Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of Pathology

• Publication date

  2000-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)64563-4PMID 10934155PMCID PMC1850142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of strain variation in murine bleomycin-induced pulmonary fibrosis.

  2015cited by this paper
• Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice.

  1999cited by this paper
• Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment.

  1999cited by this paper
• Matrix metalloproteinases. Matrix degradation and more.

  1999cited by this paper
• A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.

  1999cited by this paper
• Airway Epithelial Cell Migration Dynamics

  1999cited by this paper
• Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis.

  1999cited by this paper
• Bleomycin stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activities.

  1999cited by this paper
• Transforming Growth Factor- α Deficiency Reduces Pulmonary Fibrosis in Transgenic Mice

  1999cited by this paper
• Neutrophil emigration in the lungs, peritoneum, and skin does not require gelatinase B.

  1999cited by this paper
• Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice.

  1999cited by this paper
• HNF-3/Forkhead Homologue-4 (HFH-4) Is Expressed in Ciliated Epithelial Cells in the Developing Mouse Lung

  1999cited by this paper
• Gelatinase B: Structure, Regulation, and Function

  1998cited by this paper
• Cell-matrix interactions modulate 92-kD gelatinase expression by human bronchial epithelial cells.

  1998cited by this paper
• Collagenase and gelatinase activities in bronchoalveolar lavage fluids during bleomycin‐induced lung injury

  1998cited by this paper
• Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis.

  1998cited by this paper
• Cell-specific gene expression reveals changes in epithelial cell populations after bleomycin treatment.

  1998cited by this paper
• Immunohistochemical and gelatin zymography studies for matrix metalloproteinases in bleomycin‐induced pulmonary fibrosis

  1998cited by this paper
• Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry.

  1998cited by this paper
• Bronchiolization of the alveoli in lung cancer: Pathology, patterns of differentiation and oncogene expression

  1998cited by this paper
• MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.

  1998cited by this paper
• Matrilysin expression and function in airway epithelium.

  1998cited by this paper
• Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases.

  1998cited by this paper
• Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

  1997cited by this paper
• Granules of the human neutrophilic polymorphonuclear leukocyte.

  1997cited by this paper
• The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

  1997cited by this paper
• The pathogenesis of pulmonary fibrosis: is there a fibrosis gene?

  1997cited by this paper
• Stem cells in lung development, disease, and therapy.

  1997cited by this paper
• Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.

  1997cited by this paper
• Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor.

  1997cited by this paper
• Lung alveolar epithelial cells synthesize interstitial collagenase and gelatinases A and B in vitro.

  1997cited by this paper
• Growth factors in the extracellular matrix

  1997cited by this paper
• Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung.

  1997cited by this paper
• Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

  1996cited by this paper
• Inheritance of susceptibility to bleomycin-induced pulmonary fibrosis in the mouse.

  1996cited by this paper
• Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

  1996cited by this paper
• Gelatinase B is involved in the in vitro wound repair of human respiratory epithelium

  1996cited by this paper
• Postpneumonectomy lung growth: a model of reinitiation of tropoelastin and type I collagen production in a normal pattern in adult rat lung.

  1996cited by this paper
• Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein.

  1996cited by this paper
• Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.

  1996cited by this paper
• Participation of pulmonary alveolar epithelial cells in lung inflammation.

  1995cited by this paper
• Matrix metalloproteinase family.

  1995cited by this paper
• IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes.

  1995cited by this paper
• Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium

  1994cited by this paper
• Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation.

  1993cited by this paper
• Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

  1993cited by this paper
• Differentiated bronchiolar epithelium in alveolar ducts of rats exposed to ozone for 20 months.

  1993cited by this paper
• Bleomycin

  1992influential reference
• Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components.

  1992cited by this paper
• Cell Proliferation during the Process of Bleomycin‐induced Pulmonary Fibrosis in Rats

  1990influential reference
• Evolution of metaplastic squamous cells of alveolar walls in pulmonary fibrosis produced by paraquat

  1989cited by this paper
• Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus‐induced gene in the mouse.

  1987cited by this paper
• Structure of alveolar epithelial cells in patients with fibrotic lung disorders.

  1982cited by this paper
• Pulmonary fibrosis with small-airway disease: a model in nonhuman primates.

  1982cited by this paper
• Role of the Clara cell in renewal of the bronchiolar epithelium.

  1978cited by this paper
• Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3.

  1976cited by this paper
• Histology and ultrastructure of metaplasia of alveolar epithelium following infection of mice and hamsters with influenza virus.

  1974cited by this paper
• Morphogenesis of alveolar bronchiolization.

  1972influential reference

• Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma

  2025cites this paper
• A Review of Proteases and Antiproteases for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis

  2025cites this paper
• Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes

  2025cites this paper
• The formation of lamellar body-like structures may be a trigger of cetylpyridinium chloride-induced cell death and inflammatory response.

  2024cites this paper
• Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression

  2023cites this paper
• Immune Mechanisms of Pulmonary Fibrosis with Bleomycin

  2023cites this paper
• Age-associated H3K9me2 loss alters the regenerative equilibrium between murine lung alveolar and bronchiolar progenitors.

  2023cites this paper
• Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice

  2022cites this paper
• The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases

  2022cites this paper
• Clinical significance of MMP-9 overexpression in endometrial cancer: A PRISMA-compliant meta-analysis

  2022cites this paper
• Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play

  2022cites this paper
• Matrix metalloproteinases inhibitors in idiopathic pulmonary fibrosis: Medicinal chemistry perspectives.

  2021cites this paper
• Topical application of quercetin improves wound repair and regeneration in diabetic rats

  2021cites this paper
• Matrix Metalloproteinases

  2021cites this paper
• GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis

  2021cites this paper
• A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin–Proteasome System in Pulmonary Fibrosis

  2020cites this paper
• The profibrotic effects of chronic microaspiration of bile acids on lungs of rats at different stages.

  2020cites this paper
• Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats.

  2019cites this paper
• MMP‐9‐positive neutrophils are essential for establishing profibrotic microenvironment in the obstructed kidney of UUO mice

  2019cites this paper
• Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis.

  2019cites this paper
• Gelatinases Increase in Bleomycin-induced Systemic Sclerosis Mouse Model.

  2019cites this paper
• Resolution of organ fibrosis

  2018cites this paper
• Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets.

  2018cites this paper
• The impaired proteases and anti-proteases balance in Idiopathic Pulmonary Fibrosis.

  2018cites this paper
• Molecular study of wound healing after using biosynthesized BNC/Fe3O4 nanocomposites assisted with a bioinformatics approach

  2018cites this paper
• IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis

  2018cites this paper
• Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection.

  2018cites this paper
• Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis.

  2018cites this paper
• Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the ‘bed’ that counts and not ‘the sleepers’

  2017cites this paper
• LRP1: A chameleon receptor of lung inflammation and repair.

  2017cites this paper
• Proteases in Wound Healing and Immunity

  2017cites this paper
• Role of Proteases in Idiopathic Pulmonary Fibrosis

  2017cites this paper
• The Function of Epithelial Cells in Pulmonary Fibrosis

  2017cites this paper
• Grape seed extract ameliorates bleomycin-induced mouse pulmonary fibrosis.

  2017cites this paper
• ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity

  2016cites this paper
• Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

  2016cites this paper
• Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies.

  2016cites this paper
• Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.

  2015cites this paper
• CANINE IDIOPATHIC PULMONARY FIBROSIS CLINICAL DISEASE , BIOMARKERS AND HISTOPATHOLOGICAL FEATURES HENNA

  2015cites this paper
• TRANSLATIONAL REVIEW Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

  2015cites this paper
• Matrix remodeling by MMPs during wound repair.

  2015cites this paper
• Metalloproteinases and Wound Healing

  2015cites this paper
• Matrix metalloproteinase 9 modulates collagen matrices and wound repair

  2015cites this paper
• Matrix metalloproteinase 9 modulates collagen matrices and wound repair

  2015cites this paper
• Inflammation and wound repair.

  2014cites this paper
• Diverse functions of matrix metalloproteinases during fibrosis

  2014influential citation
• Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers

  2014cites this paper
• Cell and Molecular Mediators involved in damage and repair in emphysema using mouse models

  2014cites this paper
• Evidence for Scgb1a1(+) cells in the generation of p63(+) cells in the damaged lung parenchyma.

  2014cites this paper
• Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline.

  2013cites this paper
• Matrix metalloproteinases and epidermal wound repair

  2013cites this paper
• Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

  2013cites this paper
• SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.

  2013cites this paper
• Efficacy of Repeated Intravenous Injection of Peramivir against Influenza A (H1N1) 2009 Virus Infection in Immunosuppressed Mice

  2013cites this paper
• Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis.

  2013cites this paper
• InjuryProtects against Hyperoxic Lung Overexpression of Stat3C in Pulmonary

  2013cites this paper
• A change in the number of CCSP(pos)/SPC(pos) cells in mouse lung during development, growth, and repair.

  2013cites this paper
• The Role of Neutrophil MMP-9 in the Development of Fibrosis in Hypersensitivity Pneumonitis

  2013cites this paper
• ROLE OF ALTERNATIVE MACROPHAGE ACTIVATION IN MEDIATING FIBROSIS IN PSEUDOMONAS AERUGINOSA PNEUMONIA

  2012cites this paper
• Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis

  2012cites this paper
• Matrix Metalloproteinases: A Review of Their Structure and Role in Systemic Sclerosis

  2012cites this paper
• Genetically manipulated mouse models of lung disease: potential and pitfalls.

  2012cites this paper
• Localization of Matrix Metalloproteinase (MMP)-9 in Lung Tissue of a Murine Model of Allergic Asthma

  2012cites this paper
• A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

  2011cites this paper
• Metalloproteinases in idiopathic pulmonary fibrosis

  2011cites this paper
• Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice

  2011cites this paper
• Matrix Metalloproteinase Inhibitors as New Anti-inflammatory Drugs

  2011cites this paper
• Matrix metalloproteinases in COPD

  2011cites this paper
• Role of matrix metalloproteinases in the inflammatory process of respiratory diseases.

  2010cites this paper
• Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.

  2010cites this paper
• Epithelial and Mesenchymal Cell Biology Tissue Inhibitor of Metalloproteinase-1 Moderates Airway Re-Epithelialization by Regulating Matrilysin Activity

  2010cites this paper
• Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

  2010cites this paper
• Monocyte and macrophage regulation of pulmonary fibrosis

  2010cites this paper
• Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines.

  2010cites this paper
• The Role of Catalase in Pulmonary Fibrosis

  2010influential citation
• Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats.

  2010cites this paper
• CD47 gene knockout protects against transient focal cerebral ischemia in mice.

  2009cites this paper
• Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury.

  2009cites this paper
• Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer.

  2009cites this paper
• Role of matrix metalloproteinases in epithelial migration

  2009influential citation
• Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases.

  2009cites this paper
• Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

  2009cites this paper
• Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases

  2009cites this paper
• Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study

  2009cites this paper
• Early and Late Changes of MMP-2 and MMP-9 in Bleomycin-Induced Pulmonary Fibrosis

  2009cites this paper
• Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.

  2009cites this paper
• Important role of matrix metalloproteinase 9 in epileptogenesis

  2008cites this paper
• Role of matrix metalloproteases in pulmonary fibrosis

  2008cites this paper
• Comparative efficacies of albendazole and the Chinese herbal medicine long-dan-xie-gan-tan, used alone or in combination, in the treatment of experimental eosinophilic meningitis induced by Angiostrongylus cantonensis

  2008cites this paper
• Clara cell adhesion and migration to extracellular matrix

  2008cites this paper
• Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin.

  2008cites this paper
• Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

  2008cites this paper
• 3 SYSTEMIC SCLEROSIS Vascular , Pulmonary and Immunological Aspects

  2008cites this paper
• Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure

  2008cites this paper
• Dual-immunohistochemistry provides little evidence for epithelial–mesenchymal transition in pulmonary fibrosis

  2008cites this paper
• Approaching the degradome in idiopathic pulmonary fibrosis.

  2008cites this paper
• Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.

  2008cites this paper
• Metalloproteinases and their inhibitors: regulators of wound healing.

  2008cites this paper
• Loss of Caveolin-1 in Bronchiolization in Lung Fibrosis

  2007cites this paper
• Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.

  2007cites this paper