Negative symptoms of schizophrenia are associated with abnormal effort-cost computations.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biological Psychiatry

• Publication date

  2013-07-15

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.biopsych.2012.12.022PMID 23394903PMCID PMC3703817
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emotional experience in negative symptoms of schizophrenia--no evidence for a generalized hedonic deficit.

  2013cited by this paper
• Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence.

  2012influential reference
• Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia

  2012cited by this paper
• A new perspective on anhedonia in schizophrenia.

  2012influential reference
• Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making

  2012cited by this paper
• Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia.

  2012cited by this paper
• The brief negative symptom scale: psychometric properties.

  2011influential reference
• Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli.

  2011cited by this paper
• Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia.

  2011cited by this paper
• Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies.

  2010cited by this paper
• Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.

  2010cited by this paper
• Periods of recovery in deficit syndrome schizophrenia: a 20-year multi-follow-up longitudinal study.

  2010cited by this paper
• Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions.

  2010cited by this paper
• Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.

  2010cited by this paper
• Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia.

  2009cited by this paper
• Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine

  2009cited by this paper
• Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia

  2009cited by this paper
• Effort-Based Cost–Benefit Valuation and the Human Brain

  2009cited by this paper
• Reward processing in schizophrenia: a deficit in the representation of value.

  2008cited by this paper
• Decision-making impairments in the context of intact reward sensitivity in schizophrenia.

  2008cited by this paper
• Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction.

  2007cited by this paper
• Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction.

  2007cited by this paper
• Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

  2007cited by this paper
• Delay discounting in schizophrenia

  2007cited by this paper
• Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior.

  2007cited by this paper
• Anhedonia in schizophrenia: distinctions between anticipatory and consummatory pleasure.

  2007cited by this paper
• The structure of negative symptoms within schizophrenia: implications for assessment.

  2006cited by this paper
• The interrater reliability of the Structured Interview for DSM-IV Personality.

  2006cited by this paper
• Dementia praecox and paraphrenia

  2002cited by this paper
• A separate disease within the syndrome of schizophrenia.

  2001cited by this paper
• Structured interview for DSM-IV personality: SIDP-IV

  1998cited by this paper
• Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome.

  1998cited by this paper
• Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet

  1997cited by this paper
• Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia.

  1994cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.

  1994cited by this paper
• The Brief Psychiatric Rating Scale

  1962influential reference
• Schizotaxia, Schizotypy, Schizophrenia

  1962cited by this paper

• Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample.

  2026cites this paper
• Neural activation during cognitive effort-based decision-making: Associations with avolition in Veterans with schizophrenia and bipolar disorder.

  2026cites this paper
• Examining effects of effort and reward magnitude on effort-cost decision-making in people with major depressive disorder.

  2026cites this paper
• Understanding Effort-Cost Decision-Making Mechanisms in Mood and Psychotic Disorders: A Computational Modeling Approach Across Physical and Cognitive Effort Paradigms.

  2025cites this paper
• Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms

  2025cites this paper
• Operant effort-based decision-making task reveals sex differences in motivational behavior but no long-term effects of adolescent intermittent ethanol in Sprague Dawley rats.

  2025cites this paper
• A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm

  2025cites this paper
• Neural Responses to Reward and Psychosis Dimensions.

  2025cites this paper
• Cognitive effort-based decision making in schizophrenia and bipolar disorder: Associations with clinical symptoms and cognitive performance.

  2025cites this paper
• Adaptive Cost-Benefit Control Fueled by Striatal Dopamine.

  2025cites this paper
• Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia

  2025cites this paper
• Using the grip strength effort task to measure reward processing dysfunction in schizophrenia and major depressive disorder

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• An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology

  2025cites this paper
• Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice

  2025cites this paper
• Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms

  2025cites this paper
• Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.

  2025cites this paper
• Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.

  2025cites this paper
• Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial

  2025cites this paper
• Effort-cost decision-making associated with negative symptoms in schizophrenia and bipolar disorder.

  2024cites this paper
• Inhibition of striatal indirect pathway during second postnatal week leads to long lasting deficits in motivated behavior

  2024cites this paper
• From brain to body: exploring the connection between altered reward processing and physical fitness in schizophrenia.

  2024cites this paper
• Dampened motivation in schizophrenia: evidence from a novel effort-based decision-making task in social scenarios

  2024cites this paper
• Effort-based decision-making in ultra-high-risk for psychosis and bipolar disorder.

  2024cites this paper
• Are delusions adaptive? An empirical and philosophical study on delusions in OCD

  2024cites this paper
• Investigating disorder-specific and transdiagnostic alterations in model-based and model-free decision-making

  2024cites this paper
• Trying Harder: How Cognitive Effort Sculpts Neural Representations during Working Memory

  2024cites this paper
• Using Computational Phenotyping to Identify Divergent Strategies for Effort Allocation Across the Psychosis Spectrum.

  2024cites this paper
• Increased Sensitivity to Effort and Perception of Effort in People with Schizophrenia.

  2024cites this paper
• Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats

  2024cites this paper
• Trying harder: how cognitive effort sculpts neural representations during working memory

  2023cites this paper
• “Goals in Focus”—a targeted CBT approach for motivational negative symptoms of psychosis: study protocol for a randomized-controlled feasibility trial

  2023cites this paper
• Cognitive Control in Schizophrenia: Advances in Computational Approaches

  2023cites this paper
• Computational phenotyping of aberrant belief updating in individuals with schizotypal traits and schizophrenia

  2023cites this paper
• Gender Impacts the Relationship between Mood Disorder Symptoms and Effortful Avoidance Performance

  2023cites this paper
• Effort-based decision-making as a determinant of supported employment outcomes in psychotic disorders.

  2023cites this paper
• A Multi-task Platform for Profiling Cognitive and Motivational Constructs in Humans and Nonhuman Primates

  2023cites this paper
• Effects of an experimentally induced inflammatory stimulus on motivational behavior in remitted depressed patients.

  2023cites this paper
• The role of defeatist performance beliefs on cognitive effort-cost decision-making in schizophrenia.

  2023cites this paper
• Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task

  2023cites this paper
• Community-based multi-site randomized controlled trial of behavioral activation for patients with negative symptoms of schizophrenia.

  2023cites this paper
• Effort-Cost Decision-Making in Psychotic and Mood Disorders

  2023influential citation
• Short-active gestational photoperiod reduces effortful choice behavior in mice, partial normalization by d-amphetamine

  2023cites this paper
• Modelling effort-based decision-making: individual differences in schizophrenia and major depressive disorder.

  2023cites this paper
• The validity of a therapeutic invigoration task in avolitional schizophrenia outpatients.

  2023cites this paper
• A Transdiagnostic Study of Effort-Cost Decision-Making in Psychotic and Mood Disorders.

  2023cites this paper
• Effort-cost decision-making in psychotic and mood disorders.

  2023cites this paper
• Dissociation of Cognitive Effort-Based Decision Making and its Associations with Symptoms, Cognition, and Everyday Life Function Across Schizophrenia, Bipolar Disorder, and Depression.

  2023cites this paper
• Associations between cognitive and physical effort-based decision-making in people with schizophrenia and healthy controls.

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• Perceived chronic stress and impulsivity are associated with reduced learning about the costs and benefits of actions

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• On the normative advantages of 1 dopamine and striatal opponency for 2 learning and choice 3

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• Effort Foraging Task reveals positive correlation between individual differences in the cost of cognitive and physical effort in humans

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• Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition

  2023cites this paper
• The Neurobiology of Activational Aspects of Motivation: Exertion of Effort, Effort-Based Decision Making, and the Role of Dopamine.

  2023cites this paper
• Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co-administration of the adenosine A2A antagonist istradefylline

  2023cites this paper
• Effort-Cost Decision-making Among Individuals With Schizophrenia: A Systematic Review and Meta-analysis.

  2023cites this paper
• Impaired neural response to reward feedback in children with high schizotypal traits: Evidences from an ERP study.

  2023cites this paper
• Negative symptoms and cognitive impairment are associated with distinct motivational deficits in treatment resistant schizophrenia

  2023influential citation
• Effort-based decision making in schizotypy and its relationship with amotivation and psychosocial functioning

  2023cites this paper
• Are effort‐based decision‐making tasks worth the effort?—A study on the associations between effort‐based decision‐making tasks and self‐report measures

  2022influential citation
• Blunted pupil light reflex is associated with negative symptoms and working memory in individuals with schizophrenia.

  2022cites this paper
• Impaired Effort Allocation in Patients with Recent-Onset Schizophrenia and Its Relevance to Negative Symptoms Assessments and Persistent Negative Symptoms

  2022influential citation
• Negative symptoms, striatal dopamine, and model-free reward decision-making in schizophrenia.

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• Aberrant reward processing to positive versus negative outcomes across psychotic disorders.

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• Implicit cognitive effort monitoring impairments are associated with expressive negative symptoms in schizophrenia.

  2022cites this paper
• Preserved Unconscious Processing in Schizophrenia: The Case of Motivation.

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• Anhedonia in Depression and Schizophrenia: Brain Reward and Aversion Circuits

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• Gpr88 deletion impacts motivational control independently of striatal dopamine function

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• Negative schizotypal traits predict the reduction of reward motivation in effort–reward imbalance

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• Action selection in early stages of psychosis: an active inference approach

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• Low goal-directed behavior in negative symptoms is explained by goal setting - Results of a diary study.

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• The effect of salience of rewards on effort-based decision making in psychotic disorders

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• Anhedonia and Suicide.

  2022cites this paper
• Going the extra mile? The influence of Amisulpride on effort-based decisions.

  2022cites this paper
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