Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

No abstract is available for this paper.

• Publication year

  2002

• Venue

  The Pharmacogenomics Journal

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/sj.tpj.6500087PMID 12049174
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002cited by this paper
• The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

  2001cited by this paper
• Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

  2001cited by this paper
• The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

  2000cited by this paper
• Humanized xenobiotic response in mice expressing nuclear receptor SXR

  2000cited by this paper
• Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.

  2000cited by this paper
• Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.

  2000cited by this paper
• The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver.

  2000cited by this paper
• Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

  2000cited by this paper
• The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR

  2000cited by this paper
• Reciprocal Activation of Xenobiotic Response Genes by Nuclear Receptors Sxr/pxr and Car

  2000cited by this paper
• The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

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• Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*

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• Induction and drug development.

  2000cited by this paper
• The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene*

  1999cited by this paper
• P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

  1999cited by this paper
• Cytochrome P-450 3A4: regulation and role in drug metabolism.

  1999cited by this paper
• Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

  1999cited by this paper
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  1999cited by this paper
• Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

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  1998cited by this paper
• Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene.

  1998cited by this paper
• The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

  1998cited by this paper
• In vitro and in vivo drug interactions involving human CYP3A.

  1998cited by this paper
• The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

  1998cited by this paper
• Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

  1998cited by this paper
• IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP 3 A

  1998cited by this paper
• An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

  1998cited by this paper
• Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene*

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• Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes (*)

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• 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.

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• The role of individual human cytochromes P450 in drug metabolism and clinical response.

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