Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS).

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Molecular Biology

• Publication date

  2003-04-11

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0022-2836(03)00234-1PMID 12662931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001influential reference
• Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange.

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  1998influential reference
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  1993cited by this paper
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  1993cited by this paper
• cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.

  1990cited by this paper
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  1990cited by this paper
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• Selective protection of sulfhydryl groups in cAMP-dependent protein kinase II.

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  1981influential reference
• The kinetics of association of cyclic AMP to the two types of binding sites associated with protein kinase II from bovine myocardium

  1981cited by this paper
• An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: application to ribonuclease S peptide.

  1979cited by this paper
• Relationships between structural domains and function in the regulatory subunit of cAMP-dependent protein kinases I and II from porcine skeletal muscle.

  1979influential reference
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  1972cited by this paper

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