The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207074PMID 14724566
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

  2019cited by this paper
• Tumor suppression by Ink4a-Arf: progress and puzzles.

  2003cited by this paper
• Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model

  2003cited by this paper
• p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

  2003cited by this paper
• Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

  2002influential reference
• Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

  2002cited by this paper
• ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization

  2002cited by this paper
• Constitutive telomerase expression promotes mammary carcinomas in aging mice

  2002cited by this paper
• p19ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

  2002cited by this paper
• INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence

  2002cited by this paper
• Germline mutation of ARF in a melanoma kindred.

  2002cited by this paper
• A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

  2002influential reference
• Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

  2001cited by this paper
• Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

  2001cited by this paper
• Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

  2001influential reference
• A melanoma-associated germline mutation in exon 1β inactivates p14ARF

  2001cited by this paper
• Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

  2001cited by this paper
• Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

  2001influential reference
• Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.

  2001influential reference
• A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.

  2001cited by this paper
• Differential effects of p19Arf and p16Ink4a loss on senescence of murine bone marrow-derived preB cells and macrophages

  2001cited by this paper
• Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex

  2000cited by this paper
• Cellular senescence: mitotic clock or culture shock?

  2000cited by this paper
• Cellular senescence: mitotic clock or culture shock?

  2000cited by this paper
• Senescence of human fibroblasts induced by oncogenic Raf.

  1998cited by this paper
• Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

  1998cited by this paper
• The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.

  1998cited by this paper
• Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

  1998cited by this paper
• Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

  1998cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997influential reference
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

  1997cited by this paper
• Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

  1996cited by this paper
• Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.

  1996cited by this paper
• Role of the INK4a locus in tumor suppression and cell mortality.

  1996influential reference
• Germline p16 mutations in familial melanoma

  1994cited by this paper
• A cell cycle regulator potentially involved in genesis of many tumor types.

  1994cited by this paper
• Minireview Parsing Ink4a/arf: " Pure " P16-null Mice

  year unknowncited by this paper

• Neuroendocrine-associated epigenetic factors in cellular senescence: mechanisms and therapeutic implications

  2026cites this paper
• Regulatory Roles of Exosomes in Aging and Aging-Related Diseases

  2025cites this paper
• Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.

  2025cites this paper
• Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects.

  2025cites this paper
• Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism

  2025cites this paper
• Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies

  2025cites this paper
• Guidelines for minimal information on cellular senescence experimentation in vivo.

  2024cites this paper
• The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis

  2024cites this paper
• Targeting aging and age-related diseases with vaccines

  2024cites this paper
• SATB1, senescence and senescence‐related diseases

  2024cites this paper
• Aging microenvironment and antitumor immunity for geriatric oncology: the landscape and future implications

  2023cites this paper
• ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

  2023cites this paper
• Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.

  2023cites this paper
• Immortalized murine tenocyte cells: a novel and innovative tool for tendon research

  2023cites this paper
• CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny

  2023cites this paper
• Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

  2023cites this paper
• A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse.

  2023cites this paper
• Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

  2023cites this paper
• Vascular diseases

  2022cites this paper
• Generation of mice for evaluating endogenous p16Ink4a protein expression.

  2022cites this paper
• Genome-wide association analysis identifies a susceptibility locus for sporadic vestibular schwannoma at 9p21

  2022cites this paper
• Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice

  2022cites this paper
• Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

  2022cites this paper
• Exploiting senescence for the treatment of cancer

  2022cites this paper
• Establishment methods and research progress of livestock and poultry immortalized cell lines: A review

  2022cites this paper
• Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment

  2022cites this paper
• A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression

  2022cites this paper
• It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy

  2022cites this paper
• Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis

  2021cites this paper
• Cancer of Exocrine Pancreas

  2021cites this paper
• Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

  2021cites this paper
• Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

  2021cites this paper
• Characterization of a base-resolution common deletion region within CDKN2A gene in cancers and its biological and clinical significances

  2021cites this paper
• Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy

  2021cites this paper
• CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

  2020cites this paper
• Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

  2020cites this paper
• Cellular Senescence: Mechanisms, Morphology, and Mouse Models

  2020cites this paper
• Post-Translational Regulation of ARF: Perspective in Cancer

  2020cites this paper
• Specific deletion of p16INK4a with retention of p19ARF enhances the development of invasive oral squamous cell carcinoma.

  2020cites this paper
• CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway.

  2020cites this paper
• DNA methylation and chromatin modifiers in colorectal cancer.

  2019cites this paper
• p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.

  2019cites this paper
• The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites

  2019cites this paper
• Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

  2019cites this paper
• Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools

  2019cites this paper
• Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum

  2019cites this paper
• Investigation of the Tumour Promoting Effects of Cellular Senescence During Pituitary and Lung Tumourigenesis

  2019cites this paper
• Cellular Senescence and the Immune System in Cancer

  2019cites this paper
• Mass Spectrometry-Based Proteomics Analysis of Secreted Proteins

  2018cites this paper
• Effects of Cranial Irradiation on Adult Hippocampal Neuronal Development and the Role of p53

  2018influential citation
• The Key Role of E2F in Tumor Suppression through Specific Regulation of Tumor Suppressor Genes in Response to Oncogenic Changes

  2018cites this paper
• p16 – Connecting Cell Cycle Control to Cell Death Regulation in Human Leukemia

  2018cites this paper
• Overcoming palbociclib resistance by combined treatment with PI3K/AKT/mTOR inhibitors in mesothelioma cells

  2018cites this paper
• Mammalian Development and Cancer: A Brief History of Mice Lacking D-Type Cyclins or CDK4/CDK6

  2018cites this paper
• Two-Step Senescence-Focused Cancer Therapies.

  2018cites this paper
• Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

  2018cites this paper
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  2018cites this paper
• Ashwagandha Bioactives for Cancer Treatment: Experimental Evidence and Their Mechanism(s) of Action

  2017cites this paper
• Characterization of a Novel Mouse Model for Angiosarcoma in Which Combined Inhibition of mTOR and MEK Results in Tumor Suppression

  2017cites this paper
• 7 p 16 INK 4 A – Connecting Cell Cycle Control to Cell Death Regulation in Human Leukemia

  2017cites this paper
• Chapter 27 – Genetically Modified Animal Models

  2017cites this paper
• Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

  2017cites this paper
• IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent

  2017cites this paper
• Senotherapy: growing old and staying young?

  2017cites this paper
• Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.

  2017cites this paper
• Senescent cells: an emerging target for diseases of ageing

  2017cites this paper
• Cellular senescence in renal ageing and disease

  2017cites this paper
• Dynamics of ARF regulation that control senescence and cancer

  2016cites this paper
• Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors

  2016cites this paper
• Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles.

  2016cites this paper
• Germline hemizygous deletion of CDKN2A–CDKN2B locus in a patient presenting with Li–Fraumeni syndrome

  2016cites this paper
• The INK4a/ARF Locus

  2016cites this paper
• Phosphorylation et régulation de l’E3 ubiquitine ligase MDM2 par la protéine kinase RSK dans les mélanomes

  2016cites this paper
• Mechanisms regulating stem cell phenotype in infantile hemangioma

  2016cites this paper
• Targeting the Cell Cycle and p53 in Combination with BRAF-Directed Therapy

  2015cites this paper
• Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice

  2015cites this paper
• Dysplastic Nevi Versus Melanoma

  2015cites this paper
• Modelling the multi-step process of tumorigenesis in pigs

  2015cites this paper
• Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus.

  2015cites this paper
• Stress factor – dependent differences in molecular mechanisms of premature cell senescence

  2015cites this paper
• Epigenetics Territory and Cancer

  2015cites this paper
• Malignant Rhabdoid Tumor: Epigenetic Mechanism of Tumorogenesis

  2015cites this paper
• Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice.

  2014cites this paper
• Identification of high-risk patients with clear cell renal cell carcinoma based on interphase-FISH

  2014cites this paper
• Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a

  2014cites this paper
• Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas

  2014cites this paper
• ARF tumor suppression in the nucleolus.

  2014cites this paper
• p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation.

  2014cites this paper
• Slug regulates E‐cadherin repression via p19Arf in prostate tumorigenesis

  2014cites this paper
• Meningioma progression in mice triggered by Nf2 and Cdkn2ab inactivation

  2013cites this paper
• Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

  2013cites this paper
• Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma , including regulatory variants near CDKN 2 A / B

  2013cites this paper
• DNA Repair mechanisms in glioblastoma cancer stem cells

  2013cites this paper
• Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice

  2013cites this paper
• Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor

  2013cites this paper
• Molecular mechanisms underlying the neuroprotective effect of IGF-1 in neuroblastoma cells and the pro-metastatic effect of Dph3 in murine melanoma cells

  2013cites this paper
• Genetically Modified Animal Models

  2013cites this paper
• Role of oxidative stress and the microenvironment in breast cancer development and progression.

  2013cites this paper
• Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

  2013cites this paper
• Mechanisms that control the growth of cells in the presence of replication stress

  2013cites this paper