Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study

J. Feary,A. Venn,A. Brown,D. Hooi,Franco H Falcone,K. Mortimer,D. Pritchard,J. Britton

Published 2009 in Clinical and Experimental Allergy

ABSTRACT

Background Epidemiological evidence suggests that hookworm infection protects against asthma. However, for ethical and safety reasons, before testing this hypothesis in a clinical trial in asthma it is necessary to establish whether experimental hookworm infection might exacerbate airway responsiveness during larval lung migration.

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