Renin Gene Polymorphisms in Bangladeshi Hypertensive Population

Objective: Linkages of renin gene polymorphisms with hypertension have been implicated in several populations with contrasting results. Present study aims to assess the pattern of renin gene polymorphisms in Bangladeshi hypertensive individuals. Methodology: Introns 1, 9 of renin gene and 4063 bases upstream of promoter sequence of renin gene were amplified from the genomic DNA of the total 124 (hypertensive and normotensive) subjects using respective primers. Polymerase chain reaction-based restriction fragment length polymorphisms were performed using BglI, MboI and TaqI restriction enzymes. Results: Homozygosity was common in renin gene regarding BglI (bb=48.4%, Bb=37.9%, BB=13.7%, χ2 =1.91, P>0.05), TaqI (TT=81.5%, Tt=14.5%, tt=4.0%, χ2 =7.50, P<0.01) and MboI (mm=63.7%, Mm=32.3%, MM=4.0%, χ2=0.00, P>0.05) polymorphisms among total study population. For BglI and TaqI genotype distribution, hypertensive subjects (BglI: χ2 =6.66, P<0.05; TaqI: χ2 = 10.28, P<0.005) significantly deviate from Hardy-Weinberg Equilibrium law compared to normotensive subjects (BglI: χ2=0.51, P>0.05; TaqI: χ2=0.20, P>0.05). On the other hand, with respect to MboI polymorphisms of renin gene, only normotensive subjects deviate from the law (patients: χ2=1.28, P>0.05; vs controls: χ2=6.81, P<0.01). In the context of allelic frequency, common T allele was clearly prevalent (T frequency=0.86, t frequency = 0.14) for TaqI, but rare alleles b and m were more frequent for both BglI (b frequency=0.69, B frequency=0.31) and MboI (m frequency=0.80 M frequency=0.20) polymorphisms, respectively. Conclusion: Thus, we report that Bangladeshi hypertensive subjects did not show any distinct pattern of renin gene polymorphisms compared to their healthy control subjects with regard to their genotypic and allelic frequencies.

• Publication year

  2014

• Venue

  Journal of Genomics

• Publication date

  2014-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.7150/jgen.5193PMID 25057323PMCID 4105428
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).

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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.

  2001cited by this paper
• Cardiovascular Risk Factors: Distribution and Prevalence in a Rural Population of Bangladesh

  2001cited by this paper
• Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study

  2001cited by this paper
• Essential hypertension. Part I: definition and etiology.

  2000cited by this paper
• Genetic determination of human essential hypertension.

  2000cited by this paper
• Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)

  2000influential reference
• Linkage analysis of candidate genes and gene-gene interactions in chinese hypertensive sib pairs.

  1999cited by this paper
• Human renin gene BglI dimorphism associated with hypertension in two independent populations

  1999influential reference
• Renin gene MboI dimorphism is a discriminator for hypertension in hyperlipidaemic subjects.

  1999cited by this paper
• Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study

  1999cited by this paper
• Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy.

  1999cited by this paper
• An MboI two-allele polymorphism may implicate the human renin gene in primary hypertension.

  1998cited by this paper
• Epidemiology and the Prevention of Hypertension

  1997cited by this paper
• Parental hypertension and cardiac alterations in normotensive children and adolescents.

  1996cited by this paper
• Role of the renin-angiotensin system in blood pressure regulation and in human hypertension: new insights from molecular genetics.

  1995cited by this paper
• Correlations between RFLPs of the human renin gene locus and clinical variables of blood pressure regulation

  1995influential reference
• Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body.

  1995cited by this paper
• Molecular basis of human hypertension: the role of angiotensin.

  1995cited by this paper
• No effect of a BglI polymorphism at the renin (REN) locus on blood pressure level or variability

  1994cited by this paper
• Linkage of the angiotensinogen gene to essential hypertension.

  1994cited by this paper
• RENIN AND ANGIOTENSIN‐CONVERTING ENZYME GENOTYPES IN PATIENTS WITH ESSENTIAL HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY

  1994cited by this paper
• Linkage of the angiotensinogen gene to essential hypertension.

  1994cited by this paper
• Renin gene restriction fragment length polymorphisms in a Japanese family with a high incidence of essential hypertension.

  1992influential reference
• Renin and atrial natriuretic peptide restriction fragment length polymorphisms: association with ethnicity and blood pressure.

  1991cited by this paper
• Health implications of obesity.

  1991cited by this paper
• Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

  1990cited by this paper
• Restriction fragment length polymorphisms for the renin gene in Dahl rats

  1989cited by this paper
• A Lack of Genetic Linkage of Renin Gene Restriction Fragment Length Polymorphisms With Human Hypertension

  1989cited by this paper
• Frequency in hypertensives of alleles for a RFLP associated with the renin gene.

  1988cited by this paper
• Health implications of obesity

  1987cited by this paper
• Structure of the human renin gene.

  1984cited by this paper
• Structure of the human renin gene.

  1984cited by this paper
• The renin-angiotensin system (first of two parts).

  1974cited by this paper
• The renin-angiotensin system (second of two parts).

  1974cited by this paper

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