Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPENDO.2001.281.3.E489PMID 11500304
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The effect of PKC activation on the survival of rat retinal ganglion cells in culture.

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• Physiological regulation of G protein-linked signaling.

  1999cited by this paper
• A Gsalpha mutant designed to inhibit receptor signaling through Gs.

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• Tumor Angiogenesis as a Prognostic Predictor in Colorectal Carcinoma with Special Reference to Mode of Metastasis and Recurrence

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• Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades.

  1998cited by this paper
• The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor.

  1998cited by this paper
• Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors.

  1997cited by this paper
• G PROTEIN BETA GAMMA SUBUNITS

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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• Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors.

  1997cited by this paper
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  1996cited by this paper
• Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

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• Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

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• Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2.

  1996influential reference
• Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development.

  1995cited by this paper
• Osteoblast and chondroblast differentiation.

  1995cited by this paper
• Phosphatidylinositol 3‐kinase

  1994cited by this paper
• Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

  1994cited by this paper
• Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

  1994cited by this paper
• Antisense-mediated inhibition of parathyroid hormone-related peptide production in a keratinocyte cell line impedes differentiation.

  1994cited by this paper
• A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits.

  1994cited by this paper
• Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression

  1994cited by this paper
• Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.

  1993cited by this paper
• Effects of N-terminal, midregion, and C-terminal parathyroid hormone-related peptides on adenosine 3',5'-monophosphate and cytoplasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells.

  1993cited by this paper
• Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

  1992cited by this paper
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  1992cited by this paper
• Growth factor signaling by receptor tyrosine kinases.

  1992cited by this paper
• The direct involvement of cAMP-dependent protein kinase in the regulation of collagen synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblast-like osteosarcoma cells (UMR-106).

  1992cited by this paper
• A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

  1991cited by this paper
• Association of p21ras with phosphatidylinositol 3-kinase.

  1991cited by this paper
• Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer.

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper
• Differential effects of continuous and transient treatment with parathyroid hormone related peptide (PTHrp) on bone collagen synthesis.

  1990influential reference
• Which G protein subunits are the active mediators in signal transduction

  1987cited by this paper
• The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

  1987cited by this paper
• Parathyroid hormone-related protein purified from a human lung cancer cell line.

  1987cited by this paper
• The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

  1987cited by this paper
• Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.

  1987cited by this paper

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  2020cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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• Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone.

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• Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

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