Phosphatidylinositol 3‐kinase

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Bioessays

• Publication date

  1994-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/bies.950160810PMID 8086005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

  1994cited by this paper
• Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells.

  1994cited by this paper
• PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity.

  1994cited by this paper
• The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

  1994cited by this paper
• PI 3‐kinase: structural and functional analysis of intersubunit interactions.

  1994cited by this paper
• Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

  1994cited by this paper
• A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits.

  1994cited by this paper
• Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

  1994cited by this paper
• Role of PI 3-kinase in mitogenesis.

  1994cited by this paper
• Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

  1994cited by this paper
• A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

  1993cited by this paper
• Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

  1993cited by this paper
• The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

  1993cited by this paper
• Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

  1993cited by this paper
• SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

  1993cited by this paper
• Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.

  1993cited by this paper
• Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

  1993cited by this paper
• Protein kinase C zeta isoform is critical for mitogenic signal transduction.

  1993cited by this paper
• Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase

  1993cited by this paper
• Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

  1993cited by this paper
• Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.

  1993cited by this paper
• Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

  1993cited by this paper
• SH2 and SH3 domains.

  1993cited by this paper
• Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

  1993cited by this paper
• Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

  1993cited by this paper
• The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

  1993cited by this paper
• A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

  1993cited by this paper
• A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation

  1993cited by this paper
• Receptor stimulated accumulation of phosphatidylinositol (3,4,5)‐trisphosphate by G‐protein mediated pathways in human myeloid derived cells.

  1993cited by this paper
• The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

  1993cited by this paper
• Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

  1993cited by this paper
• Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

  1993cited by this paper
• Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

  1993cited by this paper
• Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

  1993cited by this paper
• SH2 domains recognize specific phosphopeptide sequences.

  1993cited by this paper
• GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

  1992cited by this paper
• Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

  1992cited by this paper
• Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains.

  1992cited by this paper
• Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation.

  1992cited by this paper
• Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

  1992cited by this paper
• Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.

  1992cited by this paper
• Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells

  1992cited by this paper
• Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.

  1992cited by this paper
• SH2 and SH3 domains

  1992cited by this paper
• Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.

  1992cited by this paper
• Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase

  1992cited by this paper
• Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.

  1992cited by this paper
• Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

  1992cited by this paper
• Novel polyphosphoinositides in cell growth and activation.

  1991cited by this paper
• Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor

  1991cited by this paper
• Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

  1991cited by this paper
• Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

  1991cited by this paper
• Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

  1991cited by this paper
• Oncogenes and signal transduction.

  1991cited by this paper
• Bcr encodes a GTPase-activating protein for p21rac

  1991cited by this paper
• Requirement of phosphatidylinositol-3 kinase modification for its association with p60src

  1991cited by this paper
• Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase.

  1991cited by this paper
• The trk proto-oncogene encodes a receptor for nerve growth factor.

  1991cited by this paper
• Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.

  1991cited by this paper
• cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.

  1991cited by this paper
• A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

  1991cited by this paper
• Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.

  1991cited by this paper
• growth factor and platelet-derived growth 3-kinase-associated p 85 with epidermal Interaction of phosphatidylinositol

  1991cited by this paper
• Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids.

  1991cited by this paper
• Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.

  1990cited by this paper
• Purification and characterization of phosphoinositide 3-kinase from rat liver.

  1990cited by this paper
• Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction

  1990cited by this paper
• Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper
• Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen

  1990cited by this paper
• Phosphoinositide kinases.

  1990cited by this paper
• Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

  1990cited by this paper
• Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides.

  1990cited by this paper
• Binding of GAP to activated PDGF receptors.

  1990cited by this paper
• gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein.

  1990cited by this paper
• Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.

  1989cited by this paper
• PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.

  1989cited by this paper
• Gelsolin-polyphosphoinositide interaction. Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group.

  1989cited by this paper
• Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.

  1989cited by this paper
• Binding of myosin I to membrane lipids

  1989cited by this paper
• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988cited by this paper
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988cited by this paper
• Specificity of the interaction between phosphatidylinositol 4,5‐bisphosphate and the profilin:actin complex

  1988cited by this paper
• Increased breakdown of phosphatidylinositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils.

  1988cited by this paper
• Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.

  1987cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

  1986cited by this paper
• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

  1985cited by this paper
• Regulation of the association of membrane skeletal protein 4.1 with glycophorin by a polyphosphoinositide

  1985cited by this paper
• Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1976cited by this paper
• Structure of Insulin

  1953cited by this paper

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