Xenopus aristaless‐related homeobox (xARX) gene product functions as both a transcriptional activator and repressor in forebrain development

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Developmental Dynamics

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/dvdy.20234PMID 15614781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutations of ARX are associated with striking pleiotropy and consistent genotype–phenotype correlation

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• Polyalanine expansion of ARX associated with cryptogenic West syndrome

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• A restrictive role for Hedgehog signalling during otic specification in Xenopus.

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• Opposing actions of Arx and Pax4 in endocrine pancreas development.

  2003influential reference
• How a Hedgehog might see holoprosencephaly.

  2003cited by this paper
• Embryonic expression of cholesterogenic genes is restricted to distinct domains and colocalizes with apoptotic regions in mice.

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• Lissencephaly and the molecular basis of neuronal migration.

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• The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus

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• An orphan PRD class homeobox gene expressed in mouse brain and limb development

  2002cited by this paper
• Determination of the embryonic inner ear.

  2002cited by this paper
• Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

  2002influential reference
• ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation.

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  2001influential reference
• Superactivation of Pax6-mediated Transactivation from Paired Domain-binding Sites by DNA-independent Recruitment of Different Homeodomain Proteins*

  2001cited by this paper
• Early development of Xenopus laevis : a laboratory manual

  2000influential reference
• Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis.

  2000cited by this paper
• Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.

  2000cited by this paper
• Identification of synergistic signals initiating inner ear development.

  2000influential reference
• Mutations in holoprosencephaly

  2000influential reference
• Function for Hedgehog genes in zebrafish retinal development.

  2000cited by this paper
• Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map.

  1999cited by this paper
• Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.

  1999cited by this paper
• Physical and genetic interactions between Alx4 and Cart1.

  1999cited by this paper
• Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses*

  1999cited by this paper
• Vertebrate aristaless-related genes.

  1999cited by this paper
• The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals.

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• Xenopus eomesodermin is expressed in neural differentiation.

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  1998cited by this paper
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  1998cited by this paper
• Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates.

  1998influential reference
• The Rx homeobox gene is essential for vertebrate eye development

  1997cited by this paper
• Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate.

  1997cited by this paper
• Localizing the adhesive and signaling functions of plakoglobin.

  1997cited by this paper
• xnf7 functions in dorsal-ventral patterning of the Xenopus embryo.

  1997cited by this paper
• Xotx genes in the developing brain of Xenopus laevis.

  1996cited by this paper
• Inductive processes leading to inner ear formation during Xenopus development.

  1996cited by this paper
• Cloning and characterization of four murine homeobox genes.

  1996cited by this paper
• Synergistic effects of Vg1 and Wnt signals in the specification of dorsal mesoderm and endoderm.

  1996cited by this paper
• Normal table of Xenopus laevis (Daudin)

  1995cited by this paper
• Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.

  1995cited by this paper
• Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

  1994cited by this paper
• Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals.

  1993influential reference
• A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos.

  1993cited by this paper
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  1993cited by this paper
• Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila.

  1993cited by this paper
• Planar and vertical signals in the induction and patterning of the Xenopus nervous system

  1992cited by this paper
• Planar and vertical signals in the induction and patterning of the Xenopus nervous system.

  1992cited by this paper
• Whole-mount staining of Xenopus and other vertebrates.

  1991influential reference
• Cephalic expression and molecular characterization of Xenopus En-2.

  1991cited by this paper

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  2019cites this paper
• Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis.

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  2009cites this paper
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  2008cites this paper
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