Glucocorticoid Receptor and FKBP5 Expression Is Altered Following Exposure to Chronic Stress: Modulation by Antidepressant Treatment

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Neuropsychopharmacology

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/npp.2012.225PMID 23169346PMCID PMC3572458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

  2012cited by this paper
• Developmental Influence of the Serotonin Transporter on the Expression of Npas4 and GABAergic Markers: Modulation by Antidepressant Treatment

  2012cited by this paper
• Stress-Induced Changes of Hippocampal NMDA Receptors: Modulation by Duloxetine Treatment

  2012cited by this paper
• Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus.

  2012cited by this paper
• Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

  2011cited by this paper
• Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology

  2011cited by this paper
• Antistress properties of antidepressant drugs and their clinical implications.

  2011cited by this paper
• Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice.

  2010cited by this paper
• Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.

  2010cited by this paper
• Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton-associated protein

  2010cited by this paper
• Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice.

  2010influential reference
• Long-Term Duloxetine Treatment Normalizes Altered Brain-Derived Neurotrophic Factor Expression in Serotonin Transporter Knockout Rats through the Modulation of Specific Neurotrophin Isoforms

  2010cited by this paper
• Activation of glucocorticoid receptors increases 5-HT2A receptor levels.

  2009cited by this paper
• Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

  2009influential reference
• Acute Stress Responsiveness of the Neurotrophin BDNF in the Rat Hippocampus is Modulated by Chronic Treatment with the Antidepressant Duloxetine

  2009cited by this paper
• Role of p11 in Cellular and Behavioral Effects of 5-HT4 Receptor Stimulation

  2009cited by this paper
• Reduced hippocampal neurogenesis in the GR+/− genetic mouse model of depression

  2009cited by this paper
• The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders.

  2009influential reference
• Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.

  2009cited by this paper
• Acute Stress Responsiveness of the Neurotrophin BDNF in the Rat Hippocampus is Modulated by Chronic Treatment with the Antidepressant Duloxetine

  2009cited by this paper
• Differential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder

  2009cited by this paper
• The HPA axis in major depression: classical theories and new developments.

  2008cited by this paper
• Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects.

  2008cited by this paper
• Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.

  2008cited by this paper
• Glucocorticoid receptor phosphorylation differentially affects target gene expression.

  2008influential reference
• The microtubule-associated protein doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells.

  2008influential reference
• De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells.

  2008influential reference
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

  2008cited by this paper
• Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

  2008cited by this paper
• Chronic Duloxetine Treatment Induces Specific Changes in the Expression of BDNF Transcripts and in the Subcellular Localization of the Neurotrophin Protein

  2007cited by this paper
• Duloxetine

  2007cited by this paper
• Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States

  2006influential reference
• The glucocorticoid receptor: part of the solution or part of the problem?

  2006cited by this paper
• Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children

  2005cited by this paper
• Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions

  2005cited by this paper
• Stress and the brain: from adaptation to disease

  2005cited by this paper
• Modulation of Glucocorticoid Receptor Function via Phosphorylation

  2004influential reference
• Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters

  2003cited by this paper
• Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway

  2002cited by this paper
• Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

  2002cited by this paper
• Deciphering the Phosphorylation “Code” of the Glucocorticoid Receptor in Vivo * 210

  2002influential reference
• The Corticosteroid Receptor Hypothesis of Depression

  2000influential reference
• Long‐Term Treatment with Antidepressants Increases Glucocorticoid Receptor Binding and Gene Expression in Cultured Rat Hippocampal Neurones

  1999cited by this paper
• Phosphorylation and Inhibition of Rat Glucocorticoid Receptor Transcriptional Activation by Glycogen Synthase Kinase-3 (GSK-3)

  1998influential reference
• Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor

  1997cited by this paper
• Modulation of glucocorticoid receptor function by protein kinase A.

  1992cited by this paper
• The Vulnerability of the Hippocampus to Protective and Destructive Effects of Glucocorticoids in Relation to Stress

  1992cited by this paper
• Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain.

  1991cited by this paper
• Glycogen Synthase Kinase 3 (cid:2) -Mediated Serine Phosphorylation of the Human Glucocorticoid Receptor Redirects Gene Expression Profiles (cid:1)

  year unknowncited by this paper

• Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala

  2025cites this paper
• α-synuclein in Parkinson’s disease: a central point of convergence with depression

  2025cites this paper
• Ventral hippocampal autophagy and mitophagy dynamics shape behavioral responses to chronic mild stress in adult male rats

  2025cites this paper
• Effects of prenatal iron deficiency on neurological development and related disorders in offspring

  2025cites this paper
• Mild heat stress effects on hepatic and mammary mitochondria of lactating dairy cattle.

  2025cites this paper
• Acrylamide-induced noradrenergic axon degeneration is promoted via a non-cell autonomous mechanism, involving microglial Tnfaip2/TNF-α and oxidative stress pathways.

  2025cites this paper
• Transcriptomics insight into occupational exposure to engineered nanoparticles

  2025cites this paper
• FKBP5 Deficiency Selectively Impairs NMDAR-Dependent Long-Term Depression via Enhanced Calcineurin Activity: Implications for Stress Resilience.

  2025cites this paper
• The Role of the Glucocorticoid Receptor and Its Phosphorylation in Neurological Disorders

  2025cites this paper
• Lithium Treatment Increases FKBP5 Protein but Not mRNA Expression in the Pituitary Gland of Depressive-like Rats

  2025cites this paper
• A depression-associated protein FKBP5 functions in autophagy initiation through scaffolding the VPS34 complex

  2025cites this paper
• Towards understanding and halting legacies of trauma.

  2025cites this paper
• Sex-specific fear acquisition following early life stress is linked to amygdala glutamate metabolism

  2024cites this paper
• Pathophysiology of depression: inflammation and its relation with oxidative stress and the hypothalamic-pituitary-adrenal axis

  2024cites this paper
• Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism

  2024cites this paper
• FK506 Binding Protein 5 and Solute Carrier Family 6 Member 4 Genes as Biomarkers and Treatment Responders in Major Depressive Disorder: Randomized Clinical Trial

  2024cites this paper
• Fluoxetine treatment reverses chronic stress-induced promotion on Fk506-binding protein 5 expression and multiple effects on glucocorticoid receptor phosphorylation in the paraventricular nucleus of mice.

  2024cites this paper
• Sex Differences in Contextual Extinction Learning After Single Binge-Like EtOH Exposure in Adolescent C57BL/6J Mice

  2024cites this paper
• Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

  2024influential citation
• Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone

  2024cites this paper
• Medicinal plants and plant-based traditional medicine: Alternative treatments for depression and their potential mechanisms of action

  2024cites this paper
• Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders

  2024cites this paper
• Rice bran supplement ameliorates chronic restraint stress-induced depression-like behaviors in mice.

  2024cites this paper
• Manipulation of a social signal affects DNA methylation of a stress-related gene in a free-living bird

  2024cites this paper
• Effects of antidepressant on FKBP51 mRNA expression and neuroendocrine hormones in patients with panic disorder

  2024cites this paper
• Intact Recognition Memory and Altered Hippocampal Glucocorticoid Receptor Signaling in Fkbp5-deficient Mice Following Acute Uncontrollable Stress

  2023cites this paper
• Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways

  2023cites this paper
• Mechanism of GW117 antidepressant action: Melatonin receptor-mediated regulation of sleep rhythm.

  2023cites this paper
• Rosmarinic acid alleviate CORT-induced depressive-like behavior by promoting neurogenesis and regulating BDNF/TrkB/PI3K signaling axis.

  2023cites this paper
• Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress

  2023cites this paper
• Stress circuitry: mechanisms behind nervous and immune system communication that influence behavior

  2023cites this paper
• Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery

  2023cites this paper
• Hair cortisol level might be indicative for a 3PM approach towards suicide risk assessment in depression: comparative analysis of mentally stable and depressed individuals versus individuals after completing suicide

  2022cites this paper
• Chronic clomipramine treatment reverses depressogenic-like effects of a chronic treatment with dexamethasone in rats

  2022cites this paper
• Regulatory mechanism of icariin in cardiovascular and neurological diseases.

  2022cites this paper
• Glucocorticoid-glucocorticoid receptor-HCN1 channels reduce neuronal excitability in dorsal hippocampal CA1 neurons

  2022cites this paper
• Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress

  2022cites this paper
• Higher Concentration of Adrenocorticotropic Hormone Predicts Post-Stroke Depression

  2022cites this paper
• Duration of reduction in enduring stress-induced hyperalgesia via FKBP51 inhibition depends on timing of administration relative to traumatic stress exposure.

  2022cites this paper
• Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene

  2022cites this paper
• Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity

  2022cites this paper
• Regulatory effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 expression in stress-sensitive regions of the offspring brain.

  2022cites this paper
• Chronic running-wheel exercise from adolescence leads to increased anxiety and depression-like phenotypes in adulthood in rats: Effects on stress markers and interaction with BDNF Val66Met genotype.

  2022cites this paper
• Stress‐Responsive Gene FK506‐Binding Protein 51 Mediates Alcohol‐Induced Liver Injury Through the Hippo Pathway and Chemokine (C‐X‐C Motif) Ligand 1 Signaling

  2021cites this paper
• Coping style predicts sense of security and mediates the relationship between autistic traits and social anxiety: Moderation by a polymorphism of the FKBP5 gene.

  2021cites this paper
• Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: a story of microglial remodeling.

  2021cites this paper
• Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

  2021cites this paper
• Glucocorticoid Receptor-Dependent Astrocytes Mediate Stress Vulnerability.

  2021cites this paper
• Inescapable footshocks induce molecular changes in the prefrontal cortex of rats in an amyloid-beta-42 model of Alzheimer's disease.

  2021cites this paper
• Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

  2021cites this paper
• Regulatory functions of FKBP5 intronic regions associated with psychiatric disorders.

  2021cites this paper
• Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression

  2021cites this paper
• Chronic stress and Alzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia

  2021cites this paper
• Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics

  2021cites this paper
• The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population

  2021cites this paper
• Exposure to Prenatal Stress Is Associated With an Excitatory/Inhibitory Imbalance in Rat Prefrontal Cortex and Amygdala and an Increased Risk for Emotional Dysregulation

  2021cites this paper
• Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms.

  2020cites this paper
• Behavioral appraisal by implementing a short sequence of stress resolves adaptively changed stress gains

  2020cites this paper
• The impact of FKBP5 deficiency in glucocorticoid receptor mediated regulation of synaptic transmission in the medial prefrontal cortex.

  2020cites this paper
• Chronic Sleep Disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in adolescent female mice.

  2020cites this paper
• The role of the interaction between the FKBP5 gene and stressful life events in the pathophysiology of schizophrenia: A narrative review

  2020cites this paper
• Abnormal stress responsiveness and suicidal behavior: A risk phenotype

  2020cites this paper
• Differential Phosphorylation of the Glucocorticoid Receptor in Hippocampal Subregions Induced by Contextual Fear Conditioning Training

  2020cites this paper
• Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response

  2020cites this paper
• Quantitative proteomics reveal antidepressant potential protein targets of xiaochaihutang in corticosterone induced model of depression.

  2019cites this paper
• Short- and long-term alterations of FKBP5-GR and specific microRNAs in the prefrontal cortex and hippocampus of male rats induced by adolescent stress contribute to depression susceptibility.

  2019cites this paper
• Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats

  2019cites this paper
• Chronic vortioxetine treatment improves the responsiveness to an acute stress acting through the ventral hippocampus in a glucocorticoid‐dependent way

  2019cites this paper
• "Braking" the Prefrontal Cortex: The Role of Glucocorticoids and Interneurons in Stress Adaptation and Pathology.

  2019cites this paper
• Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes.

  2019cites this paper
• Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice

  2019cites this paper
• The Human Microbiome: Composition and Change Reflecting Health and Disease

  2019cites this paper
• Corticosterone administration targeting a hypo-reactive HPA axis rescues a socially-avoidant phenotype in scarcity-adversity reared rats

  2019cites this paper
• Depressive Disorders: Mechanisms, Measurement and Management

  2019cites this paper
• Advance in Stress for Depressive Disorder.

  2019cites this paper
• Naturally Derived Polyphenols Protect Against Corticosterone-Induced Changes in Primary Cortical Neurons

  2019cites this paper
• Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection

  2019cites this paper
• Epigenetic Programming Effects of Early Life Stress: A Dual-Activation Hypothesis

  2018cites this paper
• Cognitive Performance and the Alteration of Neuroendocrine Hormones in Chronic Tension‐Type Headache

  2018cites this paper
• NPTX2 is a key component in the regulation of anxiety

  2018cites this paper
• International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets

  2018cites this paper
• From feedback loop transitions to biomarkers in the psycho‐immune‐neuroendocrine network: Detecting the critical transition from health to major depression

  2018cites this paper
• Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals—relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats

  2018cites this paper
• Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression

  2018cites this paper
• The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain

  2018cites this paper
• Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress.

  2018cites this paper
• Modulation of the Core Neural Network in Stress: The Role of Brain-Derived Neurotrophic Factor and LTP

  2018cites this paper
• Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

  2018influential citation
• Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis.

  2018cites this paper
• Proteomic characterization of hippocampus of chronically socially isolated rats treated with fluoxetine: Depression‐like behaviour and fluoxetine mechanism of action

  2018cites this paper
• Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions.

  2018cites this paper
• Hsp90 and FKBP51: complex regulators of psychiatric diseases

  2018cites this paper
• Hyperforin and Miquelianin from St. Johnʼs Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress

  2018cites this paper
• Evaluation of the Association Between Genetic Variants in Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription Factor TEF

  2018cites this paper
• Paternal Preconception Chronic Variable Stress Confers Attenuated Ethanol Drinking Behavior Selectively to Male Offspring in a Pre-Stress Environment Dependent Manner

  2018cites this paper
• FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study.

  2018cites this paper
• Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts

  2018cites this paper
• α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress

  2018influential citation
• The regulation of corticosteroid receptors in response to chronic social defeat

  2017cites this paper
• Individual differences in stress susceptibility and stress inhibitory mechanisms

  2017cites this paper