Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis.

Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10(-10)cm(-1), a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 microm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO(2), breath concentrations of CO, and the presence of trace concentrations of NH(3) in high concentrations of H(2)O.

• Publication year

  2008

• Venue

  Optics Express

• Publication date

  2008-02-18

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1364/OE.16.002387PMID 18542317
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spectroscopic investigation of methylated amines by a cavity-ringdown-based spectrometer.

  2007cited by this paper
• Portable optical spectroscopy for accurate analysis of ethane in exhaled breath

  2007cited by this paper
• Cavity-ringdown molecular spectroscopy based on an optical frequency comb at 1.45-1.65 microm.

  2007cited by this paper
• Frequency comb Vernier spectroscopy for broadband, high-resolution, high-sensitivity absorption and dispersion spectra.

  2007cited by this paper
• Molecular fingerprinting with the resolved modes of a femtosecond laser frequency comb

  2007cited by this paper
• Mid-infrared fibre-based optical comb

  2006cited by this paper
• Broadband Cavity Ringdown Spectroscopy for Sensitive and Rapid Molecular Detection

  2006cited by this paper
• Application of laser spectroscopy for measurement of exhaled ethane in patients with lung cancer.

  2006cited by this paper
• Breath analysis: potential for clinical diagnosis and exposure assessment.

  2006cited by this paper
• Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath.

  2006cited by this paper
• Evaluation of 13 C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia

  2006cited by this paper
• Broadband Cavity Ringdown Spectroscopy for Sensitive and Rapid Molecular Detection

  2006cited by this paper
• Ultra-sensitive ethylene post-harvest monitor based on cavity ring-down spectroscopy.

  2006cited by this paper
• Breath analysis: trends in techniques and clinical applications

  2005cited by this paper
• Current status of clinical breath analysis

  2005cited by this paper
• The HITRAN 2008 molecular spectroscopic database

  2005cited by this paper
• Detection of lung cancer by sensor array analyses of exhaled breath.

  2005cited by this paper
• 2-D wavelength demultiplexer with potential for >/= 1000 channels in the C-band.

  2004cited by this paper
• Widely tunable sub-30-fs pulses from a compact erbium-doped fiber source.

  2004cited by this paper
• Highly nonlinear optical fibers and their applications

  2003cited by this paper
• Mode-locked cavity-enhanced absorption spectroscopy

  2003cited by this paper
• Modelocked cavity--enhanced absorption spectroscopy.

  2002cited by this paper
• Stable isotope ratios using cavity ring-down spectroscopy: determination of 13C/12C for carbon dioxide in human breath.

  2002cited by this paper
• Breath analysis to detect recent exposure to carbon monoxide

  2002cited by this paper
• Detection and identification of odorants using an electronic nose

  2001cited by this paper
• Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy

  2001cited by this paper
• Cavity ringdown spectroscopic detection of nitric oxide with a continuous-wave quantum-cascade laser.

  2001cited by this paper
• Ultrasensitive detections in atomic and molecular physics: demonstration in molecular overtone spectroscopy

  1998cited by this paper
• Ultrashort-pulse fiber ring lasers

  1997cited by this paper
• Cavity Ringdown Laser Absorption Spectroscopy: History, Development, and Application to Pulsed Molecular Beams.

  1997cited by this paper
• Analytical and experimental study of ringing effects in a Fabry–Perot cavity. Application to the measurement of high finesses

  1997cited by this paper
• Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia.

  1990cited by this paper

• Bridging Theory and Experiment in Virtually Imaged Phased Array (VIPA) Spectrometers

  2026cites this paper
• Nonreciprocal frequency combs by two-photon driving in cavity magnonics.

  2025cites this paper
• Real-time formaldehyde and acetaldehyde sensor using a 5.72 μm QCL for multi-gas characterization lung cancer screening

  2025cites this paper
• Highly Sensitive CO/O₂ Sensor for In Situ Measurement in Industrial Heating Furnace Based on Calibration-Free Wavelength Modulation Spectroscopy

  2025cites this paper
• Design and Construction of an Affordable Adjustable Repetition-Rate Optical Frequency Comb

  2025cites this paper
• Modulated ringdown comb interferometry for sensing of highly complex gases

  2025cites this paper
• Acetone Absorption Cross-Section in the Near-Infrared of the Methyl Stretch Overtone and Application for Analysis of Human Breath

  2025cites this paper
• Quantum correlation-enhanced dual-comb spectroscopy

  2025cites this paper
• Tunable ultra-high-resolution spectral analysis using a frequency-shifted loop.

  2025cites this paper
• Frequency-stable nanophotonic microcavities via integrated thermometry

  2025cites this paper
• Mid‐ to Long‐Wave‐Infrared Nanoscopy With Lanthanide Transducers

  2025cites this paper
• Freely controllable single-optical-frequency comb for highly sensitive cavity ring-down spectroscopy

  2025cites this paper
• Design and Performance Analysis of Novel Mid-Infrared Enhanced Hollow Waveguide for Gas Isotope Ratio Measurements.

  2025cites this paper
• Advancing Molecular Spectroscopy Efficiency with Extensive Parallelism

  2024cites this paper
• High Power Near-infrared Supercontinuum Generation in All-fiber Polarization-maintaining Erbium-doped Amplifier

  2024influential citation
• 基于粒子群的虚像相位阵列光谱仪光谱反演算法

  2024cites this paper
• A short guide to recent developments in laser-based gas phase spectroscopy, applications, and tools

  2024cites this paper
• Real-Time Measurement of CH4 in Human Breath Using a Compact CH4/CO2 Sensor

  2024cites this paper
• A simple spectrogram model for high-accuracy spectral calibration of VIPA spectrometers.

  2024cites this paper
• Cavity-enhanced dual-comb spectroscopy stabilized by molecular absorption line locking

  2024cites this paper
• Toward a compact fiber comb with 1.66 × 10−12 instability based on acetylene-filled photonic microcells

  2024cites this paper
• All-Optical Noise Quenching of An Integrated Frequency Comb

  2024cites this paper
• Breath Analysis Using Quartz Tuning Forks for Predicting Blood Glucose Levels Using Artificial Neural Networks.

  2024cites this paper
• Recent developments in wearable breath sensors for healthcare monitoring

  2024cites this paper
• Broadband cavity-enhanced Kerr Comb spectroscopy on Chip

  2024cites this paper
• Comb spectroscopy of CO2 produced from microbial metabolism

  2024cites this paper
• 腔增强吸收光谱技术研究与应用进展（特邀）

  2023cites this paper
• Mid-infrared virtually imaged phased array spectrometer with optical frequency comb: fast thermometry over large dynamic range

  2023cites this paper
• WM-OA-ICOS Based Mid-Infrared Dual-Range Real-Time Trace Sensor for Formaldehyde Detection in Exhaled Breath

  2023cites this paper
• A broadband picometer resolution visible CCD spectrometer based on virtually imaged phased array technology.

  2023cites this paper
• High-resolution mid-infrared spectroscopy based on ultrafast Cr:ZnSe laser.

  2023cites this paper
• Tutorial: Nonlinear magnonics

  2023cites this paper
• Smelling the Disease: Diagnostic Potential of Breath Analysis

  2023cites this paper
• Low-Temperature Cavity-Enhanced Spectroscopy with a Diode Laser: Vibration–Rotation Absorption of CO (3ν) at 80 K and CH3C≡C–H (2ν1) at 165 K

  2023cites this paper
• 基于虚像相位阵列光谱仪的宽带高分辨率CO2吸收光谱测量技术研究

  2023cites this paper
• Enhanced performance for simultaneous atmospheric N2O and CO measurements based on ICEEMDAN and GWO-LSSVM

  2023cites this paper
• Real-time high-spectral-resolution mid-infrared spectroscopy with a signal-to-noise ratio of ten thousand.

  2022cites this paper
• Recent advances in ultrafast plasmonics: from strong field physics to ultraprecision spectroscopy

  2022cites this paper
• Advances of Semiconductor Mode-locked Laser for Optical Frequency Comb Generation

  2022cites this paper
• Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection

  2022cites this paper
• Frequency comb and machine learning-based breath analysis for COVID-19 classification

  2022cites this paper
• All-fiber acetylene-referenced optical frequency comb

  2022cites this paper
• 3-D Fabry–Pérot cavities sculpted on fiber tips using a multiphoton polymerization process

  2021cites this paper
• Dual-comb cavity ring-down spectroscopy

  2021cites this paper
• All-ber ultrafast ampli�er at 1.9 μ m based on thulium-doped normal dispersion �ber and LMA �ber compressor

  2021cites this paper
• Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics

  2021influential citation
• Increasing the free spectral range of Fabry-Perot cavities using dissimilar 1D photonic crystals

  2021cites this paper
• PAM4 optical transmission enabled by a 100 GHz quantum dot mode-locked optical frequency comb

  2021cites this paper
• Non‐invasive exhaled breath diagnostic and monitoring technologies

  2021cites this paper
• Longwave midIR femtosecond pulse sources driven by ultrafast fiber lasers ( Invited )

  2021cites this paper
• VIPA-based two-component detection for a coherent population trapping experiment

  2021cites this paper
• Multi-wavelength 128 Gbit s−1 λ −1 PAM4 optical transmission enabled by a 100 GHz quantum dot mode-locked optical frequency comb

  2021cites this paper
• Direct Comb Vernier Spectroscopy for Fractional Isotopic Ratio Determinations

  2021cites this paper
• Amplified frequency double-shifting loop enabled frequency-stepped pulse train for direct time domain CO2 measurement

  2021cites this paper
• Doubly resonant sub-ppt photoacoustic gas detection with eight decades dynamic range

  2021cites this paper
• All-fiber ultrafast amplifier at 1.9 μm based on thulium-doped normal dispersion fiber and LMA fiber compressor

  2021cites this paper
• Dispersion engineering of GaN based coupled waveguides for blue frequency combs

  2021cites this paper
• Breath analysis for the screening and diagnosis of diseases

  2020cites this paper
• Three-dimensional Fabry–Pérot cavities sculpted on fiber tips using a multiphoton polymerization process

  2020cites this paper
• Simple method for mid-infrared optical frequency comb generation with dynamic offset frequency tuning

  2020cites this paper
• Exhaled Breath Analysis in Disease Detection.

  2020cites this paper
• Ammonia Gas Sensors: Comparison of Solid-State and Optical Methods

  2020cites this paper
• Slip Rates and Slip Modes in an Actively Mode-Locked Laser

  2020cites this paper
• 11-μs time-resolved, continuous dual-comb spectroscopy with spectrally filtered mode-locked frequency combs

  2020cites this paper
• Direct Kerr frequency comb atomic spectroscopy and stabilization

  2020cites this paper
• Robust, Fast and Sensitive Near-Infrared Continuous-Filtering Vernier Spectrometer

  2020cites this paper
• Optical spectroscopy

  2020cites this paper
• Exhaled breath analysis using cavity-enhanced optical techniques: a review

  2020cites this paper
• Opportunities for photonic integrated circuits in optical gas sensors

  2020cites this paper
• Acoustic frequency combs using gas bubble cluster oscillations in liquids: a proof of concept

  2020cites this paper
• Long-Term Stable Online Acetylene Detection by a CEAS System with Suppression of Cavity Length Drift

  2019cites this paper
• Sensitive acetone detection with a mid-IR interband cascade laser and wavelength modulation spectroscopy

  2019cites this paper
• Main and side stream effects of electronic cigarettes.

  2019cites this paper
• Accurate empirical rovibrational energies and transitions of H216O.

  2019cites this paper
• Quantum-Cascade Lasers in Medicine and Biology (Review)

  2019cites this paper
• Open path incoherent broadband cavity-enhanced measurements of NO3 radical and aerosol extinction in the North China Plain.

  2019cites this paper
• Lock-in-detection dual-comb spectroscopy

  2019cites this paper
• Development of a Compact Broadband Optical Parametric Oscillator for UltraSensitive Molecular Detection

  2019cites this paper
• Sensitive acetone detection with a midIR interband cascade laser and wavelength modulation spectroscopy

  2019cites this paper
• Adaptive cavity-enhanced dual-comb spectroscopy

  2019cites this paper
• Femtosecond thulium-doped fiber-ring laser for mid-IR spectroscopic breath analysis

  2019cites this paper
• Application of Near-Infrared Optical Feedback Cavity Enhanced Absorption Spectroscopy (OF-CEAS) to the Detection of Ammonia in Exhaled Human Breath

  2019cites this paper
• Off-Axis Cavity-Enhanced Absorption Spectroscopy of 14NH3 in Air Using a Gain-Switched Frequency Comb at 1.514 μm

  2019cites this paper
• Phase-Dispersion Spectroscopy With High Spectral Resolution Using a Wideband Ultra-Linearly Swept Optical Source

  2019cites this paper
• Broadband Optical Cavity Mode Measurements at Hz-Level Precision With a Comb-Based VIPA Spectrometer

  2019cites this paper
• Breathin: A breath pattern sensing approach for user computer interaction

  2019cites this paper
• Frequency comb spectroscopy

  2019cites this paper
• Cascade laser sensing concepts for advanced breath diagnostics

  2018cites this paper
• Laser spectroscopy for breath analysis: towards clinical implementation

  2018cites this paper
• Flow immune photoacoustic sensor for real-time and fast sampling of trace gases

  2018cites this paper
• Dispersive Tunable Laser Spectroscopy with Ultrahigh Spectral Resolution

  2018cites this paper
• Near-Infrared Broadband Cavity-Enhanced Sensor System for Methane Detection Using a Wavelet-Denoising Assisted Fourier-Transform Spectrometer

  2018cites this paper
• Functional Metasurfaces towards Applications: Optical Modulation, Integrated Photonics, and Biomolecular Sensing

  2018cites this paper
• New method to generate mid-infrared optical frequency combs for molecular spectroscopy

  2018cites this paper
• Optical techniques for breath analysis: from single to multi-species detection

  2018cites this paper
• Coupling light and sound: giant nonlinearities from oscillating bubbles and droplets

  2018cites this paper
• Creation of ultracold molecules within the lifetime scale by direct implementation of an optical frequency comb

  2018cites this paper
• A Low-RIN Spectrally Pure Whispering-Gallery-Mode Resonator-Based Semiconductor Laser

  2018cites this paper
• Two-micron all-fibered dual-comb spectrometer based on electro-optic modulators and wavelength conversion

  2018cites this paper
• Direct Kerr-frequency-comb atomic spectroscopy

  2018cites this paper