The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Neuroimmune Pharmacology

• Publication date

  2014-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11481-013-9514-0PMID 24233519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
• Novel multi-functional nitrones for treatment of ischemic stroke.

  2012influential reference
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  2012cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice

  2008influential reference
• Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.

  2008cited by this paper
• Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.

  2008cited by this paper
• Neurotoxicity of MPTP to migrating neuroblasts: studies in acute and subacute mouse models of Parkinson's disease.

  2008influential reference
• Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease.

  2008cited by this paper
• Effect of Radical Scavenger N-Tert-Butyl-α-Phenylnitrone on Stroke in a Rat Model Using a Telemetric System

  2008cited by this paper
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  2007cited by this paper
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  2005cited by this paper
• Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

  2004influential reference
• Tetramethylpyrazine reduces ischemic brain injury in rats.

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Triggering and modulation of apoptosis by oxidative stress.

  2000cited by this paper
• Parkinson's disease. Second of two parts.

  1998cited by this paper
• A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

  1998cited by this paper
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  1998cited by this paper
• Understanding cell death in parkinson's disease

  1998cited by this paper
• Parkinson's disease. First of two parts.

  1998cited by this paper
• Oxidative stress and antioxidant therapy in Parkinson's disease.

  1996cited by this paper
• Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart

  1996cited by this paper
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  1989cited by this paper

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  2020cites this paper
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  2020cites this paper
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