Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cancer Research

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12615714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.

  2002cited by this paper
• Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.

  2002cited by this paper
• Quantitative Selection Constants

  2002influential reference
• Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.

  2002cited by this paper
• Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability.

  2001influential reference
• ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

  2001cited by this paper
• Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers.

  2001influential reference
• すい臓癌におけるACVR1B(ALK4、1B型アクチビン受容体)遺伝子の突然変異

  2001cited by this paper
• Structural insights on Smad function in TGFβ signaling

  2001cited by this paper
• Structural insights on Smad function in TGFbeta signaling.

  2001cited by this paper
• Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.

  2001cited by this paper
• A deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma.

  1999cited by this paper
• Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor.

  1999cited by this paper
• Structural alterations of transforming growth factor‐β receptor genes in human cervical carcinoma

  1999cited by this paper
• BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences.

  1999cited by this paper
• Familial pancreatic cancer.

  1999cited by this paper
• Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

  1999cited by this paper
• Human Smad3 and Smad4 are sequence-specific transcription activators.

  1998cited by this paper
• Genetics of pancreatic cancer. From genes to families.

  1998cited by this paper
• Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

  1998cited by this paper
• Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

  1998cited by this paper
• Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

  1998cited by this paper
• Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas.

  1998cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants

  1997cited by this paper
• Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

  1997cited by this paper
• Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

  1997cited by this paper
• Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

  1997cited by this paper
• Activation of signalling by the activin receptor complex

  1996cited by this paper
• DPC4 gene in various tumor types.

  1996cited by this paper
• Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

  1996cited by this paper
• A human Mad protein acting as a BMP-regulated transcriptional activator

  1996cited by this paper
• Receptor-associated Mad homologues synergize as effectors of the TGF-β response

  1996cited by this paper
• MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

  1996cited by this paper
• Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

  1996cited by this paper
• Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.

  1996cited by this paper
• DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

  1996cited by this paper
• Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

  1996cited by this paper
• Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

  1996cited by this paper
• MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

  1996cited by this paper
• Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers.

  1996cited by this paper
• Mad-related genes in the human

  1996cited by this paper
• Regulation of transforming growth factor (cid:98) - and activin-induced transcription by mammalian Mad proteins

  1996cited by this paper
• Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.

  1995influential reference
• Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

  1995cited by this paper
• Allelotype of pancreatic adenocarcinoma using xenograft enrichment.

  1995cited by this paper
• Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

  1995cited by this paper
• Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells (*)

  1995cited by this paper
• Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

  1994cited by this paper
• Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

  1994cited by this paper
• Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.

  1994cited by this paper
• Mechanism of activation of the TGF-beta receptor.

  1994cited by this paper
• Mechanism of activation of the TGF-β receptor

  1994cited by this paper
• Cloning of the human activin receptor cDNA reveals high evolutionary conservation.

  1992cited by this paper
• Expression cloning of an activin receptor, a predicted transmembrane serine kinase.

  1991cited by this paper
• Familial pancreatic cancer.

  1983cited by this paper
• Mendelian proportions in a mixed population. 1908.

  1908cited by this paper

• Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

  2023cites this paper
• Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer

  2022cites this paper
• Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis

  2021cites this paper
• Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer

  2021cites this paper
• The pancreatic cancer genome revisited

  2021cites this paper
• ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma

  2021cites this paper
• Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer

  2021cites this paper
• A novel 4-gene prognostic signature for hypermutated colorectal cancer

  2019influential citation
• Does the expression of the ACVR2A gene affect the development of colorectal cancer?

  2019cites this paper
• Diplomarbeit The Role of Activin A in Squamous Cell Cancer of the Lung zur Erlangung des akademischen

  2019influential citation
• Chapter 2 Molecular Genetics of Pancreatic Cancer

  2018cites this paper
• The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

  2018cites this paper
• Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview

  2018cites this paper
• MicroRNA‐194 protects against chronic hepatitis B‐related liver damage by promoting hepatocyte growth via ACVR2B

  2018cites this paper
• Next generation sequencing-based emerging trends in molecular biology of gastric cancer.

  2018cites this paper
• NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway

  2017cites this paper
• The Dual Role of Bone Morphogenetic Proteins in Cancer

  2017cites this paper
• Over-Expression of Activin-βC Is Associated with Murine and Human Prostate Disease.

  2017cites this paper
• Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.

  2016cites this paper
• A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer

  2016cites this paper
• Short mononucleotide repeat detection of MSI : towards high throughput diagnosis

  2016influential citation
• High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma

  2016influential citation
• Molecular evolution of colorectal cancer: from multistep carcinogenesis to the big bang

  2016cites this paper
• Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras

  2016cites this paper
• Esophageal squamous cell carcinoma invasion is inhibited by Activin A in ACVRIB-positive cells

  2016cites this paper
• Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma

  2015cites this paper
• Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

  2015cites this paper
• Coding Microsatellite Frameshift Mutations Accumulate in Atherosclerotic Carotid Artery Lesions: Evaluation of 26 Cases and Literature Review

  2015cites this paper
• Detection of coding microsatellite frameshift mutations in DNA mismatch repair‐deficient mouse intestinal tumors

  2015cites this paper
• Activin A balance regulates epithelial invasiveness and tumorigenesis

  2014cites this paper
• Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

  2014cites this paper
• De Novo Proteome Analysis of Genetically Modified Tumor Cells By a Metabolic Labeling/Azide-alkyne Cycloaddition Approach*

  2014cites this paper
• Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer.

  2014cites this paper
• Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis

  2014cites this paper
• by transcriptional slippage in colorectal cancer

  2013cites this paper
• Inhibition of Pancreatitis and Carcinogenesis by Capsaicin

  2013cites this paper
• TGF-ß Signaling Pathway and Colorectal Cancer

  2013cites this paper
• associated polyposis colorectal cancers

  2013cites this paper
• MLH1‐silenced and non‐silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes

  2013cites this paper
• Mismatch repair and MUTYH deficient colorectal cancers : at the crossroad of genomic stability and immune escape

  2013cites this paper
• Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells

  2012cites this paper
• Effects of Activin and TGFβ on p21 in Colon Cancer

  2012cites this paper
• Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2).

  2012influential citation
• Target genes of microsatellite sequences in head and neck squamous cell carcinoma: mononucleotide repeats are not detected.

  2012cites this paper
• Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers.

  2012cites this paper
• Whole-genome reconstruction and mutational signatures in gastric cancer

  2012cites this paper
• Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

  2011cites this paper
• The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways.

  2011cites this paper
• The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting

  2011cites this paper
• Molecular damage in cancer: an argument for mTOR-driven aging

  2011cites this paper
• The role of bone morphogenetic proteins in normal and malignant lymphocytes

  2011cites this paper
• Identification of frequently mutated genes with relevance to nonsense mediated mRNA decay in the high microsatellite instability cancers

  2011cites this paper
• The Transcriptomic and Genomic Analysis of Lamin A/C Expression in the Colon and in Colorectal Cancer

  2011cites this paper
• Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications

  2011cites this paper
• Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality.

  2011cites this paper
• Metastasis of Colorectal Cancer

  2010cites this paper
• Genesis of Pancreatic Ductal Neoplasia

  2010cites this paper
• THE GENETICS OF COLORECTAL CANCER

  2010cites this paper
• Immune evasion of microsatellite unstable colorectal cancers

  2010cites this paper
• Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.

  2010cites this paper
• The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy.

  2010cites this paper
• Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair.

  2010influential citation
• Flanking Sequence Specificity Determines Coding Microsatellite Heteroduplex and Mutation Rates with Defective DNA Mismatch Repair (MMR)

  2010influential citation
• Procédés de promotion de la croissance musculaire

  2010cites this paper
• Activin inhibits telomerase activity in cancer.

  2009cites this paper
• Cyfip1 is a putative invasion suppressor in epithelial cancers.

  2009cites this paper
• High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability.

  2009cites this paper
• Activin Signaling in Microsatellite Stable Colon Cancers Is Disrupted by a Combination of Genetic and Epigenetic Mechanisms

  2009cites this paper
• Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects

  2009cites this paper
• Activin is a potent growth suppressor of epithelial ovarian cancer cells.

  2009cites this paper
• Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.

  2009cites this paper
• Functional characterization of MutL homologue mismatch repair proteins and their variants

  2009cites this paper
• EVIEW Signal Transduction Pathway through Activin Receptors as a Therapeutic Target of Musculoskeletal Diseases and Cancer

  2008cites this paper
• Bone morphogenetic protein and activin signaling in colorectal cancer

  2008cites this paper
• Activins and the Liver

  2008cites this paper
• Genetic Pathways in Pancreatic Tumorigenesis

  2008cites this paper
• Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer.

  2008cites this paper
• Pancreatic Carcinogenesis

  2008cites this paper
• Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression

  2008cites this paper
• Molecular Genetics of Pancreatic Cancer

  2008cites this paper
• Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability

  2008cites this paper
• Mutation Rates of TGFBR2 and ACVR2 Coding Microsatellites in Human Cells with Defective DNA Mismatch Repair

  2008influential citation
• Activins and activin antagonists in hepatocellular carcinoma.

  2008cites this paper
• Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer

  2007cites this paper
• Intraovarian activins are required for female fertility.

  2007cites this paper
• Microsatellite Instability in Pediatric and Adult High‐grade Gliomas

  2007cites this paper
• FUNCTIONS OF PERK eIF2-alpha KINASE IN THE MOUSE PANCREATIC Beta-CELLS

  2007cites this paper
• Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

  2007cites this paper
• The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers

  2007cites this paper
• Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study

  2007cites this paper
• Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.

  2007cites this paper
• Deregulation of the activin/follistatin system in hepatocarcinogenesis.

  2006cites this paper
• Alterations in components of the TGF-beta superfamily signaling pathways in human cancer.

  2006influential citation
• Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: Considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers

  2006cites this paper
• Bone morphogenetic protein signaling and growth suppression in colon cancer.

  2006cites this paper
• Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer

  2006cites this paper
• Tetranucleotide repeats in coding regions: no evidence for involvement in EMAST carcinogenesis

  2006cites this paper
• Multiple-criterion evaluation of reported mutations: A proposed scoring system for the intragenic somatic mutation literature

  2006cites this paper
• Microsatellite instability in the development of DNA mismatch repair deficient tumors

  2006cites this paper
• Elegance, silence and nonsense in the mutations literature for solid tumors

  2006cites this paper