The epigenetic landscape of T-cell acute lymphoblastic leukemia.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  International Journal of Biochemistry and Cell Biology

• Publication date

  2014-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.biocel.2014.04.015PMID 24786297
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The H3K27me3 demethylase UTX in normal development and disease

  2014cited by this paper
• The molecular profile of adult T‐cell acute lymphoblastic leukemia: Mutations in RUNX1 and DNMT3A are associated with poor prognosis in T‐ALL

  2013cited by this paper
• The histone demethylase UTX regulates stem cell migration and hematopoiesis.

  2013cited by this paper
• The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα.

  2013cited by this paper
• Promoter DNA Methylation Pattern Identifies Prognostic Subgroups in Childhood T-Cell Acute Lymphoblastic Leukemia

  2013influential reference
• Transcriptional regulation by Polycomb group proteins

  2013influential reference
• Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.

  2013influential reference
• Large conserved domains of low DNA methylation maintained by Dnmt3a

  2013cited by this paper
• Mutational landscape and significance across 12 major cancer types

  2013cited by this paper
• The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy

  2013cited by this paper
• Chromatin proteins and modifications as drug targets

  2013cited by this paper
• Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms

  2013cited by this paper
• Histone variants in pluripotency and disease

  2013cited by this paper
• Acute lymphoblastic leukaemia.

  2013cited by this paper
• Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions

  2013cited by this paper
• Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis

  2013cited by this paper
• An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

  2013cited by this paper
• Early T-cell precursor acute lymphoblastic leukaemia

  2013cited by this paper
• A new face of Borjeson–Forssman–Lehmann syndrome? De novo mutations in PHF6 in seven females with a distinct phenotype

  2013cited by this paper
• A comprehensive molecular study on Coffin-Siris and Nicolaides-Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling.

  2013cited by this paper
• Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

  2013cited by this paper
• Relapsed childhood acute lymphoblastic leukaemia.

  2013cited by this paper
• The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.

  2013cited by this paper
• Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

  2012cited by this paper
• X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

  2012cited by this paper
• The molecular basis of T cell acute lymphoblastic leukemia.

  2012influential reference
• Understanding the language of Lys36 methylation at histone H3

  2012cited by this paper
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.

  2012cited by this paper
• Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome.

  2012cited by this paper
• PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis

  2012cited by this paper
• DNA methylation pattern is altered in childhood T-cell acute lymphoblastic leukemia patients as compared with normal thymic subsets: insights into CpG island methylator phenotype in T-ALL

  2012cited by this paper
• The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

  2012cited by this paper
• Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma

  2012influential reference
• Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

  2012cited by this paper
• Notch signaling during human T cell development.

  2012cited by this paper
• UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

  2012cited by this paper
• Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

  2012influential reference
• IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

  2012cited by this paper
• UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.

  2012cited by this paper
• UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

  2012cited by this paper
• Functions of DNA methylation: islands, start sites, gene bodies and beyond

  2012influential reference
• PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.

  2012cited by this paper
• The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

  2012influential reference
• Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36

  2011cited by this paper
• Trithorax group proteins: switching genes on and keeping them active

  2011cited by this paper
• Cancer biology and NuRD: a multifaceted chromatin remodelling complex

  2011cited by this paper
• Dnmt3a is essential for hematopoietic stem cell differentiation

  2011cited by this paper
• Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

  2011cited by this paper
• ETV6 mutations in early immature human T cell leukemias

  2011influential reference
• PHF6 mutations in adult acute myeloid leukemia

  2011influential reference
• Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia.

  2011cited by this paper
• PHF6 Deletions May Cause Borjeson-Forssman-Lehmann Syndrome in Females

  2011cited by this paper
• Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

  2011cited by this paper
• p53-independent Epigenetic Repression of the p21WAF1 Gene in T-cell Acute Lymphoblastic Leukemia*

  2011cited by this paper
• The Polycomb complex PRC2 and its mark in life

  2011influential reference
• A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

  2011cited by this paper
• Charting histone modifications and the functional organization of mammalian genomes

  2011influential reference
• Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

  2011cited by this paper
• Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.

  2011cited by this paper
• Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia

  2011cited by this paper
• Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia

  2011cited by this paper
• A decade of exploring the cancer epigenome — biological and translational implications

  2011influential reference
• Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.

  2010cited by this paper
• The histone demethylase UTX enables RB-dependent cell fate control.

  2010cited by this paper
• Somatic mutation of EZH2 (Y641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal Center Origin

  2010cited by this paper
• Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

  2010cited by this paper
• Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

  2010cited by this paper
• Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers

  2010influential reference
• Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b

  2010cited by this paper
• Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

  2010cited by this paper
• Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

  2010cited by this paper
• T‐cell acute lymphoblastic leukemia in association with Börjeson–Forssman–Lehmann syndrome due to a mutation in PHF6

  2010cited by this paper
• PHF6 mutations in T-cell acute lymphoblastic leukemia

  2010influential reference
• Histone variants — ancient wrap artists of the epigenome

  2010cited by this paper
• Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.

  2010cited by this paper
• Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

  2010influential reference
• Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

  2010cited by this paper
• Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.

  2009cited by this paper
• Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.

  2009cited by this paper
• Faculty Opinions recommendation of Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

  2009cited by this paper
• Heterogeneous Nuclear Ribonucleoprotein L Is a Subunit of Human KMT3a/Set2 Complex Required for H3 Lys-36 Trimethylation Activity in Vivo*

  2009cited by this paper
• C/EBPA methylation is common in T-ALL but not in M0 AML.

  2009cited by this paper
• Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.

  2009cited by this paper
• Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer

  2009cited by this paper
• Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

  2009cited by this paper
• A quantitative atlas of mitotic phosphorylation

  2008cited by this paper
• H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

  2008influential reference
• Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes.

  2008cited by this paper
• Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences

  2008cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• A histone H3 lysine 27 demethylase regulates animal posterior development

  2007influential reference
• PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex*♦

  2007cited by this paper
• A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.

  2007influential reference
• UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

  2007influential reference
• The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

  2007cited by this paper
• The multifunctional nucleolus

  2007cited by this paper
• Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

  2007cited by this paper
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007influential reference
• The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.

  2007cited by this paper
• Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination

  2007cited by this paper

• Characterization of a PRKCE::ETV6 fusion as a potential oncogenic driver in T-cell acute lymphoblastic leukemia

  2025cites this paper
• Molecularly Targeted Small Molecule Inhibitor Therapy for Pediatric Acute Lymphoblastic Leukemia: A Comprehensive Review of Clinical Trials

  2025cites this paper
• Numerical analysis of coil designs to expedite fracture healing using dielectrophoresis with S method

  2025cites this paper
• Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia

  2025cites this paper
• HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathway

  2025cites this paper
• Tet2 is a tumor suppressor in the preleukemic phase of T-cell acute lymphoblastic leukemia

  2024cites this paper
• PHF6-altered T-ALL harbor epigenetic repressive switch at bivalent promoters and respond to 5-azacitidine and venetoclax.

  2023cites this paper
• Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

  2023cites this paper
• Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence.

  2022cites this paper
• Triptolide inhibits T-cell acute lymphoblastic leukaemia by affecting aberrant epigenetic events in the Wnt signalling pathway

  2022cites this paper
• A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

  2022cites this paper
• Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?

  2022cites this paper
• T-Cell Acute Lymphoblastic Leukemia—Current Concepts in Molecular Biology and Management

  2021cites this paper
• Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

  2021cites this paper
• Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL

  2021cites this paper
• The Emerging Landscape of Immune Cell Therapies.

  2020cites this paper
• Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults

  2020cites this paper
• Epigenetic modifications in acute lymphoblastic leukemia: From cellular mechanisms to therapeutics.

  2020cites this paper
• A unified atlas of CD8 T cell dysfunctional states in cancer and infection

  2020cites this paper
• Gene regulatory network of human GM-CSF secreting T helper cells

  2019cites this paper
• The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL

  2019cites this paper
• Mutagenic players in ALL progression and their associated signaling pathways.

  2019cites this paper
• The pathogenesis of thyroid autoimmune diseases: New T lymphocytes – Cytokines circuits beyond the Th1−Th2 paradigm

  2018cites this paper
• An integrated transcriptome analysis in T‐cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression

  2018cites this paper
• genomic epigenomic abnormality in pediatric cancer

  2018cites this paper
• The genetics and molecular biology of T-ALL.

  2017cites this paper
• Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation

  2017cites this paper
• Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

  2017cites this paper
• Pediatric T‐cell acute lymphoblastic leukemia

  2017cites this paper
• Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation

  2017cites this paper
• Arsenic induced complete remission in a refractory T-ALL patient with a distinct T-cell clonal evolution without molecular complete remission: A case report.

  2016cites this paper
• Targeting childhood, adolescent and young adult non‐Hodgkin lymphoma: therapeutic horizons

  2016influential citation
• Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.

  2016cites this paper
• De rol van PHF6 in acute T-cel leukemie

  2015cites this paper
• PLZF et les protéines du groupe Polycomb : interaction et implication dans la différenciation hématopoïétique normale et pathologique

  2015cites this paper
• Autophagy in acute leukemias: a double-edged sword with important therapeutic implications.

  2015cites this paper
• Site- and allele-specific polycomb dysregulation in T-cell leukaemia

  2015cites this paper
• Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia

  2014cites this paper
• PHF6-altered T-ALL harbored epigenetic repressive switch at bivalent promoters and respond to 5-azacitidine and venetoclax

  year unknowncites this paper