Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Toxicology Letters

• Publication date

  2004-10-10

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/J.TOXLET.2004.04.023PMID 15342082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol).

  2003cited by this paper
• Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin.

  2003cited by this paper
• Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo.

  2003cited by this paper
• Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G.

  2003cited by this paper
• Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin).

  2003cited by this paper
• Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions.

  2003cited by this paper
• Non-receptor protein tyrosine kinases.

  2003cited by this paper
• Relationship of Trichothecene Structure to Cox-2 Induction in the Macrophage: Selective Action of Type B (8-Keto) Trichothecenes

  2003cited by this paper
• Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response.

  2003cited by this paper
• Induction of apoptosis by 4-acetyl-12,13-epoxyl-9-trichothecene-3,15-diol from Isaria japonica Yasuda through intracellular reactive oxygen species formation and caspase-3 activation in human leukemia HL-60 cells.

  2003cited by this paper
• Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response

  2002cited by this paper
• The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity.

  2002cited by this paper
• Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases.

  2002cited by this paper
• Fusarenon-X induced apoptosis in HL-60 cells depends on caspase activation and cytochrome c release.

  2002cited by this paper
• Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids.

  2002cited by this paper
• MAP kinases in the immune response.

  2002cited by this paper
• Protein Kinase R Regulates Double-Stranded RNA Induction of TNF-α But Not IL-1β mRNA in Human Epithelial Cells1

  2002cited by this paper
• Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells.

  2002cited by this paper
• Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3.

  2002cited by this paper
• EFFECTS OF VOMITOXIN (DEOXYNIVALENOL) ON THE BINDING OF TRANSCRIPTION FACTORS AP-1, NF-κB, AND NF-IL6 IN RAW 264.7 MACROPHAGE CELLS

  2002cited by this paper
• DIFFERENTIAL UPREGULATION OF TNF-α, IL-6, AND IL-8 PRODUCTION BY DEOXYNIVALENOL (VOMITOXIN) AND OTHER 8-KETOTRICHOTHECENES IN A HUMAN MACROPHAGE MODEL

  2001cited by this paper
• Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization.

  2001cited by this paper
• Signal Integration via PKR

  2001cited by this paper
• Post-transcriptional Control of Cyclooxygenase-2 Gene Expression

  2000cited by this paper
• Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation.

  2000cited by this paper
• The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

  2000cited by this paper
• Sick Building Syndrome. III. Stachybotrys chartarum

  2000cited by this paper
• Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol).

  2000cited by this paper
• Cyclooxygenases: structural, cellular, and molecular biology.

  2000cited by this paper
• Immunomodulation by fungal toxins.

  2000cited by this paper
• Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.

  2000cited by this paper
• Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion.

  2000cited by this paper
• Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol).

  1999cited by this paper
• Trichothecene Mycotoxins Trigger a Ribotoxic Stress Response That Activates c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase and Induces Apoptosis*

  1999cited by this paper
• Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

  1999cited by this paper
• Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

  1999cited by this paper
• MAP kinase pathways.

  1999cited by this paper
• Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol).

  1998cited by this paper
• Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery.

  1998cited by this paper
• T-2 toxin induces thymic apoptosis in vivo in mice.

  1998cited by this paper
• T-2 Toxin-Induced Apoptosis in Hematopoietic Tissues of Mice

  1998cited by this paper
• Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line.

  1998cited by this paper
• Modulation of IL-1β, IL-6 and TNF-α secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line

  1998cited by this paper
• The process of ultrastructural changes from nuclei to apoptotic body

  1998cited by this paper
• Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice.

  1998cited by this paper
• Induction of apoptosis with fusarenon-X in mouse thymocytes.

  1998cited by this paper
• Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure.

  1998cited by this paper
• Process of the development of T-2 toxin-induced apoptosis in the lymphoid organs of mice.

  1997cited by this paper
• Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin.

  1997cited by this paper
• Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta.

  1997cited by this paper
• A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis.

  1997cited by this paper
• T-2 toxin-induced apoptosis in lymphoid organs of mice.

  1997cited by this paper
• Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA

  1997cited by this paper
• Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course.

  1997cited by this paper
• Superinduction of COX‐2 mRNA by cycloheximide and interleukin‐1β involves increased transcription and correlates with increased NF‐κB and JNK activation

  1997cited by this paper
• Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability.

  1997cited by this paper
• Scab of Wheat and Barley: A Re-emerging Disease of Devastating Impact.

  1997cited by this paper
• Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β ☆

  1997cited by this paper
• An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

  1996cited by this paper
• Toxicology of deoxynivalenol (vomitoxin).

  1996cited by this paper
• Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells.

  1996cited by this paper
• Non-Macrocyclic Trichothecenes, Part 2 (1)

  1996cited by this paper
• Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells.

  1995cited by this paper
• Effects of dihydrotestosterone and estradiol on experimental IgA nephropathy induced by vomitoxin.

  1995cited by this paper
• Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells.

  1995cited by this paper
• Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition.

  1995cited by this paper
• Polyclonal autoreactive IgA increase and mesangial deposition during vomitoxin-induced IgA nephropathy in the BALB/c mouse.

  1994cited by this paper
• Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma.

  1994cited by this paper
• Role of gender and strain in vomitoxin-induced dysregulation of IgA production and IgA nephropathy in the mouse.

  1994cited by this paper
• Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection.

  1994cited by this paper
• Polyspecific and autoreactive IgA secreted by hybridomas derived from Peyer's patches of vomitoxin-fed mice: characterization and possible pathogenic role in IgA nephropathy.

  1994cited by this paper
• In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion.

  1994cited by this paper
• Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells.

  1994cited by this paper
• Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol).

  1993cited by this paper
• Persistent Dysregulation of IgA Production and IgA Nephropathy in the B6C3F1 Mouse Following Withdrawal of Dietary Vomitoxin (Deoxynivalenol)

  1993cited by this paper
• Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens.

  1992cited by this paper
• Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy.

  1991cited by this paper
• Murine lymphocyte proliferation impaired by substituted neosolaniols and calonectrins--Fusarium metabolites associated with trichothecene biosynthesis.

  1991cited by this paper
• Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells.

  1991cited by this paper
• Uptake of the naturally occurring 3-α-hydroxy isomer of T-2 toxin by a murine B cell hybridoma

  1990cited by this paper
• Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol).

  1990cited by this paper
• Immunotoxicity testing of mycotoxins T-2 and patulin on Balb/c mice.

  1990cited by this paper
• Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer's patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol).

  1990cited by this paper
• Immunosuppressive effects of four trichothecene mycotoxins.

  1990cited by this paper
• Effects of macrocyclic trichothecene congeners on the viability and mitogenesis of murine splenic lymphocytes.

  1990cited by this paper
• Uptake of the naturally occurring 3-alpha-hydroxy isomer of T-2 toxin by a murine B cell hybridoma.

  1990cited by this paper
• Effect of dietary administration of the trichothecene vomitoxin (deoxynivalenol) on IgA and IgG secretion by Peyer's patch and splenic lymphocytes.

  1990cited by this paper
• T-2 toxin impairment of murine response to Salmonella typhimurium: a histopathologic assessment

  1990cited by this paper
• Effects of macrocyclic trichothecene mycotoxins on the murine immune system

  1989cited by this paper
• Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin.

  1989cited by this paper
• Binding of T-2 toxin to eukaryotic cell ribosomes.

  1989cited by this paper
• Immunosuppressive properties of deoxynivalenol.

  1988cited by this paper
• Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin A and verrucarin A.

  1988cited by this paper
• In vitro effects of T-2 toxin on the mitogen responsiveness and antibody-producing ability of human lymphocytes.

  1988cited by this paper
• Antibody producing ability of mouse spleen cells after subacute dietary exposure to T-2 toxin.

  1988cited by this paper
• Non-macrocyclic trichothecenes.

  1988cited by this paper
• Uptake and metabolism of T-2 toxin in relation to its cytotoxicity in lymphoid cells.

  1988cited by this paper
• Effects of verrucarin A and roridin A, macrocyclic trichothecene mycotoxins, on the murine immune system.

  1988cited by this paper
• Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice.

  1988cited by this paper
• Immunological responsiveness of mouse spleen cells after in vivo or in vitro exposure to 3-acetyldeoxynivalenol.

  1987cited by this paper

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