Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

With the current access to the whole genomes of various organisms and the completion of the first draft of the human genome, there is a strong need for a structure-function classification of protein families as an initial step in moving from DNA databases to a comprehensive understanding of human biology. As a result of the explosion in nucleic acid sequence information and the concurrent development of methods for high-throughput functional characterization of gene products, the genomic revolution also promises to provide a new paradigm for drug discovery, enabling the identification of molecular drug targets in a significant number of human diseases. This molecular view of diseases has contributed to the importance of combining primary sequence data with three-dimensional structure and has increased the awareness of computational homology modeling and its potential to elucidate protein function. In particular, when important proteins or novel therapeutic targets are identified—like the family of protein tyrosine phosphatases (PTPs) (reviewed in reference 53)—a structure-function classification of such protein families becomes an invaluable framework for further advances in biomedical science. Here, we present a comparative analysis of the structural relationships among vertebrate PTP domains and provide a comprehensive resource for sequence analysis of phosphotyrosine-specific PTPs.

• Publication year

  2001

• Venue

  Molecular and Cellular Biology

• Publication date

  2001-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.21.21.7117-7136.2001PMID 11585896PMCID PMC99888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein-tyrosine phosphatase.

  2008cited by this paper
• Protein Kinases and Phosphatases: The Yin and Yang of Protein Phosphorylation and Signaling Review

  2004cited by this paper
• Combinatorial control of the specificity of protein tyrosine phosphatases.

  2001cited by this paper
• The InterPro database, an integrated documentation resource for protein families, domains and functional sites

  2001cited by this paper
• Comparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signalling.

  2001cited by this paper
• Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.

  2000cited by this paper
• Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.

  2000cited by this paper
• Protein Modules and Signaling Networks

  2000cited by this paper
• Molecular dynamics simulations of protein-tyrosine phosphatase 1B. II. substrate-enzyme interactions and dynamics.

  2000cited by this paper
• Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B*

  2000cited by this paper
• Residue 259 Is a Key Determinant of Substrate Specificity of Protein-tyrosine Phosphatases 1B and α*

  2000cited by this paper
• Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases.

  2000cited by this paper
• Identification of Tyrosine Phosphatases That Dephosphorylate the Insulin Receptor

  2000cited by this paper
• Protein tyrosine phosphatases (PTPs) as drug targets: inhibitors of PTP-1B for the treatment of diabetes.

  2000cited by this paper
• RTK mutations and human syndromeswhen good receptors turn bad.

  2000cited by this paper
• Signaling—2000 and Beyond

  2000cited by this paper
• The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

  2000cited by this paper
• HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3.

  2000cited by this paper
• Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

  2000cited by this paper
• Effects on general acid catalysis from mutations of the invariant tryptophan and arginine residues in the protein tyrosine phosphatase from Yersinia.

  2000cited by this paper
• The T-cell protein tyrosine phosphatase.

  2000cited by this paper
• Protein tyrosine kinase structure and function.

  2000cited by this paper
• RTK mutations and human syndromes: when good receptors turn bad

  2000cited by this paper
• Structural Basis for Substrate Specificity of Protein-tyrosine Phosphatase SHP-1*

  2000influential reference
• Thermodynamic Study of Ligand Binding to Protein-tyrosine Phosphatase 1B and Its Substrate-trapping Mutants*

  2000cited by this paper
• The protein tyrosine kinase family of the human genome

  2000cited by this paper
• Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

  2000cited by this paper
• Diversity in protein recognition by PTB domains.

  1999cited by this paper
• Roles of protein tyrosine phosphatases in cell migration and adhesion.

  1999cited by this paper
• Catalytic activation of the membrane distal domain of protein tyrosine phosphatase epsilon, but not CD45, by two point mutations.

  1999cited by this paper
• The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling.

  1999cited by this paper
• Crystal structure of the tandem phosphatase domains of RPTP LAR.

  1999influential reference
• Restoration of potent protein-tyrosine phosphatase activity into the membrane-distal domain of receptor protein-tyrosine phosphatase alpha.

  1999cited by this paper
• Cell signaling by protein tyrosine phosphorylation.

  1999cited by this paper
• Molecular dynamics simulations of protein-tyrosine phosphatase 1B. I. ligand-induced changes in the protein motions.

  1999cited by this paper
• [Difluro(phosphono)methyl]phenylalanine-containing peptide inhibitors of protein tyrosine phosphatases.

  1999cited by this paper
• Multiple Protein Tyrosine Phosphatases in Sponges and Explosive Gene Duplication in the Early Evolution of Animals Before the Parazoan–Eumetazoan Split

  1999cited by this paper
• Polymer principles and protein folding

  1999cited by this paper
• Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.

  1999cited by this paper
• Catalytic activation of the membrane distal domain of protein tyrosine phosphatase ϵ, but not CD45, by two point mutations

  1999cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in protein-tyrosine phosphatases.

  1998cited by this paper
• Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction

  1998cited by this paper
• Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction

  1998cited by this paper
• Crystal structure of the tyrosine phosphatase SHP-2.

  1998influential reference
• Molecular Basis for Substrate Specificity of Protein-tyrosine Phosphatase 1B*

  1998cited by this paper
• Protein tyrosine phosphatases: counting the trees in the forest.

  1998cited by this paper
• Interconversion of the Kinetic Identities of the Tandem Catalytic Domains of Receptor-like Protein-tyrosine Phosphatase PTPα by Two Point Mutations Is Synergistic and Substrate-dependent*

  1998cited by this paper
• Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation.

  1998cited by this paper
• The structure and mechanism of protein phosphatases: insights into catalysis and regulation.

  1998cited by this paper
• The Second Domain of the CD45 Protein Tyrosine Phosphatase Is Critical for Interleukin-2 Secretion and Substrate Recruitment of TCR-ζ in Vivo*

  1998cited by this paper
• The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease.

  1998cited by this paper
• Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography*

  1998cited by this paper
• Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge.

  1998influential reference
• Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis.

  1998cited by this paper
• pi-Stacking interactions. Alive and well in proteins.

  1998cited by this paper
• Crystal Structure of the Catalytic Domain of Protein-tyrosine Phosphatase SHP-1*

  1998influential reference
• Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.

  1997influential reference
• Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein-tyrosine Phosphatase α*

  1997influential reference
• Foci of amino acid residue conservation in the 3D structures of the Kunitz BPTI proteinase inhibitors: how do variants from snake venom differ?

  1997cited by this paper
• Studies of protein‐protein interfaces: A statistical analysis of the hydrophobic effect

  1997cited by this paper
• Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.

  1997cited by this paper
• Both SH2 Domains Are Involved in Interaction of SHP-1 with the Epidermal Growth Factor Receptor but Cannot Confer Receptor-directed Activity to SHP-1/SHP-2 Chimera*

  1997cited by this paper
• The Crystal Structure of Domain 1 of Receptor Protein-tyrosine Phosphatase μ*

  1997cited by this paper
• Structural, catalytic, and functional properties of low M(r), phosphotyrosine protein phosphatases. Evidence of a long evolutionary history.

  1997cited by this paper
• Molecular Cloning and Characterization of a Novel Cytoplasmic Protein-tyrosine Phosphatase That Is Specifically Expressed in Spermatocytes*

  1997cited by this paper
• Protein tyrosine phosphatases in signal transduction.

  1997cited by this paper
• Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate*

  1997cited by this paper
• Principles of protein-protein interactions.

  1996cited by this paper
• Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST

  1996cited by this paper
• Control of adhesion-dependent cell survival by focal adhesion kinase

  1996cited by this paper
• Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

  1996cited by this paper
• Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity.

  1996cited by this paper
• Reactivity of alcohols toward the phosphoenzyme intermediate in the protein-tyrosine phosphatase-catalyzed reaction: probing the transition state of the dephosphorylation step.

  1996cited by this paper
• Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases: Isolation and structural analysis

  1996cited by this paper
• Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B.

  1995influential reference
• Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon.

  1995cited by this paper
• Protein-protein interactions: a review of protein dimer structures.

  1995cited by this paper
• Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.

  1995cited by this paper
• Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif.

  1995cited by this paper
• Protein tyrosine phosphatases as adhesion receptors.

  1995cited by this paper
• Protein modules and signalling networks

  1995cited by this paper
• A Heteromorphic Protein-tyrosine Phosphatase, PTPφ, Is Regulated by CSF-1 in Macrophages (*)

  1995cited by this paper
• A ligand‐induced conformational change in the yersinia protein tyrosine phosphatase

  1995cited by this paper
• Dissecting the catalytic mechanism of protein-tyrosine phosphatases.

  1994cited by this paper
• 'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'.

  1994cited by this paper
• Crystal structure of human protein tyrosine phosphatase 1B.

  1994influential reference
• The Cys(X)5Arg catalytic motif in phosphoester hydrolysis.

  1994cited by this paper
• Identification of important functional environs in protein tertiary structures from the analysis of residue variation in 3-D: application to cytochromes c and carboxypeptidases A and B.

  1994cited by this paper
• Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

  1994cited by this paper
• A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.

  1994cited by this paper
• Purification and characterization of the cytoplasmic domain of human receptor-like protein tyrosine phosphatase RPTP mu.

  1993cited by this paper
• A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides.

  1993cited by this paper
• Mutational analysis of CD45. A leukocyte-specific protein tyrosine phosphatase.

  1992cited by this paper
• Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism.

  1992cited by this paper
• Isolation and characterization of temperature-sensitive and thermostable mutants of the human receptor-like protein tyrosine phosphatase LAR.

  1991cited by this paper
• Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

  1991cited by this paper
• Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.

  1991cited by this paper
• Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase.

  1991cited by this paper
• Basic local alignment search tool.

  1990cited by this paper

• Exploring the effect of active site loops dynamics on PTP1B/SHP2 activity through selective benzamide-based inhibitors.

  2026cites this paper
• Protein tyrosine phosphatase 1B in solid tumors: Unraveling its clinical significance.

  2026cites this paper
• Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

  2026cites this paper
• Orchestrating function: Concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases.

  2025cites this paper
• Whole-genome sequencing, as a powerful diagnostic tool in hearing loss, reveals novel variants in PTPRQ missed by whole-exome sequencing

  2025cites this paper
• Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases

  2025cites this paper
• Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors

  2025cites this paper
• Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases

  2025cites this paper
• Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

  2025cites this paper
• Insights into PTP1B inhibitors as antidiabetic agents: Current research and future perspectives.

  2025cites this paper
• Machine learning-based QSAR and molecular modeling identify promising PTP1B modulators from Ocimum gratissimum for type 2 diabetes therapy.

  2025cites this paper
• Immune targets for schistosomiasis control identified by a genome-wide association study of African snail vectors

  2025cites this paper
• Theoretical study on the design of allosteric inhibitors of diabetes associated protein PTP1B

  2024cites this paper
• Single Ion Pair Is Essential for Stabilizing SHP2's Open Conformation.

  2024cites this paper
• The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets

  2024cites this paper
• Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B.

  2024cites this paper
• Analysis of Receptor-Type Protein Tyrosine Phosphatase Extracellular Regions with Insights from AlphaFold

  2024cites this paper
• Natural Product Cell Division Cycle 25 (CDC25) Inhibitors: A Promising Source for Cancer Drug Discovery

  2024cites this paper
• Site-Specifically Modified Peptide Inhibitors of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase with Enhanced Stability and Improved In Vivo Long-Acting Activity.

  2024cites this paper
• The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis.

  2024cites this paper
• 核酸免疫识别的机制和功能及酪氨酸磷酸化修饰调控

  2024cites this paper
• Allostery in Protein Tyrosine Phosphatases is Enabled by Divergent Dynamics

  2024cites this paper
• Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation

  2024cites this paper
• Targeting Nonconserved and Pathogenic Cysteines of Protein Tyrosine Phosphatases with Small Molecules.

  2024cites this paper
• Immune targets for schistosomiasis control identified by a genome-wide association study of East African snail vectors

  2024cites this paper
• Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.

  2024cites this paper
• Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

  2024influential citation
• Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species.

  2024cites this paper
• Mining oomycete proteomes for phosphatome leads to the identification of specific expanded phosphatases in oomycetes

  2024cites this paper
• Previously Published Phosphatase Probes have Limited Utility Due to their Unspecific Reactivity

  2024cites this paper
• Three STEPs forward: A trio of unexpected structures of PTPN5

  2024cites this paper
• Allostery in Protein Tyrosine Phosphatases is Enabled by Divergent Dynamics

  2023cites this paper
• Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics

  2023cites this paper
• New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.

  2023cites this paper
• PROTHON: A Local Order Parameter-Based Method for Efficient Comparison of Protein Ensembles

  2023cites this paper
• Atomistic ensemble of active SHP2 phosphatase

  2023cites this paper
• Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer

  2023cites this paper
• A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

  2023cites this paper
• Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.

  2023cites this paper
• Condensation of the β‐cell secretory granule luminal cargoes pro/insulin and ICA512 RESP18 homology domain

  2023cites this paper
• Study on the allosteric activation mechanism of SHP2 via elastic network models and neural relational inference molecular dynamics simulation.

  2023cites this paper
• Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow

  2023cites this paper
• Unraveling the Secrets of a Double-Life Fungus by Genomics: Ophiocordyceps australis CCMB661 Displays Molecular Machinery for Both Parasitic and Endophytic Lifestyles

  2023cites this paper
• Identification of PP1c-PPP1R12A Substrates Using Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates

  2023cites this paper
• Setting sail: Maneuvering SHP2 activity and its effects in cancer.

  2023cites this paper
• Native dynamics and allosteric responses in PTP1B probed by high‐resolution HDX‐MS

  2023cites this paper
• Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.

  2023cites this paper
• Integrated use of ligand and structure-based virtual screening, molecular dynamics, free energy calculation and ADME prediction for the identification of potential PTP1B inhibitors

  2023cites this paper
• Coupling substrate-trapping with proximity-labeling to identify protein tyrosine phosphatase PTP1B signaling networks

  2023cites this paper
• A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

  2023cites this paper
• Discovery of a selective TC-PTP degrader for cancer immunotherapy

  2023cites this paper
• Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century

  2022cites this paper
• The progress of research into pseudophosphatases

  2022cites this paper
• Conserved conformational dynamics determine enzyme activity

  2022cites this paper
• The role and therapeutic implication of protein tyrosine phosphatases in Alzheimer's disease.

  2022cites this paper
• Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives

  2022influential citation
• Complex protein interactions mediate Drosophila Lar function in muscle tissue

  2022cites this paper
• Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease

  2022cites this paper
• Evolutionary genomic relationships and coupling in MK-STYX and STYX pseudophosphatases

  2022cites this paper
• Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization

  2022cites this paper
• Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine

  2022cites this paper
• Exploring protein tyrosine phosphatases (PTP) and PTP-1B inhibitors in management of diabetes mellitus.

  2022cites this paper
• Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity

  2022cites this paper
• A Polydnavirus Protein Tyrosine Phosphatase Negatively Regulates the Host Phenoloxidase Pathway

  2022cites this paper
• Clinical and Translational Advances in Glioma Immunotherapy

  2022cites this paper
• The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy

  2022cites this paper
• Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy

  2022cites this paper
• Pseudophosphatases as Regulators of MAPK Signaling

  2021cites this paper
• Phosphorus-containing compounds regulate mineralization

  2021cites this paper
• Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity.

  2021cites this paper
• Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery

  2021cites this paper
• A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis

  2021cites this paper
• Alternative Splicing of MoPTEN Is Important for Growth and Pathogenesis in Magnaporthe oryzae

  2021cites this paper
• Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?

  2021cites this paper
• Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.

  2021cites this paper
• Automatic Bayesian Weighting for SAXS Data

  2021cites this paper
• T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

  2021cites this paper
• Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play

  2021cites this paper
• Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

  2021cites this paper
• Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities

  2021cites this paper
• Protein tyrosine phosphatases in cell adhesion

  2021cites this paper
• Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate

  2021cites this paper
• Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway

  2021cites this paper
• Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion

  2021cites this paper
• Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

  2020cites this paper
• Targeting a Pathogenic Cysteine Mutation: Discovery of a Specific Inhibitor of Y279C SHP2

  2020cites this paper
• Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment

  2020cites this paper
• Antidiabetic activity in vitro and in vivo of BDB, protein tyrosine phosphatase 1B selective inhibitor from Rhodonela conferviodes.

  2020cites this paper
• Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space.

  2020cites this paper
• l‐Lactate Dehydrogenase Identified as a Protein Tyrosine Phosphatase 1B Substrate by Using K‐BIPS

  2020cites this paper
• Cooperative dynamics across distinct structural elements regulate PTP1B activity

  2020cites this paper
• Redox toxicology of environmental chemicals causing oxidative stress

  2020cites this paper
• Recent advance on PTP1B inhibitors and their biomedical applications.

  2020cites this paper
• The dead phosphatases society: a review of the emerging roles of pseudophosphatases

  2020cites this paper
• Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases

  2020influential citation
• Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction

  2020cites this paper
• Biological function of protein tyrosine phosphatase H-type receptor and its progress in tumor.

  2020cites this paper
• Inhibitor binding sites in the protein tyrosine phosphatase SHP-2.

  2020cites this paper
• Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis

  2020cites this paper
• Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2

  2020cites this paper