A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma‐like gene expression trait and epithelial‐mesenchymal transition

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Hepatology

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.25570PMID 22234953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver Cancer Stem Cells

  2011cited by this paper
• Histopathological classification of hepatocellular carcinoma.

  2010cited by this paper
• Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum

  2010cited by this paper
• Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor‐β

  2010cited by this paper
• Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells

  2010cited by this paper
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

  2010cited by this paper
• Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma.

  2010influential reference
• Scirrhous hepatocellular carcinoma: comparison with usual hepatocellular carcinoma based on CT-pathologic features and long-term results after curative resection.

  2009cited by this paper
• EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.

  2009cited by this paper
• Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

  2009cited by this paper
• Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma

  2009influential reference
• Specific characteristics of scirrhous hepatocellular carcinoma.

  2009cited by this paper
• Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.

  2009cited by this paper
• Liver stem cells and hepatocellular carcinoma

  2009cited by this paper
• Liver cancer stem cells.

  2008cited by this paper
• Participation of liver cancer stem/progenitor cells in tumorigenesis of scirrhous hepatocellular carcinoma--human and cell culture study.

  2008cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• TGFbeta in Cancer.

  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006influential reference
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  2006cited by this paper
• Clinicopathological study of scirrhous hepatocellular carcinoma

  2006influential reference
• Cellular and stromal characteristics in the scirrhous hepatocellular carcinoma: Comparison with hepatocellular carcinomas and intrahepatic cholangiocarcinomas

  2005influential reference
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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2003cited by this paper
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  2003influential reference
• Combined Hepatocellular-Cholangiocarcinoma

  1999influential reference
• Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications.

  1996cited by this paper
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  1949influential reference

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