Artemisinin-resistant malaria in Asia.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  New England Journal of Medicine

• Publication date

  2009-12-10

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1056/NEJMc0900231PMID 19641219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Malaria control--addressing challenges to ambitious goals.

  2009cited by this paper
• Evidence of artemisinin-resistant malaria in western Cambodia.

  2008cited by this paper
• Signs of Drug Resistance Rattle Experts, Trigger Bold Plan

  2008cited by this paper
• Therapeutic efficacy of quinine plus sulfadoxine-pyremethamine for the treatment of uncomplicated falciparum malaria in Bangladesh.

  2006cited by this paper
• In Vitro Antimalarial Activity of Azithromycin, Artesunate, and Quinine in Combination and Correlation with Clinical Outcome

  2006cited by this paper
• In vivo sensitivity monitoring of mefloquine monotherapy and artesunate–mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003

  2006cited by this paper

• Antimalarial drug efficacy and resistance: Insights from northern Uganda.

  2025cites this paper
• Efficacy of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in Mozambique, 2022

  2025cites this paper
• Validated antimalarial drug target discovery using genome-scale metabolic modeling

  2025cites this paper
• Acetyl-CoA synthetase mutations affect the susceptibility of Plasmodium falciparum to antimalarial drugs

  2025cites this paper
• Synthesis and in vitro/in silico evaluation of the antimalarial activity of potential amino-quinoline derivatives

  2025cites this paper
• Efficacy of praziquantel for treatment of Plasmodium falciparum infection in asymptomatic Gabonese adults: A double-blind placebo-controlled randomized phase IIb clinical trial.

  2025cites this paper
• Prevalence of Plasmodium falciparum plasmepsin2/3 gene duplication in Africa and Asia: a systematic review and meta-analysis

  2025cites this paper
• Characterization of Plasmodium Falciparum Resistance Genes to Common Antimalarial Drugs in Semi-urban Areas of Burkina Faso

  2024cites this paper
• Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

  2024cites this paper
• Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after antimalarial treatment

  2024cites this paper
• Improved anti-malarial parasite efficacy with heparin-artemisinin nanoemulsions

  2024cites this paper
• Emerging threat of artemisinin partial resistance markers (pfk13 mutations) in Plasmodium falciparum parasite populations in multiple geographical locations in high transmission regions of Uganda

  2024cites this paper
• Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets.

  2024cites this paper
• Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?

  2024cites this paper
• Detection of drug-resistant malaria in resource-limited settings: efficient and high-throughput surveillance of artemisinin and partner drug resistance.

  2024cites this paper
• A review of entamoebahistolytica genome, virulence factors, phylogenetic tree and treatment

  2024cites this paper
• Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs

  2024cites this paper
• Epidemiology of malaria in Gabon: A systematic review and meta-analysis from 1980 to 2023.

  2024cites this paper
• Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

  2023cites this paper
• Dihydroartemisinin-piperaquine efficacy in Plasmodium falciparum treatment and prevalence of drug-resistant molecular markers along China-Myanmar border in 2014-2023.

  2023cites this paper
• Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening

  2023cites this paper
• Antimalarial activities of benzothiazole analogs: A systematic review

  2023cites this paper
• Discovery of 1,3,4-oxadiazoles with slow-action activity against Plasmodium falciparum malaria parasites

  2023cites this paper
• Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.

  2023cites this paper
• PfD123 modulates K13-mediated survival and recovery after artemisinin exposure

  2022cites this paper
• Molecular Markers for Sulfadoxine/Pyrimethamine and Chloroquine Resistance in Plasmodium falciparum in Thailand

  2022cites this paper
• Impact of Drug Pressure versus Limited Access to Drug in Malaria Control: The Dilemma

  2022cites this paper
• Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger

  2022cites this paper
• Evaluation of erythrocyte viability, antioxidant capacity and antiplasmodial activity induced by alkaloid extract of Phyllanthus amarus

  2022cites this paper
• Spiral molecules with antimalarial activities: A review.

  2022cites this paper
• Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

  2021cites this paper
• Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

  2021influential citation
• In vivo efficacy and safety of artemether–lumefantrine and amodiaquine–artesunate for uncomplicated Plasmodium falciparum malaria in Mozambique, 2018

  2021cites this paper
• Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia

  2021cites this paper
• P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

  2021influential citation
• Malaria research in Australia: looking through the lens of the past towards the future.

  2021cites this paper
• Drug-induced hypersensitivity to artemisinin-based therapies for malaria.

  2021cites this paper
• Plasmodium falciparum Acetyl-CoA Synthetase is essential for parasite intraerythrocytic development and chromatin modification

  2021cites this paper
• Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

  2021cites this paper
• Evidence of Artemisinin-Resistant Malaria in Africa.

  2021cites this paper
• Distance-Based Phylogenetic Methods

  2020cites this paper
• Nucleotide Substitution Models and Evolutionary Distances

  2020cites this paper
• Altered Drug Transport by Plasmodium Falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance.

  2020cites this paper
• Cytotoxicity and antiplasmodial activity of alkaloid extracts prepared from eight African medicinal plants used in Nigeria

  2020cites this paper
• Effect of After-Treatment of Strychnos ligustrina Extract on The Percentage of Parasitemia in Mice Infected with Plasmodium berghei

  2020cites this paper
• Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

  2020influential citation
• In vivo antimalarial potential of tinospora crispa miers in mice and identification of the bioactive compound

  2020cites this paper
• Enhanced Antimalarial Efficacy Obtained by Targeted Delivery of Artemisinin in Heparin-Coated Magnetic Hollow Mesoporous Nanoparticles.

  2020cites this paper
• Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIß.

  2020cites this paper
• Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance

  2019cites this paper
• Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

  2019cites this paper
• In vitro susceptibility of Plasmodium falciparum isolates from the China-Myanmar border area to artemisinins and correlation with K13 mutations

  2019cites this paper
• High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

  2019cites this paper
• Bioinformatic Approaches for Repurposing and Repositioning Antibiotics, Antiprotozoals, and Antivirals

  2019cites this paper
• Malaria parasite resistance vicious cycle

  2019cites this paper
• Oral Administration of Clinically Relevant Antimalarial Drugs Does Not Modify the Murine Gut Microbiota

  2019cites this paper
• Origin and Spread of Evolving Artemisinin-Resistant Plasmodium falciparum Malarial Parasites in Southeast Asia.

  2019cites this paper
• Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (L.F.) Sol. Ex roem. & schult

  2019cites this paper
• Medicinal chemistry progression of antimalarial hits from phenotypic whole cell screening of SoftFocus libraries

  2019cites this paper
• The oligomeric protein interference assay method for validation of antimalarial targets

  2019cites this paper
• Variational and PDE-based methods for image processing

  2018cites this paper
• Bioinformatics and the Cell

  2018cites this paper
• Bioinformatics and Translation Initiation

  2018cites this paper
• Characterizing the gut microbiota during plasmodium infection and antimalarial treatment.

  2018cites this paper
• Explorer Artemisinin resistance in rodent malaria-mutation in the AP 2 adaptor-chain suggests involvement of endocytosis and membrane protein trafficking

  2018influential citation
• Fundamentals of Proteomics

  2018cites this paper
• String Mathematics, BLAST, and FASTA

  2018cites this paper
• Bioinformatics and Translation Elongation

  2018cites this paper
• Protein Isoelectric Point and Helicobacter pylori

  2018cites this paper
• Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.

  2018cites this paper
• Artemisinin Therapy for Malaria in Hemoglobinopathies: A Systematic Review

  2018cites this paper
• Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum

  2018cites this paper
• Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate.

  2018cites this paper
• Current Efficacy of the First Line Uncomplicated Malaria Treatment in Two Sentinels Sites of Côte d’Ivoire

  2018cites this paper
• Novel Cinchona Alkaloid Derivatives as Potential Antimalarial Agents through Receptor–Inhibitor Interaction Fingerprint and Biosynthesis Design

  2018cites this paper
• Editorial overview: Tuberculosis, malaria and schistosomiasis; understanding resistance and development of new drugs.

  2018cites this paper
• Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives

  2018cites this paper
• Antimalarial Activity of Piperine

  2018cites this paper
• Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

  2018cites this paper
• How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria.

  2017cites this paper
• A portable image-based cytometer for rapid malaria detection and quantification

  2017cites this paper
• P. falciparum malaria prevalence among blood donors in Bamako, Mali.

  2017cites this paper
• Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation.

  2017cites this paper
• Bioinformatics and Drug Discovery

  2017cites this paper
• falciparum malaria prevalence among blood donors in Bamako , Mali Prévalence de l ’ infection palustre à P . falciparum chez les donneurs de sang à Bamako , Mali

  2017cites this paper
• Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

  2017cites this paper
• Comparison of anti-malarial drug efficacy in the treatment of uncomplicated malaria in African children and adults using network meta-analysis

  2017cites this paper
• Absence of in vivo selection for K13 mutations after artemether–lumefantrine treatment in Uganda

  2017cites this paper
• Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3'-Kinase.

  2017cites this paper
• Extending the spectrum of antimalarial treatment : Artemisinin combinations for the treatment of rare Plasmodium species infections and the development of dyes as antimalarials

  2017cites this paper
• In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

  2017cites this paper
• Antimalarial Drug Resistance: Clinical Perspectives

  2017cites this paper
• A portable image-based cytometer for rapid 2 malaria detection and quantification 3 4

  2017cites this paper
• Studies of Malarial Parasite Chloroquine Resistance Transporter and Kinase Proteins: Key Targets for Evolving Drug Therapies

  2017influential citation
• Population genetics of Plasmodium falciparum parasites exposed to artemisinin treatment in patients taking part in an efficacy clinical trial in Kisumu county, western Kenya.

  2017cites this paper
• Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity

  2017cites this paper
• In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102

  2016cites this paper
• Docking, QM/MM, and molecular dynamics simulations of the hexose transporter from Plasmodium falciparum (PfHT).

  2016cites this paper
• Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites

  2016influential citation
• Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso

  2016cites this paper