Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder

No abstract is available for this paper.

• Publication year

  2011

• Venue

  NeuroImage

• Publication date

  2011-06-01

• Fields of study

  Medicine, Computer Science, Psychology

• Identifiers
  DOI 10.1016/j.neuroimage.2011.02.064PMID 21356318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies.

  2025influential reference
• Overall brain connectivity maps show cortico‐subcortical abnormalities in schizophrenia

  2010cited by this paper
• Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder.

  2010cited by this paper
• Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: A randomized cross-over study

  2010cited by this paper
• Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder.

  2010influential reference
• Social phobia and depression: prevalence and comorbidity.

  2010cited by this paper
• Toward discovery science of human brain function

  2010cited by this paper
• Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression.

  2010cited by this paper
• Selective aberrant functional connectivity of resting state networks in social anxiety disorder

  2010cited by this paper
• Neural correlates of worry in generalized anxiety disorder and in normal controls: a functional MRI study

  2009cited by this paper
• Functional connectivity of the human amygdala using resting state fMRI

  2009cited by this paper
• Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia.

  2009cited by this paper
• Correlations and anticorrelations in resting-state functional connectivity MRI: A quantitative comparison of preprocessing strategies

  2009cited by this paper
• Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder.

  2009cited by this paper
• Altered corticostriatal functional connectivity in obsessive-compulsive disorder.

  2009cited by this paper
• The Structural Integrity of an Amygdala–Prefrontal Pathway Predicts Trait Anxiety

  2009cited by this paper
• Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder.

  2009influential reference
• Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder.

  2009cited by this paper
• Resting-state functional connectivity reflects structural connectivity in the default mode network.

  2009cited by this paper
• Defining functional areas in individual human brains using resting functional connectivity MRI

  2008influential reference
• Complementary circuits connecting the orbital and medial prefrontal networks with the temporal, insular, and opercular cortex in the macaque monkey

  2008cited by this paper
• Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study.

  2008cited by this paper
• Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder.

  2008influential reference
• Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety.

  2008influential reference
• Dissociated responses in the amygdala and orbitofrontal cortex to bottom-up and top-down components of emotional evaluation

  2008cited by this paper
• Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

  2008cited by this paper
• Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/hyperactivity disorder.

  2008cited by this paper
• Mapping the functional connectivity of anterior cingulate cortex

  2007cited by this paper
• Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac Database

  2007cited by this paper
• Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder.

  2007cited by this paper
• Diminished medial prefrontal cortex activity in blood-injection-injury phobia.

  2007influential reference
• Increased amygdala and insula activation during emotion processing in anxiety-prone subjects.

  2007influential reference
• A validated network of effective amygdala connectivity

  2007influential reference
• Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.

  2007cited by this paper
• Altered default mode network activity in patient with anxiety disorders: an fMRI study.

  2007cited by this paper
• Emotion induction after direct intracerebral stimulations of human amygdala.

  2007cited by this paper
• Reduced serotonin-1A receptor binding in social anxiety disorder.

  2007cited by this paper
• The Role of the Orbitofrontal Cortex in Anxiety Disorders

  2007influential reference
• Trauma modulates amygdala and medial prefrontal responses to consciously attended fear

  2006cited by this paper
• Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli.

  2006cited by this paper
• Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia.

  2006influential reference
• Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps

  2005cited by this paper
• Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study.

  2005influential reference
• A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder.

  2005cited by this paper
• The human brain is intrinsically organized into dynamic, anticorrelated functional networks.

  2005influential reference
• Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study.

  2005cited by this paper
• Fate of unattended fearful faces in the amygdala is determined by both attentional resources and cognitive modulation

  2005cited by this paper
• Extinction learning in humans: role of the amygdala and vmPFC.

  2004cited by this paper
• Neural correlates of speech anticipatory anxiety in generalized social phobia

  2004influential reference
• Optimized 3 T EPI of the amygdalae

  2004cited by this paper
• Lateralization of amygdala activation: a systematic review of functional neuroimaging studies.

  2004cited by this paper
• Reduced Serotonin Type 1A Receptor Binding in Panic Disorder

  2004cited by this paper
• Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI

  2004cited by this paper
• Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression

  2003cited by this paper
• Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices.

  2003influential reference
• Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging

  2003cited by this paper
• Stimulation of Medial Prefrontal Cortex Decreases the Responsiveness of Central Amygdala Output Neurons

  2003cited by this paper
• Cognitive neuroscience: Cognitive neuroscience of human social behaviour

  2003cited by this paper
• Persistence and brain circuitry

  2003cited by this paper
• The Amygdala, Social Behavior, and Danger Detection

  2003cited by this paper
• Neuroimaging Studies of Amygdala Function in Anxiety Disorders

  2003influential reference
• Cellular Mechanisms of Infralimbic and Prelimbic Prefrontal Cortical Inhibition and Dopaminergic Modulation of Basolateral Amygdala Neurons In Vivo

  2002cited by this paper
• Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

  2002influential reference
• Functional connectivity in the resting brain: A network analysis of the default mode hypothesis

  2002cited by this paper
• Increased amygdala activation to angry and contemptuous faces in generalized social phobia.

  2002influential reference
• Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey.

  2002cited by this paper
• The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes

  2002influential reference
• Letter to Neuroscience INCREASED SOCIAL FEAR AND DECREASED FEAR OF OBJECTS IN MONKEYS WITH NEONATAL AMYGDALA LESIONS

  2001cited by this paper
• Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study.

  2001influential reference
• Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety.

  2001influential reference
• Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions.

  2001cited by this paper
• Activation of the left amygdala to a cognitive representation of fear

  2001cited by this paper
• An fMRI investigation of emotional engagement in moral judgment.

  2001cited by this paper
• An fMRI Investigation of Emotional Engagement in Moral Judgment

  2001cited by this paper
• Cognitive and emotional influences in anterior cingulate cortex.

  2000cited by this paper
• The amygdala modulates prefrontal cortex activity relative to conditioned fear

  1999cited by this paper
• Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.

  1999cited by this paper
• The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias.

  1999cited by this paper
• Dissociable neural responses to facial expressions of sadness and anger.

  1999cited by this paper
• The human amygdala in social judgment

  1998cited by this paper
• The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division.

  1998cited by this paper
• Face processing impairments after encephalitis: amygdala damage and recognition of fear.

  1998cited by this paper
• Face processing impairments after amygdalotomy.

  1997cited by this paper
• Amygdala activity at encoding correlated with long-term, free recall of emotional information.

  1996cited by this paper
• A differential neural response in the human amygdala to fearful and happy facial expressions

  1996cited by this paper
• Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage.

  1996cited by this paper
• Functional connectivity in the motor cortex of resting human brain using echo‐planar mri

  1995cited by this paper
• Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.

  1995cited by this paper
• Contributions of anterior cingulate cortex to behaviour.

  1995cited by this paper
• Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage.

  1994cited by this paper
• Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage.

  1985cited by this paper
• Manual for the State-Trait Anxiety Inventory

  1970cited by this paper
• STAI manual for the State-trait anxiety inventory ("self-evaluation questionnaire")

  1970cited by this paper
• NeuroImage

  year unknowncited by this paper
• See Blockindiscussions, Blockinstats, Blockinand Blockinauthor Blockinprofiles Blockinfor Blockinthis Blockinpublication

  year unknowncited by this paper

• Resting-State Functional Connectivity Changes Associated With Post-Traumatic Stress and Anxiety Symptoms in North Korean Refugees

  2026cites this paper
• Anxiety symptoms interact with approach motivations in adolescent risk-taking.

  2026cites this paper
• State and trait serotonin variations interact to shape the intrinsic connectivity and gradient architecture of the brain - a combined TPH2 genetics and tryptophan depletion study in men.

  2026cites this paper
• Bridging Neuroscience and Psychiatry through Brain Complexity and Neural Circuit Dysfunctions in Anxiety, Depression, and Schizophrenia

  2025cites this paper
• Similarities and differences of regional brain activity between first-episode drug-naïve anxious and nonanxious MDD patients

  2025cites this paper
• Functional connectivity characteristics of epilepsy with anxiety: A resting-state functional near-infrared spectroscopy study

  2025cites this paper
• Cortical thickness alterations in Parkinson's disease related anxiety: A cross-sectional 7 T MRI study

  2025cites this paper
• Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions

  2025cites this paper
• Investigating the feasibility and safety of transcranial infraslow gray noise stimulation as a potential treatment for generalized anxiety disorder

  2025cites this paper
• EXPLORING BRAIN CHANGES IN SELF-REPORTED ANXIETY: CUTTING-EDGE EXPLORATORY DIFFUSION TENSOR IMAGING STUDY REVEALS DISTINCT ALTERATIONS IN WHITE MATTER TRACT STRUCTURE AMONG NON-CLINICAL INDIVIDUALS

  2025cites this paper
• Escitalopram normalizes decreased left inferior frontal gyrus activation in social anxiety disorder during self-referential processing.

  2025cites this paper
• Brain-Body Signatures of Trait Anxiety Uniquely Characterized by Functional Dynamics, Allostatic Load and Gene Expression

  2025cites this paper
• Research progress on the neural circuits mechanisms of anxiety

  2025cites this paper
• Alterations in cerebral resting state functional connectivity associated with social anxiety disorder and early life adversities

  2025cites this paper
• Neurodevelopmental Pathways from Temperamental Fear to Anxiety.

  2025cites this paper
• Resting state connectivity patterns associated with trait anxiety in adolescence

  2025cites this paper
• Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial

  2024cites this paper
• Altered Static and Dynamic Brain Functional Topological Organization in Patients with Dysthyroid Optic Neuropathy.

  2024cites this paper
• Associations Between Changes in Psychological Resilience and Resting-State Functional Connectivity Throughout Pediatric Concussion Recovery

  2024cites this paper
• Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)

  2024cites this paper
• Association between resting-state connectivity patterns in the defensive system network and treatment response in spider phobia—a replication approach

  2024cites this paper
• Medial amygdalar tau is associated with anxiety symptoms in preclinical Alzheimer’s disease

  2024cites this paper
• Amygdala fMRI—A Critical Appraisal of the Extant Literature

  2024cites this paper
• Research hotspots and trends of neuroimaging in social anxiety: a CiteSpace bibliometric analysis based on Web of Science and Scopus database

  2024cites this paper
• Functional connectivity across the human subcortical auditory system using an autoregressive matrix-Gaussian copula graphical model approach with partial correlations

  2024influential citation
• Functional connectivity of the amygdala in relation to high stress and low mindfulness.

  2024cites this paper
• Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress

  2024cites this paper
• Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli

  2024cites this paper
• Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer's disease.

  2024cites this paper
• Microstructural white matter alterations associated with social anxiety disorders: A systematic review.

  2024cites this paper
• Frequency dependent changes of regional homogeneity in children with growth hormone deficiency.

  2023cites this paper
• Cognitive reappraisal and corresponding neural basis mediate the association between childhood maltreatment and depression

  2023cites this paper
• Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.

  2023cites this paper
• A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.

  2023cites this paper
• Amygdala-based functional connectivity mediates the relationship between thought control ability and trait anxiety.

  2023cites this paper
• A Neural Predictive Model of Negative Emotions for COVID-19

  2023cites this paper
• Structural and functional brain changes after glucocorticoid therapy in thyroid-associated ophthalmopathy.

  2023cites this paper
• Serotonin transporter (5-HTT) gene network moderates the impact of prenatal maternal adversity on orbitofrontal cortical thickness in middle childhood

  2023cites this paper
• Long-term impact of early life stress on serotonin connectivity

  2023cites this paper
• Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic

  2023cites this paper
• Default mode intranetwork resting-state functional connectivity is correlated with increased symptom severity in common anxiety disorders: A systematic review and meta-analysis.

  2023cites this paper
• Resting-state fMRI functional connectivity and clinical correlates in Afro-descendants with schizophrenia and bipolar disorder.

  2023cites this paper
• Role of Parenting and Psychosocial Correlates Contributing to Social Anxiety in Asian Adolescents: A Systematic Review.

  2023cites this paper
• The brain activation of anxiety disorders with emotional stimuli—an fMRI ALE meta-analysis

  2022cites this paper
• A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing

  2022cites this paper
• Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers

  2022cites this paper
• Functional Connectivity Between Basal Forebrain and Superficial Amygdala Negatively Correlates with Social Fearfulness.

  2022cites this paper
• A brainnetome atlas-based methamphetamine dependence identification using neighborhood component analysis and machine learning on functional MRI data

  2022cites this paper
• Amygdala-cortical collaboration in reward learning and decision making

  2022cites this paper
• Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans

  2022cites this paper
• Amygdala connectivity and implications for social cognition and disorders.

  2022cites this paper
• Watching Nature Videos Promotes Physiological Restoration: Evidence From the Modulation of Alpha Waves in Electroencephalography

  2022cites this paper
• Heterogeneity in PFC-amygdala connectivity in middle childhood, and concurrent interrelations with inhibitory control and anxiety symptoms.

  2022cites this paper
• Predicting social anxiety in young adults with machine learning of resting-state brain functional radiomic features

  2022cites this paper
• Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth

  2022influential citation
• Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder

  2022cites this paper
• Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder

  2022cites this paper
• Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial

  2022cites this paper
• Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children

  2022cites this paper
• Accelerated low-intensity rTMS does not rescue anxiety behaviour or abnormal connectivity in young adult rats following chronic restraint stress

  2022cites this paper
• A Two-Person Neuroscience Approach for Social Anxiety: A Paradigm With Interbrain Synchrony and Neurofeedback

  2022influential citation
• Topography of the Anxious Self: Abnormal Rest-Task Modulation in Social Anxiety Disorder

  2021cites this paper
• Multi-dynamic modelling reveals strongly time-varying resting fMRI correlations

  2021cites this paper
• Structural and resting state functional connectivity beyond the cortex

  2021cites this paper
• Intrinsic Network Brain Dysfunction Correlates With Temporal Complexity in Generalized Anxiety Disorder and Panic Disorder

  2021cites this paper
• Within amygdala: Basolateral parts are selectively impaired in premature-born adults

  2021cites this paper
• Joint learning of multiple Granger causal networks via non-convex regularizations: Inference of group-level brain connectivity

  2021cites this paper
• Intensified stimulation targeting lateral and medial prefrontal cortices for the treatment of social anxiety disorder: A randomized, double-blind, parallel-group, dose-comparison study

  2021cites this paper
• Resting-state neuroimaging in social anxiety disorder: a systematic review

  2021cites this paper
• The Medial Orbitofrontal Cortex–Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice

  2021cites this paper
• Neural Responsivity to Reward versus Punishment Shortly after Trauma Predicts Long-term Development of Post-Traumatic Stress Symptoms.

  2021cites this paper
• Intensified electrical stimulation targeting lateral and medial prefrontal cortices for the treatment of social anxiety disorder: A randomized, double-blind, parallel-group, dose-comparison study.

  2021cites this paper
• Joint estimation of multiple Granger causal networks: Inference of group-level brain connectivity

  2021cites this paper
• Out-of-step: brain-heart desynchronization in anxiety disorders

  2021cites this paper
• Decreased amygdala volume in adults after premature birth

  2021cites this paper
• Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

  2021cites this paper
• Differential Roles of Positive and Negative Valence Systems in the Development of Post-Traumatic Stress Psychopathology

  2021cites this paper
• Brain circuitry underlying the ABC model of anxiety.

  2021cites this paper
• To Speak or Not to Speak in Public: A Non-Randomized Controlled Trial Regarding the Effects of a Public Speaking Program

  2021cites this paper
• Altered Static and Dynamic Interhemispheric Resting-State Functional Connectivity in Patients With Thyroid-Associated Ophthalmopathy

  2021cites this paper
• A dynamic relation between whole-brain white matter microstructural integrity and anxiety symptoms in preadolescent females with pathological anxiety

  2021cites this paper
• Anxiety

  2021cites this paper
• Dynamic Causal Modeling of the Prefrontal/Amygdala Network During Processing of Emotional Faces

  2021cites this paper
• Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy

  2021cites this paper
• The Brain Activation of Anxiety Disorders During Emotional Stimulations: A Coordinate-Based Activation Likelihood Estimation Meta-Analysis

  2021cites this paper
• Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety: A Double-Blind, Placebo-Controlled Trial.

  2021cites this paper
• Altered gray matter volume and structural co-variance in adolescents with social anxiety disorder: evidence for a delayed and unsynchronized development of the fronto-limbic system

  2020cites this paper
• Amygdala activity related to perceived social support

  2020cites this paper
• Functional Characterization of Atrophy Patterns Related to Cognitive Impairment

  2020cites this paper
• Alterations in Amygdala Connectivity in Internet Addiction Disorder

  2020cites this paper
• Neural Correlates of Positive and Negative Valence System Dysfunction in Adolescents Revealed by Data-Driven Parcellation and Resting-State Network Modeling

  2020cites this paper
• Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

  2020cites this paper
• Applying a neural circuit taxonomy in depression and anxiety for personalized psychiatry

  2020cites this paper
• Relationship Between Interpersonal Depressive Symptoms and Reduced Amygdala Volume in People with Multiple Sclerosis: Considerations for Clinical Practice.

  2020cites this paper
• The Laplacian eigenmaps dimensionality reduction of fMRI data for discovering stimulus-induced changes in the resting-state brain activity

  2020cites this paper
• Connectivity Correlates of Anxiety Symptoms in Drug‐Naive Parkinson's Disease Patients

  2020cites this paper
• Intrinsic organization of cortical networks predicts state anxiety: an functional near-infrared spectroscopy (fNIRS) study

  2020cites this paper
• Investigating microstructure of white matter tracts as candidate endophenotypes of Social Anxiety Disorder – Findings from the Leiden Family Lab study on Social Anxiety Disorder (LFLSAD)

  2020cites this paper
• Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status

  2020cites this paper
• Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

  2020cites this paper