Haemoglobin: NO transporter, NO inactivator or NOne of the above?

No abstract is available for this paper.

• Publication year

  2002

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  2002-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0165-6147(02)02067-9PMID 12237152
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of endothelium-derived nitric oxide on ex vivo whole blood platelet aggregation in man

  2004cited by this paper
• The biochemistry and physiology of S-nitrosothiols.

  2002cited by this paper
• Effects of S-nitrosation of hemoglobin on hypoxic pulmonary vasoconstriction and nitric oxide flux.

  2001cited by this paper
• Modulation of nitric oxide bioavailability by erythrocytes

  2001cited by this paper
• Nitric oxide binding to oxygenated hemoglobin under physiological conditions.

  2001cited by this paper
• Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery.

  2001cited by this paper
• Export by red blood cells of nitric oxide bioactivity

  2001cited by this paper
• A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols

  2000cited by this paper
• Dynamic state of S-nitrosothiols in human plasma and whole blood.

  2000cited by this paper
• An autocatalytic mechanism of protein nitrosylation.

  2000cited by this paper
• Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.

  2000cited by this paper
• Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation.

  2000cited by this paper
• Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses.

  2000cited by this paper
• Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.

  1999cited by this paper
• The oxyhemoglobin reaction of nitric oxide.

  1999cited by this paper
• Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity.

  1999cited by this paper
• ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS

  1999cited by this paper
• Nitric oxide and iron proteins.

  1999cited by this paper
• Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

  1999cited by this paper
• Effects of S-Nitrosation on Oxygen Binding by Normal and Sickle Cell Hemoglobin*

  1999cited by this paper
• Intravascular flow decreases erythrocyte consumption of nitric oxide.

  1999cited by this paper
• Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

  1999cited by this paper
• Biochemical Characterization of HumanS-Nitrosohemoglobin

  1999cited by this paper
• Molecular mechanisms of response to low oxygen tension in the vascular wall.

  1999cited by this paper
• Nitric oxide and hemoglobin interactions in the vasculature.

  1999cited by this paper
• modeling in physiology Estimation of nitric oxide production and reaction rates in tissue by use of a mathematical model

  1998cited by this paper
• Superoxide produced in the heme pocket of the beta-chain of hemoglobin reacts with the beta-93 cysteine to produce a thiyl radical.

  1998cited by this paper
• Reactions between nitric oxide and haemoglobin under physiological conditions

  1998cited by this paper
• Electron Paramagnetic Resonance and Oxygen Binding Studies of α-Nitrosyl Hemoglobin

  1998cited by this paper
• Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation.

  1998cited by this paper
• Umbilical arterial S-nitrosothiols in stressed newborns: role in perinatal circulatory transition.

  1998cited by this paper
• Electron paramagnetic resonance and oxygen binding studies of alpha-Nitrosyl hemoglobin. A novel oxygen carrier having no-assisted allosteric functions.

  1998cited by this paper
• Diffusion-limited Reaction of Free Nitric Oxide with Erythrocytes*

  1998cited by this paper
• Endothelium‐dependent sensory NANC vasodilatation: involvement of ATP, CGRP and a possible NO store

  1998cited by this paper
• Estimation of nitric oxide production and reactionrates in tissue by use of a mathematical model.

  1998cited by this paper
• Diffusion of nitric oxide and scavenging by blood in the vasculature.

  1998cited by this paper
• Superoxide Produced in the Heme Pocket of the β-Chain of Hemoglobin Reacts with the β-93 Cysteine To Produce a Thiyl Radical†

  1998cited by this paper
• Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient.

  1997cited by this paper
• S-nitrosohemoglobin in the fetal circulation may represent a cycle for blood pressure regulation.

  1997cited by this paper
• Soluble guanylate cyclase: the forgotten sibling.

  1997cited by this paper
• Increased oxygen dissociation by nitric oxide from RBC.

  1997cited by this paper
• Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues.

  1996cited by this paper
• Hypoxia impairs nitrovasodilator-induced pulmonary vasodilation: role of Na-K-ATPase activity.

  1996cited by this paper
• Direct in situ measurement of nitric oxide in mesenteric resistance arteries. Increased decomposition by superoxide in hypertension.

  1996cited by this paper
• S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

  1996cited by this paper
• Mechanism of NO-induced oxidation of myoglobin and hemoglobin.

  1996cited by this paper
• Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells.

  1995cited by this paper
• Kinetics of Nitrosation of Thiols by Nitric Oxide in the Presence of Oxygen (*)

  1995cited by this paper
• ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats.

  1994cited by this paper
• Simulation of the diffusion and reaction of endogenously produced nitric oxide.

  1994cited by this paper
• Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.

  1993cited by this paper
• Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release.

  1993cited by this paper
• S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

  1992cited by this paper
• Biochemistry of nitric oxide and its redox-activated forms.

  1992cited by this paper
• Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

  1987cited by this paper
• Endothelium‐Derived Relaxing Factor From Pulmonary Artery and Vein Possesses Pharmacologic and Chemical Properties Identical to Those of Nitric Oxide Radical

  1987cited by this paper
• Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization.

  1986cited by this paper
• Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

  1985cited by this paper
• Inhibition of erythrocyte sickling by thiol reagents.

  1984cited by this paper
• Hb Okazaki [β93(F8) Cys → Arg], a new hemoglobin variant with increased oxygen affinity and instability

  1984cited by this paper
• Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.

  1982cited by this paper
• Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93.

  1977cited by this paper

• Exploring the therapeutic potential of L-arginine in chronic anal fissure management: a comprehensive review

  2025cites this paper
• Optimized S-nitrosohemoglobin Synthesis in Red Blood Cells to Preserve Hypoxic Vasodilation Via βCys93

  2022cites this paper
• Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.

  2020cites this paper
• Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In Mouse

  2020cites this paper
• Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species

  2018cites this paper
• Chapter 10 – Oxygen

  2017cites this paper
• S-Nitrosothiols and Nitric Oxide Biology

  2017cites this paper
• Oxidative modification of hemoglobin of isolated red blood cells in the incubation medium containing sodium nitrite and sodium selenite

  2016cites this paper
• Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells

  2015cites this paper
• Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry.

  2015cites this paper
• Concept of double salt fortification; a tool to curtail micronutrient deficiencies and improve human health status.

  2014cites this paper
• Targeted Delivery of Gaseous Ligands (CO and NO) for the Treatment of Ischemia Reperfusion Injury

  2014cites this paper
• Compositions et procédés pour réguler le tonus artériel

  2013cites this paper
• Routes for Formation of S-Nitrosothiols in Blood

  2013cites this paper
• Hemoglobin-mediated nitric oxide signaling.

  2013cites this paper
• Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity

  2013cites this paper
• Oxygen binding to partially nitrosylated hemoglobin.

  2013cites this paper
• Plasma methemoglobin as a potential biomarker of anemic stress in humans

  2012cites this paper
• Nitric Oxide Inactivation Mechanisms in the Brain: Role in Bioenergetics and Neurodegeneration

  2012cites this paper
• Peculiarities of the blood oxygen and antioxidant status in the children presenting with somatotrophic insufficiency and managed by the substitution treatment with growth hormone

  2012cites this paper
• Nitrogen Monoxide (Nitric Oxide): Bioinorganic Chemistry

  2011cites this paper
• Modulation of outer medullary NaCl transport and oxygenation by nitric oxide and superoxide.

  2011cites this paper
• Brain Nitric Oxide Inactivation Is Governed by the Vasculature

  2011cites this paper
• Nitric oxide and superoxide transport in a cross section of the rat outer medulla. I. Effects of low medullary oxygen tension.

  2010cites this paper
• Haemoglobin saturation controls the red blood cell mediated hypoxic vasorelaxation.

  2009cites this paper
• Ligand reactivity and allosteric regulation of hemoglobin-based oxygen carriers.

  2008cites this paper
• Einfluss der Stickstoff-Monoxid-Inhalation auf den sekundären Hirnschaden nach experimentellem Schädelhirntrauma

  2008cites this paper
• Modifying effect of nitric oxide on rat blood plasma proteins and hemoglobin

  2007cites this paper
• Recent developments in nitric oxide donor drugs

  2007cites this paper
• Radicals for life : the various forms of nitric oxide

  2007cites this paper
• The hemoglobin-nitric oxide axis: implications for transfusion therapeutics

  2007cites this paper
• Nitrite and nitrosospecies in blood and tissue: approaching the gap between bench and bedside

  2007cites this paper
• The anti-microbial and cytotoxic actions of nitrite, and the use of DNIC as a marker for these actions

  2007cites this paper
• Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury

  2006cites this paper
• Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics

  2006cites this paper
• Circulating NO Pool in Humans

  2006cites this paper
• S-nitrosohemoglobin: a mechanism for its formation in conjunction with nitrite reduction by deoxyhemoglobin.

  2006cites this paper
• Influence of trace precursors on mass transport and growth rate during sublimation deposition of AlN crystal

  2006cites this paper
• The influence of iron status on iodine utilization and thyroid function.

  2006cites this paper
• NO* release from MbFe(II)NO and HbFe(II)NO after oxidation by peroxynitrite.

  2006cites this paper
• Endothelial Cell Response to Hemoglobin Based Oxygen Carriers. Is the Attenuation of Pathological Reactions Possible

  2005cites this paper
• Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide: mechanism(s) and physiologic versus pathophysiologic relevance.

  2005cites this paper
• Clinical pharmacokinetics of the cyclooxygenase inhibiting nitric oxide donator (CINOD) AZD3582

  2005cites this paper
• Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis.

  2005cites this paper
• The synthesis of water soluble decalin-based thiols and S-nitrosothiols--model systems for studying the reactions of nitric oxide with protein thiols.

  2005cites this paper
• [The role of plasmatic erythrocytic membrane in formation of hypoxia in patients with chronic cardiac failure].

  2005cites this paper
• Nitric oxide and blood: a review

  2005influential citation
• The Impact of Environmental Signals on the Growth and Survival of Human T Cells

  2005cites this paper
• Pre‐clinical pharmacokinetics of the cyclooxygenase‐inhibiting nitric oxide donor (CINOD) AZD3582

  2005cites this paper
• Interplay between iron complexes, nitric oxide and sulfur ligands: Structure, (photo)reactivity and biological importance

  2005cites this paper
• Erythrocyte membrane fluidity and haemoglobin haemoporphyrin conformation: features revealed in patients with heart failure.

  2005cites this paper
• Nitric oxide consumption through lipid peroxidation in brain cell suspensions and homogenates.

  2005cites this paper
• Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobins.

  2004cites this paper
• Signal Transduction and the Gasotransmitters

  2004cites this paper
• Crystallographic analysis of the interaction of nitric oxide with quaternary-T human hemoglobin.

  2004cites this paper
• Nitric oxide, S-nitrosothiols and hemoglobin: is methodology the key?

  2004cites this paper
• Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells.

  2004cites this paper
• Regulation of vascular function by haemoglobin.

  2004cites this paper
• The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.

  2004cites this paper
• Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity

  2004cites this paper
• Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide.

  2004cites this paper
• Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues.

  2004cites this paper
• Reductive nitrosylation and S-nitrosation of hemoglobin in inhomogeneous nitric oxide solutions.

  2004cites this paper
• Vasorelaxation by Red Blood Cells and Impairment in Diabetes: Reduced Nitric Oxide and Oxygen Delivery by Glycated Hemoglobin

  2004cites this paper
• Red blood cells as modulators of T cell growth and survival.

  2004cites this paper
• The effect of micronutrient deficiencies on iodine nutrition and thyroid metabolism.

  2004cites this paper
• The Red Blood Cell and Vascular Function in Health and Disease

  2004cites this paper
• Nitric oxide reactivity and toxicity in brain tissue in vitro

  2004cites this paper
• Implicación de las especies reactivas del oxígeno en el síndrome de isquemia y reperfusión provocado por medios farmacológicos en el intestino delgado de rata

  2004cites this paper
• Nitric oxide's reactions with hemoglobin: a view through the SNO-storm

  2003cites this paper
• Sickle cell disease: loss of the blood's WD40?

  2003cites this paper
• Regulation of K+ currents by CO in carotid body type I cells and pulmonary artery smooth muscle cells.

  2003cites this paper
• EPR spectroscopy studies on the structural transition of nitrosyl hemoglobin in the arterial-venous cycle of DEANO-treated rats as it relates to the proposed nitrosyl hemoglobin/nitrosothiol hemoglobin exchange.

  2003cites this paper
• Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology

  2003cites this paper
• Reply to "NO adducts in mammalian red blood cells: too much or too little?"

  2003cites this paper
• C75 inhibits food intake by increasing CNS glucose metabolism

  2003cites this paper
• Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states.

  2003cites this paper
• Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction*

  2003cites this paper
• Oxygen transport in blood at high altitude: role of the hemoglobin–oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function

  2003influential citation
• S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action.

  2003cites this paper
• NO adducts in mammalian red blood cells: too much or too little?

  2003cites this paper
• Control of the Nitric Oxide‐Cytochrome c Oxidase Signaling Pathway under Pathological and Physiological Conditions

  2003cites this paper
• Modeling the influence of superoxide dismutase on superoxide and nitric oxide interactions, including reversible inhibition of oxygen consumption.

  2003cites this paper
• Hemoglobin and nitric oxide.

  2003cites this paper
• Nitric oxide and S-nitrosothiols in human blood.

  2003cites this paper
• A chemist's view of the nitric oxide story.

  2003cites this paper