Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Toxicology in Vitro

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.TIV.2007.05.014PMID 17637504
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium.

  2007cited by this paper
• High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

  2006cited by this paper
• Human sulfotransferases and their role in chemical metabolism.

  2006cited by this paper
• An essential role of the CAAT/enhancer binding protein-alpha in the vitamin D-induced expression of the human steroid/bile acid-sulfotransferase (SULT2A1).

  2006cited by this paper
• Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor

  2006cited by this paper
• Genetic basis of toxic reactions to drugs and chemicals.

  2006cited by this paper
• Luminogenic cytochrome P450 assays

  2006cited by this paper
• Inducibility of UDP-glucuronosyltransferase 1As by beta-naphthoflavone in HepG2 cells.

  2006cited by this paper
• Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgrounds.

  2006cited by this paper
• PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS

  2006cited by this paper
• Human SULT1A genes: cloning and activity assays of the SULT1A promoters.

  2005cited by this paper
• Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts.

  2005cited by this paper
• A comprehensive listing of bioactivation pathways of organic functional groups.

  2005cited by this paper
• An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics.

  2005cited by this paper
• Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1.

  2005cited by this paper
• Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake.

  2005cited by this paper
• Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice

  2005cited by this paper
• Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents.

  2005cited by this paper
• Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.

  2005cited by this paper
• Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

  2005cited by this paper
• Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes

  2005cited by this paper
• Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4α

  2005cited by this paper
• Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with beta-naphthoflavone.

  2005cited by this paper
• Coordinate Regulation of Drug Metabolism by Xenobiotic Nuclear Receptors: UGTs Acting Together with CYPs and Glucuronide Transporters

  2004cited by this paper
• Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.

  2004cited by this paper
• Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

  2004cited by this paper
• 5‐Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide

  2004cited by this paper
• The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein

  2004cited by this paper
• Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo.

  2004cited by this paper
• Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione.

  2004cited by this paper
• The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions.

  2004cited by this paper
• Phase I and II enzyme characterization of two sources of HepG2 cell lines

  2004cited by this paper
• Can the pharmaceutical industry reduce attrition rates?

  2004cited by this paper
• CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.

  2004cited by this paper
• Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes.

  2004cited by this paper
• Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge.

  2004cited by this paper
• The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.

  2004cited by this paper
• Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

  2004cited by this paper
• Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.

  2003cited by this paper
• Functional and structural comparison of PXR and CAR.

  2003cited by this paper
• Prediction of human drug metabolizing enzyme induction.

  2003cited by this paper
• Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.

  2003cited by this paper
• Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

  2003cited by this paper
• Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes*

  2003cited by this paper
• Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.

  2002cited by this paper
• Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

  2002cited by this paper
• Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

  2002cited by this paper
• Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

  2002cited by this paper
• Screening for recombinant glutathione transferases active with monochlorobimane.

  2002cited by this paper
• Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

  2002cited by this paper
• Fluorometric microplate assay to measure glutathione S-transferase activity in insects and mites using monochlorobimane.

  2002cited by this paper
• Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells.

  2002cited by this paper
• Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.

  2002cited by this paper
• Induction of CYP2C genes in human hepatocytes in primary culture.

  2001cited by this paper
• Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays.

  2001cited by this paper
• Indirubin and Indigo Are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine*

  2001cited by this paper
• The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery.

  2001cited by this paper
• Dehydroepiandrosterone Sulfotransferase Gene Induction by Bile Acid Activated Farnesoid X Receptor*

  2001cited by this paper
• Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.

  2000cited by this paper
• Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

  2000cited by this paper
• A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines.

  2000cited by this paper
• Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide.

  2000cited by this paper
• Human CYP2B6: expression, inducibility and catalytic activities.

  1999cited by this paper
• Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy.

  1999cited by this paper
• Expression and inducibility of the human bilirubin UDP‐glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic and environmental influences

  1999cited by this paper
• Induction of cytochrome P4501A1.

  1999cited by this paper
• P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

  1999cited by this paper
• Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.

  1999cited by this paper
• Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes.

  1999cited by this paper
• Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity.

  1998cited by this paper
• The role of oxygen free radicals in isoniazid-induced hepatotoxicity.

  1998cited by this paper
• Differential response of cytosolic, microsomal, and mitochondrial glutathione S-transferases to xenobiotic inducers.

  1998cited by this paper
• Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells.

  1998cited by this paper
• Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.

  1998cited by this paper
• Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures.

  1998cited by this paper
• Re‐expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

  1998cited by this paper
• Phenobarbital induces cytochrome P4501A2 hnRNA, mRNA and protein in the liver of C57BL/6J wild type and aryl hydrocarbon receptor knock‐out mice

  1998cited by this paper
• Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.

  1998cited by this paper
• The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.

  1997cited by this paper
• Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.

  1997cited by this paper
• Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture

  1997cited by this paper
• Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: a novel role for phase-II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones?

  1997cited by this paper
• Relationship between acetylator status, smoking, and diet and colorectal cancer risk in the north-east of England.

  1997cited by this paper
• Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin.

  1997cited by this paper
• Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone.

  1996cited by this paper
• Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

  1996cited by this paper
• A comparison of the effect of inducers on the expression of glutathione‐S‐transferases in the liver of the intact rat and in hepatocytes in primary culture

  1996cited by this paper
• Demonstration of slow acetylator genotype of N-acetyltransferase in isoniazid neuropathy using an archival hematoxylin and eosin section of a sural nerve biopsy specimen.

  1996cited by this paper
• Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome.

  1995cited by this paper
• Biochemistry and molecular biology of the human CYP2C subfamily.

  1994cited by this paper
• Historical perspectives on conjugation-dependent bioactivation of foreign compounds.

  1994cited by this paper
• Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line.

  1994cited by this paper
• Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.

  1993cited by this paper
• Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies.

  1993cited by this paper
• Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA.

  1992cited by this paper
• Dexamethasone-mediated regulation of 3-methylcholanthrene-induced cytochrome P-450d mRNA accumulation in primary rat hepatocyte cultures.

  1990cited by this paper
• The role of glutathione and glutathione transferases in chemical carcinogenesis.

  1990cited by this paper
• Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

  1989cited by this paper
• Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line.

  1988cited by this paper
• Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts.

  1987cited by this paper

• A high-throughput liver-kidney metabolic interaction chip for insights into the nephrotoxicity mechanisms of triptolide.

  2026cites this paper
• Application of Induced Pluripotent Stem Cells (iPSCs) in Hereditary and Viral Diseases of the Liver: Modeling and Treatment

  2025cites this paper
• Diverse in vitro liver models reveal comprehensive biotransformation pathways of tetrabromobisphenol A.

  2025cites this paper
• The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba.

  2025cites this paper
• Molecular Precision Medicine: Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions Between Lidocaine and Rocuronium/Propofol/Paracetamol

  2025cites this paper
• Development of a New Approach Method to Monitor and Modify Caffeine Metabolism Correlated to CYP1A2 Expression

  2025cites this paper
• Establishment and validation of an in vitro liver model based extracellular matrix for hepatotoxicity prediction

  2025cites this paper
• Boswellia carteri Birdw. Resin Extract Induces Phase-I Cytochrome P-450 Enzyme Gene Expressions in Human Hepatocarcinoma (Hep G2) Cells: In vitro and in silico Studies

  2025cites this paper
• The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment.

  2025cites this paper
• A Review on New Frontiers in Drug-Drug Interaction Predictions and Safety Evaluations with In Vitro Cellular Models

  2025cites this paper
• Experimental models of liver-stage malaria: Progress, gaps, and challenges

  2025cites this paper
• Organic cation transporter 1 and cytochrome P450s play crucial roles in coptisine- and worenine-induced hepatotoxicity.

  2025cites this paper
• Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy.

  2025cites this paper
• Lessons Learned from Liver-on-Chip Platform

  2025cites this paper
• Early prediction of potential hepatotoxic metabolites to aid lead selection in drug discovery

  2025cites this paper
• In Vitro Evaluation of the Combined Toxicity of Pirimiphos-methyl and Piperonyl Butoxide.

  2025cites this paper
• Toxicological insights into graphene family materials: Cytochrome P450 modulation and cellular stress in liver cells.

  2025cites this paper
• Distribution of amiodarone between lipid nanocapsules and residual micelles: Tangential flow filtration as a purification method and its impact on cytotoxicity.

  2025cites this paper
• A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models

  2025cites this paper
• Per- and Polyfluoroalkyl Substances as Potentiators of Hepatotoxicity in an Exposome Framework: Current Challenges of Environmental Toxicology.

  2025cites this paper
• Targeting Tris(2,3-dibromopropyl) Isocyanurate-Induced Inflammation in Hippocampal Neurons In Vitro: Mechanistic Insights and Implications for Neurodegenerative Disease Prevention

  2025cites this paper
• Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans.

  2025cites this paper
• SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.

  2024cites this paper
• Genotoxicity testing of the anthraquinone dye Alizarin Red S

  2024cites this paper
• Artificial Cells and HepG2 Cells in 3D‐Bioprinted Arrangements

  2024cites this paper
• Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins

  2024cites this paper
• Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per- and polyfluoroalkyl substances.

  2024cites this paper
• Protocol to create phenotypic primary human hepatocyte cultures using the RASTRUM 3D cell model platform

  2024cites this paper
• Antagonistic effects of a COX1/2 inhibitor drug in human HepG2 cells exposed to an environmental carcinogen.

  2024cites this paper
• Upregulation of Fatty Acid Synthesis Genes in the Livers of Adolescent Female Rats Caused by Inhalation Exposure to PCB52 (2,2',5,5'-Tetrachlorobiphenyl).

  2024cites this paper
• Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization

  2024cites this paper
• The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review.

  2023cites this paper
• Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells

  2023cites this paper
• Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen

  2023cites this paper
• In vitro simulation of the liver first-pass effect with biotransformation-competent HepG2 cells to study effects of MG-132 on liver and cancer cells

  2023cites this paper
• Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma

  2023cites this paper
• Artificial cells eavesdropping on HepG2 cells

  2023cites this paper
• Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions

  2023cites this paper
• Evaluation of chemical grouping workflows for flavor inhalation risk assessment: selected furan moiety-containing chemicals as a case study

  2023cites this paper
• Involvement of peroxisome proliferator‐activated receptor gamma (PPARγ) and autophagic pathways in the mechanism of action of the tris(2,3‐dibromopropyl) isocyanurate (TDBP‐TAZTO or TBC) flame retardant in the lung adenocarcinoma (A549) cells in vitro

  2023cites this paper
• Cell Culture Systems for Studying Hepatitis B and Hepatitis D Virus Infections

  2023cites this paper
• Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity

  2023cites this paper
• Processing and Physicochemical Properties of Magnetite Nanoparticles Coated with Curcuma longa L. Extract

  2023cites this paper
• A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development

  2023cites this paper
• A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

  2023cites this paper
• Cryopreservation of Liver-Cell Spheroids with Macromolecular Cryoprotectants

  2023cites this paper
• In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells

  2023cites this paper
• Polycarbonate nanoplastics and the in vitro assessment of their toxicological impact on liver functionality

  2023cites this paper
• Primary Hepatocyte Isolation and Cultures: Technical Aspects, Challenges and Advancements

  2023cites this paper
• Methylated and ethylated dialkylphosphate metabolites of organophosphate pesticides: DNA damage in bone marrow cells of Balb/c mice.

  2023cites this paper
• In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red Assay.

  2022cites this paper
• Fluorine-thiol displacement probes for acetaminophen's hepatotoxicity

  2022cites this paper
• CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis.

  2022cites this paper
• Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1.

  2022cites this paper
• Towards 3D-bioprinted Models of the Liver to Boost Drug Development.

  2022cites this paper
• Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

  2022cites this paper
• Sub-Lethal Concentrations of Graphene Oxide Trigger Acute-Phase Response and Impairment of Phase-I Xenobiotic Metabolism in Upcyte® Hepatocytes

  2022cites this paper
• PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link

  2022cites this paper
• Artemisia extracts Differ from Artemisinin Effects on Human Hepatic CYP450s 2B6 and 3A4 in vitro

  2022cites this paper
• Development of an ectopic huLiver model for Plasmodium liver stage infection

  2022cites this paper
• Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease.

  2022cites this paper
• Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells.

  2022cites this paper
• Correlation between in vitro toxicity of pesticides and in vivo risk guidelines in support of complex operating site risk management: A meta-analysis.

  2022cites this paper
• Effect of rosiglitazone on 20-hydroxyeicosatetraenoic acid levels and CYP4F2 expression in HepG2 cells

  2022cites this paper
• Testing for food safety using human competent liver cells (HepG2)

  2022cites this paper
• CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver

  2022cites this paper
• A HepG2 Cell-Based Biosensor That Uses Stainless Steel Electrodes for Hepatotoxin Detection

  2022cites this paper
• In vitro culture at 39 °C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions

  2022cites this paper
• Spirulina platensis Ameliorates Oxidative Stress Associated with Antiretroviral Drugs in HepG2 Cells

  2022cites this paper
• Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics

  2022cites this paper
• Biological activities and antioxidant potential of different biosynthesized nanoparticles of Moringa oleifera

  2022cites this paper
• Rubus rosifolius (Rosaceae) stem extract induces cell injury and apoptosis in human hepatoma cell line.

  2022cites this paper
• Modelling urea cycle disorders using iPSCs

  2022cites this paper
• Studying the genotoxicity caused by sodium benzoate in liver cancer cell line (HEPG2) by comet assay

  2022cites this paper
• Evaluation of DNA-Damaging Effects Induced by Different Tanning Agents Used in the Processing of Natural Leather—Pilot Study on HepG2 Cell Line

  2022cites this paper
• Genotoxicity of pyrrolizidine alkaloids in metabolically inactive human cervical cancer HeLa cells co-cultured with human hepatoma HepG2 cells

  2022cites this paper
• Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.

  2022cites this paper
• Assembly and Disassembly of the Micropatterned Collagen Sheets Containing Cells for Location-Based Cellular Function Analysis

  2021cites this paper
• A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies

  2021cites this paper
• Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential.

  2021cites this paper
• Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.

  2021cites this paper
• Genotoxicity of selected pyrrolizidine alkaloids in human hepatoma cell lines HepG2 and Huh6.

  2021cites this paper
• Mechanistic evaluation of black cohosh extract-induced genotoxicity in human cells.

  2021cites this paper
• Cytotoxic and Genotoxic Effects of Cyanobacterial and Algal Extracts—Microcystin and Retinoic Acid Content

  2021cites this paper
• High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

  2021cites this paper
• Enhancement of active ingredients and biological activities of Nostoc linckia biomass cultivated under modified BG-110 medium composition

  2021cites this paper
• Human CYP enzyme-activated genotoxicity of 2,2',4,4'-tetrabromobiphenyl ether in mammalian cells.

  2021cites this paper
• Potential Antioxidant and Anticancer Activities of Secondary Metabolites of Nostoc linckia Cultivated under Zn and Cu Stress Conditions

  2021cites this paper
• Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells

  2021cites this paper
• In vitro evaluation of chromosomal damage and DNA strand breaks after treatment with the poppy seed alkaloid thebaine.

  2021cites this paper
• Human‐Based In Vitro Experimental Approaches for the Evaluation of Metabolism‐Dependent Drug Toxicity

  2021cites this paper
• Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line

  2021cites this paper
• Three-Dimensional Liver Culture Systems to Maintain Primary Hepatic Properties for Toxicological Analysis In Vitro

  2021cites this paper
• HepGentox: a novel promising HepG2 reportergene-assay for the detection of genotoxic substances in complex mixtures

  2021cites this paper
• Safe-by-design gelatin-modified zinc oxide nanoparticles

  2021cites this paper
• Application and research progress of in vitro liver cancer cell culture models

  2021cites this paper
• Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel.

  2021cites this paper
• Human CYP enzyme-activated clastogenicity of 2-ethylhexyl diphenyl phosphate (a flame retardant) in mammalian cells.

  2021cites this paper
• Chemoprotective Effects of Xanthohumol against the Carcinogenic Mycotoxin Aflatoxin B1

  2021cites this paper
• Antigenotoxic potential of the fermentation broth produced by Paenibacillus polymyxa RNC-D in vitro.

  2021cites this paper