Apoptosis and genomic instability

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2004-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrm1443PMID 15340382
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The age of cancer.

  2006cited by this paper
• Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

  2004cited by this paper
• An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation.

  2004cited by this paper
• The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

  2004cited by this paper
• Deficiency of the Cyclin Kinase Inhibitor p21(WAF-1/CIP-1) Promotes Apoptosis of Activated/Memory T Cells and Inhibits Spontaneous Systemic Autoimmunity

  2004cited by this paper
• From polyploidy to aneuploidy, genome instability and cancer

  2004cited by this paper
• Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity

  2004cited by this paper
• Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

  2004cited by this paper
• When cells get stressed: an integrative view of cellular senescence.

  2004cited by this paper
• p73 Induces Apoptosis via PUMA Transactivation and Bax Mitochondrial Translocation*

  2004cited by this paper
• The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

  2004cited by this paper
• DNA damage tumor suppressor genes and genomic instability.

  2004cited by this paper
• [Mitotic catastrophe: a special case of apoptosis].

  2004cited by this paper
• Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

  2004cited by this paper
• DNA damage-induced apoptosis

  2004cited by this paper
• Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

  2004cited by this paper
• Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy

  2004cited by this paper
• Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy*

  2004cited by this paper
• Acute Ablation of Survivin Uncovers p53-dependent Mitotic Checkpoint Functions and Control of Mitochondrial Apoptosis*

  2004cited by this paper
• Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.

  2004cited by this paper
• Cell death by mitotic catastrophe: a molecular definition

  2004cited by this paper
• Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells

  2004cited by this paper
• Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition*

  2004cited by this paper
• Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

  2003cited by this paper
• Cell senescence and hypermitogenic arrest

  2003cited by this paper
• Control of apoptosis by p53

  2003cited by this paper
• Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of colorectal adenomas and early colorectal carcinomas

  2003cited by this paper
• Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.

  2003cited by this paper
• TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14‐3‐3 protein binding ability

  2003cited by this paper
• Drosophila p53 preserves genomic stability by regulating cell death

  2003cited by this paper
• Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation.

  2003cited by this paper
• ATM and related protein kinases: safeguarding genome integrity

  2003cited by this paper
• Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes*

  2003cited by this paper
• Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

  2003cited by this paper
• Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.

  2003cited by this paper
• Transplanted bone marrow regenerates liver by cell fusion

  2003cited by this paper
• Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

  2003cited by this paper
• Cell fusion is the principal source of bone-marrow-derived hepatocytes

  2003cited by this paper
• Gene expression and mitotic exit induced by microtubule-stabilizing drugs.

  2003cited by this paper
• p53 has a direct apoptogenic role at the mitochondria.

  2003cited by this paper
• Megakaryocyte polyploidization is associated with a functional gene amplification.

  2003cited by this paper
• The cellular geography of Aurora kinases

  2003cited by this paper
• Cell fusion: a hidden enemy?

  2003cited by this paper
• Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis*

  2003cited by this paper
• Mutations and aneuploidy: co-conspirators in cancer?

  2003cited by this paper
• Ways of dying: multiple pathways to apoptosis.

  2003cited by this paper
• HBXIP functions as a cofactor of survivin in apoptosis suppression

  2003cited by this paper
• Chromosome instability in cancer: how, when, and why?

  2003cited by this paper
• Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.

  2003cited by this paper
• Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

  2003cited by this paper
• p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.

  2003cited by this paper
• Constitutive telomerase expression promotes mammary carcinomas in aging mice

  2002cited by this paper
• Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

  2002cited by this paper
• Genomic Instability in Mice Lacking Histone H2AX

  2002cited by this paper
• RecQ family helicases: roles as tumor suppressor proteins

  2002cited by this paper
• A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

  2002cited by this paper
• Live or let die: the cell's response to p53

  2002cited by this paper
• Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

  2002cited by this paper
• Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells

  2002cited by this paper
• Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

  2002cited by this paper
• Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma

  2002cited by this paper
• Dissecting p53 tumor suppressor functions in vivo.

  2002cited by this paper
• Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription

  2002cited by this paper
• BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability

  2002cited by this paper
• The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo.

  2002cited by this paper
• Death and anti-death: tumour resistance to apoptosis

  2002cited by this paper
• If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.

  2001cited by this paper
• Chromosome segregation and cancer: cutting through the mystery

  2001cited by this paper
• BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.

  2001cited by this paper
• Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation

  2001cited by this paper
• Predictors of progression in Barrett's esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression

  2001cited by this paper
• The mitochondrion in apoptosis: how Pandora's box opens

  2001cited by this paper
• Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

  2001cited by this paper
• BCR-ABL down-regulates the DNA repair protein DNA-PKcs.

  2001cited by this paper
• The expanding role of mitochondria in apoptosis.

  2001cited by this paper
• Neither p21WAF1 nor 14-3-3sigma prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells.

  2001cited by this paper
• The age of cancer

  2000cited by this paper
• Primary cells suppress oncogene-dependent apoptosis

  2000cited by this paper
• [Mitochondria and apoptosis].

  2000cited by this paper
• Death Signal-induced Localization of p53 Protein to Mitochondria

  2000cited by this paper
• Tumour cell hybridization and metastasis revisited

  2000cited by this paper
• Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.

  2000cited by this paper
• Reduction of UV-induced cell death in the human senescent fibroblasts.

  2000cited by this paper
• The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents

  2000cited by this paper
• p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells

  1999cited by this paper
• hMutS a - and hMutL a -dependent phosphorylation of p53 in response to DNA methylator damage

  1999cited by this paper
• p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells.

  1999cited by this paper
• Suppression of apoptosis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis.

  1999cited by this paper
• p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.

  1999cited by this paper
• Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.

  1999cited by this paper
• hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.

  1999cited by this paper
• Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

  1996cited by this paper
• Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis.

  1996cited by this paper
• Inactivation of p53 and the Development of Tetraploidy in the Elastase‐SV40 T Antigen Transgenic Mouse Pancreas

  1995cited by this paper
• Androgen suppressed apoptosis is modified in p53 deficient mice.

  1995cited by this paper
• 17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.

  1994cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Enhanced lung colonization and tumorigenicity of fused cells isolated from primary MCA tumors.

  1990cited by this paper

• Busulfan-Induced Male Infertility: Mechanisms, Therapeutic Interventions, and Future Directions.

  2026cites this paper
• Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress

  2026cites this paper
• Liver Regeneration: Polyploidy and Cellular Senescence as Potential Regulators

  2025cites this paper
• Exploring the Causal Relationship between Telomere Regulation, Aging and Neurological Disorders.

  2025cites this paper
• Age-dependent effects of hyperhomocysteinemia on neural differentiation and retinal development.

  2025cites this paper
• RPA1 protects DNA damage–induced PANoptosis in limb development

  2025cites this paper
• Evolutionary adaptation and asymmetric inheritance of polyploid giant cancer cells in esophageal squamous cell carcinoma.

  2025cites this paper
• The Hallmarks of Cancer as Eco-Evolutionary Processes.

  2025cites this paper
• Propolis mitigates busulfan-induced testicular dysfunction in rats: insights into redox stabilization, PCNA modulation, and caspase-3 inhibition

  2025cites this paper
• Host DNA damage and cellular fate in bacterial infections, with a focus on Staphylococcus aureus.

  2025cites this paper
• Lemongrass Extract and Anticancer Impact: mRNA Levels of Expressing Apoptosis and Mitochondrial Fission in MCF7 Cells

  2024cites this paper
• Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma

  2024cites this paper
• Delineating the tumour-regulatory roles of EYA4.

  2023cites this paper
• Biological effects of ionizing radiation on Aquatic biota- A critical review.

  2023cites this paper
• Effect of maca (Lepidium meyenii) extract on non-obstructive azoospermia in male mice.

  2023cites this paper
• CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability

  2023cites this paper
• Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses

  2023cites this paper
• miR-653-3p promotes genomic instability of colorectal cancer cells via targeting SIRT1/TWIST1 signaling pathway.

  2023cites this paper
• The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

  2023cites this paper
• Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells

  2023cites this paper
• Chromosomal Instability as Enabling Feature and Central Hallmark of Breast Cancer

  2023cites this paper
• FOXM1 is critical for the fitness recovery of chromosomally unstable cells

  2023cites this paper
• Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

  2023cites this paper
• Importance of oxygen tension in human ovarian tissue in vitro culture.

  2023cites this paper
• Ellagic acid effects on testis, sex hormones, oxidative stress, and apoptosis in the relative sterility rat model following busulfan administration

  2022cites this paper
• Managing Apoptosis in Lung Diseases Using Nano-Assisted Drug Delivery System.

  2022cites this paper
• Identification of LncRNA Prognostic Signature Associated With Genomic Instability in Pancreatic Adenocarcinoma

  2022cites this paper
• A new bio-active asymmetric-Schiff base: synthesis and evaluation of calf thymus DNA interaction, topoisomerase IIα inhibition, in vitro antiproliferative activity, SEM analysis and molecular docking studies

  2022cites this paper
• On the intrinsic disorder status of the major players in programmed cell death pathways [version 1; peer review: 2 approved]

  2022cites this paper
• Inhibiting PARP1 Splicing along with Inducing DNA Damage as Potential Breast Cancer Therapy

  2021influential citation
• Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes

  2021cites this paper
• Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis

  2021cites this paper
• DAZAP2 acts as specifier of the p53 response to DNA damage

  2021cites this paper
• MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review

  2021cites this paper
• Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer.

  2021cites this paper
• Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells

  2021cites this paper
• USP7 Is a Master Regulator of Genome Stability

  2020cites this paper
• NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis

  2020cites this paper
• AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

  2020cites this paper
• Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H

  2020cites this paper
• Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy.

  2020cites this paper
• Genomic instability and cancer: lessons from Drosophila

  2020cites this paper
• Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H

  2020cites this paper
• Metallomic and lipidomic analysis of S. cerevisiae response to cellulosic copper nanoparticles uncovers drivers of toxicity.

  2020cites this paper
• The Antiproliferative Activity of Oxypeucedanin via Induction of G2/M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells

  2020cites this paper
• Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies.

  2019cites this paper
• Aging-independent and size-dependent genotoxic response induced by titanium dioxide nanoparticles in mammalian cells.

  2019cites this paper
• All cancer hallmarks lead to diversity

  2019cites this paper
• Signaling pathways involved in regulating apoptosis induction in host cells upon PRRSV infection

  2019cites this paper
• Subcellular targets of zinc oxide nanoparticles during the aging process: role of cross-talk between mitochondrial dysfunction and endoplasmic reticulum stress in the genotoxic response.

  2019cites this paper
• Assessment of induced genomic instability in rat primary astrocytes exposed to intermediate frequency magnetic fields.

  2019cites this paper
• A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

  2019cites this paper
• DNA replication and replication termination in Escherichia coli

  2019cites this paper
• miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition

  2019cites this paper
• High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.

  2019cites this paper
• Examining the involvement of Slx5 in the apoptotic response to chronic activation of the spindle assembly checkpoint

  2019cites this paper
• Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.

  2019cites this paper
• Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

  2018cites this paper
• Hippo signaling controls cell cycle and restricts cell plasticity in planarians

  2018cites this paper
• Cancer follows chromosome missegregation when all endogenous repair mechanisms fail.

  2018cites this paper
• Progress on the study of the mechanism of busulfan cytotoxicity

  2018cites this paper
• Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid.

  2018cites this paper
• Transcriptomic analysis of prostate cancer progression

  2018cites this paper
• Prolonged engraftment of transplanted hepatocytes in the liver by transient pro‐survival factor supplementation using ex vivo mRNA transfection

  2018cites this paper
• Conservation and divergence of mitochondrial apoptosis pathway in the Pacific oyster, Crassostrea gigas

  2017cites this paper
• Understanding the regulation of APOBEC3 expression: Current evidence and much to learn

  2017cites this paper
• Endoscopic Ultrasound-Guided Fine-Needle Aspiration Cytology Combined With Automated Quantitative DNA Cytometry Can Improve the Value in the Detection of Pancreatic Malignancy

  2017cites this paper
• Hereditary Tyrosinemia

  2017cites this paper
• ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

  2017cites this paper
• Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to Nicotine

  2017cites this paper
• Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome

  2017cites this paper
• Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

  2017cites this paper
• INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis

  2017cites this paper
• Fusion between M2-macrophages and cancer cells results in a subpopulation of radioresistant cells with enhanced DNA-repair capacity

  2017cites this paper
• Molecular Pathogenesis of Liver Injury in Hereditary Tyrosinemia 1.

  2017cites this paper
• Dicer, a new regulator of pluripotency exit and LINE‐1 elements in mouse embryonic stem cells

  2017cites this paper
• Calcium signaling and cell cycle: Progression or death.

  2017cites this paper
• Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis

  2017cites this paper
• ICLES Loss of the homeostatic balance with lower glutathione causes an excess of ROSs

  2017cites this paper
• Sperm chromatin assessment

  2017cites this paper
• Caspase-2: an orphan enzyme out of the shadows

  2017cites this paper
• Linking genomic reorganization to tumor initiation via the giant cell cycle

  2016cites this paper
• Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma

  2016cites this paper
• Evaluation of the effect of low and intermediate frequency electromagnetic waves on radiosensitivity

  2016cites this paper
• Low-dose chemotherapeutic drugs induce reactive oxygen species and initiate apoptosis-mediated genomic instability.

  2016cites this paper
• Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

  2016cites this paper
• The radioresistance of mesenchymal stromal cells and their potential role in the management of radiation injury

  2016cites this paper
• Genotoxic potential of montmorillonite clay mineral and alteration in the expression of genes involved in toxicity mechanisms in the human hepatoma cell line HepG2.

  2016cites this paper
• Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment

  2016cites this paper
• Clinical application of Sperm Chromatin Structure Assay in diagnosis and treatment of infertility

  2016cites this paper
• Involvement of ROS‐p38‐H2AX axis in novel curcumin analogues‐induced apoptosis in breast cancer cells

  2016cites this paper
• Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation

  2015cites this paper
• Assessment of DNA damage in goat preantral follicles after vitrification of the ovarian cortex.

  2015cites this paper
• Electromagnetic energy as a bridge between atomic and cellular levels in the genetics approach to cancer treatment.

  2015cites this paper
• Genomic analysis using Affymetrix standard microarray genechips (169 format) in degenerate murine retina.

  2015cites this paper
• Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis

  2015cites this paper
• Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

  2015cites this paper
• Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53

  2015cites this paper
• Exploiting Cancer Cell Signaling and Metabolism: Implications for Therapeutic Approach

  2015cites this paper
• In Vitro Apoptosis Triggering in the BT-474 Human Breast Cancer Cell Line by Lyophilised Camel's Milk.

  2015cites this paper