Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

Summary Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.

• Publication year

  2017

• Venue

  Neuron

• Publication date

  2017-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2017.03.029PMID 28426965PMCID 5418202
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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