Microbial models of mammalian metabolism.

No abstract is available for this paper.

• Publication year

  1975

• Venue

  Journal of Pharmacy and Science

• Publication date

  1975-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/JPS.2600641104PMID 1195104
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The metabolism of aromatic acids by Pseudomonas testosteroni and P. acidovorans

  2004cited by this paper
• Microbial models of mammalian metabolism. O-Dealkylation of 10,11-dimethoxyaporphine.

  1975cited by this paper
• Arene oxides: a new aspect of drug metabolism.

  1974cited by this paper
• Molecular mechanisms of oxygen activation

  1974cited by this paper
• The role of gut flora in the reduction of aromatic nitro-groups.

  1974cited by this paper
• Human fecal flora: the normal flora of 20 Japanese-Hawaiians.

  1974cited by this paper
• Stereochemical aspects and metabolite formation in the in vivo metabolism of the psychotomimetic amine, 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane.

  1974cited by this paper
• Species-strain dependence of stereoselectivity in microbial oxidation of thioethers

  1974cited by this paper
• Thin-layer chromatographic determination of simple phenols in microbial extracts.

  1974cited by this paper
• Microbial conversion of antibiotics.

  1974cited by this paper
• Field ionization mass spectrometry. New tool for the analytical chemist

  1974cited by this paper
• Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata.

  1974cited by this paper
• Microbial conversion of antibiotics.

  1974cited by this paper
• Microbial models of mammalian metabolism. Aromatic hydroxylation.

  1974cited by this paper
• Microbiological synthesis of L-dopa.

  1974cited by this paper
• Tryptophol formation by Zygosaccharomyces priorianus.

  1973cited by this paper
• Therapeutic implications of the intestinal microflora.

  1973cited by this paper
• Microbial hydroxylation of 5-anilino-1,2,3,4-thiatriazole.

  1973cited by this paper
• Microbial degradation of piperonylic acid by Pseudomonas fluorescens

  1973cited by this paper
• Properties of a yeast cytochrome P-450-containing enzyme system which catalyzes the hydroxylation of fatty acids, alkanes, and drugs.

  1973cited by this paper
• The demethylation of methamphetamine by intestinal microflora

  1973cited by this paper
• Total synthesis of prostaglandins. IV. A completely stereospecific synthesis of prostaglandin E.

  1973cited by this paper
• Gas chromatographic analysis of drugs and drug metabolites in biological samples.

  1973cited by this paper
• Metabolism of clindamycin. II. Urinary excretion products of clindamycin in rat and dog.

  1973cited by this paper
• Microbial oxygenation of dialkylbenzenes (I)

  1973cited by this paper
• Studies on an unusual N-dealkylation reaction. II. Characteristics of the enzyme system and a proposed pathway for the reaction.

  1973cited by this paper
• Monooxygenase activity in Cunninghamella bainieri: evidence for a fungal system similar to liver microsomes.

  1973cited by this paper
• Interactions of substrates with a purified 4-methoxybenzoate monooxygenase system (O-demethylating) from Pseudomonas putida.

  1973cited by this paper
• Microbiological optical resolution of a racemic synthetic prostaglandin intermediate.

  1973cited by this paper
• The influence of stereochemical factors on drug disposition.

  1973cited by this paper
• Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

  1972cited by this paper
• Metabolism of 2-(4-chlorophenyl)thiazol-4-ylacetic acid (fenclozic acid) and related compounds by microorganisms.

  1972cited by this paper
• Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.

  1972cited by this paper
• Metabolic Interactions Among Environmental Chemicals and Drugs

  1972cited by this paper
• Guaiacol-O-methyltransferase: A mammalian enzyme capable of forming di-O-methyl catecholamine derivatives

  1972cited by this paper
• N‐Oxidation of primary and secondary amines to give hydroxylamines—a general metabolic route

  1972cited by this paper
• MECHANISM OF THE AROMATIZATION OF ARENE OXIDES.

  1972cited by this paper
• Mechanisms of mammalian hydroxylation: some novel metabolites of chlorobenzene.

  1972cited by this paper
• World directory of collections of cultures of microorganisms.

  1972cited by this paper
• Synthesis and antiinflammatoy activities of .alpha.-methylfluorene-2-acetic acid and related compounds

  1972cited by this paper
• Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.

  1972cited by this paper
• The enzymatic formation of 3,4-di-O-methylated dopamine metabolites by mammalian tissues.

  1972cited by this paper
• Arene oxides as intermediates in the oxidative metabolism of aromatic compounds. Isomerization of methyl-substituted arene oxides.

  1972cited by this paper
• A note on the identification of N‐hydroxyphenmetrazine as a metabolic product of phendimetrazine and phenmetrazine

  1972cited by this paper
• Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat.

  1972cited by this paper
• Conversion of naphthalene to trans-naphthalene dihydrodiol: evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes.

  1972cited by this paper
• Chemical oxidations with microorganisms

  1972cited by this paper
• Catechol O-Methyltransferase : IV. Factors Affecting m- and p-Methylation of Substituted Catechols

  1972cited by this paper
• Chemical structure-activity correlation in the O-methylation of substituted catechols by catechol O-methyltransferase.

  1972cited by this paper
• Synthesis and antiinflammatory activities of -methylfluorene-2-acetic acid and related compounds.

  1972cited by this paper
• Quantitative Relationships Between Lipophilic Character and Drug Metabolism

  1972cited by this paper
• Stereochemistry of microbiological hydroxylation. VI. Microbiological oxygenation of acyclic N-alkylbenzamides

  1971cited by this paper
• The oxidative cleavage of alkyl-nitrogen bonds in micro-organisms.

  1971cited by this paper
• Microbial transfonmations of antibiotics

  1971cited by this paper
• The NIH shift during the hydroxylation of aromatic substrates by fungi

  1971cited by this paper
• N-oxide formation and related reactions in drug metabolism.

  1971cited by this paper
• THE METABOLISM OF CERTAIN DRUGS AND FOOD CHEMICALS IN MAN *

  1971cited by this paper
• Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon Atoms

  1971cited by this paper
• Microbial Transformation of Antibiotics: Phosphorylation of Clindamycin by Streptomyces coelicolor Müller

  1971cited by this paper
• Microbial transformation of antibiotics. V. Clindamycin ribonucleotides.

  1971cited by this paper
• Microbial transformations of antibiotics.

  1971cited by this paper
• Metabolic oxidation of aliphatic basic nitrogen atoms and their alpha-carbon atoms.

  1971cited by this paper
• In vitro metabolism of certain nornuciferine derivatives.

  1971cited by this paper
• Catechol O-methyltransferase. The para- and meta-O-methylations of noradrenaline.

  1971cited by this paper
• Cis-1,2-dihydroxy-1,2-dihydronaphthalene: a bacterial metabolite from naphthalene.

  1971cited by this paper
• Correlation of analgesic potencies of N‐substituted normeperidines and in vitroN‐dealkylation

  1971cited by this paper
• Non‐oxidative demethylation of trimethylamine N‐oxide by Pseudomonas aminovorans

  1971cited by this paper
• Reduction of niridazole by rat liver santhine oxidase.

  1971cited by this paper
• Enzymatic reduction of niridazole by rat liver microsomes.

  1971cited by this paper
• Catabolism of aromatic compounds by micro-organisms.

  1971cited by this paper
• Microbial Modification of Mycophenolic Acid

  1970cited by this paper
• [N-demethyl ajmaline].

  1970cited by this paper
• In vivo hydroxylation of the alkaloid acronine, an experimental antitumor agent.

  1970cited by this paper
• Role of the arene oxide-oxepin system in the metabolism of aromatic substrates. IV. Stereochemical considerations of dihydrodiol formation and dehyrogenation

  1970cited by this paper
• Microbial aromatization of androsta-1, 4, 7- triene-3, 17-Dione.

  1970cited by this paper
• Biologically active compounds containing 2,3-dihydroxybenzoic acid and serine formed by Escherichia coli.

  1970cited by this paper
• A comparison of brain and liver catechol O-methyltransferase.

  1970cited by this paper
• Metabolism of acetanilides and anisoles with rat liver microsomes.

  1970cited by this paper
• Influence of mode of steroid substrate addition on conversion of steroid and growth characteristics in a mixed culture fermentation.

  1970cited by this paper
• 1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene.

  1970cited by this paper
• Catechol O-Methyltransferase: III. m- and p-O-Methylation of Catecholamines and Their Metabolites

  1970cited by this paper
• Cytochrome P-450 and b5 in Claviceps purpurea: Interconversion of P-450 and P-420

  1970cited by this paper
• Importance of demethylenation in the metabolism in vivo and in vitro of methylenedioxyphenyl synergists and related compounds in mammals.

  1970cited by this paper
• Catechol O-methyltransferase. 3. M- and p-O-methylation of catecholamines and their metabolites.

  1970cited by this paper
• [35] Microbial steroid esterases

  1969cited by this paper
• Metabolism in vitro and in vivo of pentazocine.

  1969cited by this paper
• Metabolism of Coumarin in Man

  1969cited by this paper
• [Microbial transformation of thebaine].

  1969cited by this paper
• Structure-activity relationships among substrates for a rabbit kidney reductase. Quantum chemical calculation of substituent parameters.

  1969cited by this paper
• The role of gut flora in the enterohepatic circulation of stilboestrol in the rat.

  1969cited by this paper
• Indole(ethyl)amine N-Methyltransferase in the Brain

  1969cited by this paper
• Studies on the mechanism of nitro reduction by rat liver.

  1969cited by this paper
• MICROBIAL TRANSFORMATION OF ANTIBIOTICS. III

  1969cited by this paper
• The isolation and identification of 2,3-dihydroxybenzoic acid and 2-N,6-N-di-92,3-dihydroxybenzoyl)-L-lysine formed by iron-deficient Azotobacter vinelandii.

  1969cited by this paper
• Metabolic hydroxylations of trans-stilbene.

  1969cited by this paper
• Microbial transformation of antibiotics. 3. Conversion of clindamycin to 1'-demethylclindamycin and clindamycin sulfoxide by Streptomyces species.

  1969cited by this paper
• The in vitro and in vivo metabolism of optically active methylcyclohexanols and methylcyclohexanones

  1969cited by this paper
• Migration of deuterium during aryl hydroxylation. 3. Effect of ortho- and meta- substituents.

  1969cited by this paper
• Microbial transformation of antibiotics. I. Production of lincomycin sulfoxide and 1-demethylthio-1-hydroxylincomycin by S. lincolnensis.

  1969cited by this paper
• The metabolism of tolbutamide in rat liver.

  1969cited by this paper

• Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities

  2025cites this paper
• Recent advances in fungal xenobiotic metabolism: enzymes and applications

  2023cites this paper
• MICROBIAL SCREENING AND KINETICS OF METABOLISM OF CLOBAZAM

  2022cites this paper
• Biotransformation of the Phenolic Constituents from Licorice and Cytotoxicity Evaluation of Their Metabolites

  2021cites this paper
• Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice.

  2021cites this paper
• Bioactive metabolites of Cunninghamella, Biodiversity to Biotechnology

  2021cites this paper
• Microbial Biotransformation of Iridoid Glycosides from Gentiana Rigescens by Penicillium Brasilianum

  2020cites this paper
• Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review

  2020cites this paper
• Bio- and chemo- transformations of glabranin and 7-O-methylglabranin and cytotoxic evaluations of the transformed products

  2020cites this paper
• Fungal Biotransformation of Clobazam–Induction, Inhibition and Kinetic Studies

  2020cites this paper
• Identification of the production and biotransformational changes of soluble microbial products (SMP) in wastewater treatment processes: A short review.

  2020cites this paper
• New anti-neuroinflammatory steroids against LPS induced NO production in BV2 microglia cells by microbial transformation of isorhodeasapogenin.

  2020cites this paper
• Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects

  2019cites this paper
• BIOTRANSFORMATION OF METRONIDAZOLE BY CUNNINGHAMELLA ELEGANS ATCC 9245

  2019cites this paper
• Microbial biotransformation – an important tool for the study of drug metabolism

  2018cites this paper
• Screening and evaluation of fungal resources for loratadine metabolites

  2018cites this paper
• Biotransformation of Neoruscogenin by the Endophytic Fungus Alternaria eureka.

  2018cites this paper
• Identification of rotundic acid metabolites after oral administration to rats and comparison with the biotransformation by Syncephalastrum racemosum AS 3.264.

  2018cites this paper
• The analysis of toxic connections content in water by spectral methods

  2017cites this paper
• Overview on the Biochemical Potential of Filamentous Fungi to Degrade Pharmaceutical Compounds

  2017cites this paper
• Antifungal and Cytotoxic Assessment of Lapachol Derivatives Produced by Fungal Biotransformation

  2016cites this paper
• Systematic Exploration of Biotransformation Reactions of Amine-Containing Micropollutants in Activated Sludge.

  2016cites this paper
• FUNGAL BIOTRANSFORMATION STUDIES OF ZOLMITRIPTAN – A SUBSTRATE FOR CYP1A2

  2015cites this paper
• Fungal metabolism of naphthoflavones

  2015cites this paper
• Microbial transformations of buagarofuran, an anti-anxietic agent

  2014cites this paper
• Fungal Biotransformation of Fenofibrate

  2014cites this paper
• Non-terpenoid biotransformations by Mucor species

  2014cites this paper
• Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide.

  2014cites this paper
• Microbial production of 1α-hydroxyvitamin D3 from vitamin D3

  2014cites this paper
• Purification and characteristics of an inducible by polycyclic aromatic hydrocarbons NADP(+)-dependent naphthalenediol dehydrogenase (NDD) in Mucor circinelloides YR-1.

  2014cites this paper
• Characterization of in vitro and in vivo metabolites of carnosic acid, a natural antioxidant, by high performance liquid chromatography coupled with tandem mass spectrometry.

  2014cites this paper
• HPLC analysis of midodrine and desglymidodrine in culture medium: evaluation of static and shaken conditions on the biotransformation by fungi.

  2013cites this paper
• Biotransformation of 4-sec-butylphenol by Gram-positive bacteria of the genera Mycobacterium and Nocardia including modifications on the alkyl chain and the hydroxyl group

  2013cites this paper
• Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.

  2013cites this paper
• Fungal transformation of cedryl acetate and α-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites.

  2013cites this paper
• Microbial Biotransformation of Gentiopicroside by the Endophytic Fungus Penicillium crustosum 2T01Y01

  2013influential citation
• UNIVERSIDADE FEDERAL DE GOIÁS FACULDADE DE FARMÁCIA PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS

  2013cites this paper
• Terpenoid biotransformations by Mucor species

  2013cites this paper
• Microbial Metabolism of Rofecoxib, A Selective COX-2 Inhibitor

  2012cites this paper
• Chiral HPLC analysis of donepezil, 5-O-desmethyl donepezil and 6-O-desmethyl donepezil in culture medium: application to fungal biotransformation studies

  2012cites this paper
• Apple Pomace ; A source of Pharmaceuticals

  2012cites this paper
• Microbial Metabolism and Inhibition Studies of Phenobarbital

  2012cites this paper
• Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.

  2012cites this paper
• Growth of fungi on volatile aromatic hydrocarbons: environmental technology perspectives

  2012influential citation
• LC–MS–MS determination of ibuprofen, 2-hydroxyibuprofen enantiomers, and carboxyibuprofen stereoisomers for application in biotransformation studies employing endophytic fungi

  2011cites this paper
• Microbial mannosidation of bioactive chlorogentisyl alcohol by the marine-derived fungus Chrysosporium synchronum.

  2011cites this paper
• Biotransformation of bioactive (-)-mellein by a marine isolate of bacterium Stappia sp.

  2010cites this paper
• Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.

  2010cites this paper
• Microbial transformation of albendazole.

  2010cites this paper
• Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids

  2010cites this paper
• Microbiological transformation of 1,2-diphenyl-3,5 dioxo-4-n-butyl pyrazolidine (phenylbutazone)

  2010cites this paper
• Biotransformation of Celecoxib Using Microbial Cultures

  2010cites this paper
• Microbial glucosylation of flavonols by Cunninghamella echinulata.

  2010cites this paper
• Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294.

  2010cites this paper
• Oxidation of meloxicam by Streptomyces griseus

  2009cites this paper
• Microbial transformation of a monoterpene, geraniol, by the marine-derived fungus Hypocrea sp.

  2009cites this paper
• Biosimulation of drug metabolism--a yeast based model.

  2009cites this paper
• Rapid HPLC Determination of Venlafaxine in Microbial Biotransformation Studies

  2009cites this paper
• In vitro studies on metabolism of salvinorin A

  2009cites this paper
• 1 Biotransformations in Small-molecule Pharmaceutical Development

  2009cites this paper
• Metabolism of fluoroorganic compounds in microorganisms: impacts for the environment and the production of fine chemicals

  2009cites this paper
• Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac

  2009cites this paper
• Cunninghamella--a microbial model for drug metabolism studies--a review.

  2009cites this paper
• Comparative analysis on microbial and rat metabolism of ginsenoside Rb1 by high-performance liquid chromatography coupled with tandem mass spectrometry.

  2008cites this paper
• Studies on Metabolism of Losartan using Microbes

  2008cites this paper
• Stereoselective analysis of thioridazine-2-sulfoxide and thioridazine-5-sulfoxide: an investigation of rac-thioridazine biotransformation by some endophytic fungi.

  2008cites this paper
• Fungal Transformation of Dydrogesterone and Inhibitory Effect of Its Metabolites on the Respiratory Burst in Human Neutrophils

  2008cites this paper
• Microbial transformation of ginsenoside Rb1 by Acremonium strictum

  2008cites this paper
• Metabolite Generation via Microbial Biotransformations with Actinomycetes: Rapid Screening for Active Strains and Biosynthesis of Important Human Metabolites of Two Development-Stage Compounds, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methy

  2008cites this paper
• Use of yeast species as the biocomponent for priority environmental contaminants biosensor devices

  2008cites this paper
• Biosynthesis of Drug Metabolites Using Microbes in Hollow Fiber Cartridge Reactors: Case Study of Diclofenac Metabolism by Actinoplanes Species

  2008cites this paper
• Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites

  2008cites this paper
• Microbial Transformation of Nitrogenous Compounds

  2007cites this paper
• Carbocyclic Aromatic Compounds without Halogen Substituents

  2007cites this paper
• Biotransformation of gallic acid by Beauveria sulfurescens ATCC 7159

  2007cites this paper
• Oxidation of terfenadine by Streptomyces platensis: Influence of culture medium on metabolite formation

  2007cites this paper
• Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites.

  2007cites this paper
• The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by aPenicillium species

  2007cites this paper
• APPLICATION OF BIOCATALYSIS TO DRUG METABOLISM: PREPARATION OF MAMMALIAN METABOLITES OF A BIARYL-BIS-SULFONAMIDE AMPA (α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID) RECEPTOR POTENTIATOR USING Actinoplanes missouriensis

  2006cites this paper
• Microbial metabolism of evodiamine by Penicillium janthinellum and its application for metabolite identification in rat urine

  2006cites this paper
• Application of Biocatalysis to Drug Metabolism: Preparation of Mammalian Metabolites of a Biaryl-Bis-Sulfonamide AMPA Receptor Potentiator Using Actinoplanes missouriensis

  2006cites this paper
• Structure Elucidation and Antibacterial Activity of New Fungal Metabolites of Sclareol

  2006cites this paper
• Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.

  2006cites this paper
• Non-Target-Screening organischer Substanzen in Sedimenten : Mikrobieller Abbau aromatischer Verbindungen

  2006cites this paper
• Microbial and enzymatic transformations of flavonoids.

  2006cites this paper
• Microbial transformation of (-)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products.

  2005cites this paper
• Microbial Transformations of Gelomulide G: A Member of the Rare Class of Diterpene Lactones

  2005cites this paper
• Preparação de metabólitos fase I e II do derivado N- fenilpiperazínico (LASSBio 581 via bioconversão por Cunninghamella echinulata ATCC 9244 e Mortierella isabelina NRRL 1757

  2005cites this paper
• Correlation of Biological Activity and Reactor Performance in Biofiltration of Toluene with the Fungus Paecilomyces variotii CBS115145

  2005cites this paper
• Regiospecific oxidation of naphthalene and fluorene by toluene monooxygenases and engineered toluene 4-monooxygenases of Pseudomonas mendocina KR1.

  2005cites this paper
• METABOLISM OF MIXTURES OF POLYCYLIC AROMATIC

  2005cites this paper
• Microbial Models of Mammalian Metabolism: Stereoselective Metabolism of Warfarin in the Fungus Cunninghamella elegans

  2004cites this paper
• Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

  2004cites this paper
• Cinética de degradación del naftaleno por células inmovilizadas húmedas de Bacillus alcalophilus cepa IDO-225

  2004cites this paper
• Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.

  2004cites this paper
• Microbial metabolism of the environmental estrogen bisphenol A

  2003cites this paper
• Microbial transformations of S-naproxen by Aspergillus niger ATCC 9142.

  2003cites this paper
• Transformations of testosterone and related steroids in Absidia glauca culture

  2003cites this paper
• Microbial transformation of terreusinone, an ultraviolet-A (UV-A) protecting dipyrroloquinone, by Streptomyces sp.

  2003cites this paper
• Biotransformation of drugs by microbial cultures for predicting mammalian drug metabolism.

  2003cites this paper