Growth factor regulation of autophagy and cell survival in the absence of apoptosis.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cell

• Publication date

  2005-01-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELL.2004.11.046PMID 15680329
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8

  2004influential reference
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004cited by this paper
• Controlled cell death, plant survival and development

  2004cited by this paper
• Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

  2004cited by this paper
• Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.

  2004cited by this paper
• The role of autophagy during the early neonatal starvation period

  2004cited by this paper
• Alkylating DNA damage stimulates a regulated form of necrotic cell death.

  2004cited by this paper
• Role and regulation of starvation-induced autophagy in the Drosophila fat body.

  2004cited by this paper
• Autophagy in Health and Disease: A Double-Edged Sword

  2004cited by this paper
• Exploiting different ways to die.

  2004cited by this paper
• Dictyostelium Macroautophagy Mutants Vary in the Severity of Their Developmental Defects*

  2004cited by this paper
• Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells

  2004cited by this paper
• Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression.

  2003cited by this paper
• Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

  2003cited by this paper
• BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

  2003cited by this paper
• MAP‐LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis

  2003cited by this paper
• Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

  2003cited by this paper
• Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

  2003cited by this paper
• Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

  2003cited by this paper
• Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum *

  2003cited by this paper
• A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. indica)

  2002cited by this paper
• Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene1

  2002cited by this paper
• A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japonica)

  2002cited by this paper
• Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.

  2002cited by this paper
• Autophagosome formation in mammalian cells.

  2002cited by this paper
• Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

  2001cited by this paper
• A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

  2001cited by this paper
• Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

  2001cited by this paper
• BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

  2001cited by this paper
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  2001cited by this paper
• The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

  2000cited by this paper
• Autophagy as a regulated pathway of cellular degradation.

  2000cited by this paper
• [Mitochondria and apoptosis].

  2000cited by this paper
• Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells*

  2000cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.

  2000cited by this paper
• Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.

  1999cited by this paper
• Size Control in Animal Development Review and Enlarge) and Duplicate Their Contents before They

  1999cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes.

  1998cited by this paper
• Apaf1 is required for mitochondrial pathways of apoptosis and brain development.

  1998cited by this paper
• v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFα-induced cell death

  1997cited by this paper
• Programmed Cell Death in Plants.

  1997cited by this paper
• Ultrastructural and biochemical characterization of autophagy in higher plant cells subjected to carbon deprivation: control by the supply of mitochondria with respiratory substrates

  1996cited by this paper
• Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization

  1994cited by this paper
• Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line

  1994cited by this paper
• Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

  1994cited by this paper
• Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

  1993cited by this paper
• Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction

  1992cited by this paper
• Growth of factor-dependent hemopoietic precursor cell lines

  1980cited by this paper

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