The “no-reflow” phenomenon: basic science and clinical correlates

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Heart

• Publication date

  2002-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/heart.87.2.162PMID 11796561PMCID PMC1767011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recognition of the importance of embolization in atherosclerotic vascular disease.

  2000cited by this paper
• Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction.

  2000cited by this paper
• Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits.

  2000cited by this paper
• Early temporal changes in coronary flow velocity patterns in patients with acute myocardial infarction demonstrating the "no-reflow" phenomenon.

  1999cited by this paper
• Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction.

  1999cited by this paper
• Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators.

  1999cited by this paper
• Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty.

  1998cited by this paper
• Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction.

  1998cited by this paper
• Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction using myocardial contrast echocardiography one day after recanalization.

  1998cited by this paper
• Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction.

  1998cited by this paper
• Beneficial effect of intracoronary verapamil on microvascular and myocardial salvage in patients with acute myocardial infarction.

  1997cited by this paper
• Myocardial perfusion patterns related to thrombolysis in myocardial infarction perfusion grades after coronary angioplasty in patients with acute anterior wall myocardial infarction.

  1996cited by this paper
• Alternation in the coronary blood flow velocity pattern in patients with no reflow and reperfused acute myocardial infarction.

  1996cited by this paper
• Incidence and treatment of 'no-reflow' after percutaneous coronary intervention.

  1994cited by this paper
• Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography.

  1994cited by this paper
• Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion.

  1994cited by this paper
• “Reperfusion Injury” by Oxygen‐Derived Free Radicals?: Effect of Superoxide Dismutase Plus Catalase, Given at the Time of Reperfusion, on Myocardial Infarct Size, Contractile Function, Coronary Microvasculature, and Regional Myocardial Blood Flow

  1989cited by this paper
• Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow.

  1989cited by this paper
• Ultrastructural Evidence of Microvascular Damage and Myocardial Cell Injury After Coronary Artery Occlusion: Which Comes First?

  1980cited by this paper
• The "no-reflow" phenomenon after temporary coronary occlusion in the dog.

  1974cited by this paper

• The Naples Prognostic Score May Predict No Reflow in Patients Undergoing Percutaneous Coronary Intervention for Saphenous Vein Graft Stenosis

  2026cites this paper
• The Association of Peak Glycemia and No‐Reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention

  2026cites this paper
• Effect of general anesthesia combined with epidural block on hemorheology in elderly patients with laparoscopic radical resection of colorectal cancer: A randomized controlled trial

  2025cites this paper
• Prognosticating short-term outcomes in patients with STEMI-ACS and intra-procedural slow-flow/no-reflow phenomenon

  2025cites this paper
• Metabolic and Microcirculatory Changes in Severe Renal Ischemia–Reperfusion and Ischemic Preconditioning in the Rat: Are They Detectable in the First Hour of Reperfusion?

  2025cites this paper
• Research Progress of Anterior Cruciate Ligament Reconstruction under Arthroscopy

  2024cites this paper
• Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury

  2024cites this paper
• Crafting a Rigorous, Clinically Relevant Large Animal Model of Chronic Myocardial Ischemia: What Have We Learned in 20 Years?

  2024cites this paper
• Microvascular Obstruction and Intramyocardial Hemorrhage in Reperfused Myocardial Infarctions: Pathophysiology and Clinical Insights From Imaging.

  2024cites this paper
• Performance of drug-coated balloons in coronary and below-the-knee arteries: Anatomical, physiological and pathological considerations.

  2024cites this paper
• Intramyocardial Hemorrhage Leads to Higher MACE Rate by Increasing Myocardial Infarction Volume in Patients with STEMI

  2024cites this paper
• Metabolic Tissue Swelling and Local Microcirculation in Splanchnic Artery Occlusion Shock: Implications for Critical Illness

  2023cites this paper
• Assessment of systemic immune-inflammation index as an independent surrogate biomarker of no-reflow phenomenon in acute coronary syndrome patients with coronary artery bypass grafting undergoing percutaneous coronary intervention of saphenous vein graft.

  2023cites this paper
• Anti-inflammatory Therapy Progress in Major Adverse Cardiac Events after PCI: Chinese and Western Medicine

  2023cites this paper
• Growth Differentiation Factor 15 as a Predictor of the No-Reflow Phenomenon in Patients with ST-Segment Elevation Myocardial Infarction

  2022cites this paper
• Comparison of Intracoronary Epinephrine and Adenosine for No-Reflow in Normotensive Patients With Acute Coronary Syndrome (COAR Trial)

  2022cites this paper
• A Narrative Review of the Classical and Modern Diagnostic Methods of the No-Reflow Phenomenon

  2022cites this paper
• Impact of Stress Hyperglycemia on No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

  2022cites this paper
• Quantification Of Thrombus Burden As An Independent Predictor Of Intra-Procedural No-Reflow In Patients With St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Revascularization.

  2022cites this paper
• CHA2 DS2 -VASc score, a simple clinical tool for early prediction of no-reflow phenomenon in patients undergoing emergency percutaneous coronary revascularization

  2022cites this paper
• Traumatic Brain Injury Biomarkers, Simulations and Kinetics

  2022cites this paper
• Risk Factors for No-Reflow in Patients with ST-Elevation Myocardial Infarction Who Underwent Percutaneous Coronary Intervention: A Case-Control Study

  2022cites this paper
• CARDIAC ARREST AFTER INTRA-CORONARY NICORANDIL: A CATH LAB NIGHTMARE

  2022cites this paper
• Hemorheological and Microcirculatory Relations of Acute Pancreatitis

  2022cites this paper
• CHA 2 DS 2 -VASc score, a simple clinical tool for early prediction of no-reflow phenomenon in patients undergoing emergency percutaneous coronary revascularization

  2022cites this paper
• Analysis of mRNA and protein kidney injury Molecule-1 (KIM-1) expression in a kidney model during the initiation phase of ischemia reperfusion injury

  2022cites this paper
• Development and Validation of a Novel Risk Stratification Model for Slow-Flow/No-Reflow During Primary Percutaneous Coronary Intervention (the RK-SF/NR Score).

  2022cites this paper
• Role of Combination therapy on no-reflow after primarypercutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction

  2021cites this paper
• Predictors of no-reflow phenomenon following percutaneous coronary intervention for ST-segment elevation myocardial infarction.

  2021cites this paper
• Mechanism and Potential Treatment of the 'No Reflow' Phenomenon After Acute Myocardial Infarction: Role of Pericytes and GPR39.

  2021cites this paper
• Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

  2021cites this paper
• Frequency and predictors of no-reflow phenomenon in patients with COVID-19 presenting with ST-segment elevation myocardial infarction

  2021cites this paper
• Long-term outcome of rotational atherectomy according to burr-to-artery ratio and changes in coronary artery blood flow: Observational analysis

  2021cites this paper
• Neuromonitoring After Cardiac Arrest: Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?

  2021cites this paper
• Controlling Reperfusion Injury With Controlled Reperfusion: Historical Perspectives and New Paradigms

  2021cites this paper
• Acute Viral Illnesses and Ischemic Stroke

  2021cites this paper
• Characterization of infarcted myocardium by T1-mapping and its association with left ventricular remodeling.

  2021cites this paper
• The outcomes in STEMI patients with high thrombus burden treated by deferred versus immediate stent implantation in primary percutaneous coronary intervention: a prospective cohort study

  2021influential citation
• Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction

  2021cites this paper
• Clinical and Angiographic Predictors of No-Reflow Phenomenon during Primary Percutaneous Coronary Intervention

  2021cites this paper
• Association between cine CMR-based radiomics signature and microvascular obstruction in patients with ST-segment elevation myocardial infarction

  2021cites this paper
• In-Hospital Peak Glycemia in Predicting No-Reflow Phenomenon in Diabetic Patients with STEMI Treated with Primary Percutaneous Coronary Intervention

  2021influential citation
• Influence of Ischemia-reperfusion Injury on Endothelial Function in Men and Women with Similar Serum Estradiol Concentrations.

  2021cites this paper
• Strategies to Attenuate Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Pigment Epithelium-Derived Factor

  2021cites this paper
• Evaluating the Role of Deferred Stenting in ST-Segment Elevation Myocardial Infarction Patients Presented with High Thrombus Burden: A Systematic Review and Meta-Analysis

  2021cites this paper
• Rapid Lipid Modification of Endothelial Cell Membranes in Cardiac Ischemia/Reperfusion Injury: a Novel Therapeutic Strategy to Reduce Infarct Size

  2020cites this paper
• Clinical, Laboratory, and Procedural Predictors of No-Reflow in Patients Undergoing Primary Percutaneous Coronary Intervention

  2020cites this paper
• A Scoring System to Predict No-Reflow Phenomenon in Elective Percutaneous Coronary Intervention: The RECOVER Score.

  2020cites this paper
• Prediction of no-reflow phenomenon in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

  2020cites this paper
• Endothelial Dysfunction and Coronary Vasoreactivity - A Review of the History, Physiology, Diagnostic Techniques, and Clinical Relevance

  2020cites this paper
• A Mechanistic Rationale for PDE-4 Inhibitors to Treat Residual Cognitive Deficits in Acquired Brain Injury

  2020cites this paper
• Effect of nicorandil treatment adjunctive to percutaneous coronary intervention in patients with acute myocardial infarction: a systematic review and meta-analysis

  2020cites this paper
• Multivessel Coronary Artery Disease and Subsequent Thrombolysis in Myocardial Infarction Flow Grade After Primary Percutaneous Coronary Intervention

  2020cites this paper
• Effect of intravenous application of nicorandil on area of myocardial infarction in patients with STEMI during the perioperative stage of PCI

  2020cites this paper
• Clinical and procedural predictors and short-term survival of the patients with no reflow phenomenon after primary percutaneous coronary intervention.

  2019cites this paper
• Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery

  2019cites this paper
• Investigations of Pathological Conditions and Circulation during Oncological Reconstructive Surgeries

  2019cites this paper
• POSSIBILITY OF THERAPY OF ACUTE ISCHEMIC STROKE BY POLYPHENOLS OF FLAVONOID GROUP

  2019cites this paper
• HP_A_217955 65..79

  2019cites this paper
• Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

  2019cites this paper
• Acute Myocardial Infarction

  2019cites this paper
• Effects of Early Intracoronary Administration of Nicorandil During Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction.

  2019cites this paper
• Role of Oxidative Stress in Myocardial Ischemia and Infarction

  2019cites this paper
• Effect of nicorandil administration on myocardial microcirculation during primary percutaneous coronary intervention in patients with acute myocardial infarction

  2018cites this paper
• Effects and influencing factors on hemorheological variables taken into consideration in surgical pathophysiology research

  2018cites this paper
• Pathophysiologie des escarres dans le muscle squelettique

  2018cites this paper
• Predictors of no-reflow in patients with ST-segment elevation acute myocardial infarction after primary percutaneous coronary intervention

  2018cites this paper
• TROMBÜS OLDUKÇA BÜYÜKTÜ: ÖNCE ASPİRASYON YAPILMALI MIYDI ? There is a Huge Thrombus: Should we have Performed Aspiration First?

  2018cites this paper
• Trombectomia aspirativa manual durante intervenção coronária percutânea primária na prática brasileira

  2018cites this paper
• The predictors of no reflow phenomenon after percutaneous coronary intervention in patients with ST elevation myocardial infarction: A meta-analysis

  2018cites this paper
• Intracoronary Nicorandil and the Prevention of the No-Reflow Phenomenon During Primary Percutaneous Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction

  2018cites this paper
• Outcomes of direct stenting in patients with ST-elevated myocardial infarction

  2018cites this paper
• The no-reflow phenomenon: mechanisms and therapeutic targets

  2018cites this paper
• Correlates of the “No-Reflow” or “Slow-Flow” Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention

  2018cites this paper
• Effect of Platelet GPIIb/IIIa Receptor Blockade With MK383 on Infarct Size and Myocardial Blood Flow in a Canine Reocclusion Model

  2018cites this paper
• Effects of Polyethylene Glycol-20k on Postresuscitation Myocardial and Cerebral Function in a Rat Model of Cardiopulmonary Resuscitation

  2018cites this paper
• Intramyocardial dissecting hematoma in anterior wall ST elevation myocardial infarction: impact on left ventricular remodeling and prognosis

  2018cites this paper
• The influence of microvascular injury on native T1 and T2* relaxation values after acute myocardial infarction: implications for non-contrast-enhanced infarct assessment

  2017influential citation
• New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury.

  2017cites this paper
• Adverse outcomes following percutaneous transcatheter interventions

  2017cites this paper
• Relationship between residual viable myocardium and LV remodeling post-MI: Only part of the story

  2017cites this paper
• Blood rheology of angina pectoris patients with myocardial injury after ischemia reperfusion and its effect on thromboxane B2 levels

  2017cites this paper
• Predictors of no- reflow during primary angioplasty for acute myocardial infarction, from Medical College Hospital, Trivandrum

  2017cites this paper
• Microvascular dysfunction following ST-elevation myocardial infarction and its recovery over time.

  2017cites this paper
• Administration of 5-Hydroxydecanoate, a Selective Inhibitor of Mitochondrial ATP-sensitive Potassium Channels, Inhibits Apelin-Induced cardioprotection in Ischemia/Reperfusion Model of Male Rats

  2017cites this paper
• Low-Volume Resuscitation for Hemorrhagic Shock: Understanding the Mechanism of PEG-20k

  2017cites this paper
• Acute Myocardial Injury: A Perspective on Lethal Reperfusion Injury

  2017cites this paper
• The Importance of Magnesium Values in Patients With STEMI Admitted to the Emergency Department

  2017cites this paper
• Risk Factors for No-Reflow Phenomenon after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome.

  2017cites this paper
• The Relation Between No-Reflow Phenomenon and Complete Blood Count Parameters

  2017cites this paper
• Reperfusion therapy-What's with the obstructed, leaky and broken capillaries?

  2017cites this paper
• Percutaneous Coronary Intervention Predictors of Impaired Reperfusion after Percutaneous Coronary Intervention in Patients with In-Hospital Acute Stent Thrombosis: A Retrospective Analyses of 5 Years of Data

  2017cites this paper
• New and revisited approaches to preserving the reperfused myocardium

  2017cites this paper
• Chromogranin A-Derived Peptides in Cardiac Pre- and Post-conditioning

  2017cites this paper
• CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS

  2017cites this paper
• Invasive Assessment of the Coronary Microcirculation in Reperfused ST-Segment–Elevation Myocardial Infarction Patients: Where Do We Stand?

  2017cites this paper
• Administration of the Mitochondrial Permeability Transition Pore Inhibitor, TRO40303, prior to Primary Percutaneous Coronary Intervention, Does Not Affect the Levels of Pro-Inflammatory Cytokines or Acute-Phase Proteins

  2017cites this paper
• Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon

  2017cites this paper
• General Introduction and Outline of the Thesis Myocardial Reperfusion Injury Cardiovascular Magnetic Resonance after Acute Myocardial Infarction

  2016cites this paper
• Pentoxifylline attenuates the local and systemic inflammatory response after infrarenal abdominal aortic ischemia-reperfusion

  2016cites this paper