Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Trends in Biotechnology

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tibtech.2008.11.009PMID 19187989
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of activated and nonactivated platelet-rich plasma on proliferation of human osteoblasts in vitro.

  2008cited by this paper
• Topical application of autologous blood products during surgical closure following a coronary artery bypass graft.

  2008cited by this paper
• Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review.

  2008cited by this paper
• Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers.

  2008cited by this paper
• What do we use: platelet-rich plasma or platelet-leukocyte gel?

  2008cited by this paper
• Osteotome sinus floor elevation using Choukroun's platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants.

  2008cited by this paper
• Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.

  2008cited by this paper
• Benefit of Percutaneous Injection of Autologous Platelet-Leukocyte-Rich Gel in Patients with Delayed Union and Nonunion

  2008cited by this paper
• Antimicrobial activity of platelet‐leukocyte gel against Staphylococcus aureus

  2008cited by this paper
• Platelet‐rich plasma and platelet gel preparation using Plateltex®

  2008cited by this paper
• A comparative study of 2 methods for obtaining platelet-rich plasma.

  2007cited by this paper
• Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons

  2007cited by this paper
• Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis

  2007cited by this paper
• Platelet gel stimulates proliferation of human dermal fibroblasts in vitro.

  2007cited by this paper
• Comparison of Surgically Repaired Achilles Tendon Tears Using Platelet-Rich Fibrin Matrices

  2007cited by this paper
• Homologous Activated Platelets Stimulate Differentiation and Proliferation of Primary Human Bone Cells

  2007cited by this paper
• Exogenous Application of Platelet-Leukocyte Gel during Open Subacromial Decompression Contributes to Improved Patient Outcome

  2007cited by this paper
• The potential impact of the preparation rich in growth factors (PRGF) in different medical fields.

  2007cited by this paper
• Why the platelet-rich gel has antimicrobial activity?

  2007cited by this paper
• Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties.

  2007cited by this paper
• [Influence of platelet rich fibrin (PRF) on proliferation of human preadipocytes and tympanic keratinocytes: A new opportunity in facial lipostructure (Coleman's technique) and tympanoplasty?].

  2007cited by this paper
• Dose-dependent effects of platelet gel releasate on activities of human osteoblasts.

  2007cited by this paper
• Early bone formation in human bone grafts treated with platelet-rich plasma: preliminary histomorphometric results.

  2007cited by this paper
• [The relevance of Choukroun's platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman's technique): preliminary results].

  2007cited by this paper
• Influence of the application of platelet-enriched plasma in oral mucosal wound healing.

  2007cited by this paper
• Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones.

  2007cited by this paper
• Cytotoxicity analyses of Choukroun’s platelet-rich fibrin (PRF) on a wide range of human cells: The answer to a commercial controversy

  2007cited by this paper
• Platelet-rich plasma/osteoblasts complex induces bone formation via osteoblastic differentiation following subcutaneous transplantation.

  2006cited by this paper
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features.

  2006cited by this paper
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?

  2006cited by this paper
• Autologous platelet gel: an in vitro analysis of platelet-rich plasma using multiple cycles.

  2006cited by this paper
• Treatment of Chronic Elbow Tendinosis with Buffered Platelet-Rich Plasma

  2006cited by this paper
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.

  2006cited by this paper
• The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts.

  2006cited by this paper
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing.

  2006cited by this paper
• Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis.

  2006cited by this paper
• A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report.

  2006cited by this paper
• Platelet content and growth factor release in platelet‐rich plasma: a comparison of four different systems

  2006cited by this paper
• Alveolar cleft osteoplasty using tissue-engineered osteogenic material.

  2006cited by this paper
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift.

  2006cited by this paper
• Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell‐based therapy applications

  2005cited by this paper
• Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts.

  2005cited by this paper
• Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: a technical report.

  2005cited by this paper
• Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture

  2005cited by this paper
• Clinical case reports of injectable tissue-engineered bone for alveolar augmentation with simultaneous implant placement.

  2005cited by this paper
• A new simplified technique for producing platelet-rich plasma: a short technical note

  2004cited by this paper
• Effects of platelet lysates on select bone cell functions.

  2004cited by this paper
• Influence of platelet-rich plasma (PRP) on osteogenic differentiation of rat bone marrow stromal cells. An in vitro study.

  2004cited by this paper
• Autogenous Injectable Bone for Regeneration with Mesenchymal Stem Cells and Platelet-Rich Plasma: Tissue-Engineered Bone Regeneration

  2004cited by this paper
• Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro.

  2003cited by this paper
• Platelet-derived growth factors enhance proliferation of human stromal stem cells.

  2003cited by this paper
• Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro.

  2003cited by this paper
• The Harvest Smart PRePTM system versus the Friadent-Schütze platelet-rich plasma kit.

  2003cited by this paper
• Comparison of platelet, leukocyte, and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified Curasan kit, with preparations received from a local blood bank.

  2003cited by this paper
• Determination of vascular endothelial growth factor (VEGF) in circulating blood: significance of VEGF in various leucocytes and platelets

  2002cited by this paper
• The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery.

  2001cited by this paper
• Une opportunite´ en paro-implantologie: Le PRF

  2001cited by this paper
• The Structure and Biological Features of Fibrinogen and Fibrin

  2001cited by this paper
• Fibrin and Wound Healing

  2001cited by this paper
• Role of Fibrin Matrix in Angiogenesis

  2001cited by this paper
• Fibrin and wound healing.

  2001cited by this paper
• Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants.

  1999cited by this paper
• Platelet-rich plasma: Growth factor enhancement for bone grafts.

  1998cited by this paper
• Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery.

  1997cited by this paper
• Fibrin glue: the perfect operative sealant?

  1990cited by this paper
• Platelet-derived growth factors.

  1989cited by this paper

• The Feasibility of Exosome-Enriched Platelet-rich Fibrin (PRF) for the Treatment of Gingival Recessions: A Case Series of 27 Patients

  2026cites this paper
• Platelet derivatives in oral and maxillofacial surgery: classification, and clinical applications

  2026cites this paper
• Autologous Glue: Novel Use of Injectable Platelet-Rich Fibrin With Tranexamic Acid to Achieve Graft Adhesion in Pterygium Surgery.

  2026cites this paper
• Endometrial Autologous Intrauterine Platelet-Rich Plasma (PRP) Instillation Treatment and Its Potential on In Vitro Fertilization (IVF): Narrative Review.

  2026cites this paper
• Molecular and Regenerative Effects of Platelet-Rich Plasma and Related Hemocomponents in Animal Models of Liver Injury—A Systematic Review

  2026cites this paper
• Efficacy of platelet-rich plasma as a conservative and surgical adjuvant treatment for chronic midportion Achilles Tendinopathy: a systematic review and meta-analysis.

  2026cites this paper
• Ceiling effects, mechanistic mismatch, and the need for standardized reporting in autologous concentrates for temporomandibular joint disorders

  2026cites this paper
• Efficacy of Intra-articular Platelet-Rich Fibrin Injection for Periarthritis of the Shoulder: A Pilot Study

  2026cites this paper
• Effect of Reduced Centrifugation Time on Leukocyte, Platelet, and Growth Factor Levels in Platelet-Rich Fibrin (PRF) Prepared Using Low-Speed Relative Centrifugal Force (RCF): An Ex Vivo Study

  2026cites this paper
• Efficacy of Biologics for Surgical Treatment of Periodontal Suprabony Defects: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.

  2026cites this paper
• Clarification on the Terminology of Injectable Platelet-Rich Fibrin (I-PRF).

  2026cites this paper
• Anticollagenase Therapy for Canine Corneal Ulcers: A Narrative Review of Mechanisms, Efficacy, and Clinical Implementation.

  2026cites this paper
• Effects of platelet-rich plasma gel on vaginal microecology and stump healing and its underlying mechanism

  2026cites this paper
• Comparative Evaluation of Injectable Platelet-Rich Fibrin with and Without Microneedling in Periodontal Regeneration: A Prospective Split-Mouth Clinical Study

  2026cites this paper
• Traditional Chinese Medicine and Western Medicine in Promoting Diabetic Foot Ulcer Healing: Cellular and Molecular Mechanisms

  2026cites this paper
• Platelet-Rich Plasma (PRP) Before Clinical Application: Qualitative Flow Cytometric Analysis and Enzyme-Linked Immunosorbent Assay (ELISA) Exploring Platelet Activation and TGFβ Release During Storage.

  2026cites this paper
• Can we treat meniscal tears with injectables? A systematic review of clinical outcomes following platelet-rich plasma, corticosteroid, and other injective therapies for degenerative and traumatic meniscal lesions

  2026cites this paper
• In vitro investigation of the effect of laser on platelet-rich fibrins.

  2026cites this paper
• Biological Matrix‐Assisted Apexification: A Case Report Using PRF and MTA in Immature Necrotic Teeth

  2026cites this paper
• The Effectiveness, Safety and Cost‐Effectiveness of Platelet‐Rich Plasma and Platelet‐Rich Fibrin in the Treatment of Venous Leg Ulcers: A Systematic Review and Meta‐Analysis

  2026cites this paper
• Platelet-Rich Plasma in the Treatment of Musculoskeletal Disease in 2025 and Beyond.

  2026cites this paper
• How to extract leucocyte‐poor platelet‐rich plasma using a commercial platelet concentration system developed to obtain leucocyte‐rich platelet‐rich plasma: A pilot study

  2026cites this paper
• In Vitro Antimicrobial Potential of Different Platelet Concentrates Against Eight Clinically Relevant Oral Pathobionts.

  2026cites this paper
• Platelet Concentration Thresholds in PRP—The Need for Standardized Quantification and Dose-Response Modeling: Letter to the Editor

  2026cites this paper
• Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries

  2025cites this paper
• Autologous Platelet Concentrates in the Management of Medication-Related Osteonecrosis of the Jaw: A Systematic Review

  2025influential citation
• The Evolving Role of Stem Cells in Oral Health and Regeneration: A Systematic Review

  2025cites this paper
• Pure platelet-rich plasma delays intervertebral disc degeneration by activating SIRT1-mediated autophagy in nucleus pulposus cells

  2025cites this paper
• A Comparative Evaluation of Advanced Platelet-Rich Fibrin and Titanium Platelet-Rich Fibrin in Maxillary Sinus Augmentation Using the Crestal Approach

  2025cites this paper
• Centrifugation force and time influence on platelet, leukocyte, and growth factor concentrations in canine platelet-rich plasma.

  2025cites this paper
• Amniotic-Derived Exosomes in Clinical Practice: Safety and Outcomes in 608 Patients

  2025cites this paper
• Uso de Fibrina Rica em Plaquetas (PRF) em Cirurgias Parendodônticas: Uma Breve Atualização

  2025cites this paper
• Reinforcement of osteochondoral defects repair with leukocyte platelet-rich fibrin and bone marrow-derived mononuclear cells in a rabbit model

  2025cites this paper
• Clinical effectiveness of platelet rich fibrin combined with core decompression and grafting in early stage femoral head avascular necrosis

  2025cites this paper
• Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate

  2025cites this paper
• Innovative Approaches in Regenerative Dentistry: A Review on the Synergistic Effects of Injectable Platelet-Rich Fibrin (i-PRF) and Micro-Needling

  2025cites this paper
• Titanium-prepared platelet-rich fibrin enhances alveolar ridge preservation: a randomized controlled clinical and radiographic study

  2025cites this paper
• A bibliometric analysis of the global status of platelet-rich plasma in regenerative medicine from 2004 to 2023

  2025cites this paper
• The Combined Potential of PRP and Osteoinductive Carrier Matrices for Bone Regeneration

  2025cites this paper
• Leukocyte-Rich Platelet-Rich Plasma’s Clinical Effectiveness in Arthroscopic Rotator Cuff Repair: A Meta-Analysis of Randomized Controlled Trials

  2025cites this paper
• Advances in biomaterials and regenerative medicine for diabetic foot ulcer therapy.

  2025cites this paper
• Significance and clinical highlights of bone augmentation using fibrin-rich plasma and Bio-Oss®: a systematic review

  2025influential citation
• Rationale and methodology for injection therapy to treat rotator cuff disease: a scoping review

  2025cites this paper
• A microfluidic device for passive separation of platelet-rich plasma from whole blood.

  2025cites this paper
• Evaluation of clinical outcomes of different types of platelet concentrates alone or in combination with biomaterials for periodontal intra-bony defect treatment: A systematic review

  2025cites this paper
• A Comparative Evaluation of Platelet-Rich Fibrin and Platelet-Rich Fibrin Matrix in Terms of pH, Antimicrobial Potential and Histological Presentation: An In vitro Study

  2025cites this paper
• Autologous platelet concentrates: 'Ambit’ in integrated health sciences

  2025cites this paper
• A comparative study of the efficacy of autologous platelet-rich fibrin matrix versus platelet-rich plasma in the treatment of non-healing leg ulcers

  2025cites this paper
• Evaluation of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration

  2025cites this paper
• Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights

  2025cites this paper
• The role of microtrauma in hair regrowth and regeneration in non-scarring alopecia.

  2025cites this paper
• An interdisciplinary approach for the management of periapical lesion using regenerative approach: a case report

  2025cites this paper
• The use of autologous biomaterials in combination with biocompatible matrices for restoration of bone tissue defects (literature review)

  2025cites this paper
• Comparison of single-spin to double-spin platelet-rich plasma centrifugation methods in the treatment of androgenic alopecia: a systematic review and meta-analysis of randomized controlled trials

  2025cites this paper
• Research Progress of Combining High Tibial Osteotomy with Platelet-rich Plasma for Osteoarthritis Therapy

  2025cites this paper
• Platelet-Rich Concentrates in the Management of Lichen Planus—A Comprehensive Review

  2025cites this paper
• Platelet‐Derived Extracellular Vesicles Alleviate Psoriatic Inflammation via Mitochondrial Transfer to Macrophages

  2025cites this paper
• The evolution of three generations of platelet concentrates products: a leap from classical formulations to the era of extracellular vesicles

  2025cites this paper
• Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review

  2025cites this paper
• Regenerative Endodontics in the Treatment of Periapical Lesions of Endodontic Origin: A Systematic Review of Randomized Controlled Trials.

  2025cites this paper
• Effectiveness of concentrated growth factors in regenerative endodontic treatment of immature permanent teeth - A systematic review and meta-analysis

  2025cites this paper
• Comparison of platelet-rich plasma versus corticosteroid injection for adhesive capsulitis: a randomised controlled trial

  2025cites this paper
• Application of Platelet-Rich Plasma-Based Scaffolds in Soft and Hard Tissue Regeneration.

  2025cites this paper
• Conceptos actuales de los concentrados plaquetarios y su aplicación en la preservación alveolar ósea postextracción

  2025cites this paper
• Histomorphometric and microtomographic evaluation of hydroxyapatite coated implants and L-PRF in over drilled bone sites in sheep

  2025cites this paper
• Efficacy of Platelet-Rich Plasma in the Treatment of Equine Tendon and Ligament Injuries: A Systematic Review of Clinical and Experimental Studies

  2025cites this paper
• Research Progress of Platelet-Rich Plasma in the Treatment of Discogenic Low Back Pain

  2025cites this paper
• Does platelet‐rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review

  2025cites this paper
• Platelet like cells differentiated from human adipose derived mesenchymal stem cells promote healing of tendinopathy in rats

  2025cites this paper
• Development of nano-liposomal platelet-poor plasma (PPP) for topical application in wound healing and burn treatment

  2025cites this paper
• Platelet Rich Fibrin Combined with Hyaluronic Acid in the Treatment of Meniscal injuries: A Retrospective 1-Year Follow-Up Study

  2025cites this paper
• Intracavernosal platelet‐rich plasma therapy for erectile dysfunction: Current evidence and future directions

  2025cites this paper
• Endodontic Regeneration Therapy: Current Strategies and Tissue Engineering Solutions

  2025cites this paper
• Beneficial Effects of Infiltration of Platelet-Rich Plasma in the Endometrium

  2025cites this paper
• Manual platelet-rich plasma production in donkeys by double centrifugation results in leukocyte-rich platelet-rich plasma compared to single centrifugation.

  2025cites this paper
• The Effect of PRF Membrane Administration on TGF-β and IL-6 Expression in the Superior Rectus Muscle Post-Strabismus Surgery (An Experimental Study on New Zealand Rabbits): A Literature Review

  2025cites this paper
• Efficacy of manipulation under anesthesia with ultrasound-guided platelet-rich plasma injection in shoulder stiffness concomitant with rotator cuff injury

  2025cites this paper
• Comparison of Outcomes in Application of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Medial Collateral Ligament Recovery: An Animal Study

  2025cites this paper
• The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

  2025cites this paper
• Comparative analysis of cytokine profiles in canine injectable platelet-rich fibrin and platelet-rich plasma

  2025influential citation
• Platelet concentrates a new renaissance in tissue regeneration

  2025cites this paper
• Clinical and radiographic assessment of mineral trioxide aggregate with platelet rich fibrin as pulp capping biomaterials: a 12-month randomized trial

  2025cites this paper
• Evaluating the Effectiveness of Platelet Rich Plasma Therapy in Enhancing Endometrial Receptivity for Women with Infertility: A Narrative Review

  2025cites this paper
• Utilization of Platelet-Rich Plasma in Oral Surgery: A Systematic Review of the Literature

  2025cites this paper
• Innovations in Bioactive Materials for Dental Pulp Vitality Preservation in Children and Adolescents

  2025cites this paper
• Radiographic Assessment of Bone Width Improvement in Narrow Ridge Patients Managed with Ridge Split Technique: A Prospective Study

  2025cites this paper
• Platelet-rich plasma as a potential antimicrobial agent against multidrug-resistant bacteria in diabetic foot infections

  2025cites this paper
• The role of orthobiologics in bone healing and joint and tendon degeneration in the upper limb

  2025cites this paper
• The use of platelet-rich plasma for skin wound repair in clinical trials: a systematic review

  2025cites this paper
• Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review

  2025cites this paper
• Injectable homologous platelet-rich plasma, alone or in combination with oral omega-3 supplementation, for treating keratoconjunctivitis sicca in dogs

  2025cites this paper
• Biologic Therapies in the Management of Sports-Related Tendon and Ligament Injuries: A Narrative Review

  2025cites this paper
• Efficacy of platelet-rich products in preventing cerebrospinal fluid leakage following neurosurgical procedures: A systematic review and meta-analysis

  2025cites this paper
• Application of Biologics in Maxillary Sinus Augmentation Surgery: A Narrative Review.

  2025cites this paper
• Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review

  2025cites this paper
• Current and Emerging Biologic Therapies for Equine Tendon and Ligament Injuries.

  2025cites this paper
• Comparative Analysis of Regenerative Endodontic Procedures with Different Scaffold Materials

  2025cites this paper
• Comparative Evaluation of Advanced Platelet-Rich Fibrin and Blood Clot as Scaffolds in Regenerative Endodontics for Immature Necrotic Teeth: A Randomized Clinical Study

  2025cites this paper
• The use of platelet-rich fibrin in maintaining vascularity for intentionally replanted teeth

  2025cites this paper
• Quality of life changes in patients suffering from knee osteoarthritis treated with bone marrow aspirate concentrate, platelet-rich plasma and hyaluronic acid injections.

  2025cites this paper