BMP signaling is required for adult skeletal homeostasis and mediates bone anabolic action of parathyroid hormone.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Bone

• Publication date

  2016-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bone.2016.08.018PMID 27567726
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of BMP signaling dependent osteogenesis using a BMP depletable avianized bone marrow stromal cell line (TVA-BMSC).

  2016cited by this paper
• Predictors of teriparatide treatment failure in patients with low bone mass

  2015cited by this paper
• Bmp2 conditional knockout in osteoblasts and endothelial cells does not impair bone formation after injury or mechanical loading in adult mice.

  2015cited by this paper
• Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia

  2015cited by this paper
• A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling

  2014cited by this paper
• Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones.

  2014cited by this paper
• BMP-7 versus BMP-2 for the treatment of long bone nonunion.

  2014cited by this paper
• Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

  2013cited by this paper
• BRITER: A BMP Responsive Osteoblast Reporter Cell Line

  2012cited by this paper
• A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts

  2012cited by this paper
• [6]-Gingerol induces bone loss in ovary intact adult mice and augments osteoclast function via the transient receptor potential vanilloid 1 channel.

  2012cited by this paper
• The role of BMPs in bone anabolism and their potential targets SOST and DKK1.

  2012cited by this paper
• Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling

  2012cited by this paper
• A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action

  2011cited by this paper
• BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

  2011cited by this paper
• Transcriptional Regulation of BMP2 Expression by the PTH-CREB Signaling Pathway in Osteoblasts

  2011cited by this paper
• Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

  2010cited by this paper
• Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors

  2010cited by this paper
• rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model.

  2010cited by this paper
• Regional and cellular localisation of BMPs and their inhibitors’ expression in human fractures

  2009cited by this paper
• New Mouse Lines for the Analysis of Neuronal Morphology Using CreER(T)/loxP-Directed Sparse Labeling

  2009cited by this paper
• Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.

  2009cited by this paper
• Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass

  2008cited by this paper
• Potential excessive suppression of bone turnover with long-term oral bisphosphonate therapy in postmenopausal osteoporotic patients

  2008cited by this paper
• BMP4 is dispensable for skeletogenesis and fracture-healing in the limb.

  2008cited by this paper
• Hematopoietic Stem Cells Regulate Mesenchymal Stromal Cell Induction into Osteoblasts Thereby Participating in the Formation of the Stem Cell Niche

  2008cited by this paper
• Secreted Tartrate-Resistant Acid Phosphatase 5b is a Marker of Osteoclast Number in Human Osteoclast Cultures and the Rat Ovariectomy Model

  2008cited by this paper
• IGF‐I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone

  2007cited by this paper
• Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion.

  2007cited by this paper
• Interaction of bone morphogenetic proteins with cells of the osteoclast lineage: review of the existing evidence

  2007cited by this paper
• Conditional Deletion of Gremlin Causes a Transient Increase in Bone Formation and Bone Mass*

  2007cited by this paper
• Strain‐Dependent Variations in the Response of Cancellous Bone to Ovariectomy in Mice

  2006cited by this paper
• Bone marrow stromal cells induce BMP2/4 production in oxygen‐glucose‐deprived astrocytes, which promotes an astrocytic phenotype in adult subventricular progenitor cells

  2006cited by this paper
• Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis

  2006cited by this paper
• Modulations of 17-β Estradiol on Osteogenic and Adipogenic Differentiations of Human Mesenchymal Stem Cells

  2006cited by this paper
• BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing

  2006cited by this paper
• Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.

  2005cited by this paper
• The bone morphogenic protein.

  2005cited by this paper
• Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.

  2005cited by this paper
• Putting evidence-based medicine into clinical practice: comparing anti-resorptive agents for the treatment of osteoporosis

  2004cited by this paper
• Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production.

  2003cited by this paper
• A Noninvasive Genetic/Pharmacologic Strategy for Visualizing Cell Morphology and Clonal Relationships in the Mouse

  2003cited by this paper
• Parathyroid Hormone-Smad3 Axis Exerts Anti-apoptotic Action and Augments Anabolic Action of Transforming Growth Factor β in Osteoblasts*

  2003cited by this paper
• Anabolic and catabolic bone effects of human parathyroid hormone (1-34) are predicted by duration of hormone exposure.

  2003cited by this paper
• Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.

  2003cited by this paper
• Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells.

  2003cited by this paper
• Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone

  2002cited by this paper
• The Anabolic Effects of Parathyroid Hormone

  2002cited by this paper
• Anabolic Action of Parathyroid Hormone Is Skeletal Site Specific at the Tissue and Cellular Levels in Mice

  2002cited by this paper
• The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.

  2002cited by this paper
• Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-κB Ligand.

  2001cited by this paper
• Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

  2001cited by this paper
• Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand.

  2001cited by this paper
• Essential Requirement of BMPs‐2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

  2000cited by this paper
• Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.

  2000cited by this paper
• Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts.

  2000cited by this paper
• Novel Serum Markers of Bone Resorption: Clinical Assessment and Comparison with Established Urinary Indices

  1999cited by this paper
• Mechanical Tension‐Stress Induces Expression of Bone Morphogenetic Protein (BMP)‐2 and BMP‐4, but Not BMP‐6, BMP‐7, and GDF‐5 mRNA, During Distraction Osteogenesis

  1999cited by this paper
• Bone marrow stromal cells: characterization and clinical application.

  1999cited by this paper
• Trabecular remodeling processes in the ovariectomized rat: modified node-strut analysis.

  1999cited by this paper
• Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats.

  1998cited by this paper
• Short-term immobilization-induced cancellous bone loss is limited to regions undergoing high turnover and/or modeling in mature rats.

  1997cited by this paper
• Stimulatory effect of bone morphogenetic protein‐2 on osteoclast‐like cell formation and bone‐resorbing activity

  1995cited by this paper
• Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae.

  1995cited by this paper
• Phosphatidylinositol 3‐kinase

  1994cited by this paper
• A modification of the masson trichrome technique for routine laboratory purposes.

  1938cited by this paper

• Tetrapeptides derived from black bean enhance osteogenesis and alleviate ovariectomy-induced bone loss via activation of BMP-2/Smad signaling.

  2026cites this paper
• Current advances of bone homeostasis imbalance in the cause of hereditary metabolic bone diseases

  2026cites this paper
• Paratormone e paratormone peptide-relato: gemelli diversi

  2025cites this paper
• Effects of Thermal Environment on Bone Microenvironment: A Narrative Review

  2025cites this paper
• Molecular pathophysiology of chronic kidney disease-mineral and bone disorder: Focus on the fibroblast growth factor 23-Klotho axis and bone turnover dynamics.

  2025cites this paper
• Gprc5a is a novel parathyroid hormone‐inducible gene and negatively regulates osteoblast proliferation and differentiation

  2024cites this paper
• Distribution of Immunomodulation, Protection and Regeneration Factors in Cleft-Affected Bone and Cartilage

  2024cites this paper
• PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

  2024cites this paper
• Self-Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering

  2024cites this paper
• Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells

  2024cites this paper
• BMP signalling: A significant player and therapeutic target for osteoarthritis.

  2023cites this paper
• BMP signaling: A significant player and therapeutic target for osteoarthritis

  2022cites this paper
• The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

  2022cites this paper
• Title: Targeting BMP signaling mitigates osteoarthritis One Sentence Summary - Pharmacological inhibition of BMP signaling in osteoarthritis, attenuates disease progression and inflammation

  2022cites this paper
• Synthesis and Evaluation of Galloyl Conjugates of Flavanones as BMP-2 Upregulators with Promising Bone Anabolic and Fracture Healing Properties.

  2021cites this paper
• Self-Assembling Nano-Globular Peptide from Human Lactoferrin Acts as a Systemic Enhancer of Bone Regeneration: A Novel Peptide for Orthopedic Application.

  2021cites this paper
• Anabolic actions of PTH in murine models: two decades of insights

  2021cites this paper
• The Transcription Factor Foxc1 Promotes Osteogenesis by Directly Regulating Runx2 in Response of Intermittent Parathyroid Hormone (1–34) Treatment

  2020cites this paper
• Protein Kinase G1 regulates bone regeneration and rescues diabetic fracture healing.

  2020cites this paper
• Signaling pathways affected by mutations causing osteogenesis imperfecta.

  2020cites this paper
• Simultaneous differentiation of articular and transient cartilage: WNT-BMP interplay and its therapeutic implication.

  2020cites this paper
• Human BMP chimera BV261

  2019cites this paper
• Circulating noggin levels following treatment with denosumab or teriparatide in postmenopausal women with low bone mass

  2019cites this paper
• A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

  2019cites this paper
• Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

  2019cites this paper
• MicroRNA-672-5p Identified during Weaning Reverses Osteopenia and Sarcopenia in Ovariectomized Mice

  2019cites this paper
• Continuous PTH in Male Mice Causes Bone Loss Because It Induces Serum Amyloid A.

  2018cites this paper
• The Effects of High-Dose Parathyroid Hormone Treatment on Fusion Outcomes in a Rabbit Model of Posterolateral Lumbar Spinal Fusion Alone and in Combination with Bone Morphogenetic Protein 2 Treatment.

  2018cites this paper
• Transcription factors—Intricate players of the bone morphogenetic protein signaling pathway

  2018cites this paper
• BMP-7/Smad expression in dedifferentiated Schwann cells during axonal regeneration and upregulation of endogenous BMP-7 following administration of PTH (1-34)

  2018cites this paper
• Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis.

  2017cites this paper
• Osteoarthritis and Cartilage BMP signaling: A significant player and therapeutic target for osteoarthritis

  year unknowncites this paper