Biochemistry and toxicology of the diterpenoid glycoside atractyloside.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Food and Chemical Toxicology

• Publication date

  1998-04-06

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0278-6915(98)00002-7PMID 9651051
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nephrotoxic effect of Atractyloside in rats

  2004cited by this paper
• Toxicity of atractyloside in precision-cut rat and porcine renal and hepatic tissue slices.

  1998cited by this paper
• Lipid profiling in renal and hepatic tissue slices following exposure to atractyloside.

  1997cited by this paper
• Inhibition of mitochondrial respiration and oxygen uptake in isolated rat renal tubular fragments by atractyloside.

  1996cited by this paper
• Selective cytotoxicity associated with in vitro exposure of fresh rat renal fragments and continuous cell lines to atractyloside

  1996cited by this paper
• Coffee and Cancer of the Pancreas: An Italian Multicenter Study

  1995cited by this paper
• Diterpene glycosides from Iphiona aucheri.

  1994cited by this paper
• High-performance liquid chromatographic determination of atractyloside and carboxyatractyloside from Atractylis gummifera L.

  1994cited by this paper
• Extrarenal and direct renal actions of atractyloside contribute to its acute nephrotoxicity in pentobarbital-anesthetized dogs.

  1993cited by this paper
• Lifetime consumption of alcoholic beverages, tea and coffee and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

  1992cited by this paper
• Intestinal motility enhancing effect of Atractylodes lancea rhizome.

  1990cited by this paper
• Cocklebur Toxicosis in Cattle Associated with the Consumption of Mature Xanthium Strumarium

  1990cited by this paper
• [The first thirty months of kidney transplantation in Tunisia].

  1990cited by this paper
• An enzyme immunoassay for atractyloside, the nephrotoxin of Callilepis laureola (Impila).

  1990cited by this paper
• Studies on the Constiutents of Atractylodes lancea

  1989cited by this paper
• The ATP/ADP-antiporter is involved in the uncoupling effect of fatty acids on mitochondria.

  1989cited by this paper
• Observations on the use of some known and suspected toxic Liliiflorae in Zulu and Xhosa medicine.

  1989cited by this paper
• Triterpenes from Atractylis carduus L.

  1989cited by this paper
• Effect of verapamil on phosphate-induced changes in oxidative phosphorylation and atractyloside-sensitive adenine nucleotide translocase activity in two populations of rat heart mitochondria.

  1989cited by this paper
• Intracellular Ca2+ and cytotoxicity.

  1989cited by this paper
• Biochemical investigation of atractylis gummifera L. hepatotoxicyty in the rat.

  1989cited by this paper
• Duramycin effects on the structure and function of heart mitochondria. I. Structural alterations and changes in membrane permeability.

  1989cited by this paper
• Chemical constituents of two Centaurea species

  1989cited by this paper
• Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site.

  1988cited by this paper
• Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site.

  1988cited by this paper
• Hepatotoxicity due to Atractylis gummifera-L.

  1988cited by this paper
• Permeability of inner mitochondrial membrane and oxidative stress.

  1988cited by this paper
• Temperature dependence of the atractyloside-induced mitochondrial Ca2+ release.

  1988cited by this paper
• Mitochondrial transmembrane potential and pH gradient during anoxia.

  1987cited by this paper
• Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content.

  1987cited by this paper
• Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus.

  1987cited by this paper
• Inhibition of rat heart mitochondrial respiration by cadmium chloride.

  1987cited by this paper
• Cocklebur poisoning in cattle.

  1986cited by this paper
• Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver.

  1986cited by this paper
• Anion sensitive ATPase in human cornea.

  1985cited by this paper
• Binding and function of mitochondrial glycerol kinase in comparison with those of mitochondrial hexokinase.

  1985cited by this paper
• Catecholamine and vasopressin stimulation of gluconeogenesis from dihydroxyacetone in the presence of atractyloside.

  1985cited by this paper
• Effects of glucagon on the redox states of cytochromes in mitochondria in situ in perfused rat liver.

  1984cited by this paper
• Direct photoaffinity labeling of proteins with adenosine 3'-[32P]phosphate 5'-phosphosulfate. Atractyloside inhibits labeling of a Mr = 34,000 protein in an adrenal medullary Golgi fraction.

  1984cited by this paper
• Transport of ADP/ATP carrier into mitochondria. Precursor imported in vitro acquires functional properties of the mature protein.

  1984cited by this paper
• Protective role of adenine nucleotide translocase in O2-deficient hearts.

  1984cited by this paper
• Atractyloside, toxic compound from Wedelia glauca.

  1984cited by this paper
• Characteristics of adenine nucleotide fluxes and transport in human tumor mitochondria.

  1984cited by this paper
• Carboxyatractyloside: a compound from Xanthium strumarium and Atractylis gummifera with plant growth inhibiting properties. The probable «inhibitor A»

  1983cited by this paper
• Elevated intramitochondrial adenine nucleotides and mitochondrial function.

  1983cited by this paper
• Regulation of Ca2+ efflux in rat liver mitochondria. Role of membrane potential.

  1983cited by this paper
• Mitochondrial calcium transport.

  1982cited by this paper
• Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor.

  1982cited by this paper
• Cocklebur (Xanthium strumarium, L. var. strumarium) Intoxication in Swine: Review and Redefinition of the Toxic Principle

  1981cited by this paper
• The toxic extractives from wedelia asperrima —I

  1981cited by this paper
• Coffee and cancer of the pancreas.

  1981cited by this paper
• Effects of carnitine and atractyloside on canine cardiac electrical activity.

  1981cited by this paper
• Intramitochondrial adenine nucleotides and energy-linked functions of heart mitochondria.

  1981cited by this paper
• Nucleotide uptake by isolated cholinergic synaptic vesicles: evidence for a carrier of adenosine 5'-triphosphate.

  1981cited by this paper
• Atractyloside, chemistry, biochemistry and toxicologyedited by R. Santi and S. Luciani, Piccin Medical Books, Padova, Italy, 1978. $12.00 (xxii + 136 pages)

  1980cited by this paper
• Inhibitors of the adenine nucleotide translocase.

  1979cited by this paper
• Effect of diuretics on ADP incorporation in kidney mitochondria.

  1979cited by this paper
• [Determination of diterpene glycosides in coffee (author's transl)].

  1978cited by this paper
• Über ein neues Atractyligenin‐Glycosid aus grünen Kaffeebohnen

  1978cited by this paper
• Bestimmung von Diterpen-Glykosiden im Bohnenkaffee

  1978cited by this paper
• Toxicity of Callilepis laureola.

  1977cited by this paper
• Traumatic aneurysms of the superficial temporal and occipital arteries: case reports and review.

  1977cited by this paper
• Atractyloside-induced myocardial cell injury.

  1977cited by this paper
• Die Strukturen der „Kaffee‐Atractyloside”︁

  1976cited by this paper
• Atractyligenin — ein wesentlicher Bestandteil gerösteter Kaffeebohnen

  1974cited by this paper
• Struktur eines aus Menschenharn isolierten C19‐Terpenoids — 2β‐Hydroxy‐15‐oxoatractylan‐4α‐carbonsäure

  1973cited by this paper
• Acute renal failure from Callilepsis laureola.

  1971cited by this paper
• Intermediary metabolism and its regulation

  1971cited by this paper
• Site of action of atractyloside in mitochondria. II. Inhibition of oxidative phosphorylation.

  1967cited by this paper
• COMPETITIVE REVERSAL BY ADENINE NUCLEOTIDES OF ATRACTYLOSIDE EFFECT ON MITOCHONDRIAL ENERGY TRANSFER.

  1965cited by this paper
• THE SITES OF ACTION OF ATRACTYLOSIDE AND OLIGOMYCIN IN THE MITOCHONDRIAL ENERGY-TRANSFER SYSTEM.

  1964cited by this paper
• Pharmacological properties and mechanism of action of atractyloside

  1964cited by this paper
• The Effects of Guanidine and Alkylguanidines on the Energy Transfer Reactions of Mitochondria

  1963cited by this paper
• Action of potassium atractylate on oxidative phosphorylation in mitochondria and in submitochondrial particles.

  1962cited by this paper
• Atractyloside as inhibitor of energy-transfer reactions in liver mitochondria

  1962cited by this paper
• The medicinal and poisonous plants of southern and eastern Africa.

  1962cited by this paper
• Potassium Atractylate, a New Inhibitor of the Tricarboxylic Acid Cycle

  1958cited by this paper
• [Pharmacological research on the active principle of Atractylis gummifera. I. General effects].

  1955cited by this paper

• Study on the processing transformation law of CATR and ATR in Xanthii Fructus and the metabolomics mechanism of their transformation products in LO2 cells

  2026cites this paper
• Pharmacokinetics of primary atractyligenin metabolites after coffee consumption.

  2025cites this paper
• LC-ESI(±)-LTQ MSn‑Based Metabolomic Profiling of Coffee: Fragmentation Pathways for Identification of Major Polar Compounds

  2025cites this paper
• Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

  2025influential citation
• HRMS Characterization and Antioxidant Evaluation of Costa Rican Spent Coffee Grounds as a Source of Bioactive Polyphenolic Extracts

  2025cites this paper
• The cytotoxic, genotoxic and mitotoxic effects of Atractylis gummifera extract in vitro

  2024cites this paper
• Ent-Kaurane Diterpenoids from Coffea Genus: An Update of Chemical Diversity and Biological Aspects

  2024influential citation
• Multiorgan failure caused by Chinese herbal medicine Xanthii Fructus poisoning: a case report

  2023cites this paper
• Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H+ leak

  2023cites this paper
• The Detection of Toxic Compounds in Extracts of Callilepis laureola (Oxeye Daisy) and Senecio latifolius (Ragwort) by Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS/MS).

  2022cites this paper
• Puerarin mitigates oxidative injuries, opening of mitochondrial permeability transition pores and pathological damage associated with liver and kidney in Xanthium strumarium-intoxicated rats.

  2022cites this paper
• A case of carboxyatractyloside intoxication by ingestion of the cocklebur (Xanthium strumarium) in a Korean native cow.

  2022cites this paper
• Time-Based Effects of Xanthium strumarium Extract on Rats

  2022cites this paper
• Pascalia glauca poisoning in ruminants: Report of 12 outbreaks in northwestern Argentina.

  2022cites this paper
• Reproductive Toxicity of Carlina gummifera L. Incense Inhalation in Adult Male Wistar Rats

  2022cites this paper
• Toxicological Significance of Bioactive Compounds of Plant Origin

  2021cites this paper
• Phytochemical profile of Atractylis gummifera rhizome, acute toxicity to Wistar rat and rat poisoning effect in the field

  2021cites this paper
• Mitochondrial toxicity induced by plant molecules

  2021cites this paper
• Spontaneous outbreak of Pascalia glauca poisoning in sheep in Argentina

  2021cites this paper
• Coffee Leaves: An Upcoming Novel Food?

  2021cites this paper
• The influence of Ginkgo biloba on birth weight and histomorphometric characteristics of neonatal kidneys in albino rats

  2020cites this paper
• Atractyloside targets cancer-associated fibroblasts and inhibits the metastasis of colon cancer

  2020cites this paper
• Phytochemical investigation, in vitro and in vivo antioxidant properties of aqueous and organic extracts of toxic plant: Atractylis gummifera L.

  2020cites this paper
• Aperçu sur quelques plantes toxiques à usage médicinal: Cas du Moyen Atlas central- Maroc Overview of some toxic plants for medicinal use: the case of the central Middle Atlas – Morocco

  2020cites this paper
• Ethnoveterinary for food-producing animals and related food safety issues: A comprehensive overview about terpenes.

  2020cites this paper
• Potential Hepatotoxins Found in Herbal Medicinal Products: A Systematic Review

  2020cites this paper
• Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review

  2019cites this paper
• Simultaneous quantification of atractyloside and carboxyatractyloside in rat plasma by LC-MS/MS: Application to a pharmacokinetic study after oral administration of Xanthii Fructus extract.

  2019cites this paper
• Attenuation of Toxic Power of Atractylis Gummifera

  2018cites this paper
• Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes, Diterpenes, Sterols, Cardiac Glycosides and Steroid Saponins

  2018cites this paper
• Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F1-ATPase-mediated HDL endocytosis pathway on hepatocytes.

  2017cites this paper
• Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies

  2017cites this paper
• Wound healing potential of Terminalia sericea

  2016cites this paper
• CONTRIBUTION À UNE ÉTUDE BOTANIQUE ET CHIMIQUE DU CHARDON À GLU, Atractylis gummifera L., FAMILLE DES ASTERACEAE

  2016cites this paper
• [Acute toxicity of Xanthium spinosum leaves in BALB/C mice].

  2016cites this paper
• Qualität vier chinesischer Heilpflanzen aus bayerischem Versuchsanbau im Vergleich zu Importware — heimisch produzierte TCM-Drogen für den Praxisalltag

  2016cites this paper
• Identification of new highly selective inhibitors of the human ADP/ATP carriers by molecular docking and in vitro transport assays.

  2016cites this paper
• Study of composition of espresso coffee prepared from various roast degrees of Coffea arabica L. coffee beans.

  2016cites this paper
• Accidental poisoning with Wedelia glauca (“sunchillo”) in a bull confirmed by analysis of rumen content

  2016cites this paper
• Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide.

  2016cites this paper
• Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

  2016cites this paper
• Bioactive Principles from Medicinal Plants

  2015influential citation
• Medicinal Potentials and Toxicity Concerns of Bioactive Principles

  2015cites this paper
• Chemical characterization of plant materials and development of analytical methodologies for metabolite determination

  2015cites this paper
• Influence of Processing on the Content of Toxic Carboxyatractyloside and Atractyloside and the Microbiological Status of Xanthium sibiricum Fruits (Cangʼerzi)

  2015cites this paper
• Comparison of the toxicities, activities and chemical profiles of raw and processed Xanthii Fructus

  2015cites this paper
• Implication médico-légale des toxiques d'origine végétale : approche analytique

  2014cites this paper
• A validated method for quantifying atractyloside and carboxyatractyloside in blood by HPLC-HRMS/MS, a non-fatal case of intoxication with Atractylis gummifera L.

  2014cites this paper
• Raw coffee based dietary supplements contain carboxyatractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase.

  2014cites this paper
• Harmful and Protective Effects of Terpenoids from African Medicinal Plants

  2014cites this paper
• Cardiotoxicity and Cardioprotective Effects of African Medicinal Plants

  2014cites this paper
• Chinese Herbal Medicine-induced Liver Injury

  2014cites this paper
• New Biomarkers of Coffee Consumption Identified by the Non-Targeted Metabolomic Profiling of Cohort Study Subjects

  2014cites this paper
• Toxicology of some important medicinal plants in southern Africa.

  2013cites this paper
• The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

  2013cites this paper
• 2-O-β-D-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting.

  2013cites this paper
• RRLC-MS/MS method for the quantitation of atractyloside in Fructus Xanthii (Xanthium sibiricum)

  2013cites this paper
• Discrimination of arabica coffee cultivars by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and chemometrics

  2013cites this paper
• Chardon à glu

  2013cites this paper
• Toxicity attenuation of atractyloside in traditional chinese medicinal herbs after hydrothermal processing

  2012influential citation
• In vivo and in vitro genotoxicity studies of aqueous extract of Xanthium spinosum

  2012cites this paper
• Déterminations des teneurs en atractyloside dans les racines d’Atractylis gummifera L. provenant de six régions d’Algérie

  2012cites this paper
• Mortality of a captive axis deer (Axis axis) and a llama (Lama glama) due to ingestion of Wedelia glauca

  2012cites this paper
• [Atractylis gummifera: from poisoning to the analytic methods].

  2012cites this paper
• Thirteen. Asteraceae Martinov

  2012cites this paper
• [Poisoning by Atractylis gummifera L. Morocco poison control center data].

  2011cites this paper
• Intoxication par Atractylis gummifera L. Données du centre antipoison et de pharmacovigilance du Maroc

  2011cites this paper
• Toxicological Risks of Chinese Herbs

  2010cites this paper
• Intoxication par Atractylis gummifera L : à propos de deux cas cliniques

  2009cites this paper
• Chapter 18 Toxicological aspects of herbal remedies

  2008cites this paper
• The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells

  2008cites this paper
• The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells~!2008-03-12~!2008-05-20~!2008-06-12~!

  2008cites this paper
• [Study of four cases of poisoning by Atractylis gummifera L. in Morocco].

  2008cites this paper
• PharmacovigilanceÉtude de quatre cas d’intoxication par Atractylis gummifera L. au Maroc

  2008cites this paper
• The study on the chromatographic fingerprint of Fructus xanthii by microwave assisted extraction coupled with GC-MS.

  2007cites this paper
• Isoprenoide als Inhaltsstoffe

  2007cites this paper
• [Atractylis gummifera poisoning in a pregnant woman].

  2006cites this paper
• Identification of atractyloside by LC-ESI-MS in alleged herbal poisonings.

  2006cites this paper
• Intoxication par le chardon à glu chez une femme enceinte

  2006cites this paper
• The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.

  2006cites this paper
• Chemical analysis of medicinal and poisonous plants of forensic importance in South Africa.

  2005cites this paper
• Atractylis gummifera L. poisoning: an ethnopharmacological review.

  2005cites this paper
• Nephrotoxicity Associated With Exposure to Plant Toxins, With Particular Reference to Africa

  2005cites this paper
• Carboxyatractyloside poisoning in humans

  2005cites this paper
• Hépatotoxicité de la phytothérapie : données cliniques, biologiques, histologiques et mécanismes en cause pour quelques exemples caractéristiques

  2004cites this paper
• [Hepatotoxicity associated with herbal remedies: clinical, biological, histological data and the mechanisms involved in some typical examples].

  2004cites this paper
• IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.

  2004cites this paper
• Chapter 25 – Plants

  2004cites this paper
• IFN-β Induces Caspase-Mediated Apoptosis by Disrupting Mitochondria in Human Advanced Stage Colon Cancer Cell Lines

  2004cites this paper
• Determination of atractyloside in Callilepis laureola using solid-phase extraction and liquid chromatography-atmospheric pressure ionisation mass spectrometry.

  2004cites this paper
• Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells.

  2002cites this paper
• The toxicity of Callilepis laureola, a South African traditional herbal medicine.

  2001influential citation
• Review of toxic glycosides in rangeland and pasture forages.

  2001cites this paper
• COMMENT ON DRAFT GOVERNMENT NOTICE NO . 480 : 1 JUNE 01 DEPT HEALTH : DRAFT REGULATIONS IN TERMS OF ACT 101 OF 1965

  2001cites this paper
• Effects of the calcium channel blocker verapamil and sulphydryl reducing agent dithiothreitol on atractyloside toxicity in precision-cut rat renal cortical and liver slices.

  2001cites this paper
• Atractyloside nephrotoxicity: in vitro studies with suspensions of rat renal fragments and precision-cut cortical slices.

  2000cites this paper
• The anti-oxidant ebselen antagonizes the release of the apoptogenic factor cytochrome c induced by Fe2+/citrate in rat liver mitochondria.

  2000cites this paper
• Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells.

  2000cites this paper
• The Biochemistry and Toxicity of Atractyloside: A Review

  2000cites this paper
• Optimizing preincubation conditions for precision-cut rat kidney and liver tissue slices: effect of culture media and antioxidants.

  1998cites this paper