics of epithelial-mesenchymal transition.

  2009cited by this paper
• Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.

  2009cited by this paper
• Placenta percreta and the urologist.

  2009cited by this paper
• Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

  2009cited by this paper
• Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst.

  2009cited by this paper
• Epithelial-mesenchymal transitions in development and disease.

  2009cited by this paper
• Epithelial to mesenchymal transition and breast cancer

  2009cited by this paper
• The angiogenic response is dictated by β3 integrin on bone marrow–derived cells

  2008cited by this paper
• The Superorganism: The Beauty, Elegance, and Strangeness of Insect Societies

  2008cited by this paper
• Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

  2008cited by this paper
• Adrenal gland development and defects.

  2008cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.

  2008cited by this paper
• Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

  2008cited by this paper
• Direct evidence for epithelial-mesenchymal transitions in breast cancer.

  2008cited by this paper
• Life and the Homeostatic Organization View of Biological Phenomena

  2008cited by this paper
• Resident cellular components of the lung: developmental aspects.

  2008cited by this paper
• Mesenchymal to Epithelial Transition in Development and Disease

  2007cited by this paper
• Rethinking the proximodistal axis of the vertebrate limb in the molecular era.

  2007cited by this paper
• Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells

  2007cited by this paper
• Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression

  2007cited by this paper
• Osteopontin gene expression determines spontaneous metastatic performance of orthotopic human breast cancer xenografts.

  2007cited by this paper
• Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.

  2007cited by this paper
• Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs

  2006cited by this paper
• Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis.

  2006cited by this paper
• Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency.

  2006cited by this paper
• Osteopontin expression correlates with prognostic variables and survival in clear cell renal cell carcinoma

  2006cited by this paper
• Tumor–stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis

  2006cited by this paper
• Regulation of early lung morphogenesis: questions, facts and controversies

  2006cited by this paper
• Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea.

  2006cited by this paper
• Osteopontin Expression and Prognostic Significance in Non–Small Cell Lung Cancer

  2005cited by this paper
• Plasma osteopontin levels are predictive of disease stage in patients with transitional cell carcinoma of the bladder

  2005cited by this paper
• The origin of vimentin expression in invasive breast cancer: epithelial–mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?

  2005cited by this paper
• The fallacy of epithelial mesenchymal transition in neoplasia.

  2005cited by this paper
• Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

  2005cited by this paper
• The benefits of a gynecologic oncologist: a pattern of care study for endometrial cancer treatment.

  2004cited by this paper
• Epithelial-mesenchymal transitions: twist in development and metastasis.

  2004cited by this paper
• Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

  2004cited by this paper
• The role of Osteopontin in tumor metastasis.

  2004cited by this paper
• Epithelial-mesenchymal interactions in the developing lung.

  2004cited by this paper
• Epithelial-mesenchymal transition and its implications for fibrosis.

  2003cited by this paper
• Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein.

  2003cited by this paper
• Role of stroma in carcinogenesis of the prostate.

  2002cited by this paper
• The re-emergence of "emergence": A venerable concept in search of a theory

  2002cited by this paper
• Epithelial–mesenchymal transitions in tumour progression

  2002cited by this paper
• Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling.

  2002cited by this paper
• Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis.

  2002cited by this paper
• Molecular mechanisms regulating hair follicle development.

  2002cited by this paper
• Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

  2001cited by this paper
• Developmental Biology, 6th edition

  2000cited by this paper
• Invasive lobular carcinoma: correlations between morphological features, vimentin expression, oestrogen receptor status and prognosis

  1997cited by this paper
• Viable offspring derived from fetal and adult mammalian cells

  1997cited by this paper
• Viable offspring derived from fetal and adult mammalian cells

  1997cited by this paper
• Progressive loss of CD44 gene expression in invasive bladder cancer.

  1996cited by this paper
• Histogenesis and organogenesis of the gonads in human embryos

  1994cited by this paper
• Correlation of VLA-4 integrin expression with metastatic potential in various human tumour cell lines.

  1993cited by this paper
• Metastatic model for human prostate cancer using orthotopic implantation in nude mice.

  1992cited by this paper
• Histogenesis and organogenesis of the gonad in human embryos.

  1991cited by this paper
• Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.

  1988cited by this paper
• A new animal model for human colon cancer metastasis

  1987cited by this paper
• Cellular immortality, clonogenicity, tumorigenicity and the metastatic phenotype.

  1986cited by this paper
• Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice.

  1986cited by this paper
• Dormant tumor cells in liver and brain. An autopsy study on metastasizing tumors.

  1985cited by this paper
• Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.

  1984cited by this paper
• Epithelial-mesenchymal interactions in prostatic development. II. Biochemical observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder

  1983cited by this paper
• Epithelial-mesenchymal interactions in prostatic development. I. morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder

  1983cited by this paper
• Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

  1980cited by this paper
• Experimental study of the pathogenesis of carcinoma

  1977cited by this paper
• Fundamental Aspects of Metastasis

  1977cited by this paper
• The transmission of morphogenetic signals from amphibian mesoderm to ectoderm in primary induction.

  1976cited by this paper
• Etiological factors, stages, and the role of the foreign body in foreign body tumorigenesis: a review.

  1975cited by this paper
• Foreign-body tumorigenesis: in vitro isolation and expansion of preneoplastic clonal cell populations.

  1975cited by this paper
• Ultrastructural features of ectodermal--mesenchymal relationships in the developing limb of Xenopus laevis.

  1974cited by this paper
• Am Autopsy Study of Some Routes of Dissemination of Cancer of the Breast

  1973cited by this paper
• Tumorigenesis by Millipore filters in mice: histology and ultrastructure of tissue reactions as related to pore size.

  1973cited by this paper
• [Paraneoplastic syndromes].

  1973cited by this paper
• Tissue interactions in carcinogenesis

  1972cited by this paper
• Ultrastructural features of neural induction in Xenopus laevis.

  1972cited by this paper

• STAR (stroma-tumor AI risk) assessment: association of AI-derived tumor-stroma proportion with patient survival provides added prognostic value beyond KELIM in epithelial ovarian cancer

  2026cites this paper
• BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma

  2025cites this paper
• A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

  2025cites this paper
• Quantitative and qualitative metrics of tumor stroma in predicting ovarian cancer outcomes and expansion of its study with AI-based tools

  2025cites this paper
• Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

  2024cites this paper
• Bioelectric Pharmacology of Cancer: A Systematic Review of Ion Channel Drugs Affecting the Cancer Phenotype.

  2024cites this paper
• Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

  2023cites this paper
• Emerging histopathological parameters in the prognosis of oral squamous cell carcinomas.

  2023cites this paper
• Advanced Fibroblast Activation Protein-Ligand Developments: FAP Imaging Agents: A Review of the Structural Requirements.

  2023cites this paper
• Identification of Breast Cancer Subtypes Based on Gene Expression Profiles in Breast Cancer Stroma.

  2022cites this paper
• Bioelectrical approaches to cancer as a problem of the scaling of the cellular self.

  2021cites this paper
• Mitochondria Targeting as an Effective Strategy for Cancer Therapy

  2020cites this paper
• Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis

  2020cites this paper
• The changes of angiogenesis and immune regulations in stromal microenvironment of cutaneous melanomas.

  2019cites this paper
• Stromal Barriers Within the Tumor Microenvironment and Obstacles to Nanomedicine

  2019cites this paper
• Similar Characteristics of Endometrial and Endometriotic Epithelial Cells

  2019cites this paper
• Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma

  2018cites this paper
• Prognostic impact of tumour–stroma ratio in early‐stage oral tongue cancers

  2018cites this paper
• The role of epithelial-mesenchymal transition in squamous cell carcinoma of the oral cavity

  2018cites this paper
• ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance

  2018cites this paper
• Composition of the Stroma in the Human Endometrium and Endometriosis

  2018cites this paper
• Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis

  2017cites this paper
• Cancer as a disorder of patterning information: computational and biophysical perspectives on the cancer problem

  2017cites this paper
• Évaluation moléculaire de la maladie métastatique : pourquoi l'anatomopathologie reste(ra) indispensable ?

  2016cites this paper
• Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice.

  2016cites this paper
• ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance

  2016cites this paper
• [Not Available].

  2016cites this paper
• Malignant transformation of host stromal fibroblasts derived from the bone marrow traced in a dual-color fluorescence xenograft tumor model.

  2015cites this paper
• Neoplasia of the gastrointestinal tract

  2015cites this paper
• Prognostic Significance of the Tumor-Stroma Ratio in Epithelial Ovarian Cancer

  2015cites this paper
• Neuroimmune mechanisms in cancer pain

  2015cites this paper
• Carcinosarcoma and spindle cell carcinoma—monoclonal neoplasms undergoing epithelial-mesenchymal transition

  2015cites this paper
• The dynamic control of signal transduction networks in cancer cells

  2015cites this paper
• Stearoyl-CoA desaturase 1 and paracrine diffusible signals have a major role in the promotion of breast cancer cell migration induced by cancer-associated fibroblasts

  2015influential citation
• Smoldering multiple myeloma: pathophysiologic insights, novel diagnostics, clinical risk models, and treatment strategies.

  2014cites this paper
• Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer.

  2014cites this paper
• Using logistic regression to improve the prognostic value of microarray gene expression data sets: application to early-stage squamous cell carcinoma of the lung and triple negative breast carcinoma

  2014cites this paper
• Update on clinical and mechanistic aspects of paraneoplastic syndromes

  2013cites this paper