Integrated Transcriptional and Proteomic Analysis of Growth Hormone Suppression Mediated by Trichothecene T-2 Toxin in Rat GH3 Cells.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Toxicological Sciences

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/toxsci/kfv131PMID 26141394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2007cited by this paper
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  2003influential reference
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• Effect of intraperitoneal infusion of deoxynivalenol on feed consumption and weight gain in the pig.

  1998cited by this paper
• Identification of Protoceratium reticulatum as the biogenetic origin of yessotoxin.

  1998cited by this paper
• Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

  1997cited by this paper
• Generation and analysis of 280,000 human expressed sequence tags.

  1996cited by this paper
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  1996cited by this paper
• Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae.

  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Hsp90 chaperones protein folding in vitro

  1992cited by this paper
• Distribution of deoxynivalenol in cerebral spinal fluid following administration to swine and sheep.

  1990cited by this paper
• Transmission of residues to eggs following long-term administration of 14C-labelled deoxynivalenol to laying hens.

  1989cited by this paper
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  1975cited by this paper

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