Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2000-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPCELL.2000.279.3.C691PMID 10942719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence for extracellular calcium‐sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87)

  1999cited by this paper
• The Extracellular Calcium‐Sensing Receptor Is Expressed in Rat Microglia and Modulates an Outward K+ Channel

  1999cited by this paper
• Inhibitory effects of 1,25-dihydroxyvitamin D3 and 9-cis-retinoic acid on parathyroid hormone-related protein expression by oral cancer cells (HSC-3).

  1998cited by this paper
• Characterization of the cell-specific expression of parathyroid hormone-related protein in normal and neoplastic prostate tissue.

  1998cited by this paper
• The calcium-sensing receptor (CaR) permits Ca2+ to function as a versatile extracellular first messenger.

  1998cited by this paper
• Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney.

  1998cited by this paper
• Distribution of the perivascular nerve Ca2+ receptor in rat arteries

  1998cited by this paper
• Extracellular Calcium (Ca2+o)-Sensing Receptor in a Murine Bone Marrow-Derived Stromal Cell Line (ST2): Potential Mediator of the Actions of Ca2+o on the Function of ST2 Cells.

  1998cited by this paper
• Ca(2+) receptor from brain to gut: common stimulus, diverse actions.

  1998cited by this paper
• Coexpression of parathyroid hormone-related protein and its receptor in breast carcinoma: a potential autocrine effector system.

  1998cited by this paper
• Extracellular calcium‐sensing receptor in rat oligodendrocytes: Expression and potential role in regulation of cellular proliferation and an outward K+ channel

  1998cited by this paper
• Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells.

  1998cited by this paper
• Functional analysis of the PTH/PTHrP network of ligands and receptors.

  1998cited by this paper
• Mouse Osteoblastic Cell Line (MC3T3‐E1) Expresses Extracellular Calcium (Ca2+o)–Sensing Receptor and Its Agonists Stimulate Chemotaxis and Proliferation of MC3T3‐E1 Cells

  1998cited by this paper
• Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney.

  1998cited by this paper
• Parathyroid hormone-related protein (PTHrP) inhibits proliferation of Chinese hamster ovary cells stably transfected with a PTH/PTHrP receptor cDNA.

  1997cited by this paper
• Parathyroid hormone-related protein, an autocrine growth inhibitor of alveolar type II cells.

  1997cited by this paper
• Parathyroid hormone‐related protein and bone metastases

  1997cited by this paper
• Calcium-sensing receptor in the rat hippocampus: a developmental study.

  1997cited by this paper
• Cao-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons.

  1997cited by this paper
• Parathyroid hormone-related peptide and hypercalcemia of malignancy.

  1997cited by this paper
• Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization.

  1997cited by this paper
• Antiproliferative effect of the C‐terminal fragments of parathyroid hormone‐related protein, PTHrP‐(107–111) and (107–139), on osteoblastic osteosarcoma cells

  1997cited by this paper
• Modulation by Polycationic Ca2+-Sensing Receptor Agonists of Nonselective Cation Channels in Rat Hippocampal Neurons

  1996cited by this paper
• Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism.

  1996cited by this paper
• Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion.

  1996cited by this paper
• Expression and Characterization of Inactivating and Activating Mutations in the Human Ca2+o-sensing Receptor*

  1996cited by this paper
• Structure of a parathyroid hormone/parathyroid hormone-related peptide receptor of the human cerebellum and functional expression in human neuroblastoma SK-N-MC cells.

  1996cited by this paper
• Expression and action of parathyroid hormone-related peptide in human cervical epithelial cells.

  1996cited by this paper
• Defining the roles of parathyroid hormone-related protein in normal physiology.

  1996cited by this paper
• Modulation by polycationic Ca(2+)-sensing receptor agonists of nonselective cation channels in rat hippocampal neurons.

  1996cited by this paper
• Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours.

  1995cited by this paper
• Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: evidence for growth-inhibiting and invasion-promoting effects.

  1995cited by this paper
• Molecular Cloning and Functional Expression of Human Parathyroid Calcium Receptor cDNAs (*)

  1995cited by this paper
• Demonstration of parathyroid hormone-related protein in meninges and its receptor in astrocytes: evidence for a paracrine meningo-astrocytic loop.

  1995cited by this paper
• Epidermal growth factor-stimulated parathyroid hormone-related protein expression involves increased gene transcription and mRNA stability.

  1995cited by this paper
• Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

  1995cited by this paper
• Expression of parathyroid hormone-related protein and its receptor in human umbilical cord: evidence for a paracrine system involving umbilical vessels.

  1994cited by this paper
• Regulation of parathyroid hormone-related protein production in a human lung squamous cell carcinoma line.

  1994cited by this paper
• Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes.

  1994cited by this paper
• Parathyroid hormone-like protein: alternative messenger RNA splicing pathways in human cancer cell lines.

  1994cited by this paper
• Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

  1993cited by this paper
• Regulation of parathyroid hormone-related protein production by a squamous carcinoma cell line in vitro.

  1993cited by this paper
• Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression.

  1991cited by this paper
• Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system.

  1990cited by this paper
• Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes.

  1990cited by this paper
• Transcriptional regulation of the parathyroid hormone-related peptide gene by glucocorticoids and vitamin D in a human C-cell line.

  1989cited by this paper
• Glucocorticoid regulation of parathyroid hormone-related peptide gene transcription in a human neuroendocrine cell line.

  1989cited by this paper
• A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.

  1987influential reference
• The clinical course of bone metastases from breast cancer.

  1987cited by this paper

• Calcium-sensing receptor in GtoPdb v.2025.3

  2025cites this paper
• Calcium-sensing receptor in GtoPdb v.2023.1

  2023cites this paper
• Calcium-sensing receptor in GtoPdb v.2021.3

  2021cites this paper
• CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes

  2020cites this paper
• Calcium-sensing receptor (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

  2020cites this paper
• Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

  2020cites this paper
• Calcium-sensing receptor (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Intractable Generalized Epilepsy and Autosomal Dominant Hypocalcemia: A Case Report

  2019cites this paper
• Parathyroid hormone related peptide (PTHrP): a mini‒review;

  2019cites this paper
• Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons

  2019cites this paper
• An Unusual Case of Meningioma Showing Increased CaSR Expression with Parathyroid Carcinoma

  2018cites this paper
• Parathyroid Hormone Related Peptide (PTHrP): A Mini-Review

  2017cites this paper
• Rôle des astrocytes dans la décharge rythmique neuronale du noyau sensoriel principal du trijumeau

  2017cites this paper
• Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population

  2017cites this paper
• Regulation of Differentiation by Calcium-Sensing Receptor in Normal and Tumoral Developing Nervous System

  2016cites this paper
• Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro.

  2016cites this paper
• Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

  2016cites this paper
• Ion Homeostasis in Rhythmogenesis: The Interplay Between Neurons and Astroglia.

  2015cites this paper
• Between Neurons and Astroglia Ion Homeostasis in Rhythmogenesis : The Interplay

  2015cites this paper
• Differential expression of the calcium-sensing receptor in the ischemic and border zones after transient focal cerebral ischemia in rats.

  2015cites this paper
• The Paracrine Feedback Loop Between Vitamin D3 (1,25(OH)2D3) and PTHrP in Prehypertrophic Chondrocytes

  2014cites this paper
• Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

  2014cites this paper
• Regulation of the calcium-sensing receptor by amyloid-beta-42 : implications for Alzheimer's disease

  2013influential citation
• Roles of the calcium sensing receptor in the central nervous system.

  2013cites this paper
• Padrão de distribuição e localização de expressão das proteínas VILIP-1, receptor sensor de cálcio e receptor metabotrópico do glutamato 1 em tecidos de pacientes com epilepsia do lobo temporal

  2012cites this paper
• Signaling through the extracellular calcium-sensing receptor (CaSR).

  2012cites this paper
• The role of the calcium-sensing receptor in human disease.

  2012cites this paper
• The calcium-sensing receptor: a molecular perspective.

  2011cites this paper
• Vitamin D: a potential role in reducing suicide risk?

  2011cites this paper
• Diverse roles of extracellular calcium‐sensing receptor in the central nervous system

  2010influential citation
• Parathyroid hormone-related peptide and primary hyperparathyroidism.

  2010cites this paper
• Therapeutic agents for reduction of parathyroid hormone levels

  2010cites this paper
• Calcium-sensing receptor (CaSR) in human brain's pathophysiology: roles in late-onset Alzheimer's disease (LOAD).

  2009cites this paper
• Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.

  2009cites this paper
• The calcium‐sensing receptor and parathyroid hormone‐related protein are expressed in differentiated, favorable neuroblastic tumors

  2009cites this paper
• The role of the calcium-sensing receptor in the development and progression of cancer.

  2009cites this paper
• Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain.

  2009cites this paper
• Calcium-sensing receptor in cancer: good cop or bad cop?

  2009cites this paper
• PARATHYROID HORMONE-RELATED PROTEIN I 127

  2009cites this paper
• An idiopathic epilepsy syndrome linked to 3q13.3‐q21 and missense mutations in the extracellular calcium sensing receptor gene

  2008cites this paper
• Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells.

  2008cites this paper
• Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: Potential impact on reduced myelin basic protein in CaR‐null mice

  2008cites this paper
• Proteins associated with the intracellular signalling tail of the calcium-sensing receptor and their impact on receptor function

  2008cites this paper
• Chapter 26. Parathyroid Hormone-Related Protein

  2008cites this paper
• Gαq-TRPC6-mediated Ca2+ Entry Induces RhoA Activation and Resultant Endothelial Cell Shape Change in Response to Thrombin*

  2007cites this paper
• The parathyroid hormone family of peptides: structure, tissue distribution, regulation, and potential functional roles in calcium and phosphate balance in fish.

  2007cites this paper
• Parathyroid hormone-related protein in teleost fish.

  2007cites this paper
• Meningiomas: science and surgery.

  2007cites this paper
• Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines

  2007cites this paper
• Calcium‐sensing receptor stimulates secretion of an interferon‐γ‐induced monokine (CXCL10) and monocyte chemoattractant protein‐3 in immortalized GnRH neurons

  2007cites this paper
• Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy.

  2006cites this paper
• Calcium-Sensing Receptor Stimulation Induces Nonselective Cation Channel Activation in Breast Cancer Cells

  2006cites this paper
• Hypercalcemia in glioblastoma multiforme.

  2006cites this paper
• Calcium Sensing by the Mammary Gland

  2005cites this paper
• Calcium as an extracellular signalling molecule: perspectives on the Calcium Sensing Receptor in the brain.

  2005cites this paper
• Roles of Ca2+ and the Ca2+‐sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)‐2 and its BH4 (tetrahydrobiopterin)‐dependent activation in cytokine‐stimulated adult human astrocytes

  2005influential citation
• THE CALCIUM-SENSING RECEPTOR IN NORMAL PHYSIOLOGY AND PATHOPHYSIOLOGY: A Review

  2005cites this paper
• Functional role of TRPC channels in the regulation of endothelial permeability

  2005cites this paper
• Essential Role of a Ca2+-Selective, Store-Operated Current (ISOC) in Endothelial Cell Permeability: Determinants of the Vascular Leak Site

  2005cites this paper
• Activation of the Endothelial Store-Operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 With TRPC4

  2005cites this paper
• Extracellular Ca2+-sensing receptors--an overview.

  2004cites this paper
• Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation.

  2004cites this paper
• P2Y receptor-mediated Ca(2+) signaling increases human vascular endothelial cell permeability.

  2004cites this paper
• Extracellular calcium sensing receptor: an overview of physiology, pathophysiology and clinical perspectives.

  2004cites this paper
• Parathyroid hormone–related protein expression is correlated with clinical course in patients with glial tumors

  2004cites this paper
• Calbindin-D28k and calcium sensing receptor cooperate in MCF-7 human breast cancer cells.

  2004cites this paper
• The role of the calcium-sensing receptor in cancer.

  2004influential citation
• Calcium-sensing receptor in the brain.

  2004cites this paper
• Regulation of a Ca2+‐activated K+ channel by calcium‐sensing receptor involves p38 MAP kinase

  2004cites this paper
• Calcium Receptor-mediated Signaling

  2003cites this paper
• Functions of the Calcium-Sensing Receptor in the Gastrointestinal System

  2003cites this paper
• Expression and characterization of the extracellular Ca(2+)-sensing receptor in melanotrope cells of Xenopus laevis.

  2003cites this paper
• PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation.

  2003cites this paper
• The calcium-sensing receptor in human disease.

  2003cites this paper
• T-type calcium current in sickle cell disease: a channel to therapy?

  2003cites this paper
• Expression and Functions of Calcium-Sensing Receptor in the Central Nervous System

  2003cites this paper
• P2Y receptor‐mediated enhancement of permeation requires Ca2+ signalling in vascular endothelial cells

  2003cites this paper
• Cloning of the cDNA for the putative calcium-sensing receptor and its tissue distribution in sea bream (Sparus aurata).

  2002cites this paper
• Rat brain expresses serum calcium-decreasing factor (caldecrin).

  2002cites this paper
• Calcium‐sensing receptors and parathyroid hormone‐related protein in the caudal neurosecretory system of the flounder (Platichthys flesus)

  2002influential citation
• Parathyroid hormone-related protein (PTHrP) induction in reactive astrocytes following brain injury: a possible mediator of CNS inflammation.

  2001cites this paper
• Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion.

  2001cites this paper
• Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

  2001cites this paper
• Secretory Meningiomas: Clinical and Immunohistochemical Observations

  2001cites this paper
• Gα Minigenes Expressing C-terminal Peptides Serve as Specific Inhibitors of Thrombin-mediated Endothelial Activation*

  2001cites this paper