Radiation countermeasure agents: an update (2011 – 2014)

Introduction: Despite significant scientific advances over the past 60 years towards the development of a safe, nontoxic and effective radiation countermeasure for the acute radiation syndrome (ARS), no drug has been approved by the US FDA. A radiation countermeasure to protect the population at large from the effects of lethal radiation exposure remains a significant unmet medical need of the US citizenry and, thus, has been recognized as a high priority area by the government. Area covered: This article reviews relevant publications and patents for recent developments and progress for potential ARS treatments in the area of radiation countermeasures. Emphasis is placed on the advanced development of existing agents since 2011 and new agents identified as radiation countermeasure for ARS during this period. Expert opinion: A number of promising radiation countermeasures are currently under development, seven of which have received US FDA investigational new drug status for clinical investigation. Four of these agents, CBLB502, Ex-RAD, HemaMax and OrbeShield, are progressing with large animal studies and clinical trials. G-CSF has high potential and well-documented therapeutic effects in countering myelosuppression and may receive full licensing approval by the US FDA in the future.

• Publication year

  2014

• Venue

  Expert Opinion on Therapeutic Patents

• Publication date

  2014-10-15

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1517/13543776.2014.964684PMID 25315070PMCID 4438421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review.

  2015cited by this paper
• A Basic Fibroblast Growth Factor Analog for Protection and Mitigation against Acute Radiation Syndromes

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• Myeloid Progenitors Mitigate Radiation Injury and Improve Intestinal Integrity after Whole-Body Irradiation

  2014cited by this paper
• Development of a New Minipig Model to Study Radiation-Induced Gastrointestinal Syndrome and its Application in Clinical Research.

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• Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation

  2014cited by this paper
• A Pilot Study in Rhesus Macaques to Assess the Treatment Efficacy of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant (AEOL 10150) in Mitigating Radiation-induced Lung Damage

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  2013cited by this paper
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  2013cited by this paper
• Keratinocyte growth factor pretreatment prevents radiation-induced intestinal damage in a mouse model

  2013cited by this paper
• Enhanced hematopoietic protection from radiation by the combination of genistein and captopril.

  2013cited by this paper
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  2013influential reference
• Filgrastim Improves Survival in Lethally Irradiated Nonhuman Primates

  2013influential reference
• Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death

  2013influential reference
• Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure.

  2013cited by this paper
• Clinical applications of palifermin: amelioration of oral mucositis and other potential indications

  2013cited by this paper
• [Radiation protection effect of rhIL-12 on monkey hematopoietic system].

  2013influential reference
• The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body γ-irradiation.

  2013cited by this paper
• Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival.

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• Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures

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• Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation.

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• Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.

  2013influential reference
• Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD® in mice

  2012cited by this paper
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  2012cited by this paper
• A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute

  2012cited by this paper
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• Amifostine

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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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• Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial.

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• An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

  2008influential reference
• Radioprotection by the soy isoflavone genistein.

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• Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival

  2007cited by this paper
• Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.

  2007cited by this paper
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• IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation.

  2007cited by this paper
• Tocotrienols in health and disease: the other half of the natural vitamin E family.

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• New therapy for the prevention and prophylactic treatment of acute radiation syndrome

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• 5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression.

  2007cited by this paper
• Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury.

  2007cited by this paper
• Radiobiology for the Radiologist, 6th Edition

  2006cited by this paper
• AEOL-10150 (Aeolus).

  2006cited by this paper
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  2006cited by this paper

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• New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome

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  2024cites this paper
• Cell Therapies for Acute Radiation Syndrome

  2024cites this paper
• DAMPs and radiation injury

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• Synthetic Genistein: A Possible Active Pharmaceutical Substance for the Development of Radiation Countermeasure Agents

  2024cites this paper
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  2024cites this paper
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  2023cites this paper
• The potential value of 5-androstenediol in countering acute radiation syndrome.

  2023cites this paper
• Mitigation of acute radiation syndrome (ARS) with human umbilical cord blood

  2023cites this paper
• Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Development of gamma-tocotrienol as a radiation medical countermeasure for the acute radiation syndrome: current status and future perspectives

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018influential citation
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  2018cites this paper
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