Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy

The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT1 receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and known to counterbalance many of the deleterious effects of AngII. AT1R signaling triggered by β-arrestin-biased agonists has been associated to cardioprotection. Because position 8 in AngII is important for G protein activation, we hypothesized that Ang-(1-7) could be an endogenous β-arrestin-biased agonist of the AT1R. Here we show that Ang-(1-7) binds to the AT1R without activating Gq, but triggering β-arrestins 1 and 2 recruitment and activation. Using an in vivo model of cardiac hypertrophy, we show that Ang-(1-7) significantly attenuates heart hypertrophy by reducing both heart weight and ventricular wall thickness and the increased end-diastolic pressure. Whereas neither the single blockade of AT1 or Mas receptors with their respective antagonists prevented the cardioprotective action of Ang1-7, combination of the two antagonists partially impaired the effect of Ang-(1-7). Taken together, these data indicate that Ang-(1-7) mediates at least part of its cardioprotective effects by acting as an endogenous β-arrestin-biased agonist at the AT1R.

• Publication year

  2017

• Venue

  Scientific Reports

• Publication date

  2017-09-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/s41598-017-12074-3PMID 28928410PMCID 5605686
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Long-Term Biased &bgr;-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy

  2017cited by this paper
• Cardioprotective Angiotensin-(1–7) Peptide Acts as a Natural-Biased Ligand at the Angiotensin II Type 1 Receptor

  2016cited by this paper
• Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists

  2015cited by this paper
• Effects of the angiotensin-(1-7)/Mas/PI3K/Akt/nitric oxide axis and the possible role of atrial natriuretic peptide in an acute atrial tachycardia canine model

  2015cited by this paper
• International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

  2015cited by this paper
• Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).

  2015cited by this paper
• Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure).

  2015cited by this paper
• Angiotensin 1–7 Reduces Mortality and Rupture of Intracranial Aneurysms in Mice

  2014cited by this paper
• Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.

  2014cited by this paper
• Do Interventions Designed to Support Shared Decision-Making Reduce Health Inequalities? A Systematic Review and Meta-Analysis

  2014cited by this paper
• Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and Omega-Hydroxylase in a Rat Model of Type 1 Diabetes

  2014cited by this paper
• Pyridostigmine Restores Cardiac Autonomic Balance after Small Myocardial Infarction in Mice

  2014cited by this paper
• Angiotensin-(1-7).

  2014cited by this paper
• Autocrine and paracrine function of Angiotensin 1-7 in tissue repair during hypertension.

  2014cited by this paper
• Discovery and Characterization of Alamandine: A Novel Component of the Renin–Angiotensin System

  2013cited by this paper
• Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus: Involvement of Thimet Oligopeptidase

  2013cited by this paper
• Possible mechanism of the cardio-renal protective effects of AVE-0991, a non-peptide Mas-receptor agonist, in diabetic rats

  2012cited by this paper
• Angiotensin Type 2 Receptor Agonist Compound 21 Reduces Vascular Injury and Myocardial Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats

  2012cited by this paper
• Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs

  2012cited by this paper
• TRV120027, a Novel &bgr;-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

  2012cited by this paper
• Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart.

  2012cited by this paper
• Deciphering biased-agonism complexity reveals a new active AT1 receptor entity.

  2012cited by this paper
• β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury.

  2012cited by this paper
• TRV120027, a Novel Beta-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

  2011cited by this paper
• Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.

  2011cited by this paper
• Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines: A Novel Therapeutic Strategy for Acute Heart Failure

  2011cited by this paper
• Angiotensin-(1-7) Blockade Attenuates Captopril- or Hydralazine-induced Cardiovascular Protection in Spontaneously Hypertensive Rats Treated With NG-nitro-l-Arginine Methyl Ester

  2011cited by this paper
• Cardiorenal Actions of TRV 120027 , a Novel ß-Arrestin – Biased Ligand at the Angiotensin II Type I Receptor , in Healthy and Heart Failure Canines A Novel Therapeutic Strategy for Acute Heart Failure

  2011cited by this paper
• Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats.

  2011cited by this paper
• Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.

  2011cited by this paper
• Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor

  2010cited by this paper
• Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

  2010cited by this paper
• Vasoprotective and Atheroprotective Effects of Angiotensin (1-7) in Apolipoprotein E–Deficient Mice

  2010cited by this paper
• The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor.

  2009cited by this paper
• [Angiotensin- (1-7)].

  2009cited by this paper
• Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

  2009cited by this paper
• The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats.

  2008cited by this paper
• Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction.

  2008cited by this paper
• Structural basis of protein kinase C isoform function.

  2008cited by this paper
• A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

  2007cited by this paper
• The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction.

  2007cited by this paper
• Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats.

  2007cited by this paper
• Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene.

  2007cited by this paper
• Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent Pathways

  2007cited by this paper
• The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts.

  2007cited by this paper
• Resonance energy transfer approaches in molecular pharmacology and beyond.

  2007cited by this paper
• A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

  2007cited by this paper
• The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

  2007cited by this paper
• Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function

  2007cited by this paper
• Mesangial AT1/B2 receptor heterodimers contribute to angiotensin II hyperresponsiveness in experimental hypertension

  2007cited by this paper
• Probing the activation-promoted structural rearrangements in preassembled receptor–G protein complexes

  2006cited by this paper
• Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice

  2006cited by this paper
• Up-regulation of the Angiotensin II Type 1 Receptor by the MAS Proto-oncogene Is Due to Constitutive Activation of Gq/G11 by MAS*

  2006cited by this paper
• β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

  2006cited by this paper
• 345 Endothelial dysfunction by genetic deletion or inhibition of the G protein‐coupled receptor Mas ‐ a new target to improve endothelial function

  2006cited by this paper
• Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET

  2005cited by this paper
• G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor

  2005cited by this paper
• Stable Interaction between β-Arrestin 2 and Angiotensin Type 1A Receptor Is Required for β-Arrestin 2-mediated Activation of Extracellular Signal-regulated Kinases 1 and 2*

  2004cited by this paper
• Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas

  2003cited by this paper
• Angiotensin-(1–7) Attenuates the Development of Heart Failure After Myocardial Infarction in Rats

  2002cited by this paper
• Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors.

  2002cited by this paper
• Downregulation of the AT1A Receptor by Pharmacologic Concentrations of Angiotensin-(1-7)

  2001cited by this paper
• International union of pharmacology. XXIII. The angiotensin II receptors.

  2000cited by this paper
• Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes.

  2000cited by this paper
• Angiotensin-(1-7) binds at the type 1 angiotensin II receptors in rat renal cortex.

  1999cited by this paper
• , Akira Degradation of Phenol Denitrifying Spirillum Capable of Anaerobic Isolation and Characterization of a New

  1999cited by this paper
• Angiotension-(1-7) and antihypertensive mechanisms.

  1998cited by this paper
• Angiotension-(1-7) and antihypertensive mechanisms.

  1998cited by this paper
• Interaction of Phe8 of Angiotensin II with Lys199 and His256 of AT1 Receptor in Agonist Activation (*)

  1995cited by this paper
• Angiotensin-(1-7) binding at angiotensin II receptors in the rat brain.

  1995cited by this paper
• A new myocardial conversion of angiotensin I

  1994influential reference
• Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.

  1994cited by this paper
• Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.

  1994cited by this paper
• Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.

  1992cited by this paper
• Production of angiotensin-(1-7) by human vascular endothelium.

  1992influential reference
• Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

  1992cited by this paper
• Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.

  1987cited by this paper
• Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.

  1986cited by this paper
• The journal of pharmacology and experimental therapeutics

  year unknowncited by this paper

• Deciphering complexity of GPCR signaling and modulation: implications and perspectives for drug discovery

  2025cites this paper
• Ameliorative effects of Daidzein on heart, lung, and liver injuries in ovariectomized female Wistar rats undergoing unilateral ureteral obstruction: Role of angiotensin receptor blockers

  2025cites this paper
• Old and New Molecular Targets in the Treatment of Hypertension

  2025cites this paper
• Endothelial Dysfunction and Therapeutic Advances in Chronic Kidney Disease

  2025cites this paper
• Clinical significance of intervention in the renin-angiotensin-aldosterone-apelinergic system.

  2025cites this paper
• Sustained Gαs signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent.

  2025cites this paper
• Angiotensin-II type 2 receptor-mediated renoprotection is independent of receptor Mas in obese Zucker rats fed high-sodium diet

  2024cites this paper
• Functional consequences of spatial, temporal and ligand bias of G protein-coupled receptors

  2024cites this paper
• G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling

  2024cites this paper
• Impacts of SARS-CoV-2 on brain renin angiotensin system related signaling and its subsequent complications on brain: a theoretical perspective.

  2024cites this paper
• The 2023 Lewis K. Dahl Memorial Lecture: Angiotensin-Converting Enzyme 2 Posttranslational Modifications-Implications for Hypertension and SARS-CoV-2 Infection.

  2024cites this paper
• Application of Photodynamic Therapy in Cardiology

  2024cites this paper
• Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting.

  2024cites this paper
• Alternative Renin-Angiotensin System

  2024cites this paper
• The Counteracting Effects of Ang II and Ang-(1-7) on the Function and Growth of Insulin-secreting NIT-1 Cells.

  2024cites this paper
• Angiotensin 1–7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart—The signaling mechanism

  2024cites this paper
• Muscle mass, muscle strength and the renin-angiotensin system.

  2024cites this paper
• Angiotensin-(1-7) and Central Control of Cardiometabolic Outcomes: Implications for Obesity Hypertension

  2024cites this paper
• Angiotensin 1-7 – a peptide that increases the resistance of the heart to ischemia and reperfusion: narrative review

  2024cites this paper
• Targeting the epidermal growth factor receptor (EGFR/ErbB) for the potential treatment of renal pathologies

  2024cites this paper
• Understanding the impact of nuclear-localized GPCRs on cellular signalling.

  2024cites this paper
• Receptor endocytosis orchestrates the spatiotemporal bias of β-arrestin signaling

  2023cites this paper
• Interactions between AT1R and GRKs: the determinants for activation of signaling pathways involved in blood pressure regulation

  2023cites this paper
• The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury

  2023cites this paper
• Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure.

  2023cites this paper
• G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts.

  2023cites this paper
• Renin-Angiotensin System Modulation in Adults With COVID-19-Reply.

  2023cites this paper
• Targeting the renin angiotensin system for respiratory diseases.

  2023cites this paper
• The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System

  2023cites this paper
• Insights Into the Role of Angiotensin-II AT1 Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease.

  2023cites this paper
• The effect of daidzein on renal injury in ovariectomized rats: interaction of angiotensin receptors and long non-coding RNAs H19, GAS5, MIAT, and Rian

  2023cites this paper
• Angiotensin-Related Peptides and Their Role in Pain Regulation

  2023cites this paper
• Angiotensin-(1-7) mediated calcium signalling by MAS.

  2023cites this paper
• Beta-arrestins in the context of cardiovascular diseases: Focusing on type 1 angiotensin II receptor (AT1R).

  2022cites this paper
• GPR83 Engages Endogenous Peptides from Two Distinct Precursors to Elicit Differential Signaling

  2022cites this paper
• Evolutionary information helps understand distinctive features of the angiotensin II receptors AT1 and AT2 in amniota

  2022cites this paper
• Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system

  2022cites this paper
• Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a

  2022cites this paper
• Biased agonists differentially modulate the receptor conformation ensembles in Angiotensin II type 1 receptor.

  2022cites this paper
• β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin

  2022cites this paper
• Alamandine alleviated heart failure and fibrosis in myocardial infarction mice

  2022cites this paper
• The Impact of Angiotensin-Converting Enzyme-2/Angiotensin 1-7 Axis in Establishing Severe COVID-19 Consequences

  2022cites this paper
• Biochemical and physiological insights into TRH receptor-mediated signaling

  2022cites this paper
• Angiotensin receptors - affinitiy and beyond.

  2022cites this paper
• Renin-Angiotensin System in Pathogenesis of Atherosclerosis and Treatment of CVD

  2021cites this paper
• Renin-Angiotensin-Aldosterone System

  2021cites this paper
• Angiotensin II type 1 receptor heterodimers in the kidney

  2021cites this paper
• 125I-Angiotensin 1–7 binds to a different site than angiotensin 1–7 in tissue membrane preparations

  2021cites this paper
• CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor

  2021cites this paper
• The Angiotensin II Type 1(AT1) Receptor and Cardiac Hypertrophy: Did We Have It Wrong All Along?

  2021cites this paper
• Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19

  2021cites this paper
• Decoding Angiotensin II Type 1 Receptor Allosteric Communication to Gq and β-arrestin

  2021cites this paper
• Molecular evolution of the Angiotensin II receptors AT1 and AT2: Specificity of the sodium binding site in amniota

  2021cites this paper
• Caloric Restriction and Cardiovascular Health: the Good, the Bad, and the Renin-Angiotensin System.

  2021cites this paper
• Beta-Arrestins in the Treatment of Heart Failure Related to Hypertension: A Comprehensive Review

  2021cites this paper
• Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes

  2021cites this paper
• Receptors | Angiotensin Receptors

  2021cites this paper
• Role of the Renin–Angiotensin–Aldosterone and Kinin–Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID

  2021cites this paper
• Role of GRK5/β-arrestin2 pathway in mediating the cardioprotective effects of carvedilol in 5/6 nephrectomized rats

  2021cites this paper
• Attenuated Function of Angiotensin-(1-7) in Placental Artery During Preeclampsia not through MAS1 Receptor

  2021cites this paper
• [New perspectives in the management of arterial hypertension].

  2021cites this paper
• Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time

  2021cites this paper
• Countering the classical renin-angiotensin system.

  2021cites this paper
• CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor

  2021cites this paper
• Receptors | Angiotensin Receptors

  2021cites this paper
• Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells

  2020cites this paper
• Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists.

  2020cites this paper
• Research Progress of Alzheimer’s Disease Therapeutic Drugs: Based on Renin-Angiotensin System Axis

  2020cites this paper
• Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II

  2020cites this paper
• β-Arrestin as a Therapeutic Target in Heart Failure

  2020cites this paper
• ACE2 as therapeutic agent.

  2020cites this paper
• Angiotensin‐(1‐7) prevents T3‐induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF‐ĸB

  2020cites this paper
• ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19

  2020cites this paper
• Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7

  2020cites this paper
• ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.

  2020cites this paper
• Targeting the Protective Arm of the Renin-Angiotensin System to Reduce Systemic Lupus Erythematosus Related Pathologies in MRL-lpr Mice

  2020cites this paper
• Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

  2020cites this paper
• Angiotensin-(1–7) Treatment Restores Pancreatic Microcirculation Profiles

  2020cites this paper
• The renin angiotensin aldosterone system and COVID-19

  2020cites this paper
• Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals

  2020cites this paper
• β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

  2020cites this paper
• New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery.

  2020cites this paper
• The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation

  2020cites this paper
• Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways

  2019cites this paper
• Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma

  2019cites this paper
• Positive Modulation of Angiotensin II Type 1 Receptor–Mediated Signaling by LVV–Hemorphin-7

  2019cites this paper
• Angiotensin-II Drives Human Satellite Cells Toward Hypertrophy and Myofibroblast Trans-Differentiation by Two Independent Pathways

  2019cites this paper
• Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.

  2019cites this paper
• β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts

  2019cites this paper
• Angiotensin-(1-7) and the Heart

  2019cites this paper
• Counter-regulatory renin–angiotensin system in cardiovascular disease

  2019influential citation
• Calcimimetic R568 improved cardiac remodeling by classic and novel renin-angiotensin system in spontaneously hypertensive rats

  2019cites this paper
• Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential.

  2019cites this paper
• Biased Receptor Signaling in Drug Discovery

  2019cites this paper
• Therapeutic Potential of Targeting ß-Arrestin

  2019cites this paper
• Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations

  2019cites this paper
• Future pharmacological therapy in hypertension

  2018cites this paper
• Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors

  2018cites this paper
• Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

  2018cites this paper
• G-Protein–Coupled Receptors in Heart Disease

  2018cites this paper