Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Chemical Biology

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/NCHEMBIO711PMID 16408008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

  2005cited by this paper
• Growth factor regulation of autophagy and cell survival in the absence of apoptosis.

  2005cited by this paper
• Structure-activity relationship study of novel necroptosis inhibitors.

  2005cited by this paper
• Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

  2004cited by this paper
• Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

  2004cited by this paper
• Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury.

  2004cited by this paper
• Autophagy as a cell death and tumor suppressor mechanism

  2004cited by this paper
• The role of autophagy during the early neonatal starvation period

  2004cited by this paper
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

  2004cited by this paper
• Apoptosis and necrosis in health and disease: role of mitochondria.

  2003cited by this paper
• Neurological diseases: Mechanisms, challenges and opportunities in stroke

  2003cited by this paper
• Diversity in the mechanisms of neuronal cell death.

  2003cited by this paper
• Animal models of stroke: do they have value for discovering neuroprotective agents?

  2003cited by this paper
• A decade of caspases

  2003cited by this paper
• A Role for Tumor Necrosis Factor Receptor-2 and Receptor-interacting Protein in Programmed Necrosis and Antiviral Responses*

  2003cited by this paper
• Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis

  2002cited by this paper
• Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.

  2001cited by this paper
• Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

  2001cited by this paper
• Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells

  2000cited by this paper
• Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

  2000cited by this paper
• Fas (CD95/APO‐1) plays a role in the pathophysiology of focal cerebral ischemia

  2000cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• Necrotic Death Pathway in FAS Receptor Signaling

  2000cited by this paper
• Autophagy as a regulated pathway of cellular degradation.

  2000cited by this paper
• Tumor necrosis factor receptor and Fas signaling mechanisms.

  1999influential reference
• Caspase-independent programmed cell death with necrotic morphology

  1999cited by this paper
• The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.

  1999cited by this paper
• CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

  1999cited by this paper
• More than one way to die: apoptosis, necrosis and reactive oxygen damage

  1999cited by this paper
• TNFalpha-induced IEC-6 cell apoptosis requires activation of ICE caspases whereas complete inhibition of the caspase cascade leads to necrotic cell death.

  1999cited by this paper
• Resistance to the Cytotoxic Effects of Tumor Necrosis Factor α Can Be Overcome by Inhibition of a FADD/Caspase-dependent Signaling Pathway*

  1999cited by this paper
• Early detection of apoptosis with annexin V-enhanced green fluorescent protein.

  1999cited by this paper
• Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

  1998cited by this paper
• Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family

  1998cited by this paper
• Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

  1998cited by this paper
• Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

  1997cited by this paper
• Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro.

  1995cited by this paper
• Divergent signalling via APO‐1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

  1994cited by this paper
• Fas antigen mRNA induction in postischemic murine brain.

  1994cited by this paper

• Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis

  2026cites this paper
• Copper potentiates PUFA-mediated antitumor activity by activating Lipophagy.

  2026cites this paper
• Cabozantinib inhibits necroptosis by targeting MLKL oligomerization and alleviates psoriasis in vivo.

  2026cites this paper
• Small-molecule modulators of the necroptotic pathway: A medicinal chemistry perspective.

  2026cites this paper
• Extracellular vesicle-integrated core-shell nanofibers synergize multi-target healing mechanisms for accelerated repair of large-volume skin defects

  2026cites this paper
• The role of necroptosis in adiposity-based chronic disease (ABCD): A review

  2026cites this paper
• Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

  2026cites this paper
• Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death.

  2026cites this paper
• Signaling pathways regulating VDAC1 overexpression associated with apoptosis, pyroptosis, and ferroptosis

  2026cites this paper
• Receptor-Interacting Protein Kinase 1 (RIPK1): A Potential Therapeutic Target in Ischemic Stroke

  2026cites this paper
• Adenylate kinase 4 promotes radioresistance by suppressing radiation-induced ferroptosis through metabolic regulation in glioblastoma.

  2026cites this paper
• Spinal motor neuron degeneration after brachial plexus avulsion: mechanisms and therapeutic targets.

  2026cites this paper
• Non-Apoptotic Programmed Cell Death: From Ultrastructural Characterization to Emerging Therapeutic Opportunities

  2026cites this paper
• Cell Death in Orthodontic Tooth Movement: Recent Advances and Emerging Insights

  2026cites this paper
• Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer

  2026cites this paper
• Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death.

  2026cites this paper
• Z-DNA binding protein 1 mediates necroptotic cell death in primary murine microglia following herpes simplex virus-1 infection

  2026cites this paper
• Tissue Specific Necroptosis in the Cervix, Uterus, and Placenta in an LPS-induced Preterm Birth Model.

  2026cites this paper
• Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases

  2026cites this paper
• Spotted: RIPK3 and MLKL assembling necroptotic complexes.

  2026cites this paper
• CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies

  2026cites this paper
• Unravelling the Potential Role of Nanoplastics and Microplastics‐Induced Toxicity in Freshwater Fish: Emerging Role of Programmed Cell Death Mechanisms

  2026cites this paper
• Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer.

  2026cites this paper
• Cell death pathways in graft-versus-host disease.

  2026cites this paper
• Design, synthesis, and anti-necroptotic activity of novel Phenylbenzothiazole receptor-interacting protein kinase 1 (RIPK1) inhibitors.

  2026cites this paper
• Cell death and cancer: Metabolic interconnections

  2025cites this paper
• IFN‐γ Synergizes with TNF‐α to Induce RIPK1‐Independent Necroptosis of Mesenchymal Stem/Stromal Cells

  2025cites this paper
• Macrophage regulated cell death: implications and mechanisms in organ transplantation

  2025cites this paper
• Necrosis as a fundamental driver of loss of resilience and biological decline: what if we could intervene?

  2025cites this paper
• Fundamental mechanisms of cell death for polycystic ovary syndrome

  2025cites this paper
• Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

  2025cites this paper
• From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases

  2025cites this paper
• Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia

  2025cites this paper
• Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species

  2025cites this paper
• Identification of potential DAMPs released by necroptosis in estrogen-receptor positive breast cancer cells and their effect on macrophage differentiation

  2025cites this paper
• A bibliometric analysis of the literature published on autophagy, ferroptosis, necroptosis, and pyroptosis in cardiovascular disease from 2009 to 2023

  2025cites this paper
• Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

  2025cites this paper
• The kinase domain of RIPK3 tunes its scaffolding functions

  2025cites this paper
• Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives

  2025cites this paper
• The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia–reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis

  2025cites this paper
• The Ways to Die: Cell Death in Liver Pathophysiology

  2025cites this paper
• New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis

  2025cites this paper
• From death to birth: how osteocyte death promotes osteoclast formation

  2025cites this paper
• Natural compounds and programmed necrosis: pioneering a new frontier in cancer treatments

  2025cites this paper
• Discovery and Characterization of Novel Receptor-Interacting Protein Kinase 1 Inhibitors Using Deep Learning and Virtual Screening.

  2025cites this paper
• Particulate matter 2.5 stimulates pyroptosis and necroptosis via the p38 MAPK/Akt/NF-κB signaling pathway in human corneal epithelial cells.

  2025cites this paper
• UVB-Induced necroptosis of the skin cells via RIPK3-MLKL activation independent of RIPK1 kinase activity

  2025influential citation
• Necroptosis: a significant and promising target for intervention of cardiovascular disease.

  2025cites this paper
• PANoptosis: a potential target of atherosclerotic cardiovascular disease

  2025cites this paper
• Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro.

  2025cites this paper
• Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease

  2025cites this paper
• Discovery of quinazoline derivatives as RIPK3 inhibitors that switch cell death from necroptosis to apoptosis for psoriasis treatment.

  2025cites this paper
• Synthesis and characterization of a new Carbon-11 labeled positron emission tomography radiotracer for RIPK1 neuroimaging

  2025cites this paper
• Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies.

  2025cites this paper
• Receptor-interacting protein kinase 3: A macromolecule with multiple cellular actions and its perspective in the diagnosis and treatment of heart disease.

  2025cites this paper
• Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells

  2025cites this paper
• Research advances of PANoptosis in gastrointestinal tumors.

  2025cites this paper
• RIPK1: A Promising Target for Intervention Neuroinflammation

  2025cites this paper
• Deacetylation of nuclear AIF provides a braking mechanism for caspase-independent chromatinolysis and necrotic brain injury

  2025cites this paper
• Harnessing Natural Products for Myocardial Infarction Therapy: Mechanistic Insights and Translational Opportunities.

  2025cites this paper
• Mechanisms of Acute Kidney Injury–Chronic Kidney Disease Transition: Unraveling Maladaptive Repair and Therapeutic Opportunities

  2025cites this paper
• Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement

  2025influential citation
• The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective

  2025cites this paper
• Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death

  2025cites this paper
• Theranostic Rhenium Complexes as Suborganelle-Targeted Copper Ionophores To Stimulate Cuproptosis for Cancer Immunotherapy.

  2025cites this paper
• Upregulation of Receptor Interacting Protein 1 Induced by UVB Contributes to Photodamage of the Skin Through NF‐κB Pathway In Vivo and In Vitro

  2025cites this paper
• Molecular mechanism of programmed cell death in drug-induced neuronal damage: a special focus on ketamine-induced neurotoxicity.

  2025cites this paper
• New insights into pulmonary arterial hypertension: interaction between PANoptosis and perivascular inflammatory responses

  2025cites this paper
• Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine‐Induced Excessive Mitophagy and Neuronal Necroptosis

  2025cites this paper
• Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches

  2025cites this paper
• Activation of FANCC attenuates mitochondrial ROS-driven necroptosis by targeting TBK1-dependent mitophagy in astrocytes after spinal cord injury

  2025cites this paper
• RIPK1 in necroptosis and recent progress in related pharmaceutics

  2025influential citation
• Cyclometalated iridium(III)-lonidamine conjugates: Mitochondrial targeting and pyroptosis induction.

  2025cites this paper
• A cellular danse macabre: the choreography of programmed cell death

  2025cites this paper
• Insights on the crosstalk among different cell death mechanisms

  2025cites this paper
• Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells.

  2025cites this paper
• Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies

  2025cites this paper
• Progress in Research on Regulated Cell Death in Cerebral Ischaemic Injury After Cardiac Arrest

  2025cites this paper
• Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia

  2025cites this paper
• Noncanonical feedback loop between “RIP3–MLKL” and “4EBP1–eIF4E” promotes neuronal necroptosis

  2025cites this paper
• Harnessing ferroptosis for precision oncology: challenges and prospects

  2025cites this paper
• The role of necroptosis in pathological pregnancies: Mechanisms and therapeutic opportunities.

  2025cites this paper
• Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke

  2025cites this paper
• A novel necroptosis-related miRNA signature for predicting the prognosis of esophageal cancer and immune infiltration analysis

  2025cites this paper
• Effectiveness of Wharton’s jelly mesenchymal stem cell medium on burn wound healing: Focus on apoptosis, necrosis, and autophagy

  2025cites this paper
• From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

  2025cites this paper
• Discovery of a novel quinoline RIP1 inhibitor and its treatment of acute liver injury in mice.

  2025cites this paper
• Suppression of necroptosis-driven cell death and inflammation in hypoxic neuroblastoma (SH-SY5Y) cells by necrostatin-1

  2025influential citation
• Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity

  2025cites this paper
• Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity.

  2025cites this paper
• Dilated cardiomyopathy: from genes and molecules to potential treatments

  2025cites this paper
• Cadmium exposure induces Leydig cell injury via necroptosis caused by oxidative stress and TNF-α/TNFR1 signaling.

  2025cites this paper
• Development and validation of hierarchical signature for precision individualized therapy based on the landscape associated with necroptosis in clear cell renal cell carcinoma

  2025cites this paper
• Osteosarcoma Cell and Osteosarcoma Stem Cell Potent Immunogenic Bi‐Nuclear Gallium(III) Complexes

  2025cites this paper
• Molecular mechanism of PANoptosis and programmed cell death in neurological diseases.

  2025cites this paper
• The Role of Post-Translational Modifications in Necroptosis

  2025cites this paper
• ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1.

  2025cites this paper
• Natural products and ferroptosis: A novel approach for heart failure management.

  2025cites this paper
• The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease

  2025cites this paper
• The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments

  2025cites this paper