The Transcriptional Response of Cryptococcus neoformans to Ingestion by Acanthamoeba castellanii and Macrophages Provides Insights into the Evolutionary Adaptation to the Mammalian Host

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Eukaryotic Cell

• Publication date

  2013-03-22

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/EC.00073-13PMID 23524994PMCID PMC3647765
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amoeba provide insight into the origin of virulence in pathogenic fungi.

  2012cited by this paper
• Immunity to fungal infections

  2011cited by this paper
• Cryptococcus neoformans Capsular Enlargement and Cellular Gigantism during Galleria mellonella Infection

  2011cited by this paper
• Dynamics of Cryptococcus neoformans-Macrophage Interactions Reveal that Fungal Background Influences Outcome during Cryptococcal Meningoencephalitis in Humans

  2011cited by this paper
• Phospholipids Trigger Cryptococcus neoformans Capsular Enlargement during Interactions with Amoebae and Macrophages

  2011cited by this paper
• Cryptococcus neoformans responds to mannitol by increasing capsule size in vitro and in vivo

  2010cited by this paper
• An efficient gene-disruption method in Cryptococcus neoformans by double-joint PCR with NAT-split markers.

  2009cited by this paper
• Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.

  2008cited by this paper
• Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival

  2008cited by this paper
• Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

  2008cited by this paper
• Upregulation of glyoxylate cycle genes upon Paracoccidioides brasiliensis internalization by murine macrophages and in vitro nutritional stress condition.

  2008cited by this paper
• Characterization of genes differentially expressed within macrophages by virulent and attenuated Mycobacterium tuberculosis identifies candidate genes involved in intracellular growth.

  2008cited by this paper
• Early transcriptional response of Paracoccidioides brasiliensis upon internalization by murine macrophages.

  2007cited by this paper
• The Cryptococcal Enzyme Inositol Phosphosphingolipid-Phospholipase C Confers Resistance to the Antifungal Effects of Macrophages and Promotes Fungal Dissemination to the Central Nervous System

  2006cited by this paper
• Report Expulsion of Live Pathogenic Yeast by Macrophages

  2006cited by this paper
• Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans.

  2006cited by this paper
• Characterization and Regulation of the Trehalose Synthesis Pathway and Its Importance in the Pathogenicity of Cryptococcus neoformans

  2006cited by this paper
• The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense

  2006cited by this paper
• Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages.

  2006cited by this paper
• Cryptococcus neoformans α Strains Preferentially Disseminate to the Central Nervous System during Coinfection

  2005cited by this paper
• Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.

  2005cited by this paper
• The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans.

  2005cited by this paper
• Effects of Culture Conditions on Ergosterol Biosynthesis by Saccharomyces cerevisiae

  2005cited by this paper
• Thioredoxin Reductase Is Essential for Viability in the Fungal Pathogen Cryptococcus neoformans

  2005cited by this paper
• Cryptococcus neoformans Gene Expression during Murine Macrophage Infection

  2005cited by this paper
• Immunity to fungal infections

  2004cited by this paper
• Identification of Cryptococcus neoformans Temperature-Regulated Genes with a Genomic-DNA Microarray

  2004cited by this paper
• Transcriptional Response of Candida albicans upon Internalization by Macrophages

  2004influential reference
• The importance of a functional trehalose biosynthetic pathway for the life of yeasts and fungi.

  2004cited by this paper
• Extrathymic T-cell differentiation in vitro

  2004cited by this paper
• Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

  2004cited by this paper
• Cryptococcus neoformans Virulence Is Enhanced after Growth in the Genetically Malleable Host Dictyostelium discoideum

  2003cited by this paper
• Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.

  2003cited by this paper
• Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages

  2003cited by this paper
• The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans.

  2003cited by this paper
• 'Ready made' virulence and 'dual use' virulence factors in pathogenic environmental fungi--the Cryptococcus neoformans paradigm.

  2003cited by this paper
• Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

  2003cited by this paper
• A phagosome of one's own: a microbial guide to life in the macrophage.

  2002cited by this paper
• Life and Death in a Macrophage: Role of the Glyoxylate Cycle in Virulence

  2002cited by this paper
• Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity.

  2002cited by this paper
• Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores virulence in a murine lung infection.

  2002cited by this paper
• The glyoxylate cycle is required for fungal virulence

  2001cited by this paper
• Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages

  2001influential reference
• Effects of Anoxia and the Mitochondrion on Expression of Aerobic Nuclear COX Genes in Yeast

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Intracellular parasitism of macrophages by Cryptococcus neoformans.

  2001cited by this paper
• Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection

  2000cited by this paper
• Cryptococcus neoformans Resides in an Acidic Phagolysosome of Human Macrophages

  1999cited by this paper
• Identification of extracellular phospholipase B, lysophospholipase, and acyltransferase produced by Cryptococcus neoformans

  1997cited by this paper
• Effect of serum IgG1 to Cryptococcus neoformans glucuronoxylomannan on murine pulmonary infection.

  1997cited by this paper
• Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

  1997cited by this paper
• The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence

  1996cited by this paper
• Virulence factors of medically important fungi

  1996cited by this paper
• Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans.

  1996cited by this paper
• Regulation of mannitol biosynthesis and degradation by Cryptococcus neoformans

  1994cited by this paper
• Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA

  1993cited by this paper
• Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis

  1990cited by this paper
• Ecology, life cycle, and infectious propagule of Cryptococcus neoformans.

  1990cited by this paper
• Influence of oxygen tension on the respiratory activity of Mycobacterium phlei.

  1988cited by this paper
• Rapid changes of heat and desiccation tolerance correlated with changes of trehalose content in Saccharomyces cerevisiae cells subjected to temperature shifts

  1987cited by this paper
• Control of Cryptococcus neoformans in nature by biotic factors.

  1982cited by this paper
• Cryptococcus neoformans: gastronomic delight of a soil ameba.

  1979cited by this paper
• Production of D-mannitol and glycerol by yeasts.

  1968cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Integrative Transcriptomic and Systems Biology Analyses Identify TCB1 as a Calcium-Responsive Gene in Cryptococcus neoformans

  2026cites this paper
• Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

  2025cites this paper
• Peroxisomes regulate virulence and cell density sensing in Cryptococcus neoformans

  2025cites this paper
• Genetic Factors of Campylobacter jejuni Required for Its Interactions with Free-Living Amoeba

  2025cites this paper
• Reconstruction and exploitation of a dedicated Genome-Scale Metabolic Model of the human pathogen C. neoformans

  2025cites this paper
• Unveiling new features of the human pathogen Cryptococcus neoformans through the reconstruction and exploitation of a dedicated genome-scale metabolic model

  2025cites this paper
• Free-living amoebae: a journey into historical aspects and to current discoveries

  2025cites this paper
• Cryptococcal nutrient acquisition and pathogenesis: dining on the host

  2025influential citation
• The influence of amoeba metal homeostasis on antifungal activity against Cryptococcus gattii

  2024cites this paper
• Modelling dynamics between free-living amoebae and bacteria.

  2024cites this paper
• Using Acanthamoeba spp. as a cell model to evaluate Leishmania infections

  2024cites this paper
• Inhibition of Microbicidal Activity of Canine Macrophages DH82 Cell Line by Capsular Polysaccharides from Cryptococcus neoformans

  2024cites this paper
• Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

  2023cites this paper
• Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity

  2023cites this paper
• Yeast-amoeba interaction influences murine cryptococcosis.

  2023cites this paper
• Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species

  2023cites this paper
• Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis

  2023cites this paper
• A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans

  2023cites this paper
• Recognition of Cell Wall Mannosylated Components as a Conserved Feature for Fungal Entrance, Adaptation and Survival Within Trophozoites of Acanthamoeba castellanii and Murine Macrophages

  2022cites this paper
• Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity

  2022cites this paper
• A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans

  2022cites this paper
• Acanthamoeba, an environmental phagocyte enhancing survival and transmission of human pathogens.

  2022cites this paper
• A history of over 40 years of potentially pathogenic free-living amoeba studies in Brazil - a systematic review

  2022cites this paper
• The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection

  2022cites this paper
• Post-transcriptional and translational control of the morphology and virulence in human fungal pathogens.

  2021cites this paper
• “Feast-Fit-Fist-Feat”: Overview of Free-living Amoeba Interactions with Fungi and Virulence as a Foundation for Success in Battle

  2021cites this paper
• Glycans of the Pathogenic Yeast Cryptococcus neoformans and Related Opportunities for Therapeutic Advances

  2021cites this paper
• Transcriptomic response of Cryptococcus neoformans to ecologically relevant nitrogen concentrations.

  2021cites this paper
• Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence

  2020cites this paper
• Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence.

  2020cites this paper
• Nitrogen concentration affects amphotericin B and fluconazole tolerance of pathogenic cryptococci.

  2020cites this paper
• The virulence of the Cryptococcus neoformans VNIa-5 lineage is highly plastic and associated with isolate background

  2020cites this paper
• The transcription factor Pdr802 regulates Cryptococcus neoformans Titan cell production and pathogenicity

  2020influential citation
• Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection

  2020cites this paper
• Ecology of Cryptococcus neoformans in Vietnam

  2019cites this paper
• Protein Kinases at the Intersection of Translation and Virulence

  2019cites this paper
• Polymicrobial interactions involving fungi and their importance for the environment and in human disease.

  2019cites this paper
• Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype

  2019cites this paper
• The enigmatic role of fungal annexins: the case of Cryptococcus neoformans

  2019cites this paper
• Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

  2019cites this paper
• A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp

  2019cites this paper
• Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection

  2019cites this paper
• Fungal evolution: major ecological adaptations and evolutionary transitions

  2019cites this paper
• How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.

  2019cites this paper
• Seasons of change: Mechanisms of genome evolution in human fungal pathogens.

  2019cites this paper
• Role of Cryptococcus neoformans Pyruvate Decarboxylase and Aldehyde Dehydrogenase Enzymes in Acetate Production and Virulence

  2019influential citation
• Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal Virulence

  2018cites this paper
• Cryptococcus neoformans Escape From Dictyostelium Amoeba by Both WASH-Mediated Constitutive Exocytosis and Vomocytosis

  2018cites this paper
• Cryptococcal Traits Mediating Adherence to Biotic and Abiotic Surfaces

  2018cites this paper
• Transcriptional Heterogeneity of Cryptococcus gattii VGII Compared with Non-VGII Lineages Underpins Key Pathogenicity Pathways

  2018cites this paper
• Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence

  2018cites this paper
• Characterisation of the virulence and determinants of virulence of C. neoformans var. grubii genotypes from HIV infected and uninfected patients in Vietnam

  2018cites this paper
• Molecular Mechanisms of Fungal Adaptive Evolution

  2018cites this paper
• Amebas de vida libre: detección en aguas de consumo y alimentos

  2018cites this paper
• Transcriptional heterogeneity of VGII compared with non-VGII lineages underpins key pathogenicity pathways

  2018cites this paper
• Divalent Metal Cations Potentiate the Predatory Capacity of Amoeba for Cryptococcus neoformans

  2017cites this paper
• Metabolic adaptation of intracellular bacteria and fungi to macrophages.

  2017cites this paper
• Transcriptional Analysis Allows Genome Reannotation and Reveals that Cryptococcus gattii VGII Undergoes Nutrient Restriction during Infection

  2017cites this paper
• Investigating the molecular mechanisms of vomocytosis

  2017cites this paper
• Analysis of multiple components involved in the interaction between Cryptococcus neoformans and Acanthamoeba castellanii.

  2017cites this paper
• Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis.

  2017cites this paper
• Genomic Analysis of the Population Structure and Virulence of the Human Pathogen, Cryptococcus Neoformans Var. Grubii

  2017cites this paper
• It's not all about us: evolution and maintenance of Cryptococcus virulence requires selection outside the human host

  2017cites this paper
• Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi

  2017cites this paper
• Exploring Virulence Determinants of Filamentous Fungal Pathogens through Interactions with Soil Amoebae

  2017cites this paper
• Pathogenic potential of environmental resident fungi from ornithogenic soils of Antarctica.

  2017cites this paper
• Nutritional Requirements and Their Importance for Virulence of Pathogenic Cryptococcus Species

  2017cites this paper
• Modulation of Zinc Homeostasis in Acanthamoeba castellanii as a Possible Antifungal Strategy against Cryptococcus gattii

  2017cites this paper
• Fungi that Infect Humans

  2017cites this paper
• Alterations of zinc homeostasis in response to Cryptococcus neoformans in a murine macrophage cell line.

  2017cites this paper
• What makes Cryptococcus gattii a pathogen?

  2016cites this paper
• Disease dynamics, invasion and biological control of environmentally growing pathogens

  2016cites this paper
• Acanthamoeba spp. as a universal host for pathogenic microorganisms: One bridge from environment to host virulence.

  2016cites this paper
• A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals

  2016cites this paper
• Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

  2015cites this paper
• Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies

  2015cites this paper
• Fungal Pathogens: Survival and Replication within Macrophages.

  2015cites this paper
• Fungal serotype-specific differences in bacterial-yeast interactions

  2015cites this paper
• Cryptococcus neoformans Host Adaptation: Toward Biological Evidence of Dormancy

  2015cites this paper
• New technology and resources for cryptococcal research.

  2015cites this paper
• Analysis of the Fungal Virulence of Cryptococcus and Exploration of Novel Antifungals Against Cryptococcosis

  2014cites this paper
• Fungal Pathogens : Survival and Replication within Macrophages

  2014cites this paper
• The tools for virulence of Cryptococcus neoformans.

  2014cites this paper
• Large-Scale Chromosomal Changes and Associated Fitness Consequences in Pathogenic Fungi

  2014cites this paper
• Macrophage–Cryptococcus Interactions: An Update

  2014cites this paper
• The intracellular life of Cryptococcus neoformans.

  2014cites this paper
• Could Acanthamoeba have hosted and trained Leishmania to evade innate immune response?

  2014cites this paper
• Regulation of vacuolar trafficking by Vps45p in the pathogenic fungus Cryptococcus neoformans

  2014cites this paper