Metalloproteinases in biology and pathology of the nervous system

Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and discuss the possible mechanisms of MMP action. We then consider some of the beneficial functions of MMPs during neural development and speculate on their roles in repair after brain injury. We also introduce a family of proteins known as ADAMs (a disintegrin and metalloproteinase), as some of the properties previously ascribed to MMPs are possibly the result of ADAM activity.

• Publication year

  2001

• Venue

  Nature Reviews Neuroscience

• Publication date

  2001-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/35081571PMID 11433375PMCID 7097548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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