One-Carbon Metabolism in Health and Disease.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cell Metabolism

• Publication date

  2017-01-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.cmet.2016.08.009PMID 27641100PMCID PMC5353360
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic control of methylation and acetylation.

  2016cited by this paper
• Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

  2016cited by this paper
• Spatial colocalization and functional link of purinosomes with mitochondria

  2016cited by this paper
• Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma

  2016cited by this paper
• MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.

  2016cited by this paper
• Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

  2016cited by this paper
• Mitochondrial dysfunction remodels one-carbon metabolism in human cells

  2016cited by this paper
• NRF 2 regulates serine biosynthesis in non-small cell lung cancer

  2016cited by this paper
• Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

  2016influential reference
• A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

  2016cited by this paper
• Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

  2016cited by this paper
• Homocysteine, B Vitamins, and Cognitive Impairment.

  2016cited by this paper
• Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.

  2016cited by this paper
• mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

  2016cited by this paper
• Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

  2016cited by this paper
• Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

  2016cited by this paper
• Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

  2015cited by this paper
• Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?

  2015cited by this paper
• Effects of choline on health across the life course: a systematic review.

  2015cited by this paper
• An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

  2015cited by this paper
• Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development

  2015cited by this paper
• Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.

  2015cited by this paper
• Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

  2015cited by this paper
• Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis

  2015cited by this paper
• Targeting MTHFD2 in acute myeloid leukemia

  2015cited by this paper
• Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism.

  2015cited by this paper
• Oxidative stress inhibits distant metastasis by human melanoma cells

  2015cited by this paper
• Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

  2015cited by this paper
• NRF2 regulates serine biosynthesis in non-small cell lung cancer

  2015cited by this paper
• Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

  2015cited by this paper
• Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

  2015cited by this paper
• Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein.

  2015cited by this paper
• SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

  2015cited by this paper
• Increased MTHFD2 expression is associated with poor prognosis in breast cancer

  2014cited by this paper
• Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency*

  2014cited by this paper
• Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

  2014cited by this paper
• Biology of the major facilitative folate transporters SLC19A1 and SLC46A1.

  2014cited by this paper
• Quantitative flux analysis reveals folate-dependent NADPH production

  2014cited by this paper
• Bioinformatics analysis of the serine and glycine pathway in cancer cells

  2014cited by this paper
• Serine and glycine metabolism in cancer☆

  2014cited by this paper
• Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.

  2014cited by this paper
• Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

  2014cited by this paper
• Serine catabolism regulates mitochondrial redox control during hypoxia.

  2014cited by this paper
• Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.

  2014cited by this paper
• Differential Expression of Enzymes Associated with Serine/Glycine Metabolism in Different Breast Cancer Subtypes

  2014cited by this paper
• An isotope-dilution, GC–MS assay for formate and its application to human and animal metabolism

  2014cited by this paper
• Characterization of the usage of the serine metabolic network in human cancer.

  2014cited by this paper
• Mammalian Mitochondrial and Cytosolic Folylpolyglutamate Synthetase Maintain the Subcellular Compartmentalization of Folates*

  2014cited by this paper
• Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.

  2014cited by this paper
• The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer☆

  2013cited by this paper
• Serine, glycine and one-carbon units: cancer metabolism in full circle

  2013cited by this paper
• Formate: an essential metabolite, a biomarker, or more?

  2013cited by this paper
• Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

  2013cited by this paper
• Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.

  2013cited by this paper
• Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

  2013cited by this paper
• Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues*

  2013influential reference
• Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain

  2013cited by this paper
• Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain

  2013cited by this paper
• Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.

  2013cited by this paper
• Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  2012cited by this paper
• Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells

  2012cited by this paper
• Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis

  2012cited by this paper
• Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis*

  2012influential reference
• Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

  2012cited by this paper
• Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

  2012cited by this paper
• Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

  2012cited by this paper
• Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

  2012influential reference
• High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

  2012cited by this paper
• Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

  2011cited by this paper
• Nuclear Localization of de Novo Thymidylate Biosynthesis Pathway Is Required to Prevent Uracil Accumulation in DNA*

  2011cited by this paper
• Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.

  2011cited by this paper
• Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans

  2011cited by this paper
• Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.

  2011cited by this paper
• Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

  2011cited by this paper
• Competition between Sumoylation and Ubiquitination of Serine Hydroxymethyltransferase 1 Determines Its Nuclear Localization and Its Accumulation in the Nucleus*

  2011influential reference
• Deletion of Betaine-Homocysteine S-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas*

  2011cited by this paper
• Choline and betaine in health and disease

  2011cited by this paper
• Effect of Folic Acid Supplementation on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

  2011cited by this paper
• Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer

  2011cited by this paper
• Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues*

  2010cited by this paper
• Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

  2010cited by this paper
• Compartmentalization of Mammalian folate-mediated one-carbon metabolism.

  2010cited by this paper
• ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase*

  2010cited by this paper
• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  2010cited by this paper
• Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primates.

  2010cited by this paper
• Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition.

  2009cited by this paper
• SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

  2009cited by this paper
• Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels*

  2009cited by this paper
• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

  2009cited by this paper
• Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

  2009cited by this paper
• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  2009cited by this paper
• Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*

  2009cited by this paper
• Mthfd1 Is an Essential Gene in Mice and Alters Biomarkers of Impaired One-carbon Metabolism*

  2009cited by this paper
• Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview.

  2009cited by this paper
• Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice*

  2008cited by this paper
• Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia.

  2008cited by this paper
• Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

  2008cited by this paper
• Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

  2007cited by this paper
• Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

  2007cited by this paper
• High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort.

  2007cited by this paper

• Trimethoprim: bactericidal or bacteriostatic activity is dependent on bacterial growth conditions.

  2026cites this paper
• Microbiome-generated antifolates.

  2026cites this paper
• A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

  2026cites this paper
• Taxonomy and Virulence Factors in the Root Canal Microbiome: Metagenomic Insights by Lesion Size and Clinical Factors in Primary Endodontic Infections.

  2026cites this paper
• Flexibility of systemic one-carbon metabolism partially buffers dietary methyl donor deficiency

  2026cites this paper
• Associations between prenatal metal exposure, gene variants, and birth size in Taiwan Birth Panel Study.

  2026cites this paper
• Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer

  2026cites this paper
• Proteomic insights into the dynamic inflammatory and metabolic networks of renal ischemia-reperfusion injury.

  2026cites this paper
• RNAseq Analysis of the Cerebellum Reveals Significant Gene Dysregulation That May Explain Chronic Disease Progression in Mild Traumatic Brain Injury

  2026cites this paper
• Evidence for Propioniciclava as a novel polyphosphate-accumulating organism and construction of its metabolic profile.

  2026cites this paper
• Prevention of Neural Tube Defects in India

  2026cites this paper
• Genomic Insights into the Origins, Population Structure, and Local Adaptation of Philippine Visayan Native Cattle.

  2026cites this paper
• Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming

  2026cites this paper
• Stability of non-canonical nucleic acid structure as a potential modulator of cell fate

  2026cites this paper
• Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

  2026cites this paper
• Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

  2026cites this paper
• Metabolomic Markers Reveal How hCG–Ketoprofen Intervention Increase Pregnancy Percentage Following Timed Artificial Insemination in Dairy Cows

  2026cites this paper
• Dietary Vitamin B9 and B12 Deficiencies Alter Gut Homeostasis in Sprague-Dawley Rats.

  2026cites this paper
• The astrocyte marker ALDH1L1 also identifies a stromal cell population in the lymph node

  2026cites this paper
• From Alpha Diversity to Zeitgebers: Functional Implications and Potential Mechanisms Linking the Gut Microbiome to Sleep and Circadian Disruption (Part II).

  2026cites this paper
• A meta-analysis of potential genetic factors associated with antipsychotic-induced weight gain in adults with severe mental illness.

  2026cites this paper
• The molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer.

  2026cites this paper
• Gut microbiota dysbiosis and metabolic reprogramming in pediatric migraine: a multi-omics analysis revealing diagnostic biomarkers.

  2026cites this paper
• Epigenetic regulation in MASLD - insight for therapeutic target discovery.

  2026cites this paper
• Higher Serum Levels of Propionylcarnitine and Methionine are Associated with Reduced Cortical Amyloid Burden in Alzheimer’s Disease

  2026cites this paper
• Higher dietary choline and betaine intakes are associated with lower likelihood of central nervous system demyelination in Australian women

  2026cites this paper
• Folic Acid Metabolism and Its Impact on Neurogenesis: Molecular Mechanisms and Therapeutic Potential

  2026cites this paper
• Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism.

  2026cites this paper
• Biodegradable Piezoelectric Materials: Powering the Future of Bioelectronic Medicine

  2026cites this paper
• The Effect of Selenium Supplementation on Amino Acid Accumulation by the Yeast Saccharomyces cerevisiae and Rhodotorula glutinis

  2026cites this paper
• Evolutionary and Structural Constraints Define a Mutation-Resistant Catalytic Core in E. coli Serine Hydroxy methyltransferase (SHMT)

  2026cites this paper
• Age-Dependent Effects of Heavy Metals on the Hypothalamic–Pituitary–Testicular Axis-Related Hormones in Men

  2026cites this paper
• MTHFR 677C/T gene polymorphism and dietary habits: effects on trace element levels, amino acids, and biochemical parameters

  2026cites this paper
• Spatio-temporal metabolic alterations in cachexia

  2026cites this paper
• NMR-based metabolomics in a clinical cohort: deciphering the metabolic characteristics of gout with the dampness-heat syndrome and elucidate the efficacy of Simiao Pill

  2026cites this paper
• Methylenetetrahydrofolate dehydrogenase 2 promotes cutaneous squamous cell carcinoma progression by reprogramming metabolism and interacting with fatty acid synthase.

  2026cites this paper
• The association of Alzheimer’s disease-related SNPs with mild cognitive impairment susceptibility in the Chinese population

  2026cites this paper
• ¹H-NMR serum metabolomic profiling from clinical routine identifies signatures of progressive melanoma metastasis

  2026cites this paper
• Understanding microbial mercury methylation via metabolic pathways: Processes associated with one-carbon metabolism.

  2026cites this paper
• Dietary serine supplementation improves growth performance and intestinal immunity and modulates gut microbiota in chronic oxidative stress-induced weaned piglets

  2026cites this paper
• Heterogeneous graph neural networks reveal molecular mechanisms of folate deficiency in placental insufficiency through multiomics integration.

  2026cites this paper
• NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry.

  2026cites this paper
• Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.

  2026influential citation
• ATIC facilitates the malignant progression of bladder cancer by modulating AMPK-mTOR-S6K1 axis under folate reprogramming.

  2026cites this paper
• Self-assembled Lentinus edodes ergosterol-amyloid fiber hydrogel for zebrafish enteritis mitigation: Role of intestinal flora regulation and metabolomic remodeling

  2026cites this paper
• RASGEF1B suppresses hepatocellular carcinoma through the ALDH7A1/Betaine/SNAI1 metabolic‒epigenetic axis.

  2026cites this paper
• Cancer Metabolism and Its Historical & Molecular Foundations: An Overview

  2026cites this paper
• Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.

  2026cites this paper
• Specific SLC25 carriers regulate mitochondrial protein synthesis.

  2026cites this paper
• 16S rRNA Gene and Metagenomic Analysis Revealed an Association Between Cecal Microbiota and Pork Umami.

  2026cites this paper
• Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity by maintaining NADPH homeostasis.

  2026cites this paper
• Cobalamin Metabolism Is a Key Process of Breast Cancer Cells That Offers New Ways for Diagnosis and Treatment

  2026cites this paper
• The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1

  2026cites this paper
• Metabolic Overdrive in Elite Sport: A Systems Model of AMPK-mTOR Oscillation, NAD+ Economy, and Epigenetic Drift.

  2026cites this paper
• ALDH1L1 reverses CD8+ T cell exhaustion in the oral squamous cell carcinoma microenvironment by reprogramming L-glutamate metabolism.

  2026cites this paper
• Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation

  2026cites this paper
• AHCY: A Metabolic Gatekeeper at the Interface of Methylation, Redox Balance, and Cellular Stress Response.

  2026cites this paper
• DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma

  2026cites this paper
• Design, synthesis and antibacterial evaluation of piperazine urea-pyrazole-pyrimidine hybrids: in-vitro and in-silico studies.

  2026cites this paper
• Metabolic traits of T cells and the implications in autoimmune diseases.

  2026cites this paper
• Unveiling novel susceptibility genes for kidney stone disease by a cross-tissue transcriptome-wide association study

  2026cites this paper
• Identification of novel antibacterial DHFR inhibitors against MRSA through pharmacophore-based virtual screening and molecular dynamics simulation

  2026cites this paper
• Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes

  2026cites this paper
• SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistance

  2026influential citation
• Trogocytosis-mediated transfer of FOLR2 from nurse-like cells to CLL cells is associated with their activation and proliferation

  2026cites this paper
• Mitochondria and Epigenetic Regulation: Bidirectional Crosstalk and Emerging Mitochondria-Targeted Degron Tools

  2026cites this paper
• Mechanism and Therapeutic Progress of One-Carbon Metabolic Key Enzyme: Serine Hydroxymethyltransferase 2 in Cancer

  2025cites this paper
• One-carbon metabolism, insulin resistance, and fecundability in a Singapore prospective preconception cohort study.

  2025cites this paper
• Ex vivo study on prebiotic & choline combination to modulate gut bacteria, enhance choline bioavailability, and reduce TMA production

  2025cites this paper
• DmdA‐independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions

  2025cites this paper
• Analysis of stress response in multiple bacterial pathogens using a network biology approach

  2025cites this paper
• Vitamins and dietary supplements in cancer treatment: is there a need for increased usage?

  2025cites this paper
• The oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity

  2025influential citation
• SYNLAC Prime probiotics alleviate Enterocytozoon hepatopenaei-induced damage in white shrimp, Penaeus vannamei by enhancing growth, immunity, and resistance to Vibrio parahaemolyticus.

  2025cites this paper
• One-carbon metabolism enzyme Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

  2025cites this paper
• The delicate balance of bacterial purine homeostasis

  2025cites this paper
• 5-Formyltetrahydrofolate in a Cohort of Pregnant Women Following Folic Acid Supplementation

  2025cites this paper
• Targeting MTHFD2 alters metabolic homeostasis and synergizes with bortezomib to inhibit multiple myeloma

  2025cites this paper
• Association between oxidative balance score and methylation cycle biomarkers in US adults: insights from the national health and nutrition examination survey

  2025cites this paper
• Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis

  2025cites this paper
• Dysfunctional one-carbon metabolism identifies vitamins B6, B9, B12, and choline as neuroprotective in glaucoma

  2025cites this paper
• Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis

  2025cites this paper
• MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type

  2025cites this paper
• Inhibition Of One-Carbon Metabolism In Ewing Sarcoma Results In Profound And Prolonged Growth Suppression Associated With Purine Depletion

  2025cites this paper
• G-quadruplex in cancer energy metabolism: A potential therapeutic target.

  2025cites this paper
• Folate from probiotic bacteria and its therapeutic applications

  2025cites this paper
• Identifying Aberrant 1CM-Related Pathways by Multi-Omics Analysis and Validating Tumor Inhibitory Effect of One-Carbon Donor Betaine in Gastric Cancer

  2025cites this paper
• Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV

  2025cites this paper
• How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity

  2025cites this paper
• Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health

  2025cites this paper
• Targeting SHMT2‐mediated membrane phospholipid remodeling for enhanced anti‐GCSCs treatment

  2025cites this paper
• Folic Acid-Targeted Liposome-Based Nanoparticle Loaded with Sorafenib for Liver Cancer Therapy

  2025cites this paper
• Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation

  2025cites this paper
• The Role of AHCY Expression in Bladder Urothelial Carcinoma: A Bioinformatics and Experimental Analysis

  2025cites this paper
• Emodin and Aloe-Emodin Reduce Cell Growth and Disrupt Metabolic Plasticity in Human Melanoma Cells

  2025cites this paper
• Higher serum vitamin B6 is associated with lower all-cause mortality among cancer survivors in the National Health and Nutrition Examination Survey.

  2025cites this paper
• Betaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases

  2025cites this paper
• Epigenetic and metabolic regulation of developmental timing in neocortex evolution.

  2025cites this paper
• CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity

  2025influential citation
• MTHFD2: A metabolic checkpoint altering trophoblast invasion and migration by remodeling folate-nucleotide metabolism in recurrent spontaneous abortion.

  2025cites this paper