Hedonic Hot Spots in the Brain

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The Neuroscientist

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1177/1073858406293154PMID 17079516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds

  2006cited by this paper
• Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

  2006cited by this paper
• Neurons in the orbitofrontal cortex encode economic value

  2006cited by this paper
• Cannabinoid Modulation of Opiate Reinforcement through the Ventral Striatopallidal Pathway

  2006cited by this paper
• Mice with Chronically Elevated Dopamine Exhibit Enhanced Motivation, but not Learning, for a Food Reward

  2006cited by this paper
• Neurochemical modulation of ingestive behavior in the ventral pallidum

  2006cited by this paper
• Orbitofrontal ensemble activity monitors licking and distinguishes among natural rewards.

  2006cited by this paper
• Anhedonia after a selective bilateral lesion of the globus pallidus.

  2006cited by this paper
• Mu‐opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating

  2006cited by this paper
• Ventral pallidum firing codes hedonic reward: when a bad taste turns good.

  2006cited by this paper
• Relative reward processing in primate striatum

  2005cited by this paper
• Endogenous opioids are necessary for benzodiazepine palatability enhancement: naltrexone blocks diazepam-induced increase of sucrose-'liking'.

  2005cited by this paper
• The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake

  2005influential reference
• Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine

  2005cited by this paper
• The human orbitofrontal cortex: linking reward to hedonic experience

  2005cited by this paper
• Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output.

  2005cited by this paper
• Motivational Effects of Cannabinoids and Opioids on Food Reinforcement Depend on Simultaneous Activation of Cannabinoid and Opioid Systems

  2005cited by this paper
• Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

  2005influential reference
• UC San Francisco UC San Francisco Previously Published Works Title Encoding of palatability and appetitive behaviors by distinct neuronal populations in the nucleus accumbens

  2005cited by this paper
• Dynamic regulation of integrin activation by intracellular and extracellular signals controls oligodendrocyte morphology

  2005cited by this paper
• Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors

  2005cited by this paper
• Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards.

  2005cited by this paper
• Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards.

  2004cited by this paper
• Activity in the hypothalamus, amygdala, and cortex generates bilateral and convergent modulation of pontine gustatory neurons.

  2004cited by this paper
• Feelings and Emotions: FEELINGS, EMOTIONS, AND MORALITY

  2004cited by this paper
• Amygdalectomy and ventromedial prefrontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward

  2004cited by this paper
• A bi-directional μ-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat

  2004cited by this paper
• Food for thought: hedonic experience beyond homeostasis in the human brain

  2004cited by this paper
• Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes

  2004cited by this paper
• Compartment-specific localization of cannabinoid 1 (CB1) and mu-opioid receptors in rat nucleus accumbens.

  2004cited by this paper
• Feelings and Emotions: Pleasure, Unfelt Affect, and Irrational Desire

  2004cited by this paper
• Pleasures of the brain.

  2003cited by this paper
• Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task

  2003cited by this paper
• Pleasures of the brain

  2003cited by this paper
• Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness.

  2003cited by this paper
• Human cortical responses to water in the mouth, and the effects of thirst.

  2003cited by this paper
• Different representations of pleasant and unpleasant odours in the human brain

  2003cited by this paper
• Dissociation of neural representation of intensity and affective valuation in human gustation.

  2003cited by this paper
• Effects of Buprenorphine Maintenance Dose on μ-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers

  2003cited by this paper
• Amygdaloid projections to ventromedial striatal subterritories in the primate.

  2002cited by this paper
• Opioid peptides and the control of human ingestive behaviour.

  2002cited by this paper
• Neural responses during anticipation of a primary taste reward.

  2002cited by this paper
• Opioid modulation of taste hedonics within the ventral striatum.

  2002cited by this paper
• Predictability Modulates Human Brain Response to Reward

  2001cited by this paper
• The Role of Dopamine in the Nucleus Accumbens and Striatum during Sexual Behavior in the Female Rat

  2001cited by this paper
• Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates.

  2001cited by this paper
• Changes in brain activity related to eating chocolate: from pleasure to aversion.

  2001cited by this paper
• Endogenous cannabinoids and appetite

  2001cited by this paper
• Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and fos expression.

  2000cited by this paper
• Opioid site in nucleus accumbens shell mediates eating and hedonic 'liking' for food: map based on microinjection Fos plumes.

  2000influential reference
• Sensory‐specific satiety‐related olfactory activation of the human orbitofrontal cortex

  2000cited by this paper
• Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns.

  2000influential reference
• Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.

  2000cited by this paper
• Emotion, decision making and the orbitofrontal cortex.

  2000cited by this paper
• An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens.

  2000cited by this paper
• Electrophysiological properties of cholinergic and noncholinergic neurons in the ventral pallidal region of the nucleus basalis in rat brain slices.

  2000cited by this paper
• The hedonic impact and intake of food are increased by midazolam microinjection in the parabrachial nucleus.

  2000influential reference
• Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

  2000cited by this paper
• On the neural computation of utility: implications from studies of brain stimulation reward

  1999cited by this paper
• Orbitofrontal Cortex and Representation of Incentive Value in Associative Learning

  1999cited by this paper
• The representation of pleasant touch in the brain and its relationship with taste and olfactory areas.

  1999cited by this paper
• Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat

  1999cited by this paper
• Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats.

  1999cited by this paper
• Neural systems for reinforcement and inhibition of behavior: Relevance to eating, addiction, and depression.

  1999cited by this paper
• The functions of the orbitofrontal cortex.

  1999cited by this paper
• Relative reward preference in primate orbitofrontal cortex

  1999cited by this paper
• Opioid Modulation of Ventral Pallidal Inputs

  1999cited by this paper
• Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study.

  1998cited by this paper
• Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning

  1998cited by this paper
• Drug-activation of brain reward pathways.

  1998cited by this paper
• Predictive reward signal of dopamine neurons.

  1998cited by this paper
• Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity.

  1997cited by this paper
• Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways.

  1997cited by this paper
• Dynamic Changes in Nucleus Accumbens Dopamine Efflux During the Coolidge Effect in Male Rats

  1997cited by this paper
• Cellular mechanisms underlying reinforcement-related processing in the nucleus accumbens: electrophysiological studies in behaving animals.

  1997cited by this paper
• Presynaptic Versus Postsynaptic Localization of μ and δ Opioid Receptors in Dorsal and Ventral Striatopallidal Pathways

  1997cited by this paper
• Food reward: brain substrates of wanting and liking.

  1996influential reference
• Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration

  1996cited by this paper
• Morphine enhancement of sucrose palatability: analysis by the taste reactivity test.

  1996cited by this paper
• Hyperphagia induced by direct administration of midazolam into the parabrachial nucleus of the rat.

  1996cited by this paper
• Addiction

  1996cited by this paper
• Brainstem mediates diazepam enhancement of palatability and feeding: microinjections into fourth ventricle versus lateral ventricle.

  1996cited by this paper
• Descartes' Error: Emotion, Reason and the Human Brain

  1995cited by this paper
• Central enhancement of taste pleasure by intraventricular morphine.

  1995cited by this paper
• Neuropharmacology of the nucleus accumbens: Iontophoretic applications of morphine and nicotine have contrasting effects on single‐unit responses evoked by ventral pallidal and fimbria stimulation

  1995cited by this paper
• A topographically organized gamma‐aminobutyric acid projection from the ventral pallidum to the nucleus accumbens in the rat

  1994cited by this paper
• Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats

  1994cited by this paper
• Neuropharmacology of appetite and taste preferences

  1994cited by this paper
• Descartes' error: emotion, reason, and the human brain. avon books

  1994cited by this paper
• Endogenous cannabinoids

  1994cited by this paper
• Morphine enhances hedonic taste palatability in rats.

  1993cited by this paper
• Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.

  1993cited by this paper
• Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?

  1993cited by this paper
• Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents.

  1993cited by this paper
• Morphine- and naltrexone-induced modification of palatability: analysis by the taste reactivity test.

  1992cited by this paper
• Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat

  1992cited by this paper
• Electrophysiological evidence for reciprocal connectivity between the nucleus accumbens septi and ventral pallidal region.

  1992cited by this paper
• What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?

  1991cited by this paper
• Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo.

  1989cited by this paper
• Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: implications for arousal and anhedonia hypotheses of dopamine function.

  1989cited by this paper

• A Metabolic Framework for Reward: Redefining Dopamine and Opioids as Physiological Agents.

  2026cites this paper
• Intrauterine growth restriction and sugar consumption at two years of age in the BRISA cohort

  2025cites this paper
• Neuroaesthetics: exploring the role of aesthetic experience in neurorehabilitation

  2025cites this paper
• PACAP induces increased excitability in D1- and D2-expressing nucleus accumbens medium spiny neurons.

  2025cites this paper
• Neurospirituality Connectome - Role in Neurology and Reward Deficiency Syndrome (RDS).

  2025cites this paper
• Effects of Voluntary Ingestion of Synthetic Delta-9-Tetrahydrocannabinol on the Hedonic Value of Rewarding and Aversive Substances and CB1 Receptor Expression

  2025cites this paper
• Edulcorantes no calóricos

  2025cites this paper
• Similarities and Differences in Neurobiology.

  2025cites this paper
• Dopaminergic modulation: revisiting a promising novel pathway for pharmacologic treatment of chronic pain.

  2025cites this paper
• Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation

  2025cites this paper
• Chst9 marks a spatially and transcriptionally unique population of Oprm1-expressing neurons in the nucleus accumbens

  2024cites this paper
• Behavioral separation of liking and wanting in response to olfactory and visual food cues.

  2024cites this paper
• The Endogenous Opioid System as a Pathway of Positive Emotions.

  2024cites this paper
• Is music a drug? How music listening may trigger neurochemical responses in the brain

  2024cites this paper
• Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation

  2024cites this paper
• Distinct neural networks of task engagement and choice response in moral, risky, and ambiguous decision-making: An ALE meta-analysis

  2024cites this paper
• The neural processes in food decision-making and their effect on daily diet management in successful and unsuccessful restrained eaters.

  2023cites this paper
• Nuts, Energy Balance and Body Weight

  2023cites this paper
• Significance of pleasant touch and state-of-the-art neuroscience technologies in acupuncture research

  2023cites this paper
• Aberrant reward dynamics in depression with anticipatory anhedonia.

  2023cites this paper
• Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards

  2023cites this paper
• Behavioral dissection of hunger states in Drosophila

  2023cites this paper
• Chst9 Marks a Spatially and Transcriptionally Unique Population of Oprm1-Expressing Neurons in the Nucleus Accumbens

  2023cites this paper
• Functional architecture of dopamine neurons driving fear extinction learning.

  2023cites this paper
• The neurophysiological Behavioral Perspective Model of consumer choice and its contribution to the intentional behaviorist research programme

  2023cites this paper
• Affective Touch as Immediate and Passive Wearable Intervention

  2022cites this paper
• Towards a Better Understanding of the Neurobiological Basis of Problematic Social Media use in Young Adults

  2022cites this paper
• Increment in the consummatory response induced by reward delay: An animal model of binge-like eating episodes

  2022cites this paper
• Birdsong and the Neural Regulation of Positive Emotion

  2022cites this paper
• Dopamine receptor and dopamine transporter in obesity: A meta‐analysis

  2022cites this paper
• Positive valence systems in youth anxiety development: A scoping review.

  2022cites this paper
• A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity

  2022cites this paper
• Musical Enjoyment and Reward: From Hedonic Pleasure to Eudaimonic Listening

  2022cites this paper
• Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect

  2022cites this paper
• Investigating a role of orexin and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell in binge eating of male rats and the relationship with impulsivity.

  2022cites this paper
• Theories and models of negative symptoms in schizophrenia and clinical implications

  2022cites this paper
• Distinct limbic dopamine regulation across olfactory‐tubercle subregions through integration of in vivo fast‐scan cyclic voltammetry and optogenetics

  2022cites this paper
• Differences in dopamine and opioid receptor ratios in the nucleus accumbens relate to physical contact and undirected song in pair-bonded zebra finches.

  2021cites this paper
• The Paraventricular Thalamus as a Critical Node of Motivated Behavior via the Hypothalamic-Thalamic-Striatal Circuit

  2021cites this paper
• Linking of NMDA receptors and mGluR5 in the nucleus accumbens core to repeated cocaine‐induced 50‐kHz ultrasonic vocalization in rats

  2021cites this paper
• Reward and emotion: an affective neuroscience approach

  2021cites this paper
• Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study

  2021cites this paper
• The effects of voluntary adolescent alcohol consumption on alcohol taste reactivity in Long Evans rats

  2021cites this paper
• Visual cues associated with sweet taste increase short-term eating and grab attention in healthy volunteers.

  2021cites this paper
• 'Defrosting' music chills with naltrexone: The role of endogenous opioids for the intensity of musical pleasure.

  2021cites this paper
• The Neurobiology of Binge-Eating Disorder Differs from Obesity: Implications for Differential Therapeutics

  2021cites this paper
• Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet

  2021cites this paper
• Neural Correlates of Music Listening: Does the Music Matter?

  2021cites this paper
• Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks.

  2021cites this paper
• Understanding sweet-liking phenotypes and their implications for obesity: narrative review and future directions.

  2021cites this paper
• Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats.

  2020cites this paper
• Effect and mechanism of high-fat diet on the preference for sweeteners on mice.

  2020cites this paper
• Correction for Makary et al., Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

  2020cites this paper
• Rajyoga meditation induces grey matter volume changes in regions that process reward and happiness

  2020cites this paper
• Reward Contributions to Serotonergic Functions.

  2020cites this paper
• Motivación: un recorrido histórico y teórico de los principales marcos conceptuales

  2020cites this paper
• Modeling the symptoms of psychopathology: A pluralistic approach

  2020cites this paper
• There are no aesthetic emotions: Comment on Menninghaus et al. (2019).

  2020cites this paper
• Operant learning is disrupted when opioid reward pathways are blocked in the domesticated hen

  2020cites this paper
• Dopamine receptors in obesity: a meta-analysis

  2020cites this paper
• HPA axis- Interaction with Behavioral Systems

  2020cites this paper
• A mu-Opioid Feedback Model of Human Social Behavior.

  2020cites this paper
• Effectiveness of Physical Activity Related to Food Addiction in Obese and Overweight Healthy Adults: A Systematic Review

  2020cites this paper
• Engaging endogenous opioid circuits in pain affective processes

  2020cites this paper
• Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain

  2020cites this paper
• A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

  2020cites this paper
• From Multisensory Assessment to Functional Interpretation of Social Behavioral Phenotype in Transgenic Mouse Models for Autism Spectrum Disorders

  2020cites this paper
• A novel mouse model of glucagon‐like peptide‐1 receptor expression: A look at the brain

  2020cites this paper
• The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics.

  2020cites this paper
• Food Reward and Food Choice. An Inquiry Through The Liking and Wanting Model

  2020cites this paper
• Valence Encoding Signals in the Human Amygdala and the Willingness to Eat

  2020influential citation
• Hormonal dysregulation after prolonged HPA axis activation can be explained by 2 changes of adrenal and corticotroph masses

  2020cites this paper
• Psychobiology of Appetite and Food Reward in Adults with Type 1 and Type 2 Diabetes: Is there a Role for Exercise?

  2020cites this paper
• The nature of beauty: behavior, cognition, and neurobiology

  2020cites this paper
• Lateral Septum Mu Opioid Receptors in Stimulation of Feeding.

  2020cites this paper
• The nature of perception and emotion in aesthetic appreciation: A response to Makin’s challenge to empirical aesthetics.

  2019cites this paper
• Interactions of hedonic and homeostatic systems in compulsive overeating

  2019cites this paper
• Genetics and epigenetics of food addiction

  2019cites this paper
• Cannabinoide im täglichen Einsatz: Evidenz – Realität – Vision

  2019cites this paper
• Neurobiological Perspectives in Behavioral Addiction

  2019cites this paper
• Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.

  2019cites this paper
• Dopamine modulates the reward experiences elicited by music

  2019cites this paper
• Primate ventromedial prefrontal cortex and the physiological and behavioural dysfunction characteristic of mood and anxiety disorders

  2019cites this paper
• Emotional Perception

  2019cites this paper
• Efecto de la proporción de los componentes de la dieta en distintos aspectos del metabolismo de la rata en un contexto de obesidad

  2019cites this paper
• µ-Opioid and Dopamine-D2 Receptor Expression in the Nucleus Accumbens of Male Sprague-Dawley Rats Whose Sucrose Consumption, but not Preference, Decreases after Nerve Injury.

  2019cites this paper
• Differential rearing alters taste reactivity to ethanol, sucrose, and quinine

  2019cites this paper
• Aesthetic Appreciation: The View From Neuroimaging

  2019cites this paper
• Dynamic associations between opioid use and anhedonia: A longitudinal study in opioid dependence

  2018cites this paper
• Challenges to Body Fluid Homeostasis Differentially Recruit Phasic Dopamine Signaling in a Taste-Selective Manner

  2018cites this paper
• Reasons and theories of sensory affect

  2018cites this paper
• Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need

  2018cites this paper
• An electrophysiological investigation of the extrinsic modulation of ventral pallidum neurons by dopamine and serotonin

  2018cites this paper
• Pleasure: The missing link in the regulation of sleep

  2018cites this paper
• How does fatty mouthfeel, saltiness or sweetness of diets contribute to dietary energy intake?

  2018cites this paper
• Behaviour and Neural Indices of the Abuse Liability associated with Intraoral Self-administration of High Fructose Corn Syrup

  2018cites this paper
• The United States: Self-Interest

  2018cites this paper
• The United States: Fairness vs. Equality

  2018cites this paper
• The Rise and Fall of Political Orders

  2018cites this paper
• Why Do Orders Form

  2018cites this paper