Interactive toxicity of usnic acid and lipopolysaccharides in human liver HepG2 cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Applied Toxicology

• Publication date

  2012-09-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/jat.2768PMID 22777745
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture

  2012cited by this paper
• A Metabonomic Characterization of (+)-Usnic Acid-Induced Liver Injury by Gas Chromatography–Mass Spectrometry-Based Metabolic Profiling of the Plasma and Liver in Rat

  2011cited by this paper
• Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures.

  2011cited by this paper
• Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.

  2011cited by this paper
• Assessment of usnic acid toxicity in rat primary hepatocytes using ¹³C isotopomer distribution analysis of lactate, glutamate and glucose.

  2011cited by this paper
• Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

  2010cited by this paper
• Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture

  2010cited by this paper
• Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos.

  2010cited by this paper
• Decreased expression of the voltage-dependent anion channel in differentiated PC-12 and SH-SY5Y cells following low-level Pb exposure.

  2010influential reference
• Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress.

  2010cited by this paper
• Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.

  2010cited by this paper
• The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol.

  2009cited by this paper
• Small‐Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag

  2009cited by this paper
• Are in vitro tests suitable for regulatory use?

  2009cited by this paper
• Toxicity testing in the 21st century: bringing the vision to life.

  2009cited by this paper
• Dynamic nature of alterations in the endocrine system of fathead minnows exposed to the fungicide prochloraz.

  2009cited by this paper
• Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens

  2009cited by this paper
• Toxicity testing in the 21st century: a view from the chemical industry.

  2009cited by this paper
• Iron-induced oxidative injury differentially regulates PI3K/Akt/GSK3beta pathway in synaptic endings from adult and aged rats.

  2009cited by this paper
• Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2009cited by this paper
• Cell Cycle Arrest Induced by Hydrogen Peroxide Is Associated with Modulation of Oxidative Stress Related Genes in Breast Cancer Cells

  2009cited by this paper
• Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes.

  2009cited by this paper
• S-Adenosylhomocysteine promotes the invasion of C6 glioma cells via increased secretion of matrix metalloproteinase-2 in murine microglial BV2 cells.

  2009cited by this paper
• Cellular stress response pathway system as a sentinel ensemble in toxicological screening.

  2009cited by this paper
• Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects.

  2009cited by this paper
• Effects of 18 perfluoroalkyl compounds on mRNA expression in chicken embryo hepatocyte cultures.

  2009influential reference
• Pragmatic Challenges for the Vision of Toxicity Testing in the 21st Century in a Regulatory Context: Another Ames Test? …or a New Edition of “the Red Book”?

  2009cited by this paper
• Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway.

  2009cited by this paper
• Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  2009cited by this paper
• Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices.

  2008cited by this paper
• The role of mitochondrial and oxidative injury in BDE 47 toxicity to human fetal liver hematopoietic stem cells.

  2008cited by this paper
• Altered regulation of Prox1-gene-expression in liver tumors

  2008influential reference
• A Cell-based High-throughput Assay System Reveals Modulation of Oxidative and Nonoxidative Glucose Metabolism due to Commonly Used Organic Solvents

  2008cited by this paper
• Rat liver clone‐9 cells in culture as a model for screening hepatotoxic potential of food‐related products: hepatotoxicity of deoxynivalenol

  2008cited by this paper
• Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements.

  2008cited by this paper
• Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

  2007cited by this paper
• Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation.

  2007cited by this paper
• In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.

  2007cited by this paper
• Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761).

  2007cited by this paper
• Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

  2007cited by this paper
• Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.

  2007cited by this paper
• Toxicological highlight : Mixed messages

  2007cited by this paper
• Concentration dependence of the mechanisms of tributyltin-induced apoptosis.

  2007influential reference
• Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury.

  2006cited by this paper
• High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

  2006cited by this paper
• Microarrays Reveal Distinct Gene Signatures in the Thymus of Seropositive and Seronegative Myasthenia Gravis Patients and the Role of CC Chemokine Ligand 21 in Thymic Hyperplasia1

  2006cited by this paper
• Severe hepatotoxicity associated with use of a dietary supplement containing usnic acid.

  2006cited by this paper
• Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake.

  2005cited by this paper
• Lipopolysaccharide: an endotoxin or an exogenous hormone?

  2005cited by this paper
• Severe tissue damage

  2005cited by this paper
• Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?

  2005cited by this paper
• Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents.

  2005cited by this paper
• Toxicity and roles of reactive oxygen species.

  2005cited by this paper
• Phase I and II enzyme characterization of two sources of HepG2 cell lines

  2004cited by this paper
• Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress.

  2004cited by this paper
• Fulminant Liver Failure Due to Usnic Acid for Weight Loss

  2004cited by this paper
• Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells.

  2004influential reference
• A Fluorescence in Situ Hybridization Map of 6q Deletions in Acute Lymphocytic Leukemia

  2004cited by this paper
• Hepatotoxic effect of (+)usnic acid from Usnea siamensis Wainio in rats, isolated rat hepatocytes and isolated rat liver mitochondria.

  2004cited by this paper
• High prevalence of potentially hepatotoxic herbal supplement use in patients with fulminant hepatic failure.

  2003cited by this paper
• The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.

  2003cited by this paper
• Endotoxin: is it an environmental factor in the cause of Parkinson’s disease?

  2003cited by this paper
• Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis.

  2003cited by this paper
• Usnic acid.

  2002cited by this paper
• Severe Hepatotoxicity Associated with the Dietary Supplement LipoKinetix

  2002cited by this paper
• Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically.

  2002influential reference
• Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action.

  2002cited by this paper
• Perceptions about Complementary Therapies Relative to Conventional Therapies among Adults Who Use Both: Results from a National Survey

  2001cited by this paper
• Defining the impact of weakly estrogenic chemicals on the action of steroidal estrogens.

  2001cited by this paper
• Induction of apoptosis by the O-hydroxyethyl-D(Ser)(8)-cyclosporine A derivative SDZ IMM 125 in rat hepatocytes.

  2000cited by this paper
• Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

  2000cited by this paper
• Mitochondrial permeability transition is a central coordinating event in N-(4-hydroxyphenyl)retinamide-induced apoptosis.

  2000influential reference
• Evaluation of alamar blue reduction for the in vitro assay of hepatocyte toxicity.

  1999cited by this paper
• Candidate Tumor Suppressor Gene

  1998cited by this paper
• Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors.

  1997cited by this paper
• Newin vitro fluorimetric microtitration assays for toxicological screening of drugs

  1994cited by this paper
• HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen.

  1993cited by this paper
• Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

  1992cited by this paper
• DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water.

  1990cited by this paper
• Drug metabolism by the human hepatoma cell, Hep G2.

  1987cited by this paper
• Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes.

  1987cited by this paper
• Catabolism of human low density lipoproteins by human hepatoma cell line HepG2.

  1984cited by this paper
• Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes.

  1981cited by this paper
• Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.

  1980cited by this paper
• Behavioral medicine: an emergent field.

  1980cited by this paper
• Localization of mitochondria in living cells with rhodamine 123.

  1980cited by this paper
• Endotoxin : is it an environmental factor in the cause of Parkinson ’ s disease ?

  year unknowncited by this paper

• Natural Product Usnic Acid as an Antibacterial Therapeutic Agent: Current Achievements and Further Prospects.

  2025cites this paper
• Oxidative DNA damage contributes to usnic acid‐induced toxicity in human induced pluripotent stem cell‐derived hepatocytes

  2024cites this paper
• Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

  2023cites this paper
• Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW 264.7 Macrophage Cells Reducing its Toxicity.

  2023cites this paper
• Toxicity of Usnic Acid: A Narrative Review

  2022cites this paper
• The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo

  2021cites this paper
• New complexes of usnate with lanthanides ions: La(III), Nd(III), Tb(III), Gd(III), synthesis, characterization, and investigation of cytotoxic properties in MCF-7 cells

  2020cites this paper
• Usnic acid: from an ancient lichen derivative to promising biological and nanotechnology applications

  2020cites this paper
• Review: Usnic acid-induced hepatotoxicity and cell death.

  2020cites this paper
• Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2

  2019cites this paper
• Risk Assessment, Regulation, and the Role of Biomarkers for the Evaluation of Dietary Ingredients Present in Dietary Supplements

  2019cites this paper
• Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2

  2018cites this paper
• Haplotype-resolved and integrated genome analysis of ENCODE cell line HepG2

  2018cites this paper
• Usnic acid biological activity: history, evaluation and usage

  2017cites this paper
• Extraction, Solubility and Antimicrobial Activity of (-) Usnic Acid in Ethanol, a Pharmaceutically Relevant Solvent

  2017cites this paper
• Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects

  2016cites this paper
• Altered global gene expression profiles in human gastrointestinal epithelial Caco2 cells exposed to nanosilver

  2016cites this paper
• Review of the biological properties and toxicity of usnic acid

  2015influential citation
• Classification of hepatotoxicants using HepG2 cells: A proof of principle study.

  2014cites this paper
• MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells.

  2014cites this paper
• An Overview of Toxicogenomics Approaches to Mechanistically Understand and Predict Kidney Toxicity

  2014cites this paper
• Biomarkers of toxicity for dietary ingredients contained in dietary supplements

  2014cites this paper
• Autophagy in drug-induced liver toxicity

  2014cites this paper
• Lichens: a promising source of antibiotic and anticancer drugs

  2013cites this paper
• Updates on chemical and biological research on botanical ingredients in dietary supplements

  2013cites this paper
• Impact of High EGCG Consumption on Mouse Liver

  2012cites this paper
• Iranian Journal of Basic Medical Sciences the Protective Effects of Epigallocatechin Gallate on Lipopolysa Ccharide-induced Hepatotoxicity: an in Vitro Study on Hep3b Cells

  year unknowncites this paper