Rotenone-Induced Death of RGC-5 Cells is Caspase Independent, Involves the JNK and p38 Pathways and is Attenuated by Specific Green Tea Flavonoids

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neurochemical Research

• Publication date

  2012-02-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s11064-012-0713-5PMID 22350517
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies

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  2011cited by this paper
• Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies.

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• AIF‐mediated caspase‐independent necroptosis: A new chance for targeted therapeutics

  2011influential reference
• Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1995cited by this paper
• Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells

  1994cited by this paper
• Structure-activity studies of flavonoids as inhibitors of hyaluronidase.

  1990cited by this paper
• Crystal and molecular structures of flavonoids.

  1989cited by this paper
• Mitochondrial myopathies.

  1989cited by this paper
• Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.

  1988cited by this paper
• Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism.

  1986cited by this paper
• Mitochondrial myopathies

  1985cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
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  1970cited by this paper

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  2022cites this paper
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