Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Neurotrauma

• Publication date

  2014-07-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1089/neu.2013.3250PMID 24428562PMCID PMC4108941
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amantadine Improves Cognitive Outcome and Increases Neuronal Survival after Fluid Percussion Traumatic Brain Injury in Rats

  2014cited by this paper
• The Rho-Kinase (ROCK) Inhibitor Y-27632 Protects Against Excitotoxicity-Induced Neuronal Death In Vivo and In Vitro

  2013cited by this paper
• Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling.

  2013cited by this paper
• NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia.

  2013cited by this paper
• The regulation of N‐methyl‐d‐aspartate receptors by Src kinase

  2012cited by this paper
• Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.

  2012cited by this paper
• The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients

  2012cited by this paper
• Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

  2012cited by this paper
• n improved method of transcutaneous cisterna magna puncture for erebrospinal fluid sampling in rats ahamad

  2012cited by this paper
• Regulation of NMDA receptors by the tyrosine kinase Fyn

  2012cited by this paper
• Endogenous anticoagulants.

  2012cited by this paper
• Neurosurgical complications of direct thrombin inhibitors--catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatran.

  2012cited by this paper
• Cooperative Role of Caveolin-1 and C-Terminal Src Kinase Binding Protein in C-Terminal Src Kinase-Mediated Negative Regulation of c-Src

  2011cited by this paper
• Cell Cycle Phase Transitions: Signposts for Aberrant Cell Cycle Reentry in Dying Mature Neurons

  2011cited by this paper
• Gastric Schwannoma, an Unusual Synchronous Tumor with Renal Cell

  2011cited by this paper
• Intracranial hemorrhage: mechanisms of secondary brain injury.

  2011cited by this paper
• The dual role of SRC kinases in intracerebral hemorrhage.

  2011cited by this paper
• Effect of Src Kinase Phosphorylation on Disordered C-terminal Domain of N-Methyl-d-aspartic Acid (NMDA) Receptor Subunit GluN2B Protein*

  2011cited by this paper
• Hippocampal Theta Dysfunction after Lateral Fluid Percussion Injury

  2010cited by this paper
• Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths, 2002-2006

  2010cited by this paper
• Experimental traumatic brain injury

  2010cited by this paper
• Fluid-percussion–induced traumatic brain injury model in rats

  2010cited by this paper
• Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop.

  2010cited by this paper
• Blood–brain barrier breakdown and repair by Src after thrombin‐induced injury

  2010influential reference
• Technique for collection of cerebrospinal fluid from the cisterna magna in rat.

  2010cited by this paper
• Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle

  2009cited by this paper
• BMC Emergency Medicine BioMed Central

  2008cited by this paper
• Lactation failure in Src knockout mice is due to impaired secretory activation

  2008cited by this paper
• Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons.

  2008cited by this paper
• Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo.

  2007cited by this paper
• NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo

  2007cited by this paper
• Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage

  2007cited by this paper
• Impairment of decidualization in SRC-deficient mice

  2007cited by this paper
• Mechanisms of brain injury after intracerebral haemorrhage.

  2006cited by this paper
• Combination of Thrombin and Matrix Metalloproteinase-9 Exacerbates Neurotoxicity in Cell Culture and Intracerebral Hemorrhage in Mice

  2006cited by this paper
• Asymptomatic sinovenous thrombosis in a healthy neonate

  2006cited by this paper
• Activation of Rho after traumatic brain injury and seizure in rats.

  2006cited by this paper
• Prevalence and prognosis of traumatic intraventricular hemorrhage in patients with blunt head trauma.

  2006cited by this paper
• Development of a Percutaneous Cerebrospinal Fluid Collection Technique in F-344 Rats and Evaluation of Cell Counts and Total Protein Concentrations

  2006cited by this paper
• Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths

  2006cited by this paper
• Inactivation of Src Family Tyrosine Kinases by Reactive Oxygen Species in Vivo*

  2005cited by this paper
• Intracerebral Hemorrhage

  2005cited by this paper
• Long term survival after primary intracerebral haemorrhage: a retrospective population based study

  2005cited by this paper
• Impairment of Decidualization in SRC-Deficient Mice1

  2005cited by this paper
• Lateral Fluid Percussion Brain Injury: A 15-Year Review and Evaluation

  2005cited by this paper
• Src family kinases, key regulators of signal transduction

  2004cited by this paper
• Src kinases: a hub for NMDA receptor regulation

  2004cited by this paper
• The neurophysiology of brain injury.

  2004cited by this paper
• Experimental Intracerebral Hemorrhage in Rat Glutamate Receptor Blockade Attenuates Glucose Hypermetabolism in Perihematomal

  2004cited by this paper
• Neuroprotection in the rat lateral fluid percussion model of traumatic brain injury by SNX-185, an N-type voltage-gated calcium channel blocker.

  2004cited by this paper
• Thrombin Signaling in the Brain: The Role of Protease-Activated Receptors

  2003cited by this paper
• Drug delivery to the central nervous system: a review.

  2003cited by this paper
• The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

  2002cited by this paper
• PAR3 is a cofactor for PAR4 activation by thrombin

  2000cited by this paper
• Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.

  1999cited by this paper
• NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

  1997cited by this paper
• Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

  1997cited by this paper
• Cellular functions regulated by Src family kinases.

  1997cited by this paper
• Protease-activated receptor 3 is a second thrombin receptor in humans

  1997cited by this paper
• Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

  1996cited by this paper
• Expression Cloning and Characterization of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation

  1992cited by this paper
• Intracerebral hemorrhage

  1992cited by this paper
• Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.

  1992cited by this paper
• Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

  1991cited by this paper
• Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

  1989cited by this paper
• Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations.

  1989cited by this paper
• Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

  1989cited by this paper
• Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.

  1989cited by this paper
• A fluid percussion model of experimental brain injury in the rat.

  1987cited by this paper
• Developments of a water-maze procedure for studying spatial learning in the rat.

  1984cited by this paper
• Mechanism of autooxidation for hemoglobins and myoglobins. Promotion of superoxide production by protons and anions.

  1982cited by this paper

• Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024)

  2025cites this paper
• Temporal characterisation and electrophysiological implications of TBI-induced serine/threonine kinase activity in mouse cortex

  2025cites this paper
• Claudin-1 impairs blood–brain barrier by downregulating endothelial junctional proteins in traumatic brain injury

  2025cites this paper
• Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways

  2024cites this paper
• Traumatic MicroRNAs: Deconvolving the Signal After Severe Traumatic Brain Injury

  2022cites this paper
• Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis

  2022cites this paper
• Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury

  2022cites this paper
• FDA-Approved Kinase Inhibitors in Preclinical and Clinical Trials for Neurological Disorders

  2022cites this paper
• Preclinical Western Blot in the Era of Digital Transformation and Reproducible Research, an Eastern Perspective

  2021cites this paper
• Roles of adenosine A1 receptors in the regulation of SFK activity in the rat forebrain

  2021cites this paper
• Tackling Alzheimer's Disease with Existing Drugs: Playing Dirty for Bypassing Obstacles.

  2020cites this paper
• Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke

  2020cites this paper
• MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage

  2020cites this paper
• Glucocorticoid receptors signaling impairment potentiates amyloid‐β oligomers‐induced pathology in an acute model of Alzheimer’s disease

  2020cites this paper
• Anti-mouse CX3CR1 antibody alleviates cognitive impairment, neuronal loss and myelin deficits in an animal model of brain ischemia.

  2020cites this paper
• Amphetamine activates non‐receptor tyrosine kinase Fyn and stimulates ERK phosphorylation in the rat striatum in vivo

  2019cites this paper
• Hemorrhage Associated Mechanisms of Neuroinflammation in Experimental Traumatic Brain Injury

  2019cites this paper
• Muscarinic Acetylcholine Receptors Inhibit Fyn Activity in the Rat Striatum In Vivo

  2018cites this paper
• Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach

  2018cites this paper
• Mechanisms underlying executive function deficits

  2017cites this paper
• Repurposing cancer drugs to treat neurological diseases – Src inhibitors as examples

  2017cites this paper
• Inhibition of Src family kinases improves cognitive function after intraventricular hemorrhage or intraventricular thrombin

  2017influential citation
• Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain

  2017cites this paper
• ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders.

  2017cites this paper
• Examining Infarct Sizes In Female Sprague Dawley Rats In Response To A Delayed Post-Stroke Pharmacological Treatment In Combination With Physical Rehabilitation

  2016cites this paper
• Src Family Kinase Inhibitors and their Role in the Treatment of Traumatic Brain Injuries

  2016cites this paper
• Src Family Kinases in Brain Edema After Acute Brain Injury.

  2016cites this paper
• Intercellular cross-talk in intracerebral hemorrhage.

  2015cites this paper
• Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury

  2015cites this paper
• Temporal Changes in Caspase-1 and Caspase-8 Activities Following Brain Hypoxia With and Without Src kinase Inhibition in a Piglet Animal Model

  2015cites this paper
• Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue

  2014cites this paper