Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Genes & Development

• Publication date

  1996-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.10.15.1845PMID 8756343
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signal transduction by the lymphocyte-specific tyrosine protein kinase p56lck.

  1996cited by this paper
• Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

  1996cited by this paper
• p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.

  1996cited by this paper
• Involvement of Fyn tyrosine kinase in progression of cytokinesis of B lymphocyte progenitor

  1996cited by this paper
• Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.

  1996cited by this paper
• Regulation, substrates and functions of src.

  1996cited by this paper
• Involvement of p59fynT in interleukin-5 receptor signaling [published erratum appears in J Exp Med 1995 Oct 1;182(4):1179]

  1995cited by this paper
• Activation of p58c-fgr and p53/56lyn in adherent human neutrophils: evidence for a role of divalent cations in regulating neutrophil adhesion and protein tyrosine kinase activities.

  1995cited by this paper
• Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.

  1995cited by this paper
• Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice.

  1995cited by this paper
• Structure and Catalytic Properties of Protein Tyrosine Phosphatases a

  1995cited by this paper
• Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

  1995cited by this paper
• The non-receptor tyrosine kinase Lyn is localised in the developing murine blood-brain barrier.

  1995cited by this paper
• Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

  1995cited by this paper
• Allo‐skin graft rejection, tumor rejection and natural killer activity in mice lacking p56lck

  1995cited by this paper
• fyn tyrosine kinase is involved in keratinocyte differentiation control.

  1995cited by this paper
• Growth cones are actively influenced by substrate-bound adhesion molecules

  1995cited by this paper
• Immature B lymphocytes are deficient in expression of the src-family kinases p59fyn and p55fgr1.

  1995cited by this paper
• Signal transduction through integrins: A central role for focal adhesion kinase?

  1995cited by this paper
• c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

  1995cited by this paper
• Activation of src-related tyrosine kinases by IL-3.

  1995cited by this paper
• Temporal activation of nontransmembrane protein-tyrosine kinases following mast cell Fc epsilon RI engagement.

  1995cited by this paper
• Protein tyrosine kinases in the initiation of antigen receptor signaling.

  1995cited by this paper
• Regulation of the Src protein tyrosine kinase

  1995cited by this paper
• Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

  1995cited by this paper
• Induction of Lytic Pathways in T Cell Clones Derived from Wild‐type or Protein Tyrosine Kinase Fyn Mutant Mice

  1995cited by this paper
• T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.

  1995cited by this paper
• Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.

  1995cited by this paper
• Src family protein tyrosine kinases and cellular signal transduction pathways.

  1995cited by this paper
• Integrins and signal transduction pathways: the road taken.

  1995cited by this paper
• Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.

  1995cited by this paper
• Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae

  1995cited by this paper
• A signaling pathway governing early thymocyte maturation.

  1995cited by this paper
• Myristylation and palmitylation of Src family members: the fats of the matter.

  1994cited by this paper
• Association of the amino‐terminal half of c‐Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

  1994cited by this paper
• Initial events of myelination involve Fyn tyrosine kinase signalling

  1994cited by this paper
• microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.

  1994cited by this paper
• NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice

  1994cited by this paper
• Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

  1994cited by this paper
• Signal transduction by lymphocyte antigen receptors.

  1994cited by this paper
• Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn

  1994cited by this paper
• Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

  1994cited by this paper
• Surface IgM‐stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59 fyn‐/‐ mice

  1994cited by this paper
• Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.

  1994cited by this paper
• Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

  1994cited by this paper
• Csk suppression of Src involves movement of Csk to sites of Src activity

  1994cited by this paper
• Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.

  1994cited by this paper
• Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK

  1994cited by this paper
• Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1.

  1994cited by this paper
• The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.

  1994cited by this paper
• Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells.

  1994cited by this paper
• Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes.

  1994cited by this paper
• An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

  1994cited by this paper
• Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

  1994cited by this paper
• Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases.

  1994cited by this paper
• Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase

  1994cited by this paper
• Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils

  1994cited by this paper
• A dominant‐negative transgene defines a role for p56lck in thymopoiesis.

  1993cited by this paper
• Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.

  1993cited by this paper
• Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells.

  1993cited by this paper
• A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice

  1993cited by this paper
• Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ.

  1993cited by this paper
• Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

  1993cited by this paper
• Constitutive activation of Src family kinases in mouse embryos that lack Csk.

  1993cited by this paper
• Fc gamma RIIA-mediated phagocytosis and receptor phosphorylation in cells deficient in the protein tyrosine kinase Src.

  1993cited by this paper
• Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.

  1993cited by this paper
• A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues.

  1993cited by this paper
• Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.

  1993cited by this paper
• Activation of Src family kinases by colony stimulating factor‐1, and their association with its receptor.

  1993cited by this paper
• Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

  1993cited by this paper
• T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases.

  1993cited by this paper
• A kinase-independent function of Lck in potentiating antigen-specific T cell activation.

  1993cited by this paper
• Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

  1993cited by this paper
• Thinking about genetic redundancy.

  1993cited by this paper
• The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

  1993cited by this paper
• Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.

  1993cited by this paper
• Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn.

  1993cited by this paper
• Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.

  1992cited by this paper
• Association of p60c-src with endosomal membranes in mammalian fibroblasts

  1992cited by this paper
• The human p50csk tyrosine kinase phosphorylates p56lck at Tyr‐505 and down regulates its catalytic activity.

  1992cited by this paper
• Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

  1992cited by this paper
• Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

  1992cited by this paper
• Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

  1992cited by this paper
• Src-related protein tyrosine kinases and T-cell receptor signalling.

  1992cited by this paper
• Profound block in thymocyte development in mice lacking p56lck

  1992cited by this paper
• pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells.

  1992cited by this paper
• The Src family of tyrosine protein kinases in hemopoietic signal transduction

  1992cited by this paper
• Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.

  1992cited by this paper
• Bone and haematopoietic defects in mice lacking c-fos

  1992cited by this paper
• Pleiotropic effects of a null mutation in the c-fos proto-oncogene.

  1992cited by this paper
• Osteoclasts express high levels of pp60c-src in association with intracellular membranes

  1992cited by this paper
• Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.

  1992cited by this paper
• Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization

  1991cited by this paper
• Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase.

  1991cited by this paper
• Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus

  1991cited by this paper
• Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

  1991cited by this paper
• Delayed thymocyte development induced by augmented expression of p56lck

  1991cited by this paper
• Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

  1991cited by this paper
• Alternatively spliced murine lyn mRNAs encode distinct proteins

  1991cited by this paper
• Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

  1990cited by this paper

• Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis

  2024cites this paper
• Fyn, an important molecule in the brain, is a potential therapeutic target for brain tumours

  2024cites this paper
• PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling

  2023cites this paper
• Medicinal Chemistry Perspectives on Recent Advances in Src Kinase Inhibitors as a Potential Target for the Development of Anticancer Agents: Biological Profile, Selectivity, Structure‐Activity Relationship

  2023cites this paper
• Src: coordinating metabolism in cancer

  2022cites this paper
• Differentiation of Cells Isolated from Human Femoral Heads into Functional Osteoclasts

  2022cites this paper
• The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN

  2022cites this paper
• The Src-family kinase Lyn in immunoreceptor signaling.

  2021cites this paper
• Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation

  2021cites this paper
• Kinases/Phosphatases | Src Family of Protein Tyrosine Kinases

  2021cites this paper
• The osteoclast cytoskeleton – current understanding and therapeutic perspectives for osteoporosis

  2020cites this paper
• Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

  2020influential citation
• c-Src kinase inhibits osteogenic differentiation via enhancing STAT1 stability

  2020cites this paper
• A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

  2020cites this paper
• SFKs in intestine

  2020cites this paper
• Membrane anchoring of Hck kinase via the intrinsically disordered SH4-U and lengthscale associated with subcellular localization.

  2019cites this paper
• Chondroitin sulfate-D promotes neurite outgrowth by acting as an extracellular ligand for neuronal integrin αVβ3.

  2019cites this paper
• A Fyn - specific biosensor reveals localized, pulsatile kinase activity and spatially regulated signaling crosstalk

  2019cites this paper
• SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

  2019cites this paper
• RACK1 interaction with c-Src is essential for osteoclast function

  2019cites this paper
• Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans

  2019cites this paper
• Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice

  2019cites this paper
• Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation.

  2018cites this paper
• Signalling through Src family kinase isoforms is not redundant in models of thrombo‐inflammatory vascular disease

  2018cites this paper
• Src Family of Protein Tyrosine Kinases

  2018cites this paper
• Tyrosine kinase Fyn regulates iNOS expression in LPS-stimulated astrocytes via modulation of ERK phosphorylation.

  2018cites this paper
• Transient c‐Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte‐Like Cells

  2018cites this paper
• Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

  2018cites this paper
• Src signaling in a low-complexity unicellular kinome

  2018cites this paper
• An Update on Src Family of Nonreceptor Tyrosine Kinases Biology.

  2017cites this paper
• Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice

  2017cites this paper
• A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice

  2017cites this paper
• Novel small molecule inhibiting CDCP1‐PKCδ pathway reduces tumor metastasis and proliferation

  2017cites this paper
• CSF-1-induced Src signaling can instruct monocytic lineage choice.

  2017cites this paper
• Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

  2017cites this paper
• Cyclooxygenase 2: protein-protein interactions and posttranslational modifications.

  2017cites this paper
• Src family tyrosine kinase inhibitors suppress Nav1.1 expression in cultured rat spiral ganglion neurons

  2016cites this paper
• BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares

  2016cites this paper
• Tyrosine kinase signaling pathways in neutrophils

  2016cites this paper
• SIMULTANEOUS INHIBITION OF DRIVER AND EFFECTOR KINASES PROMOTES POTENT GROWTH ARREST OF AML CELLS IN VITRO AND IN VIVO

  2016cites this paper
• Integrins: Regulation of Adhesion and Downstream Signaling

  2016cites this paper
• BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts

  2016cites this paper
• The role of Src family kinases in macrophage motility and invasive capacity

  2016influential citation
• Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF‐1‐induced macrophage migration

  2016cites this paper
• SRC FAMILY KINASES MEDIATE INDIVIDUAL CELL RESPONSES TO RECEPTOR TYROSINE KINASE SIGNALING IN NEUROBLASTOMA CELLS

  2016cites this paper
• Regulation of pulmonary endothelial barrier function by kinases.

  2016cites this paper
• The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

  2016cites this paper
• The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology.

  2015cites this paper
• The role of the COPII complex in neuroblastoma differentiation by N2-Src

  2015cites this paper
• Src controls neuronal migration by regulating the activity of FAK and cofilin.

  2015cites this paper
• The Mammalian Blood-Testis Barrier: Its Biology and Regulation.

  2015cites this paper
• The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets*

  2015cites this paper
• The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin (cid:2) IIb (cid:3) 3 to Initiate Outside-in Signaling in Platelets *

  2015cites this paper
• c‐Src function is necessary and sufficient for triggering microglial cell activation

  2015influential citation
• Dual role of Src kinase in governing neuronal survival.

  2015cites this paper
• Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

  2014cites this paper
• Common themes in PrP signaling: the Src remains the same

  2014cites this paper
• Biology and Regulation of Blood-Tissue Barriers

  2014cites this paper
• Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.

  2014cites this paper
• c-Src drives intestinal regeneration and transformation

  2014cites this paper
• Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms

  2014cites this paper
• Podosome organization drives osteoclast-mediated bone resorption

  2014cites this paper
• Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury

  2014cites this paper
• The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts*

  2014influential citation
• Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β‐catenin signalling

  2014cites this paper
• Cytotoxic-T-Lymphocyte Antigen 4 Receptor Signaling for Lymphocyte Adhesion Is Mediated by C3G and Rap1

  2014cites this paper
• Transcriptional profiling of the human fibrillin/LTBP gene family, key regulators of mesenchymal cell functions

  2014cites this paper
• The role of N-Src kinases in neuronal differentiation

  2014cites this paper
• The Inhibition of Src Family Kinase Suppresses Pancreatic Cancer Cell Proliferation, Migration, and Invasion

  2014cites this paper
• Expression, localisation and functional analysis of cytoskeletal motor proteins in bone resorbing osteoclasts

  2013cites this paper
• From Fas/fas Ligand Interaction via Mitochondrial Pathway Independent Apoptosis in Jurkat and Peripheral T Cells -dependent Lck Rosmarinic Acid Induces P56

  2013cites this paper
• FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration.

  2013cites this paper
• Molecular mechanisms implicated in bone resorption

  2013cites this paper
• Src Family Tyrosine Kinase Signaling in Mouse and Human Embryonic Stem Cells

  2013influential citation
• Distinct roles for N‐Cadherin linked c‐Src and fyn kinases in lens development

  2013cites this paper
• Regulation of osteoclasts by membrane-derived lipid mediators

  2013cites this paper
• INDOLE DERIVATIVES AS SRC FAMILY KINASE AND GLUTATHIONE S-TRANSFERASE INHIBITORS: EVALUATION OF THEIR SELECTIVITY AND DRUG RESISTANCE PROPERTIES

  2012cites this paper
• The integrin equilibrium: Balancing protein-protein and protein-lipid interactions

  2012cites this paper
• Fyn positively regulates the activation of DAP12 and FcRγ-mediated costimulatory signals by RANKL during osteoclastogenesis.

  2012cites this paper
• Nonreceptor Tyrosine Kinases and Their Roles in Cancer

  2012cites this paper
• C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.

  2012cites this paper
• Synthesis and Biological Study of Novel Indole-3-Imine-2-on Derivatives as Src Kinase and Glutathione S-Transferase Inhibitors

  2012cites this paper
• Osteogenic Effects of a Potent Src-over-Abl-Selective Kinase Inhibitor in the Mouse

  2012cites this paper
• Impaired IL-7 / IL-7Ralpha Signaling in HIV Infection: Role of the Transcriptional Repressor GFI1 in Suppressing IL-7Ralpha Expression and Driving the Proliferation of Human CD8 T Lymphocytes

  2011cites this paper
• Are SRC family kinases responsible for imatinib- and dasatinib-resistant chronic myeloid leukemias?

  2011cites this paper
• Src family kinases and paclitaxel sensitivity

  2011influential citation
• Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia.

  2011cites this paper
• X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

  2011cites this paper
• An Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis

  2011cites this paper
• Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - is it all BCR-ABL?

  2011cites this paper
• Species-Specific Interactions of Src Family Tyrosine Kinases Regulate Chlamydia Intracellular Growth and Trafficking

  2011cites this paper
• Developmental expression of SRC-related tyrosine kinases in the mouse testis.

  2011cites this paper
• Src family kinase potentiates the activity of nicotinic acetylcholine receptor in rat autonomic ganglion innervating urinary bladder.

  2011cites this paper
• Regulation of Endothelial Barrier Function

  2011cites this paper
• Charakterisierung der Interaktion von Sam68 mit SH3-Domänen – Implikationen für die HIV-Replikation

  2010cites this paper
• Signaling Targets in Myeloid Leukemias

  2010cites this paper
• Non-classical actions of testosterone and spermatogenesis

  2010cites this paper
• From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.

  2010cites this paper
• Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells

  2010cites this paper
• Mouse models of human B lymphoid neoplasms

  2010cites this paper