The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecules and Cells

• Publication date

  2010-11-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2010.10.024PMID 21055983PMCID PMC3031522
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair

  2010cited by this paper
• Cul8/Rtt101 Forms a Variety of Protein Complexes That Regulate DNA Damage Response and Transcriptional Silencing*

  2010cited by this paper
• Homologous recombination in cancer development, treatment and development of drug resistance.

  2010cited by this paper
• The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

  2009cited by this paper
• HARPing on about the DNA damage response during replication.

  2009cited by this paper
• Introduction to molecular combing: genomics, DNA replication, and cancer.

  2009cited by this paper
• Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.

  2009cited by this paper
• A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

  2009cited by this paper
• The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

  2009cited by this paper
• Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage.

  2008cited by this paper
• Mechanisms of Dealing with DNA Damage-Induced Replication Problems

  2008influential reference
• A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

  2008influential reference
• Rtt101 and Mms1 in budding yeast form a CUL4DDB1‐like ubiquitin ligase that promotes replication through damaged DNA

  2008cited by this paper
• ATR: an essential regulator of genome integrity

  2008cited by this paper
• Recombination proteins and rescue of arrested replication forks.

  2007cited by this paper
• Large-scale mapping of human protein–protein interactions by mass spectrometry

  2007cited by this paper
• Human CtIP promotes DNA end resection

  2007cited by this paper
• Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

  2007cited by this paper
• Replication fork barriers: pausing for a break or stalling for time?

  2007cited by this paper
• The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses

  2007cited by this paper
• Regulation of Replication Fork Progression Through Histone Supply and Demand

  2007cited by this paper
• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

  2007cited by this paper
• The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.

  2007cited by this paper
• The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

  2007cited by this paper
• Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks.

  2007cited by this paper
• The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

  2007cited by this paper
• Mms22 Preserves Genomic Integrity During DNA Replication in Schizosaccharomyces pombe

  2007cited by this paper
• Topoisomerase I inhibitors: camptothecins and beyond

  2006cited by this paper
• Gaps and forks in DNA replication: Rediscovering old models.

  2006cited by this paper
• Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

  2006cited by this paper
• DNA double-strand break repair: all's well that ends well.

  2006cited by this paper
• TONSOKU is expressed in S phase of the cell cycle and its defect delays cell cycle progression in Arabidopsis.

  2005cited by this paper
• Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

  2005influential reference
• Requirement for RecFOR‐mediated recombination in priA mutant

  2004cited by this paper
• BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.

  2004cited by this paper
• MGOUN3, an Arabidopsis gene with TetratricoPeptide-Repeat-related motifs, regulates meristem cellular organization.

  2004cited by this paper
• A novel Arabidopsis gene TONSOKU is required for proper cell arrangement in root and shoot apical meristems.

  2004cited by this paper
• RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair.

  2003cited by this paper
• DNA Damage-Induced Replication Fork Regression and Processing in Escherichia coli

  2003cited by this paper
• Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage

  2002cited by this paper
• Increased error-prone non homologous DNA end-joining – a proposed mechanism of chromosomal instability in Bloom's syndrome

  2002influential reference
• The DNA replication checkpoint response stabilizes stalled replication forks

  2001cited by this paper
• Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

  2001cited by this paper
• Genes required for ionizing radiation resistance in yeast

  2001cited by this paper
• Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.

  2001influential reference
• BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

  1999cited by this paper
• Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.

  1999cited by this paper
• Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

  1998cited by this paper
• Sister-chromatid exchanges (SCE) induction by inhibitors of DNA topoisomerases in cultured human lymphocytes.

  1996cited by this paper
• Cloning of a Differentially Expressed IB-related Protein (*)

  1995influential reference
• Cloning of a differentially expressed I kappa B-related protein.

  1995influential reference
• A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.

  1974influential reference

• Single-cell RNA and ATAC sequencing reveals cell subsets characteristics in adipose-derived stem cells.

  2026cites this paper
• Treatment Response and Outcomes of Prostate Cancer Patients Carrying the Germline MMS22L F722fs Mutation.

  2026cites this paper
• Carboplatin-resistance-related DNA damage repair prognostic gene signature and its association with immune infiltration in breast cancer

  2025cites this paper
• Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability

  2025cites this paper
• Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

  2025cites this paper
• FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.

  2025cites this paper
• The TONSL-MMS22L complex and FANCM form an interdependent complex on chromatin to counter replication stress

  2025cites this paper
• Replication stress promotes cellular transformation in Drosophila epithelium

  2025cites this paper
• MulNet: a scalable framework for reconstructing intra- and intercellular signaling networks from bulk and single-cell RNA-seq data

  2025cites this paper
• H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability

  2025cites this paper
• A case report of SPONASTRIME dysplasia with novel TONSL mutation: genetic analysis, clinical manifestations, and the effect of growth hormone treatment

  2025cites this paper
• Maize ZmDLR2/BRU1 Is Required for Lateral Root Primordium Emergence by Participating in DNA Repair

  2025cites this paper
• MMS22L is a novel key actor of normal and pathological erythropoiesis

  2025cites this paper
• Transcriptome analysis of porcine oocytes during postovulatory aging.

  2024cites this paper
• Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish

  2024cites this paper
• CoREST Complex Stabilizes MYC Protein to Promote Cancer Cell Genome Stability

  2024cites this paper
• H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability

  2024cites this paper
• CRISPR/Cas9 Technology Providing the Therapeutic Landscape of Metastatic Prostate Cancer

  2024cites this paper
• Roles of Histone H2B, H3 and H4 Variants in Cancer Development and Prognosis

  2024cites this paper
• The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity.

  2024cites this paper
• Mechanisms and regulation of replication fork reversal.

  2024cites this paper
• Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys

  2024cites this paper
• Predictomes: A classifier-curated database of AlphaFold-modeled protein-protein interactions

  2024cites this paper
• TFIP11 promotes replication fork reversal to preserve genome stability

  2024cites this paper
• Modus operandi: Chromatin recognition by α-helical histone readers.

  2023cites this paper
• TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer.

  2023influential citation
• The Role of Histone Modification in DNA Replication-Coupled Nucleosome Assembly and Cancer

  2023cites this paper
• Mitotic inheritance of genetic and epigenetic information via the histone H3.1 variant.

  2023cites this paper
• Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells

  2023cites this paper
• Exploiting the DNA Damage Response for Prostate Cancer Therapy

  2023cites this paper
• Variation is important: Warranting chromatin function and dynamics by histone variants.

  2023cites this paper
• TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis.

  2023cites this paper
• Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

  2023cites this paper
• The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication

  2022cites this paper
• Analyses of gene copy number variation in diverse epigenetic regulatory gene families across plants: Increased copy numbers of BRUSHY1/TONSOKU/MGOUN3 (BRU1/TSK/MGO3) and SILENCING DEFECTIVE 3 (SDE3) in long-lived trees

  2022cites this paper
• The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes

  2022influential citation
• Identification of new RAD51D-regulating microRNAs that also emerge as potent inhibitors of the Fanconi Anemia/homologous recombination pathways.

  2022cites this paper
• CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

  2022cites this paper
• MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC

  2022cites this paper
• Colon fibroblasts from Pirc rats (F344/NTac‐Apc am1137) exhibit a proliferative and inflammatory phenotype that could support early stages of colon carcinogenesis

  2021cites this paper
• Homologous recombination, cancer and the ‘RAD51 paradox’

  2021cites this paper
• Homologous recombination in mammalian cells: From molecular mechanisms to pathology

  2021cites this paper
• The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer.

  2021cites this paper
• Targeting Non-Oncogene Addiction for Cancer Therapy

  2021cites this paper
• MMS22L Expression as a Predictive Biomarker for the Efficacy of Neoadjuvant Chemoradiotherapy in Oesophageal Squamous Cell Carcinoma

  2021cites this paper
• Mitochondrial DNA: cellular genotoxic stress sentinel.

  2021cites this paper
• Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

  2021cites this paper
• Chromatin dynamics and DNA replication roadblocks.

  2021cites this paper
• The SOX9-MMS22L Axis Promotes Oxaliplatin Resistance in Colorectal Cancer

  2021cites this paper
• Transcriptome analysis uncover differential regulation in cell cycle, immunity, and metabolism in Anopheles albimanus during immune priming with Plasmodium berghei.

  2021cites this paper
• Histone and Chromatin Dynamics Facilitating DNA repair.

  2021cites this paper
• Novel TONSL variants cause SPONASTRIME dysplasia and associate with spontaneous chromosome breaks, defective cell proliferation and apoptosis.

  2020cites this paper
• Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing

  2020cites this paper
• Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress

  2020cites this paper
• MOB: Pivotal Conserved Proteins in Cytokinesis, Cell Architecture and Tissue Homeostasis

  2020cites this paper
• RAD51: Beyond the break

  2020cites this paper
• Advances in understanding DNA processing and protection at stalled replication forks

  2019cites this paper
• DNA double-strand break repair-pathway choice in somatic mammalian cells

  2019cites this paper
• Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.

  2019cites this paper
• University of Birmingham Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

  2019influential citation
• MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer

  2019cites this paper
• Retention of a chromosomal inversion from an anadromous ancestor provides the genetic basis for alternative freshwater ecotypes in rainbow trout

  2019cites this paper
• Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes.

  2019cites this paper
• Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia.

  2019influential citation
• A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks.

  2019cites this paper
• The histone chaperoning pathway: from ribosome to nucleosome

  2019cites this paper
• Chromatin as a Platform for Modulating the Replication Stress Response

  2018cites this paper
• BRUSHY1/TONSOKU/MGOUN3 is required for heat stress memory.

  2018cites this paper
• RPA and RAD51: fork reversal, fork protection, and genome stability

  2018cites this paper
• Integrating DNA damage repair with the cell cycle.

  2018cites this paper
• The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.

  2018cites this paper
• Ecological disturbance influences adaptive divergence despite high gene flow in golden perch (Macquaria ambigua): Implications for management and resilience to climate change

  2018cites this paper
• Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity.

  2018cites this paper
• Homologous recombination defects and how they affect replication fork maintenance

  2018cites this paper
• Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

  2018cites this paper
• Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast

  2017cites this paper
• DNA replication through a chromatin environment

  2017cites this paper
• Reading chromatin signatures after DNA double-strand breaks

  2017cites this paper
• CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination

  2017cites this paper
• Regulation of Replication Fork Advance and Stability by Nucleosome Assembly

  2017influential citation
• MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion

  2017cites this paper
• Building up and breaking down: mechanisms controlling recombination during replication

  2017cites this paper
• Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair

  2017cites this paper
• Patent Highlights April-May 2017.

  2017cites this paper
• RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

  2017cites this paper
• Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

  2017cites this paper
• Role of Histone H3 Lysine 56 Acetylation in the Response to Replicative stress

  2017cites this paper
• The Roles of Cullin RING Ligases and the Anaphase Promoting Complex/Cyclosome in the Regulation of DNA Double Strand Break Repair

  2017cites this paper
• INVESTIGATION OF THE ROLES OF ASF1 AND CAF-1-MEDIATED CHROMATIN ASSEMBLY IN THE HUMAN DNA DAMAGE RESPONSE

  2017cites this paper
• Rtt101‐Mms1‐Mms22 coordinates replication‐coupled sister chromatid cohesion and nucleosome assembly

  2017cites this paper
• Application of multivariate statistics and machine learning to phenotypic imaging and chemical high-content data

  2016cites this paper
• A Genome-scale RNA Interference Screen Identifies Novel Regulators of DNA Double-strand Break Repair

  2016cites this paper
• The MMS22L–TONSL heterodimer directly promotes RAD51‐dependent recombination upon replication stress

  2016influential citation
• Epigenome maintenance in response to DNA damage

  2016cites this paper
• The control of DNA repair by the cell cycle

  2016cites this paper
• Gene expression signatures of human cell and tissue longevity

  2016cites this paper
• The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling

  2016cites this paper
• A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing

  2016cites this paper
• Defects in homologous recombination repair behind the human diseases: FA and HBOC.

  2016cites this paper
• H4 K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex

  2016cites this paper