Age-related changes in the collagen network and toughness of bone.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Bone

• Publication date

  2002-07-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/S8756-3282(01)00697-4PMID 12110404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• When bone mass fails to predict bone failure

  2005cited by this paper
• Bone age, mineral density, and fatigue damage

  2005cited by this paper
• Influence of nonenzymatic glycation on biomechanical properties of cortical bone.

  2001cited by this paper
• Effect of Collagen Denaturation on the Toughness of Bone

  2000cited by this paper
• Posttranslational Modifications of Bone Collagen Type I are Related to the Function of Rat Femoral Regions

  2000cited by this paper
• Examination of bone chemical composition in osteoporosis using fluorescence-assisted synchrotron infrared microspectroscopy.

  2000cited by this paper
• Collagen and Bone Strength

  1999cited by this paper
• Age-Related Changes in the Biochemical Properties of Human Cancellous Bone Collagen: Relationship to Bone Strength

  1999cited by this paper
• The role of collagen in the declining mechanical properties of aging human cortical bone.

  1999cited by this paper
• Heterogeneity of the mechanical properties of demineralized bone.

  1999cited by this paper
• Comparative differences in the composition and biomechanical properties of tibiae of seven- and seventy-two-week-old male and female broiler breeder chickens.

  1999cited by this paper
• Osteoporosis in clinical practice--bone densitometry and fracture risk.

  1998cited by this paper
• Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage.

  1998cited by this paper
• Bone Elasticity and Ultrasound Velocity Are Affected by Subtle Changes in the Organic Matrix

  1998cited by this paper
• Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance.

  1998cited by this paper
• The effects of diabetes mellitus on the material properties of human metatarsal bones.

  1998cited by this paper
• Crack growth resistance in cortical bone: concept of microcrack toughening.

  1997cited by this paper
• A simplified measurement of degraded collagen in tissues: application in healthy, fibrillated and osteoarthritic cartilage.

  1997cited by this paper
• Rotated plywood structure of primary lamellar bone in the rat: orientations of the collagen fibril arrays.

  1997cited by this paper
• Sensitive fluorimetric quantitation of pyridinium and pentosidine crosslinks in biological samples in a single high-performance liquid chromatographic run.

  1997cited by this paper
• Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles.

  1997cited by this paper
• Effects of ionizing radiation on the mechanical properties of human bone

  1997cited by this paper
• Collagen fiber organization is related to mechanical properties and remodeling in equine bone. A comparison of two methods.

  1996cited by this paper
• Low bone mineral content is common but osteoporotic fractures are rare in elderly rural Gambian women

  1996cited by this paper
• Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone

  1996cited by this paper
• Direct measurement of crosslinks, pyridinoline, deoxypyridinoline, and pentosidine, in the hydrolysate of tissues using high-performance liquid chromatography.

  1995cited by this paper
• Biochemical changes in the collagenous matrix of osteoporotic avian bone.

  1995cited by this paper
• Prediction of thoracic and lumbar vertebral body compressive strength: correlations with bone mineral density and vertebral region.

  1995cited by this paper
• Contribution of collagen and mineral to the elastic anisotropy of bone

  1994cited by this paper
• Thermal stability of cortical bone collagen in relation to age in normal individuals and in individuals with osteopetrosis.

  1994cited by this paper
• TYPE OF FALL AND RISK OF HIP AND WRIST FRACTURES: THE STUDY OF OSTEOPOROTIC FRACTURES

  1993cited by this paper
• Biochemical changes in the collagen of human osteoporotic bone matrix.

  1993cited by this paper
• The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties.

  1993cited by this paper
• Type of Fall and Risk of Hip and Wrist Fractures: The Study of Osteoporotic Fractures

  1993cited by this paper
• Effects of severe diabetes and insulin on the femoral neck of the immature rat

  1993cited by this paper
• Maillard Reaction-Mediated Molecular Damage to Extracellular Matrix and Other Tissue Proteins in Diabetes, Aging, and Uremia

  1992cited by this paper
• Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia.

  1991cited by this paper
• Age and bone mass as predictors of fracture in a prospective study.

  1988cited by this paper
• Stiffness of compact bone: effects of porosity and density.

  1988cited by this paper
• Bone mineral content and mechanical strength. An ex vivo study on human femora at autopsy.

  1988cited by this paper
• "Glycated" osteocalcin in human and bovine bone. The effect of age.

  1986cited by this paper
• Mechanical properties of collagen from decalcified rat femur in relation to age andin vitro maturation

  1986cited by this paper
• Relations between age, mineral density and mechanical properties of human femoral compacta.

  1976cited by this paper
• Contribution of collagen and mineral to the elastic-plastic properties of bone.

  1975cited by this paper
• Hard tissue as a composite material. I. Bounds on the elastic behavior.

  1971cited by this paper

• Differences in predominant collagen fiber orientation between dorsal and plantar trabecular bone tracts of adult mule deer calcanei suggest strain-mode-specific adaptation.

  2026cites this paper
• Pentosidine as a biomarker for bone fragility: Molecular mechanisms, clinical relevance, and detection strategies.

  2026cites this paper
• Fluorescent collagen hybridizing peptide for quantifying collagen denaturation in cortical bone

  2025cites this paper
• Risk of bony endplate failure during vertebral fracture.

  2025cites this paper
• Therapeutic potential of fish collagen hydrolysates in osteoporosis prevention: a narrative review based on cellular, molecular, and clinical evidence.

  2025cites this paper
• Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness

  2025cites this paper
• Reconstruction of a complex bullet path in gunshot wound: a multidisciplinary approach

  2025cites this paper
• Pathophysiology of Bone Fragility in Type 2 Diabetes Mellitus

  2025cites this paper
• The role of collagen in mechanotransduction and its influence on bone metabolic activity.

  2025cites this paper
• Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity

  2025cites this paper
• Advanced glycation end-product adducts alter the bone collagen network and human cortical bone fracture resistance

  2025cites this paper
• Post-yield Behavior and Failure Mechanisms of Murine Cortical Bone at the Microscale across Different Ages Depend on Alterations in Mineralized Collagen Fibrils' Arrangement.

  2025cites this paper
• Ultrashort echo time quantitative magnetization transfer MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones

  2025cites this paper
• Specific collagen peptides in osteoporosis management: Unraveling therapeutic potential through expert perspectives and scientific insights

  2024cites this paper
• Bone collagen tensile properties of the aging human proximal femur

  2024influential citation
• Quantifying the Relation Between Aging-related Trabecular Bone Microstructure and Mechanical Properties with Digital Volume Correlation Approach

  2024cites this paper
• Roles of collagen cross-links and osteon collagen/lamellar morphotypes in equine third metacarpals in tension and compression tests

  2024cites this paper
• Assessment of bovine cortical bone fracture behavior using impact microindentation as a surrogate of fracture toughness

  2024cites this paper
• Total body irradiation is associated with long-term deficits in femoral bone structure but not mechanical properties in male rhesus macaques

  2024cites this paper
• In vivo glycation-interplay between oxidant and carbonyl stress in bone.

  2024cites this paper
• Multiscale and multidisciplinary analysis of aging processes in bone

  2024influential citation
• Mechanistic implications of diabetes leading to bone pathology

  2024cites this paper
• Shining light on the Mary Rose: Identifying chemical differences in human aging and handedness in the clavicles of sailors using Raman spectroscopy

  2024cites this paper
• Synthesis Studies and the Evaluation of C6 Raloxifene Derivatives.

  2024cites this paper
• In Vivo Assessment of Bone Quality Without X-rays

  2024cites this paper
• Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.

  2024cites this paper
• Osseodensification technique in crestal maxillary sinus elevation—A narrative review

  2024cites this paper
• An epidemiological qualitative/quantitative SWOT‐AHP analysis in order to highlight the positive or critical aspects of dental implants: A pilot study

  2024cites this paper
• In-silico simulation of nanoindentation on bone using a 2D cohesive finite element model.

  2024cites this paper
• [Translated article] Mechanical properties variations of immature bone in the earliest stages of development.

  2024cites this paper
• Bone Biomarkers Based on Magnetic Resonance Imaging

  2024cites this paper
• Variation in Juvenile Long Bone Properties as a Function of Age: Mechanical and Compositional Characterization

  2023cites this paper
• Effect of ribose incubation on physical, chemical, and mechanical properties of human cortical bone.

  2023cites this paper
• Role of advanced glycation endproducts in bone fragility in type 1 diabetes.

  2023cites this paper
• The alteration of advanced glycation end products and its potential role on bone loss under microgravity

  2023cites this paper
• When Cortical Bone Matrix Properties Are Indiscernible between Elderly Men with and without Type 2 Diabetes, Fracture Resistance Follows Suit

  2023cites this paper
• Micro-CT evaluation of frozen and embalmed human cadavers on the effect of root canal preparation on microcrack formation in old dentin

  2023cites this paper
• Development of an US, MRI, and CT imaging compatible realistic mouse phantom for thermal ablation and focused ultrasound evaluation.

  2023cites this paper
• Bone collagen quality in lumbar fusion patients: the association between volumetric bone mineral density and advanced glycation endproducts

  2023cites this paper
• Effects of aging and diabetes on the deformation mechanisms and molecular structural characteristics of collagen fibrils under daily activity.

  2023cites this paper
• Age-Related Factors Associated with Hip Fracture Risk.

  2023cites this paper
• Relation between mechanical and densimetric properties to fractal dimension in human rib cortical bone.

  2023cites this paper
• Evaluation of age variation changes in cervical vertebrae: 2-Dimensional (2D) geometric morphometrics approach

  2023cites this paper
• Advanced glycation and glycoxidation end products in bone.

  2023cites this paper
• Effect of in vitro ribosylation on the dynamic fracture behavior of mature bovine cortical bone.

  2023cites this paper
• Implant stability changes over time following implant placement in elderly patients: a prospective study.

  2023cites this paper
• Assessment of bovine cortical bone fracture behavior using impact microindentation as a surrogate of fracture toughness

  2023cites this paper
• Age-Related Changes in Post-Translational Modifications of Proteins from Whole Male and Female Skeletal Elements

  2023cites this paper
• Osteosarcopenia in the Spine Beyond Bone Mineral Density

  2023cites this paper
• Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility

  2023cites this paper
• Multiscale theoretical model shows that aging-related mechanical degradation of cortical bone is driven by microstructural changes in addition to porosity.

  2023cites this paper
• In Vivo Assessment of Skin Surface Pattern: Exploring Its Potential as an Indicator of Bone Biomechanical Properties

  2023cites this paper
• Structural role of osteocalcin and its modification in bone fracture.

  2023cites this paper
• Assessment of glycosaminoglycan content in bone using Raman spectroscopy.

  2023cites this paper
• Aging-related mechanical degradation of cortical bone is driven by microstrucural changes in addition to porosity

  2023cites this paper
• Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products

  2023cites this paper
• Fracture Toughness: Bridging the Gap Between Hip Fracture and Fracture Risk Assessment

  2023cites this paper
• Evaluation of Implant Stability According to Implant Placement Site and Duration in Elderly Patients: A Prospective Multi-Center Cohort Study

  2023cites this paper
• Mechanical properties variations of immature bone in the earliest stages of development.

  2023cites this paper
• Can Synbone^® cylinders and deer femurs reproduce ballistic fracture patterns observed in human long bones?

  2023cites this paper
• Influence of aging on mechanical properties of the femoral neck using an inverse method

  2022cites this paper
• Assessing biocompatibility & mechanical testing of 3D-printed PEEK versus milled PEEK

  2022cites this paper
• Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen

  2022cites this paper
• Associated changes in stiffness of collagen scaffolds during osteoblast mineralisation and bone formation

  2022cites this paper
• Unraveling the effect of collagen damage on bone fracture using in situ synchrotron microtomography with deep learning

  2022cites this paper
• Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility.

  2022cites this paper
• Association of Urinary Pentosidine Levels With the Risk of Fractures in Patients With Severe Osteoporosis: The Japanese Osteoporosis Intervention Trial‐05 (JOINT‐05)

  2022cites this paper
• A critical evaluation of cortical bone fracture toughness testing methods.

  2022cites this paper
• Structural equation modelling of mercury intra-skeletal variability on archaeological human remains.

  2022cites this paper
• Mechanical behaviour of femur and humerus at the three-point bending and axial compression tests in the crab-eating fox (Cerdocyon thous, Linnaeus 1776)

  2022cites this paper
• Micro-computed tomography assessment of bone structure in aging mice

  2022cites this paper
• Prediction of Femoral Strength Based on Bone Density and Biochemical Markers in Elderly Men With Type 2 Diabetes Mellitus

  2022cites this paper
• Methods for bone quality assessment in human bone tissue: a systematic review

  2022cites this paper
• Domain knowledge-enhanced variable selection for biomedical data analysis

  2022cites this paper
• Effects of Chemical Sterilization and Gamma Irradiation on the Biochemical and Biomechanical Properties of Human Tendon Allografts In Vitro Study

  2022cites this paper
• Coronal dentin differs between young and mature adult humans: A systematic review.

  2022cites this paper
• Bone structural, biomechanical, and histomorphometric characteristics of the hindlimb skeleton in the marsh rice rat (Oryzomys palustris)

  2022cites this paper
• Effect of collagen damage induced by heat treatment on the mixed-mode fracture behavior of bovine cortical bone under elevated loading rates

  2022cites this paper
• A review on experimental and numerical investigations of cortical bone fracture

  2022cites this paper
• The importance of rate-dependent effects in modelling the micro-damage process zone in cortical bone fracture

  2022cites this paper
• Influence of Metastatic Bone Lesion Type and Tumor Origin on Human Vertebral Bone Architecture, Matrix Quality, and Mechanical Properties

  2022cites this paper
• Suboptimal Plasma Vitamin C Is Associated with Lower Bone Mineral Density in Young and Early Middle-Aged Men: A Retrospective Cross-Sectional Study

  2022cites this paper
• Impact of test environment on the fracture resistance of cortical bone.

  2022cites this paper
• A síndrome da imunodeficiência humana adquirida como fator na redução da espessura e aumento do colágeno nas trabéculas ósseas de adultos e idosos

  2021cites this paper
• Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases

  2021cites this paper
• Dose-dependent effects of pharmaceutical treatments on bone matrix properties in ovariectomized rats

  2021cites this paper
• DIABETES MELLITUS AND BONE HEALTH

  2021cites this paper
• Multiscale characterization of pathological bone tissue

  2021cites this paper
• Secondary Osteoporosis.

  2021cites this paper
• Removal of glycosaminoglycans affects the in situ mechanical behavior of extrafibrillar matrix in bone.

  2021cites this paper
• [Gly²]-GLP-2, But Not Glucagon or [D-Ala²]-GLP-1, Controls Collagen Crosslinking in Murine Osteoblast Cultures

  2021cites this paper
• Experimental evaluation of fracture properties of bovine hip cortical bone using elastic–plastic fracture mechanics

  2021cites this paper
• A cross-sectional study: an assessment of low muscle mass and osteoporosis in type 2 diabetes mellitus patients with a high glycated hemoglobin level

  2021cites this paper
• A comparison of rib cortical bone compressive and tensile material properties: Trends with age, sex, and loading rate.

  2021cites this paper
• Bone Structural, Biomechanical and Histomorphometric Characteristics of the Postcranial Skeleton of the Marsh Rice Rat (Oryzomys palustris)

  2021cites this paper
• Relations Between Bone Quantity, Microarchitecture, and Collagen Cross‐links on Mechanics Following In Vivo Irradiation in Mice

  2021cites this paper
• Bone mineral density and oxidative stress in adolescent girls with anorexia nervosa

  2021cites this paper
• MicroRNA-124-3p Plays a Crucial Role in Cleft Palate Induced by Retinoic Acid

  2021cites this paper
• Potential Role of Perilacunar Remodeling in the Progression of Osteoporosis and Implications on Age-Related Decline in Fracture Resistance of Bone

  2021cites this paper
• Effects of Osteoporosis on Bone Morphometry and Material Properties of Individual Human Trabeculae in the Femoral Head

  2021cites this paper